Heterocyclic Building Blocks-Thiazines

92-30-8, 2-(Trifluoromethyl)-10H-phenothiazine is a thiazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of hydroxy compounds, sulfhydryl compounds oramino compounds (1.0 eq) and propargyl bromide (1.2 eq) inacetone (20 ml) was added NaOH (1.5 eq), the mixturewas refluxedfor about 6 h. Upon completion, the residue was purified withcolumn chromatography (hexane:EtOAc 7:1) to obtain analogue13a~13m. Sulfonyl chlorides (1.0 eq) and propynylamine (1.2 eq) inCH2Cl2 (20 ml) was added Et3N (1.5 eq), the mixture was stirred atroom temperature for about 6 h. Upon completion, the residue waspurified with column chromatography (hexane:EtOAc 9:1) toobtain analogue 13n~13o.

92-30-8 2-(Trifluoromethyl)-10H-phenothiazine 7082, athiazines compound, is more and more widely used in various.

Reference£º
Article; Fu, Dong-Jun; Li, Ping; Wu, Bo-Wen; Cui, Xin-Xin; Zhao, Cheng-Bin; Zhang, Sai-Yang; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 309 – 322;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

272437-84-0, 3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid is a thiazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The acid (a) in tetrahydrofuran (50 ml) and triethylamine (4.7 ml) was cooled to [0C] and [ISOBUTYLCHLOROFORMATE] (4.02 ml) was added dropwise and the solution was stirred at [0C] for 2 hours, when it was filtered into a stirred solution of sodium borohydride (3.14 g) in ice/water (50 ml). The mixture was stirred at [0C] for 1 hour and allowed to warm to room temperature. It was acidified with 2M hydrochloric acid, evaporated to half volume, and the resulting product was collected, washed with water and dried in vacuo, to give a white solid (4.5 g). MS (-ve ion electrospray) [M/Z] 194 (M-H)-

The synthetic route of 272437-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/2992; (2004); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92-30-8,2-(Trifluoromethyl)-10H-phenothiazine,as a common compound, the synthetic route is as follows.

2-Trifluoromethylphenothiazine (2.00 g, 7.4831 mmol) was placed in a 500 mL flask, THF (100 mL) dried overanhydrous K2CO3 was added, and then 60% NaH was added sequentially under N2 protection. Mineral oil(1.1973 g, 29.9323 mmol) and 1-bromo-3-chloropropane (2.9601 mL, 29.9323 mmol) were refluxed overnightat a bath temperature of 65 C. After cooling to room temperature, the reaction mixture was poured into EtOAc EtOAc (EtOAc)EtOAc. Ethylacetate (50 mL) was added to dissolve, and silica gel powder (20 g) was added to the solution to dryness, and theresidue was applied to a silica gel column, eluted with ethyl acetate and petroleum ether, and the product wascollected, dried, and dried in vacuo. Product 2-10 (4.9444 g, yield 69.8%).

As the paragraph descriping shows that 92-30-8 is playing an increasingly important role.

Reference£º
Patent; Dalian University of Technology; Li Gaoquan; Xie Aiyun; Zhang Cuifang; Chen Maofen; (23 pag.)CN104829554; (2018); B;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92-30-8,2-(Trifluoromethyl)-10H-phenothiazine,as a common compound, the synthetic route is as follows.

General procedure: A stirred mixture of phenothiazine (100 mg, 0.5 mmol),3,5-dimethylphenol (183 mg, 1.5 mmol), and K2CO3 (69 mg,0.5 mmol) in ODCB (1.5 mL) was heated to 130 oC for 6 h under O2 balloon atmosphere. After the usual aqueous extractive workup and column chromatographic purification process (hexanes/EtOAc, 20:1) para-3a (103 mg, 64percent) and ortho-3a (34 mg, 21percent) were obtained as white solids. Other compounds were synthesized similarly, and the spectroscopic data of 3a-3m and the sulfoxide of 3g are as follows.

As the paragraph descriping shows that 92-30-8 is playing an increasingly important role.

Reference£º
Article; Yu, Jin; Moon, Hye Ran; Kim, Su Yeon; Kim, Jae Nyoung; Bulletin of the Korean Chemical Society; vol. 36; 11; (2015); p. 2765 – 2768;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

3939-23-9, 3-Bromo-10H-phenothiazine is a thiazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tri-tert-butylphosphine (4.4 mL of a 1.0 M solution in toluene, 1.48 g, 0.05 mmol), palladium acetate (0.4 g,1.83 mmol) and sodium tert-butoxide (52.7 g, 549 mmol) were added to 2-6-a (20.423 g, 73.42 mmol) and 2-6-c(11.53 g, 73.42 mmol) a solution in degassed toluene (500 mL), and the mixture was warmed under reflux for 2 hr.The reaction mixture was cooled to room temperature, diluted with toluene and filtered over EtOAc. Dilute the filtrate with water and use aThe benzene was extracted and the organic phases were combined and evaporated under vacuum. The residue was passed through silica gel (heptane / dichloromethane)Filtration was carried out and crystallized from isopropanol. Obtaining 2-6-b 19.51 g, yield 75%; the resulting bromide 2-6-b(7.89 g, 20 mmol), pinacol borate (6.22 g, 24 mmol), 1,1′-bis(diphenylphosphino)-ferrocene-palladium dichloride(II) dichloromethane complex (0.49 g, 0.6 mmol), potassium acetate (5.90 g, 60 mmol) and 79 ml of toluene were reacted under refluxAfter 16 hours, cool, add 26 ml of water and stir for 30 minutes.The organic phase is separated and filtered through a short bed of diatomaceous earth, followed by organicThe solvent was distilled off and the crude product was recrystallized from heptane / toluene.The compound 2-6 was obtained in an amount of 6.58 g, yield 82%.

3939-23-9 3-Bromo-10H-phenothiazine 283308, athiazines compound, is more and more widely used in various.

Reference£º
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhang Hong; Cai Hui; (36 pag.)CN108530418; (2018); A;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

272437-84-0, 3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid is a thiazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Oxo-3,4-dihydro-2H-benzo[l,4]thiazine-6-carboxylic acid (31 mg, 0.14 mmol, 1.0 eq) is added at room temperature to a stirred solution of l-(6-methoxy-3,4-dihydro-2H-l-oxa-9-aza- phenanthrene-3-yl)-piperidin-4-ylamine (50 mg, 0.14 mmol, 1.0 eq) in N,N- dimethylformamide (3 mL), followed by 1-hydroxybenzotriazole (21 mg, 0.15 mmol, 1.1 eq), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (31 mg, 0.16 mmol, 1.15 eq) and NN-diisopropylethylamine (53 mu, 0.31 mmol, 2.25 eq). After 15 hours stirring at room temperature, solvent is evaporated and the residue is extracted with dichloromethane (3 x 10 mL) and water (10 mL). The combined organic layers are dried over sodium sulfate, filtered and concentrated to give a crude product that is purified by preparative HPLC to afford 3-oxo-3,4- dihydro-2H-benzo[ 1 ,4]thiazine-6-carboxylic acid [ 1 -(6-methoxy-3 ,4-dihydro-2H- 1 -oxa-9- aza-phenanthrene-3-yl)-piperidin-4-yl] -amide as an off-white lyophilizated powder (24 mg, 33% yield). 1H-NMR (400 MHz, DMSO-dtf) delta ppm: 10.66 (br, 1H), 8.33 (s, 1H), 8.24 (d, J = 7.6 Hz, 1H), 7.81 (d, J = 9.0 Hz, 1H), 7.42 (m, 2H), 7.38 (m, 1H), 7.20 (m, 2H), 4.47 (d, J = 11.0 Hz, 1H), 4.02 (m, 1H), 3.93 (s, 3H), 3.78 (m, 1H), 3.50 (s, 2H), 3.20 (m, 1H), 3.08 (m, 2H), 3.00 (m, 2H), 2.42 (m, 2H), 1.81 (m, 2H), 1.58 (m, 2H).MS m/z (+ESI): 505.2 [M+H]+.

272437-84-0 3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid 760993, athiazines compound, is more and more widely used in various.

Reference£º
Patent; BASILEA PHARMACEUTICA AG; GAUCHER, Berangere; DANEL, Franck, Hubert; TANG, XiaoHu; XIE, Tong; XU, Lin; WO2011/73378; (2011); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3939-23-9,3-Bromo-10H-phenothiazine,as a common compound, the synthetic route is as follows.

Step 2, 132 mmol of 9-BBN was dissolved in THF at 0 C, 44 mmol of 1-2, Stirring for 15min, warming to 35 degrees Celsius, reaction 3h, and then transferred to the mixture containing 5-1 66mmoltetrakis(triphenylphosphine)palladium 0.88 mmol, sodium carbonate 132 mmol in toluene: ethanol: water = 4: 1: 1, and the temperature was raised to reflux temperature reaction24h. The crude product was passed through a silica gel column to give the product 20 mmol, 5-2.

As the paragraph descriping shows that 3939-23-9 is playing an increasingly important role.

Reference£º
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Sun Keyi; Cai Hui; (31 pag.)CN106946934; (2017); A;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92-30-8,2-(Trifluoromethyl)-10H-phenothiazine,as a common compound, the synthetic route is as follows.

A solution of2- (trifluoromethyl)-lOH-phenothiazine (2.04g, 7.6mmol) and DMF (16mL) was mixed with CS2C03 (7.5g, 22.9mmol) and l-bromo-3-chloropropane (1.1 mL, 11.5mmol). The reaction mixture was heated at 65 C for 12h. Once no starting material was observed by analytical LCMS, EtOAC (250mL) and brine (250mL) were added. The organic layer was separated, and the aqueous layer was washed with EtOAC (3 chi l00mL). The combined organic extracts were washed with brine (2 chi lOOmL), dried over MgSO iota, and concentrated to afford the title compound.

92-30-8 2-(Trifluoromethyl)-10H-phenothiazine 7082, athiazines compound, is more and more widely used in various.

Reference£º
Patent; INCEPTION 1, INC.; CHEN, Austin, Chih-Yu; SCOTT, Jill, Melissa; STEARNS, Brian, Andrew; STOCK, Nicholas, Simon; TRUONG, Yen, Pham; WO2013/43744; (2013); A2;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

272437-84-0, 3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid is a thiazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of 3-oxo-3,4-dihydro-2H-benzo[l,41thiazine-6-carboxylic acid [tra/? -4-(8- methoxy-l,2-dihydro-3-oxa-5,9-diaza-cyclopenta[alnaphthalen-2-ylmethyl)-cyclohexyll- amide:3-Oxo-3,4-dihydro-2H-benzo[l,4]thiazine-6-carboxylic acid (31 mg, 0.14 mmol, 1.0 eq) is added at room temperature to a stirred solution of tra?s-4-(8-methoxy-l,2-dihydro-3-oxa-5,9- diaza-cyclopenta[a]naphthalen-2-ylmethyl)-cyclohexylamine (47 mg, 0.14 mmol, 1.0 eq) in N,N-dimethylformamide (4 mL), followed by 1-hydroxybenzotriazole (24 mg, 0.16 mmol, 1.1 eq), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (32 mg, 0.16 mmol, 1.15 eq) and NN-diisopropylethylamine (56 mu, 0.32 mmol, 2.25 eq). After 15 hours stirring at room temperature, solvent is evaporated and the residue is extracted with dichloromethane (3 x 10 mL) and water (10 mL). The combined organic layers are dried over sodium sulfate, filtered and concentrated to give a crude product that is purified by preparative HPLC to afford 3-oxo-3,4- dihydro-2H-benzo[l,4]thiazine-6-carboxylic acid [tra?s-4-(8-methoxy-l,2-dihydro-3-oxa- – -5,9-diaza-cyclopenta[a]naphthalen-2-ylmethyl)-cyclohexyl]-amide as a white lyophilized powder (16 mg, 21% yield).1H-NMR (400 MHz, DMSO- 6) delta ppm: 10.67 (s, 1H), 8.49 (s, 1H), 8.23 (d, J = 7.9 Hz, 1H), 8.19 (d, J = 9.0 Hz, 1H), 7.44 (m, 3H), 7.06 (d, J = 9.1 Hz, 1H), 5.21 (m, 1H), 4.01 (s, 3H), 3.74 (m, 2H), 3.51 (s, 2H), 3.14 (dd, J = 7.9, 16.8 Hz, 1H), 1.80-2.00 (m, 5H), 1.66 (m, 1H), 1.57 (m, 1H), 1.39 (m, 2H), 1.13 (m, 2H).MS m/z (+ESI): 505.5 [M+H]+.

The synthetic route of 272437-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BASILEA PHARMACEUTICA AG; GAUCHER, Berangere; DANEL, Franck Hubert; XIE, Tong; XU, Lin; WO2012/171860; (2012); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

3080-99-7, 3,4-Dihydro-2H-benzo[b][1,4]thiazine is a thiazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a manner similar to the method described in Example 1-1, using 3,4-dihydro-2H-benzo[1,4]thiazine in place of 1,2,3,4-tetrahydroquinoline, 239 mg (yield: 63%) of the captioned compound was obtained.1H-NMR (ppm) (300 MHz, CDCl3) 6.98 (1H, dd, J = 1.8, 7.9 Hz), 6.86 (1H, ddd, J = 1.8, 7.3, 8.5 Hz), 6.78 (1H, d, J = 8.2 Hz), 6.69-6.65 (2H, m), 6.61-6.5 (1H, ddd, J = 1.2, 7.6, 8.5 Hz), 4.61 (1H, d, J = 8.2 Hz), 3.85 (3H, s), 3.60-3.51 (3H, m), 3.14-2.96 (4H, m), 2.55-2.50 (1H, m), 2.41 (3H, s), 2.38-2.32 (1H, m), 2.23-2.12 (2H, m), 1.91-1.47 (5H, m), 1.12-1.00 (1H, m) IR (cm-1) (KBr) 2924, 1735, 1606, 1584, 1483, 1438, 1373, 1338, 1275, 1257, 1176, 1148, 1112, 1079, 1047, 1006, 937, 907, 891, 854, 793, 744

3080-99-7 3,4-Dihydro-2H-benzo[b][1,4]thiazine 151064, athiazines compound, is more and more widely used in various.

Reference£º
Patent; TORAY INDUSTRIES, INC.; EP1555266; (2005); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem