With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.188614-01-9,Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate,as a common compound, the synthetic route is as follows.
At 40 in to methyl-3-oxo-3,4-dihydro -2H-1,4- benzothiazine-6-carboxylate (475mg, 2.00mmol), borohydride the mixture of sodium (151mg, 3.99mmol) in tetrahydrofuran (2.0mL) dropwise addition of methanol (640mg). After stirring for 1 hour at 40 , under ice-cooling, use 1mol / L diluted hydrochloric acid, and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered, concentrated, and the use of silica gel column chromatography (hexane: ethyl acetate = 1: 1) and the residue was purified to obtain the title compound (130mg, 31%) .
The synthetic route of 188614-01-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUMITOMO DAINIPPON PHARMA CO., LTD.; YOSHINAGA, HIDEFUMI; URUNO, YOSHIHARU; SAWAMURA, KIYOTO; GOTO, NANA; IKUMA, YOHEI; (165 pag.)TW2016/5858; (2016); A;,
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