Tag: M.W:200-300

Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. , Name: 2-(Trifluoromethyl)-10H-phenothiazine, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Kandile, Nadia G., introduce the new discover.

New pyrano[2,3-c]pyridazine derivatives with antimicrobial activity synthesized using piperidine as the organocatalyst

A simple and efficient method for the synthesis of highly diverse pyrano[2,3-c]pyridazines was achieved by a one pot multicomponent reaction using piperidine as the organocatalyst. The synthesis of a series of heterocyclic derivatives with varying functionality (e. g. thiazine, tetrazole and pyrimidine) incorporating the pyrano[2,3-c]pyridazine moiety were achieved via reaction of 2a-e with different reagents. The structures of the synthesized derivatives were elucidated by FTIR, MS, H-1 and C-13 NMR spectroscopy. A number of the newly synthesized targeted compounds 2b-e, 3a-c and 4a-c were evaluated for their in vitro antibacterial activity and were compared with chloramphenicol and nystatin as broad spectrum reference standard antibiotics. Tests were carried out against Staphylococcus aureus (MTCC3160) and Enterococcusi fecalis as Gram-positive bacteria, and Escherichia coli (MTCC1652) and Klebsiella pneumonia as Gram-negative bacteria. Antifungal potential against Candida albicans, and Aspergillus albicans strains were also evaluated. The results revealed that compounds 3a and 3c showed strong significant activity relative to the reference against these bacterial and fungal strains.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 92-30-8. Name: 2-(Trifluoromethyl)-10H-phenothiazine.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New month, new HOT articles! We are pleased to share a selection of our referee-recommended HOT articles in 2021. We hope you enjoy reading these articles. , HPLC of Formula: https://www.ambeed.com/products/56-17-7.html, 56-17-7, Name is 2,2′-Disulfanediyldiethanamine dihydrochloride, molecular formula is C4H14Cl2N2S2, belongs to thiazines compound. In a document, author is Sudarsan, S., introduce the new discover.

Ecofriendly pH-Tunable Hydrogels for Removal of Perilous Thiazine Dye

Reactive dyes are extremely toxic and harmful to the environment even present at very low concentration. In this study, sodium alginate based reusable hydrogels was prepared for the removal of methylene blue from waste water. pH-tunable hydrogels was prepared by the introduction of ionic pendant functionalities on sodium alginate (SA) by the utilization of ethylene glycol and acrylic acid through condensation followed by free radical polymerization. The structure, formation and thermal stability of hydrogel was identified by Fourier transform infra red spectroscopy and thermogravimetric analysis respectively. Swelling nature at different pH ranges and the humidity contents of both dried and dye adsorbed hydrogels was investigated. The morphology of the dry and dye adsorbed hydrogel was also studied using scanning electron microscopy. The swelling studies infer that pronounced swelling obtained at higher pH than at lower pH. The surface morphology of plain hydrogel before and after adsorption of methylene blue (MB) was examined by SEA analysis. The adsorption tendency of the SEA hydrogel in MB was steadily investigated at different pH, contact time, concentration dye and adsorbent dosage. All prepared hydrogels were performed well in the removal of MB from waste water up to 80-98%. Recycling of hydrogels has a vital role for waste water treatment and it can be done by desorption studies which shows that 0.1 N HCl revealed higher elution efficiency i.e. 90.00%. Furthermore, adsorption-desorption studies suggested that SA based hydrogels contributes to enhance the removal efficacy, which renders the hydrogels well-designed for the efficient removal of cationic dyes (MB). However, polyol based hydrogels have been chosen for an adsorbent because of low-cost, ecofriendly, biocompatible and efficient biosorbents. [GRAPHICS] .

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Knowledge is power! The discovery of a new compound of 139-65-1 can be both undesirable and beneficial. Unexpected comples compound may bring with it unwanted properities, but intentionally finding one can lead to intentional improvenments of the physiochenical properties of the material, Product Details of 139-65-1.

Synthesis of Antifungal Agents from Xanthene and Thiazine Dyes and Analysis of Their Effects

Indoor fungi growth is an increasing home health problem as our homes are more tightly sealed. One thing that limits durability of the antifungal agents is the scarcity of reactive sites on many surfaces to attach these agents. In order to increase graft yield of photosensitizers to the fabrics, poly(acrylic acid-co-styrene sulfonic acid-co-vinyl benzyl rose bengal or phloxine B) were polymerized and then grafted to electrospun fabrics. In an alternative process, azure A or toluidine blue O were grafted to poly(acrylic acid), which was subsequently grafted to nanofiber-based and microfiber-based fabrics. The fabrics grafted with photosensitizers induced antifungal effects on all seven types of fungi in the order of rose bengal > phloxine B > toluidine blue O > azure A, which follows the quantum yield production of singlet oxygen for these photoactive dyes. Their inhibition rates for inactivating fungal spores decreased in the order of P. cinnamomi, T. viride, A. niger, A. fumigatus, C. globosum, P. funiculosum, and M. grisea, which is associated with lipid composition in membrane and the morphology of fungal spores. The antifungal activity was also correlated with the surface area of fabric types which grafted the photosensitizer covalently on the surface as determined by the bound color strength.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Read on for other articles about 139-65-1. Product Details of 139-65-1.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 139-65-1, Name is 4,4-Thiodianiline, belongs to thiazines compound, is a common compound. In a pantent, author is Lv, Xin-Mei, once mentioned the new application about 139-65-1, COA of Formula: https://www.ambeed.com/products/139-65-1.html.

Comparative transcriptome analysis of Anguilla japonica livers following exposure to methylene blue

The thiazine dye methylene blue is widely used as a disinfectant and antidote in veterinary medicine. Here, we compared transcriptome differences in the liver of Anguilla japonica exposed to methylene blue using Illumina RNA sequencing technology. A total of 75,953,174 and 86,499,866 clean reads with an average length of 126bp from control and treatment groups respectively. A total of 148,238 transcripts were assembled, with 62,152 components were assembled. Overall, 416,991 unigenes were checked against the National Center of Biotechnology Information, Non-redundant, Cluster of Orthologous Groups (COG), and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Of these, 18,541 genes were judged to be differently expressed. The gene ontology (GO) terms molecular function and biological process were the most enriched in protein binding, followed by ATP binding and regulation of transcription, and DNA-dependent. KEGG pathway analysis revealed significant enrichment of N-glycan biosynthesis and the citrate cycle. This study determined that unigenes related to transmembrane transport and drug metabolism in A.japonica were differentially expressed following exposure to methylene blue. These findings can shed insight into the mechanism of methylene blue metabolism in this economically important species.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. In a pantent, Crystal structure of Brinzolamide: a carbonic anhydrase inhibitor. SDS of cas: 92-30-8.

Crystal structure of Brinzolamide: a carbonic anhydrase inhibitor

In crystal structure of the title compound, C12H21N3O5S3 [systematic name: (R)-4-ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide], there exist three kinds of hydrogen-bonding interactions. The sulfonamide group is involved in hydrogen bonding with the secondary amine and the methoxy O atom, resulting in the formation of layers parallel to the bc plane. The layers are linked by an N-H center dot center dot center dot O hydrogen bond involving a sulfonamide O atom as acceptor and the secondary amine H atom as donor, which gives rise to the formation of a unique bilayer structure. The absolute structure of the molecule in the crystal was determined by resonant scattering [Flack parameter = 0.01 (4)].

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 92-30-8 help many people in the next few years. SDS of cas: 92-30-8.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. , Recommanded Product: N-Cyclohexyltaurine, 103-47-9, Name is N-Cyclohexyltaurine, molecular formula is C8H17NO3S, belongs to thiazines compound. In a document, author is Haggam, R. A., introduce the new discover.

One-Pot Multicomponent Synthesis and Anticancer Activity of 1,3-Cyclopentathiazine and Pyrimidothiazine Derivatives

Novel 1,3-cyclopentathiazine and pyrimidothiazine derivatives were synthesized starting from 7-benzyl-4-phenylcyclopenta[d][1,3]thiazin-2-amine (CTA) prepared by a one-pot multicomponent reaction of cyclopentanone, benzaldehyde, and thiourea. Cyclocondensation of CTA with benzylidenemalononitrile gave a pyrimidothiazine. Oxidation of cyclopentathiazine with hydrogen peroxide afforded the corresponding epoxide, while its alkylation with ethyl iodide yielded anN-ethyl derivative. Cyclopentylidenemalononitrile was reacted with formaline and carbon disulfide to obtain pyridine-4-carbonitrile and thiapyrane, respectively, and the reactions of cyclopentylidenemalononitrile with aryl isocyanate and aryl isothiocyanate gave condensed diimino-substituted cyclopentanaphthyridine-1,6-dione and dithiaacenaphthylene-3,8-diylidedibenzamide, respectively. Heating cyclopentanone with benzoyl isothiocyanate and benzoyl chloride produced a sulfide derivative and an enolic dione, respectively. The structures of the newly synthesized compounds were confirmed by spectral analysis, and some products were screened for anticancer activity.

As always, wish you can browse a selection of our May HOT articles below about 103-47-9, Recommanded Product: N-Cyclohexyltaurine.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. In a pantent, Methylene blue induces an analgesic effect by significantly decreasing neural firing rates and improves pain behaviors in rats. SDS of cas: 92-39-7.

Methylene blue induces an analgesic effect by significantly decreasing neural firing rates and improves pain behaviors in rats

Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings. Notably, there have been several attempts to introduce MB for attenuating pain in the last decade. Some clinical studies reported remarkable results, which, however, have been much debated. In addition, accumulating evidence have revealed that MB diminishes voltage-gated sodium channel currents. Accordingly, in the present study, we conducted in vivo experiments, including in vivo single nerve recording and behavioral test, to investigate whether MB dampens neural firing rates and ultimately contributes to pain relief. As a result, neural firing rates significantly decreased and finally converged to zero after MB administration. This event lasted longer than that of lidocaine and was dose-dependently modulated. Furthermore, there was a marked improvement in pain behaviors. The withdrawal threshold and latency of hind paws significantly rose post-MB administration. Therefore, these results demonstrate that MB lessens pain by significantly weakening neural excitability, which implies a strong possibility that this dye may be developed as a pain-relieving medication in the future. This is the first in vivo study to elucidate the effect of MB on nerves and pain relief. (C) 2021 Elsevier Inc. All rights reserved.

SDS of cas: 92-39-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 92-39-7.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. , Related Products of 103-47-9, 103-47-9, Name is N-Cyclohexyltaurine, molecular formula is C8H17NO3S, belongs to thiazines compound. In a document, author is Ziolkowska, Dorota, introduce the new discover.

Spectral Study on Association of Thiazine Dyes with Anionic Polymers

Feasible method of quantitative determination of anionic polymers in aqueous solutions was described using poly(styrene sulfonate) and poly(acrylate) sodium salts as an example. The method consists in absorbance measurements while titrating with thiazine dye. Volume of dye solution needed to attain specified value of absorbance is linearly dependent on polymer concentration. Optimal wavelengths are 666nm and 640nm for Methylene Blue dye and Toluidine Blue dye, respectively. Calibration plots are straight lines (r(2) > 0.99) ensuring good accuracy of the method developed. Range of measurable concentrations is dependent on chosen value of end-point absorbance.

Related Products of 103-47-9, The π-electrons of these planar compounds are free to cycle around the circular arrangements of atoms found in the aromatic moieties. This stems from the resonance found in planar ring systems, like benzene, and 103-47-9.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry built the modern world, from the materials that make up the everyday objects around us, the batteries in our devices and cleaning products that help to maintain sanitation. , Recommanded Product: 92-39-7, 92-39-7, Name is 2-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS, belongs to thiazines compound. In a document, author is Szczesniak-Siega, Berenika M., introduce the new discover.

Synthesis and biological evaluation as well as in silico studies of arylpiperazine-1,2-benzothiazine derivatives as novel anti-inflammatory agents

Novel arylpiperazine-1,2-benzothiazine derivatives have been designed and synthesized as potential antiinflammatory agents. Their structure and properties have been studied using spectroscopic techniques (H-1 NMR, C-13 NMR, FT-IR), MS, elemental analyses, and single-crystal X-ray diffraction (SCXRD, for compound 7b). This study aimed to evaluate the inhibitory activity of new derivatives against both cyclooxygenase isoforms COX-1 and COX-2 due to the similarity of new compounds to oxicams drugs from the NSAIDs group. All new compounds were divided into two series – A and B – with a different linker between thiazine and piperazines nitrogens. Series A included the three-carbon aliphatic linker and series B – two-carbon with a carbonyl group. According to in vitro and molecular docking studies all new compounds exhibited cyclooxygenase inhibitory activity. The series of A compounds included COX-1 inhibitors only. In contrast, the B series showed inhibition of both COX-1 and COX-2, which suggested the importance of the acetoxy linker for COX-2 inhibition. Moreover, the most selective compound 7b, towards COX-2, was non-toxic for the normal human cell line (in concentration of 10 mu M) comparable to reference drug meloxicam. Additionally, investigation of influence on model membranes confirmed the ability of the compound 7b to penetrate lipid bilayers which seemed to be important to the influence with membrane protein-cyclooxygenase.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

New month, new HOT articles! We are pleased to share a selection of our referee-recommended HOT articles in 2021. We hope you enjoy reading these articles. , Name: 2,2′-Disulfanediyldiethanamine dihydrochloride, 56-17-7, Name is 2,2′-Disulfanediyldiethanamine dihydrochloride, molecular formula is C4H14Cl2N2S2, belongs to thiazines compound. In a document, author is Thakur, Alok Singh, introduce the new discover.

Synthesis and oral hypoglycemic effect of novel thiazine containing trisubstituted benzenesulfonylurea derivatives

A new series of 3-(4-substituted phenyl)-1-(4-(4,6-dimethyl-6H-1,3-thiazin-2-yl)phenylsulfonyl)-1-substituted urea (5a-o) was synthesized by an effectual route via sulfonylcarbamates and explores the novel site for substitution in sulfonylurea as well as the way of thiazine can be prepared. The molecules were established by elemental analysis and spectroscopic viz. IR, H-1 NMR, C-13 NMR and MS techniques. All the fifteen derivatives were shown very prominent oral hypoglycemic effect at the dose of 40 mg/kg body weight (p.o.) in respect of standard drug glibenclamide and control. The hypoglycemic effect was studied using oral glucose tolerance test in normal and NIDDM in STZ-rat model. The compounds 5a, 5d, 5f, 5i, 5k and 5n were dominant out of fifteen derivatives for blood glucose lowering activity (more than 80%) when comparing with NIDDM control. These derivatives were either containing simply phenyl ring (5a, 5f and 5k) on to the second amine of sulfonylurea (R’ = H) or nitro group at the para position in compound 5d, Si and 5n (R’ = NO2) to produce significant oral hypoglycemic effect. Other structural activity relationship is also observed regarding the heteroaromatic and substituted aromatic group at R and R’ position respectively. (C) 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride, We very much hope you enjoy reading the articles and that you will join us to present your own research about 56-17-7.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem