Tag: M.W=200-250

I found the field of Chemistry very interesting. Saw the article Preparation of functionalized star polymer nanoparticles by RAFT polymerization and their application in positionally assembled enzymes for cascade reactions published in 2019.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Cao, H; Tan, TW (corresponding author), Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A well-defined functional star polymer nanoparticle was prepared using an “ arm first” approach via RAFT polymerization. In this work, N-adamantylacrylamide and N-succinimidyl acrylate were copolymerized with N-isopropylacrylamide sucessfully. The obtained diblock copolymer regarded as an “ arm” endowed the star polymer with multiple conjugate functions. By adjusting the amount of crosslinking agent, the size and polydispersity of the star polymer were controlled. With the star polymer as the scaffold, a sequential multi-enzyme system was constructed, where HRP was placed in the inner layer through covalent conjugation, and b-cyclodextrin-modified GOx was assembled in the outer layer through hostguest recognition. More interestingly, the activity of the enzyme modified by b-cyclodextrin was improved. In addition to the enhanced thermal stability, this multienzyme system also exhibited a reduced Km value (from 2.18 mM to 0.39 mM) and an excellent substrate affinity. The specificity constant (Kcat/Km) for GOx in the star polymer@ HRP@ GOx system was 1.7-fold higher than that of the free HRP with free GOx system. This strategy will promote the development of biocatalysis reactions and biosensors as a promising method.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Investigation on vitamin e succinate based intelligent hyaluronic acid micelles for overcoming drug resistance and enhancing anticancer efficacy WOS:000493896400007 published article about REDOX-RESPONSIVE MICELLES; MULTIDRUG-RESISTANCE; DELIVERY SYSTEM; CO-DELIVERY; TARGETING DELIVERY; IN-VITRO; PACLITAXEL; NANOPARTICLES; DOCETAXEL in [Hou, Lin; Tian, Chunyu; Chen, Dandan; Yuan, Yujie; Yan, Yingshan; Huang, Qianxiao; Zhang, Huijuan; Zhang, Zhenzhong] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou, Henan, Peoples R China; [Hou, Lin; Huang, Qianxiao; Zhang, Huijuan; Zhang, Zhenzhong] Key Lab Targeting Therapy & Diag Crit Dis, Zhengzhou, Henan, Peoples R China; [Hou, Lin; Huang, Qianxiao; Zhang, Huijuan; Zhang, Zhenzhong] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou, Henan, Peoples R China; [Tian, Chunyu; Chen, Dandan; Yuan, Yujie; Yan, Yingshan; Huang, Qianxiao] Zhengzhou Univ, Modern Anal & Comp Ctr, Zhengzhou, Henan, Peoples R China in 2019.0, Cited 29.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. SDS of cas: 56-17-7

Multidrug resistance (MDR) is a major reason for anticancer chemotherapy failure, and P-glycoprotein (P-gp) over-expressing on tumor cells is considered as the important target to overcome MDR. Emerging reports have showed that vitamin E (VE) can cause significant reversal of MDR due to inhibition of ATPase activity. Accordingly, we synthesized hyaluronic acid (HA) conjugated vitamin E succinate (VES) polymer, which can self-assemble into micelles and thus achieve high drug (paclitaxel (PTX) used as model drug) encapsulation as well as tumor accumulation owing to the enhanced permeability and retention (EPR) effect and HA active targeting ability. In addition, the linker between HA and VES utilized in this work was disulfide bond with reduction-sensitive property, which would respond to high glutathione (GSH) concentration in tumor cytoplasmic environment and trigger HA-CYS-VES polymer disassociation and drug release. In vitro, PTX loaded HA-CYS-VES demonstrated enhanced cytotoxicity, high apoptosis-inducing activities and reversal effects of PTX on MCF-7/Adr cells, compared to PTX. Also, cellular uptake and intracellular PTX accumulation tests displayed that PTX loaded HA-CYS-VES could more efficiently enter tumor cells and selectively release drug in cytosol so as to facilitate its function on microtubule. More importantly, PTX loaded HA-CYS-VES showed better tumor targeting ability, improved antitumor efficacy and low adverse effects on tumor-bearing mice. In conclusion, PTX loaded HA-CYS-VES exhibited a great potential for reversing MDR in anticancer chemotherapeutics.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. Recently I am researching about ANTIGEN; SIRNA; NANOPARTICLES; LIPOSOMES; NANOGELS; ADJUVANT; IMMUNITY; AMINE)S, Saw an article supported by the Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Yuan, HY; Yang, Y; Xue, W; Liu, ZH. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

Category: thiazines. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Atrial Arrhythmias in Clinically Manifest Cardiac Sarcoidosis: Incidence, Burden, Predictors, and Outcomes WOS:000566953100021 published article about FIBRILLATION; PREVALENCE in [Weng, Willy; Wiefels, Christiane; Nery, Pablo B.; Celiker-Guler, Emel; Promislow, Steven; Medor, Maria C.; Spence, Stewart; Odabashian, Roupen; Alqarawi, Wael; Juneau, Daniel; de Kemp, Rob; Leung, Eugene; Beanlands, Rob; Birnie, David] Univ Ottawa, Heart Inst, Div Cardiol, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada; [Chakrabarti, Santabhanu] Univ British Columbia, Div Cardiol, Vancouver, BC, Canada; [Healey, Jeff S.] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada; [Hruczkowski, Tomasz W.] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB, Canada; [Quinn, F. Russell] Libin Cardiovasc Inst Alberta, Calgary, AB, Canada; [Juneau, Daniel] Univ Montreal, Ctr Hosp, Dept Nucl Med & Radiol, Montreal, PQ, Canada in 2020.0, Cited 19.0. Product Details of 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Background: Recent data have suggested a substantial incidence of atrial arrhythmias (AAs) in cardiac sarcoidosis (CS). Our study aims were to first assess how often AAs are the presenting feature of previously undiagnosed CS. Second, we used prospective follow-up data from implanted devices to investigate AA incidence, burden, predictors, and response to immunosuppression. Methods and Results: This project is a substudy of the CHASM-CS (Cardiac Sarcoidosis Multicenter Prospective Cohort Study; NCT01477359). Inclusion criteria were presentation with clinically manifest cardiac sarcoidosis, treatment-naive status, and implanted with a device that reported accurate AA burden. Data were collected at each device interrogation visit for all patients and all potential episodes of AA were adjudicated. For each intervisit period, the total AA burden was obtained. A total of 33 patients met the inclusion criteria (aged 56.1 +/- 7.7 years, 45.5% women). Only 1 patient had important AAs as a part of the initial CS presentation. During a median follow-up of 49.1 months, 11 of 33 patients (33.3%) had device-detected AAs, and only 2 (6.1%) had a clinically significant AA burden. Both patients had reduced burden after CS was successfully treated and there was no residual fluorodeoxyglucose uptake on positron emission tomography scan. Conclusions: First, we found that AAs are a rare presenting feature of clinically manifest cardiac sarcoidosis. Second, AAs occurred in a minority of patients at follow-up; the burden was very low in most patients. Only 2 patients had clinically significant AA burden, and both had a reduction after CS was treated. REGISTRATION: URL: https://www.clinicaltrials.gov; unique identifier NCT01477359.

Welcome to talk about 56-17-7, If you have any questions, you can contact Weng, W; Wiefels, C; Chakrabarti, S; Nery, PB; Celiker-Guler, E; Healey, JS; Hruczkowski, TW; Quinn, FR; Promislow, S; Medor, MC; Spence, S; Odabashian, R; Alqarawi, W; Juneau, D; de Kemp, R; Leung, E; Beanlands, R; Birnie, D or send Email.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2019.0 BIOCONJUGATE CHEM published article about HOST-DEFENSE PEPTIDES; MOLECULAR TRANSPORTERS; ARGININE; GENE; DNA; SURFACE; DESIGN; CHARGE; HELIX; INTERNALIZATION in [Douat, Celine; Bornerie, Megane; Antunes, Stephanie; Guichard, Gilles] Univ Bordeaux, CNRS, CBMN, UMR 5248,Inst Europeen Chim & Biol, 2 Rue Robert Escarpit, F-33607 Pessac, France; [Douat, Celine] Ludwig Maximilians Univ Munchen, Dept Pharm, Butenandtstr 5-13, D-81377 Munich, Germany; [Kichler, Antoine] Univ Strasbourg, CNRS, Fac Pharm, Equipe 3Bio,CAMB 7199, 74 Route Rhin, F-67401 Illkirch Graffenstaden, France in 2019.0, Cited 54.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Sequence specific molecules with high folding ability (i.e., foldamers) can be used to precisely control the distribution and projection of side chains in space and have recently been introduced as tailored systems for delivering nucleic acids into cells. Designed oligourea sequences with an amphipathic distribution of Arg- and His-type residues were shown to form tight complexes with plasmid DNA, and to effectively promote the release of DNA from the endosomes. Herein, we report the synthesis of new cell-penetrating foldamer sequences in which the foldamer segment is conjugated via a reducible disulfide bond to a ligand that binds cell-surface expressed nucleoproteins with the idea that this system could facilitate both assemblies with nucleic acids and cell entry. This new system was evaluated for delivery of DNA in several cell lines and was found to compare favorably with all comparators tested (DOTAP and b-PEI as well as a number of known cell penetrating peptides) in various cell lines and particularly in culture medium containing up to 50% of serum. These results suggest that this dual molecular platform which is long lasting and noncytotoxic could be of practical use for in vivo applications.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about LIQUID-CRYSTALLINE ELASTOMERS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21774063]; Natural Science Foundation of TianjinNatural Science Foundation of Tianjin [11JCYBJC01500]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Guo, C; Gao, JF; Ma, SK; Zhang, HQ. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Chemically crosslinked recyclable photodeformable azobenzene (azo) polymer actuators with good stability (toward organic solvents and higher temperatures) and high processability and reconstruction ability hold great promise in many applications, but their development remains a challenging task. Herein, we report on for the first time a facile and highly efficient post-crosslinking method for addressing this issue. It involves first the synthesis of side-chain polymers bearing N-hydroxysuccinimide (NHS) carboxylate-substituted azo mesogens, fabrication of uniaxially oriented fibers from these azo polymers by the simple melt spinning method, and their subsequent post-crosslinking with cystamine (a diamine containing a disulfide bond) under mild conditions. The resulting chemically crosslinked fibers not only showed rapid and reversible photoinduced bending and unbending at ambient temperature as well as high mechanical strength and good solvent/heating stability, but also could be easily recycled into processable azo polymers in the presence of a reducing agent that can cleave the disulfide bond into thiol groups (i.e., tributylphosphine). In particular, the occurrence of the post-crosslinking reaction only on the thin surface layers of the azo polymer fibers afforded recycled polymers with large amounts of NHS carboxylate-substituted azo mesogens (together with a small amount of oxygen/heating-sensitive thiolsubstituted ones) in the first several (at least 5) recycling processes, thus allowing highly efficient reconstruction of photodeformable fibers with excellent photomobile properties by applying melt spinning and post-cross-linking (by using cystamine) methods. The strategy presented here opens the new possibility to the facile and efficient development of various advanced chemically crosslinked recyclable photodriven actuators.

Welcome to talk about 56-17-7, If you have any questions, you can contact Guo, C; Gao, JF; Ma, SK; Zhang, HQ or send Email.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 GREEN CHEM published article about BLOCK-COPOLYMER MICELLES; POLYMERIC MICELLES; LOADING CAPACITY; DOXORUBICIN; RELEASE; ISOXAZOLINE; ELASTOMERS; REDUCTION; LIGNIN; PEG in [Biswas, Gargi; Sahoo, Satyagopal; Samanta, Pousati; Dhara, Dibakar] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India; [Jena, Bikash Chandra; Mandal, Mahitosh] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India in 2019.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Polymer based core cross-linked nanoparticles (CCNPs) have generated a lot of interest as potential stimuli-responsive drug delivery systems. In the present work, we have synthesized smart redox-responsive water soluble polymeric CCNPs by cross-linking water-soluble PEG based copolymers with bis(acryloyl)cystamine via isoxazoline bond formation through a 1,3-dipolar cycloaddition reaction (click reaction) without using a copper catalyst, in a water-THF mixed solvent. The successful synthesis of CCNPs was confirmed by NMR, GPC and FT-IR measurements. Size distribution of the precursor copolymers and the CCNPs was determined by DLS measurement. AFM and FESEM images have confirmed globular morphology of these CCNPs. Their high stability in a physiological environment makes them effective as potent drug carriers with high loading capacity. MTT assays confirmed the biocompatibility of the synthesized CCNPs. Favourable cellular internalization of these DOX loaded CCNPs into cancer cells and redox-responsive release of DOX therefrom make these CCNP potentially smart vehicles to deliver anticancer drugs into cancer cells.

Category: thiazines. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. Authors Yang, X; Cheng, Q; Monnier, V; Charles, L; Karoui, H; Ouari, O; Gigmes, D; Wang, RB; Kermagoret, A; Bardelang, D in WILEY-V C H VERLAG GMBH published article about in [Yang, Xue; Charles, Laurence; Karoui, Hakim; Ouari, Olivier; Gigmes, Didier; Kermagoret, Anthony; Bardelang, David] Aix Marseille Univ, CNRS, ICR, Marseille, France; [Cheng, Qian; Wang, Ruibing] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macau, Peoples R China; [Monnier, Valerie] Aix Marseille Univ, CNRS, Cent Marseille, FSCM,Spectropole, Marseille, France in 2021.0, Cited 87.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Molecular machines are ubiquitous in nature and function away from equilibrium by consuming fuels to produce appropriate work. Chemists have recently excelled at mimicking the fantastic job performed by natural molecular machines with synthetic systems soluble in organic solvents. In efforts toward analogous systems working in water, we show that guest molecules can be exchanged in the synthetic macrocycle cucurbit[7]uril by involving kinetic traps, and in such a way as modulating energy wells and kinetic barriers using pH, light, and redox stimuli. Ditolyl-viologen can also be exchanged using the best kinetic trap and interfaced with alginate, thus affording pH-responsive blue, fluorescent hydrogels. With tunable rate and binding constants toward relevant guests, cucurbiturils may become excellent ring molecules for the construction of advanced molecular machines working in water.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW in WILEY-V C H VERLAG GMBH published article about ELECTRON-TRANSFER; BISIMIDE DYES; FLUORESCENCE; ASSEMBLIES; DESIGN in [Yip, Alex Man-Hei; Shum, Justin; Liu, Hua-Wei; Lo, Kenneth Kam-Wing] City Univ Hong Kong, Dept Chem, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China; [Zhou, Huipeng; Jia, Meiqi; Niu, Niu; Li, Yongxin; Yu, Cong] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China; [Niu, Niu; Yu, Cong] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China; [Lo, Kenneth Kam-Wing] City Univ Hong Kong, State Key Lab Terahertz & Millimeter Waves, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China; [Lo, Kenneth Kam-Wing] City Univ Hong Kong, Ctr Funct Photon, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China in 2019.0, Cited 41.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

This communication reports novel luminescent rhenium(I)-polypyridine complexes appended with a perylene diimide (PDI) or benzoperylene monoimide (BPMI) moiety through a non-conjugated linker. The photophysical and photochemical properties originating from the interactions of the metal polypyridine and perylene units were exploited to afford new cellular reagents with thiol-sensing capability and excellent photocytotoxic activity.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Wang, T; Du, J; Ye, S; Tan, LH; Fu, JJ in [Wang, Ting; Du, Juan; Ye, Sheng; Fu, JiaJun] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China; [Ye, Sheng; Tan, Linghua] Nanjing Univ Sci & Technol, Natl Special Superfine Powder Engn Res Ctr, Nanjing 210094, Jiangsu, Peoples R China published Triple-Stimuli-Responsive Smart Nanocontainers Enhanced Self-Healing Anticorrosion Coatings for Protection of Aluminum Alloy in 2019.0, Cited 45.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Novel acid/alkali/corrosion potential triple stimuli -responsive smart nanocontainers (TSR-SNs) were successfully assembled to regulate the release of an encapsulated corrosion inhibitor, benzotriazole (BTA), by installing specially structured bistable pseudorotaxanes as supramolecular nanovalves onto orifices of mesoporous silica nanoparticles. In normal conditions, BTA molecules were sealed in the mesopores. Upon any stimulus of acid, alkali, or corrosion potential, BTA molecules were quickly released because of the open states of the supramolecular nanovalves. TSR-SNs as smart nanocontainers were added into the SiO2 ZrO2 sol gel coating to fabricate a stimuli-feedback, corrosion-compensating self-healing anticorrosion coating (SF-SHAC). Compared with the conventional pH-responsive smart nanocontainers synthesized for the SHAC, TSR-SNs not only respond to the pH changes occurring on corrosive microregions but also, and more importantly, feel the corrosion potential of aluminum alloys and give quick feedback. This design avoids wasting smart nanocontainers because of the local-dependent, gradient pH stimulus intensities and obviously enhances the response sensitivity of the SF-SHAC. Electrochemical impedance spectroscopy and salt spray tests prove the excellent physical barrier of the SF-SHAC. Through scanning vibrating electrode technique measurements, the SF-SHAC doped with TSR-SNs demonstrates inhibiting rates for corrosive microcathodic/anodic current densities that are faster than other control SHACs. The new incorporated corrosion potential-responsive function ensures the efficient working efficiency of TSR-SNs and makes full use of the preloaded corrosion inhibitors as repair factors.

Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, T; Du, J; Ye, S; Tan, LH; Fu, JJ or send Email.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem