Heterocyclic Building Blocks-Thiazines

I found the field of Chemistry very interesting. Saw the article Preparation of functionalized star polymer nanoparticles by RAFT polymerization and their application in positionally assembled enzymes for cascade reactions published in 2019.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Cao, H; Tan, TW (corresponding author), Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A well-defined functional star polymer nanoparticle was prepared using an “ arm first” approach via RAFT polymerization. In this work, N-adamantylacrylamide and N-succinimidyl acrylate were copolymerized with N-isopropylacrylamide sucessfully. The obtained diblock copolymer regarded as an “ arm” endowed the star polymer with multiple conjugate functions. By adjusting the amount of crosslinking agent, the size and polydispersity of the star polymer were controlled. With the star polymer as the scaffold, a sequential multi-enzyme system was constructed, where HRP was placed in the inner layer through covalent conjugation, and b-cyclodextrin-modified GOx was assembled in the outer layer through hostguest recognition. More interestingly, the activity of the enzyme modified by b-cyclodextrin was improved. In addition to the enhanced thermal stability, this multienzyme system also exhibited a reduced Km value (from 2.18 mM to 0.39 mM) and an excellent substrate affinity. The specificity constant (Kcat/Km) for GOx in the star polymer@ HRP@ GOx system was 1.7-fold higher than that of the free HRP with free GOx system. This strategy will promote the development of biocatalysis reactions and biosensors as a promising method.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Wang, T; Du, J; Ye, S; Tan, LH; Fu, JJ in [Wang, Ting; Du, Juan; Ye, Sheng; Fu, JiaJun] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China; [Ye, Sheng; Tan, Linghua] Nanjing Univ Sci & Technol, Natl Special Superfine Powder Engn Res Ctr, Nanjing 210094, Jiangsu, Peoples R China published Triple-Stimuli-Responsive Smart Nanocontainers Enhanced Self-Healing Anticorrosion Coatings for Protection of Aluminum Alloy in 2019.0, Cited 45.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Novel acid/alkali/corrosion potential triple stimuli -responsive smart nanocontainers (TSR-SNs) were successfully assembled to regulate the release of an encapsulated corrosion inhibitor, benzotriazole (BTA), by installing specially structured bistable pseudorotaxanes as supramolecular nanovalves onto orifices of mesoporous silica nanoparticles. In normal conditions, BTA molecules were sealed in the mesopores. Upon any stimulus of acid, alkali, or corrosion potential, BTA molecules were quickly released because of the open states of the supramolecular nanovalves. TSR-SNs as smart nanocontainers were added into the SiO2 ZrO2 sol gel coating to fabricate a stimuli-feedback, corrosion-compensating self-healing anticorrosion coating (SF-SHAC). Compared with the conventional pH-responsive smart nanocontainers synthesized for the SHAC, TSR-SNs not only respond to the pH changes occurring on corrosive microregions but also, and more importantly, feel the corrosion potential of aluminum alloys and give quick feedback. This design avoids wasting smart nanocontainers because of the local-dependent, gradient pH stimulus intensities and obviously enhances the response sensitivity of the SF-SHAC. Electrochemical impedance spectroscopy and salt spray tests prove the excellent physical barrier of the SF-SHAC. Through scanning vibrating electrode technique measurements, the SF-SHAC doped with TSR-SNs demonstrates inhibiting rates for corrosive microcathodic/anodic current densities that are faster than other control SHACs. The new incorporated corrosion potential-responsive function ensures the efficient working efficiency of TSR-SNs and makes full use of the preloaded corrosion inhibitors as repair factors.

Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, T; Du, J; Ye, S; Tan, LH; Fu, JJ or send Email.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW in WILEY-V C H VERLAG GMBH published article about ELECTRON-TRANSFER; BISIMIDE DYES; FLUORESCENCE; ASSEMBLIES; DESIGN in [Yip, Alex Man-Hei; Shum, Justin; Liu, Hua-Wei; Lo, Kenneth Kam-Wing] City Univ Hong Kong, Dept Chem, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China; [Zhou, Huipeng; Jia, Meiqi; Niu, Niu; Li, Yongxin; Yu, Cong] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China; [Niu, Niu; Yu, Cong] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China; [Lo, Kenneth Kam-Wing] City Univ Hong Kong, State Key Lab Terahertz & Millimeter Waves, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China; [Lo, Kenneth Kam-Wing] City Univ Hong Kong, Ctr Funct Photon, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China in 2019.0, Cited 41.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

This communication reports novel luminescent rhenium(I)-polypyridine complexes appended with a perylene diimide (PDI) or benzoperylene monoimide (BPMI) moiety through a non-conjugated linker. The photophysical and photochemical properties originating from the interactions of the metal polypyridine and perylene units were exploited to afford new cellular reagents with thiol-sensing capability and excellent photocytotoxic activity.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. Authors Yang, X; Cheng, Q; Monnier, V; Charles, L; Karoui, H; Ouari, O; Gigmes, D; Wang, RB; Kermagoret, A; Bardelang, D in WILEY-V C H VERLAG GMBH published article about in [Yang, Xue; Charles, Laurence; Karoui, Hakim; Ouari, Olivier; Gigmes, Didier; Kermagoret, Anthony; Bardelang, David] Aix Marseille Univ, CNRS, ICR, Marseille, France; [Cheng, Qian; Wang, Ruibing] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macau, Peoples R China; [Monnier, Valerie] Aix Marseille Univ, CNRS, Cent Marseille, FSCM,Spectropole, Marseille, France in 2021.0, Cited 87.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Molecular machines are ubiquitous in nature and function away from equilibrium by consuming fuels to produce appropriate work. Chemists have recently excelled at mimicking the fantastic job performed by natural molecular machines with synthetic systems soluble in organic solvents. In efforts toward analogous systems working in water, we show that guest molecules can be exchanged in the synthetic macrocycle cucurbit[7]uril by involving kinetic traps, and in such a way as modulating energy wells and kinetic barriers using pH, light, and redox stimuli. Ditolyl-viologen can also be exchanged using the best kinetic trap and interfaced with alginate, thus affording pH-responsive blue, fluorescent hydrogels. With tunable rate and binding constants toward relevant guests, cucurbiturils may become excellent ring molecules for the construction of advanced molecular machines working in water.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 GREEN CHEM published article about BLOCK-COPOLYMER MICELLES; POLYMERIC MICELLES; LOADING CAPACITY; DOXORUBICIN; RELEASE; ISOXAZOLINE; ELASTOMERS; REDUCTION; LIGNIN; PEG in [Biswas, Gargi; Sahoo, Satyagopal; Samanta, Pousati; Dhara, Dibakar] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India; [Jena, Bikash Chandra; Mandal, Mahitosh] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India in 2019.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Polymer based core cross-linked nanoparticles (CCNPs) have generated a lot of interest as potential stimuli-responsive drug delivery systems. In the present work, we have synthesized smart redox-responsive water soluble polymeric CCNPs by cross-linking water-soluble PEG based copolymers with bis(acryloyl)cystamine via isoxazoline bond formation through a 1,3-dipolar cycloaddition reaction (click reaction) without using a copper catalyst, in a water-THF mixed solvent. The successful synthesis of CCNPs was confirmed by NMR, GPC and FT-IR measurements. Size distribution of the precursor copolymers and the CCNPs was determined by DLS measurement. AFM and FESEM images have confirmed globular morphology of these CCNPs. Their high stability in a physiological environment makes them effective as potent drug carriers with high loading capacity. MTT assays confirmed the biocompatibility of the synthesized CCNPs. Favourable cellular internalization of these DOX loaded CCNPs into cancer cells and redox-responsive release of DOX therefrom make these CCNP potentially smart vehicles to deliver anticancer drugs into cancer cells.

Category: thiazines. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about LIQUID-CRYSTALLINE ELASTOMERS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21774063]; Natural Science Foundation of TianjinNatural Science Foundation of Tianjin [11JCYBJC01500]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Guo, C; Gao, JF; Ma, SK; Zhang, HQ. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Chemically crosslinked recyclable photodeformable azobenzene (azo) polymer actuators with good stability (toward organic solvents and higher temperatures) and high processability and reconstruction ability hold great promise in many applications, but their development remains a challenging task. Herein, we report on for the first time a facile and highly efficient post-crosslinking method for addressing this issue. It involves first the synthesis of side-chain polymers bearing N-hydroxysuccinimide (NHS) carboxylate-substituted azo mesogens, fabrication of uniaxially oriented fibers from these azo polymers by the simple melt spinning method, and their subsequent post-crosslinking with cystamine (a diamine containing a disulfide bond) under mild conditions. The resulting chemically crosslinked fibers not only showed rapid and reversible photoinduced bending and unbending at ambient temperature as well as high mechanical strength and good solvent/heating stability, but also could be easily recycled into processable azo polymers in the presence of a reducing agent that can cleave the disulfide bond into thiol groups (i.e., tributylphosphine). In particular, the occurrence of the post-crosslinking reaction only on the thin surface layers of the azo polymer fibers afforded recycled polymers with large amounts of NHS carboxylate-substituted azo mesogens (together with a small amount of oxygen/heating-sensitive thiolsubstituted ones) in the first several (at least 5) recycling processes, thus allowing highly efficient reconstruction of photodeformable fibers with excellent photomobile properties by applying melt spinning and post-cross-linking (by using cystamine) methods. The strategy presented here opens the new possibility to the facile and efficient development of various advanced chemically crosslinked recyclable photodriven actuators.

Welcome to talk about 56-17-7, If you have any questions, you can contact Guo, C; Gao, JF; Ma, SK; Zhang, HQ or send Email.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Biodegradable reduction-responsive polymeric micelles for enhanced delivery of melphalan to retinoblastoma cells WOS:000506713000101 published article about DRUG-RELEASE; SENSITIVE MICELLES; REDOX; NANOPARTICLES; DOXORUBICIN in [Li, Jia; Wang, Jihong; Zhang, Xuetong; Xia, Xin; Zhang, Chenchen] Jiangnan Univ, Dept Ophthalmol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China in 2019.0, Cited 32.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Computed Properties of C4H14Cl2N2S2

Melphalan (MEL) is an effective chemotherapeutic agent for treatment of retinoblastoma (Rb) which is the most common childhood malignancy. However, the inherent cardiopulmonary toxicity and hazardous integration limit its therapeutic effect on RB. N-Acetylheparosan (AH), a natural heparin-like polysaccharide in mammals with long circulation effect and good biocompatibility, was linked by d-alpha-tocopherol acid succinate (VES) via and cystamine (CYS) to synthesize reduction-responsive N-acetylheparosan-CYS-Vitamin E succinate (AHV) copolymers. In addition, CYS was replaced by adipic acid dihydrazide (ADH) to obtain a control of non-reduction-responsive polymers N-acetylheparosan-ADH-Vitamin E succinate (ADV). MEL-loaded AHV micelles (MEL/AHV) as well as ADV micelles (MEL/ADV) were prepared with small particle size and high drug loading content. In vitro drug release showed that MEL/AHV micelles presented obvious reduction-triggered release behavior compared with MEL/ADV. In vitro antitumor effects were investigated using WERI-Rb-1 retinoblastoma cells. Cytotoxicity experiments showed that the IC50 of MEL/AHV was significantly lower than that of free MEL and MEL/ADV, suggesting that MEL/AHV enhanced the cytotoxicity against retinoblastoma cells. Furthermore, MEL/AHV micelles were more easily uptaken by multiple pathways compared with MEL/ADV and free MEL. Therefore, MEL/AHV might be a potential delivery system for enhanced delivery of melphalan to Rb cells. (C) 2019 Elsevier B.V. All rights reserved.

Welcome to talk about 56-17-7, If you have any questions, you can contact Li, J; Wang, JH; Zhang, XT; Xia, X; Zhang, CC or send Email.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Wang, Y; Li, C; Ma, L; Wang, XY; Wang, K; Lu, XH; Cai, YL in [Wang, Ye; Li, Chao; Ma, Lei; Wang, Xiyu; Wang, Kai; Lu, Xinhua; Cai, Yuanli] Soochow Univ, Coll Chem Chem Engn & Mat Sci, State Local Joint Engn Lab Novel Funct Polymer Ma, Suzhou 215123, Peoples R China published Interfacial Liquid-Liquid Phase Separation-Driven Polymerization-Induced Electrostatic Self-Assembly in 2021.0, Cited 54.0. HPLC of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Development of spatially restricted liquid-liquid phase separation (LLPS) systems emulating biomolecular condensates is a major challenge in coacervating materials science, due to lack of approaches for spatially restricted coacervation of sequence-defined zwitterionic segments resembling intrinsically disordered proteins. Herein, we present interfacial LLPS-driven polymerization-induced electrostatic self-assembly, namely, interfacial LLPS-PIESA. The asymmetric charge sequence patterning of zwitterionic growing segments is achieved via spontaneous polymerization of ion-pair monomers within a nanopartide core-shell interface. We show that charge sequence can profoundly affect the self-coacervation, leading to droplet dispersions, dense coacervates, and free-standing hydrogels. Moreover, the interfacial LLPS-PIESA shows a programmed hierarchical condensation self-assembly mechanism involving vesicles-to-lamellae transition, interfacial self-coacervation, lamellae-to-sheets transition, layer-by-layer sheet self-assembly, spatially restricted condensation and agglomeration, and redispersing into fibril network condensates under dynamic evolving surface charge regulation. The spatially restricted asymmetric charge sequence patterning, interfacial self-coacervation, and programmed hierarchical condensation self-assembly, all these elements can serve as the primary principles for the asymmetric charge sequence patterning design of hierarchically nanostructured condensates that emulate cellular biomolecular condensates.

Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, Y; Li, C; Ma, L; Wang, XY; Wang, K; Lu, XH; Cai, YL or send Email.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. Authors Saxena, R; Srivastav, S in ELSEVIER published article about in [Saxena, Rahul; Srivastav, Sudha] Jaypee Inst Informat Technol, Dept Biotechnol, Nanobiotechnol Lab, A-10 Sect 62, Noida 201309, UP, India in 2019.0, Cited 10.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

We present a sensitive single step nanobiosensor for thyroid disease diagnosis. Nanoparticles modified screen printed carbon electrode catalyzes the formation of peptide bond between anti-TSH antibody and amino coated gold nanoparticles rendering a covalently coupled antibody. The nanobiosensor detects and quantifies the thyroid stimulating hormone in the sample by sensing the effective resistance offered by electrode. As the TSH concentration increases in serum sample, more is the immunocomplex formed and higher is the resistance offered by electrode. Gold nanoparticles functionalization with cystamine dihydrochloride facilitates a covalent bonding between surface amino group and carboxylic Fc ensuring maximizing available active antibody. This strategy ensures a much lower limit of detection in addition to improved detection range due to increased loading capacity as a result of larger effective surface area offered by gold nanoparticles. These two aspects of immunosensor fabrication resulted in limit of detection as low as 0.001 mu IU/mL and an enhanced detection range of 0.001-150 mu IU/mL. This makes the developed immunosensor suitable for diagnostic purpose covering the clinically relevant range and a simple detection technique makes it potential candidate for fabrication of a Point-of-Care device for detection of Thyroid dysfunctioning. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 56-17-7, If you have any questions, you can contact Saxena, R; Srivastav, S or send Email.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. In 2020.0 ACS OMEGA published article about FLUORESCENCE TURN-ON; MOLECULAR-STRUCTURE; LIVING CELLS; COLORIMETRIC SENSOR; ALZHEIMERS-DISEASE; REVERSIBLE SENSOR; IRON-METABOLISM; AQUEOUS-MEDIA; ALUMINUM IONS; LUMO ANALYSIS in [Devi, Duraisamy Parimala; Abiram, Angamuthu] Karunya Inst Technol & Sci Deemed Be Univ, Dept Phys, Coimbatore 641114, Tamil Nadu, India; [David, Charles Immanuel; Bhuvanesh, Nanjan; Jayaraj, Haritha; Prabhu, Jeyaraj; Nandhakumar, Raju] Karunya Inst Technol & Sci Deemed Be Univ, Dept Chem, Coimbatore 641114, Tamil Nadu, India; [Thamilselvan, Annadurai] CSIR, Electro Organ Div, Cent Electrochem Res Inst, CECRI, Karaikkudi 630003, Tamil Nadu, India in 2020.0, Cited 105.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A simple S-S (disulfide)-bridged dimeric Schiff base probe, L, has been designed, synthesized, and successfully characterized for the specific recognition of Al3+ and Fe2+ ions as fluorometric and colorimetric turn-on responses in a dimethylformamide (DMF)-H2O solvent mixture, respectively. The probe L and each metal ion bind through a 1:1 complex stoichiometry, and the plausible sensing mechanism is proposed based on the inhibition of the photoinduced electron transfer process (PET). The reversible chemosensor L showed high sensitivity toward Al3+ and Fe2+ ions, which was analyzed by fluorescence and UV-vis spectroscopy techniques up to nanomolar detection limits, 38.26 X 10(-9) and 17.54 x 10(-9) M, respectively. These experimental details were advocated by density functional theory (DFT) calculations. The practical utility of the chemosensor L was further demonstrated in electrochemical sensing, in vitro antimicrobial activity, molecular logic gate function, and quantification of the trace amount of Al3+ and Fe2+ ions in real water samples.

Welcome to talk about 56-17-7, If you have any questions, you can contact David, CI; Bhuvanesh, N; Jayaraj, H; Thamilselvan, A; Devi, DP; Abiram, A; Prabhu, J; Nandhakumar, R or send Email.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem