Category: 92-30-8

Research speed reading in 2021. Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. , Electric Literature of 92-30-8, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Edayadulla, Naushad, introduce the new discover.

Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1, 1-dioxide derivatives as potent anticonvulsant agents

An efficient synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives has been achieved under aqueous medium for the first time in good to excellent yields. All the synthesized compounds were tested for anticonvulsant activity using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) screens, which are the most broadly employed seizure models for early identification of candidate anticonvulsants. Their neurotoxicity was determined applying the rotarod test. Seven compounds 4a, 4d, 4f, 4h, 4o, 4p and 4q showed promising anticonvulsant activities in both models employed for anticonvulsant evaluation. The most active compound 4d showed the MES-induced seizures with ED50 value of 10.2 mg/kg and TD50 value of 288.6 mg/kg after intraperitoneal injection to mice, which provided compound 4d with a protective index (TD50/ED50) of 28.3 in the MES test. (C) 2014 Elsevier Masson SAS. All rights reserved.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, belongs to thiazines compound, is a common compound. In a pantent, author is Pluta, Krystian, once mentioned the new application about 92-30-8, COA of Formula: https://www.ambeed.com/products/92-30-8.html.

Azaphenothiazines – promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties

For the last two decades, classical phenothiazines have attracted attention of researchers, as the hitherto investigations have revealed many significant biological activities within this class of compounds, other than originally discovered neuroleptic ones. Important, new pharmaceutical results on phenothiazines, as 10-substituted dibenzothiazines, were recently highlighted in several reviews. Azaphenothiazines are structurally modified phenothiazines by substitution of one or both benzene rings in the phenothiazine ring system with the azine rings, such as: pyridine, pyridazine, pyrimidine, pyrazine, 1,2,4-triazine, quinoline, quinoxaline, benzoxazine and benzothiazine. They form over 50 different heterocyclic systems, of tri-, tetra-, penta- and hexacyclic structures, and contain from one to even four azine nitrogen atoms. This review summarizes the methodical knowledge on azaphenothiazines, referring to their nomenclature, synthesis, structure analysis and above all significant varied biological activities, examined in vitro and in vivo. It describes, in addition, current trends in the synthesis of azaphenothiazines. The influence of the azaphenothiazine ring system, the nature of the substituents, predominantly at the thiazine nitrogen atom, as well as at the azine nitrogen atom and carbon atom, on the biological activities, were also discussed. (C) 2017 Elsevier Masson SAS. All rights reserved.

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 92-30-8, COA of Formula: https://www.ambeed.com/products/92-30-8.html.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, belongs to thiazines compound, is a common compound. In a pantent, author is Chandarana, Helly, once mentioned the new application about 92-30-8, Product Details of 92-30-8.

Surface functionalizedCasuarina equisetifoliapine powder for the removal of hetero-polyaromatic dye: characteristics and adsorption

The seed ofCasuarina equisetifolia, the genus of Pinus of the familyPinaceaewas examined for the potentiality of adsorbing a thiazine-based hetero-polyaromatic dye from water system. For which, the surface functionalization ofCasuarina equisetifolia(SFCE) was achieved through H(2)SO(4)acidic bath to treat methylene blue (MB) dye contaminated water. The SFCE was characterised using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) to analyse morphological, physical and chemical behaviour after surface modification. The effects of adsorption process influencing variables such as pH, concentration of MB dye, contact time and temperature was examined. The maximum adsorption capacity of 0.5 gL(-1)SFCE for the concentration ranging from 20 to 100 mgL(-1)of MB was investigated using different variables. The effect of parameters including pH, time and temperature were optimised at a speed of agitation of 150 rpm. The adsorption data retrieved from batch experiments were fit with Langmuir, Freundlich, Temkin and Dubinin-Raduskevich (D-R) isotherm models, and as a result, Freundlich presents the best fit (R-2 > 0.97). Pseudo-second order kinetic was superior indicating that SFCE-MB system has undergone the chemisorption mechanism (R-2 > 0.99) spontaneously. Overall, the tested system with synergistic effect was witnessed with maximum adsorption efficiency of 42.19 mg g(-1)to remove dye from industrial wastewater.

Product Details of 92-30-8, The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 92-30-8.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, belongs to thiazines compound, is a common compound. In a pantent, author is Koyioni, Maria, once mentioned the new application about 92-30-8, Reference of 92-30-8.

Synthesis of Fused 1,2,4-Dithiazines and 1,2,3,5-Trithiazepines

Reacting (Z)-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-1H-pyrazol-5-amines 5 with Et2NH and then with concd H2SO4 gives 5H-pyrazolo[3,4-e][1,2,4]dithiazine-3-carbonitriles 7 in good yields (74-85%) and 6H-pyrazolo[3,4-f][1,2,3,5]trithiazepine-4-carbonitriles 9 as minor products (0-6%). Furthermore, the 1,3-dimethylpyrazole analogue 5a was transformed into the dithiazine 7a in two discrete steps, allowing the isolation of a disulfide intermediate (Z)-2-[(diethylamino)disulfan-yl]-2-[(1H-pyrazol-5-yl)imino]acetonitrile (8a). The one-pot, two-step reaction also worked with electron-rich hydroxy- and methoxy-substituted anilines. Thermolysis of the pyrazolo[3,4-e][1,2,4]dithiazines 7 gave the ring-contracted 1H-pyrazolo[3,4-d]thiazole-5-carbonitriles 6 (94-100%). With active sulfur, 1,3-dimethyl-5H-pyrazolo[3,4-e][1,2,4]dithiazine-3-carbonitrile (7a) gave 1,3-dimethyl-6H-pyrazolo[3,4-f][1,2,3,5]trithiazepine-4-carbonitrile (9a), but on prolonged reaction times, it gave 5,7-dimethyl-5H-[1,2,3]dithiazolo[4,5-b]pyrazolo[3,4-e][1,4]thiazine (13). Finally, in the absence of acid, heating a solution of (Z)-2-[(diethylamino)disulfanyl]-2-[(1,3-dimethyl-1H-pyrazol-5-yl)imino]acetonitrile (8a) gave 4,6,10,12-tetramethyl-6H-pyrazolo[3,4-f]pyrazolo[3′,4′:4,5]pyrimido[6,1-d][1,2,3,5]trithiazepine-8,12b(10H)-dicarbonitrile (19) (67%).

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. , Synthetic Route of 92-30-8, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Dar’in, Dmitrii, introduce the new discover.

Realizing the Trifunctional Potential of Alkyl 4-Chloro-2-diazo-3-oxobutanoates: Convenient Assembly of 6,7-Dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]thiazine Core

The first example of exploiting the trifunctional character of alkyl 4-chloro-2-diazo-3-oxobutanoates in the reactions with vicinal N , S -bis-nucleophiles leading to the formation of bicyclic 6,7-dihydro-4 H -[1,2,3]triazolo[5,1- c ][1,4]thiazines is presented. The key to the successful realization of the atom-economical synthetic strategy is the initial S (N) 2 event, which facilitates the subsequent domino 1,2,3-triazole formation via the Wolff reaction. Equally important is the choice of sodium acetate as the base: acetic acid formed in the course of the initial nucleophilic substitution acts as an efficient catalyst for the Wolff reaction, which suppresses the competing, unwanted fragmentation path (observed when other bases are used).

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. , Quality Control of 2-(Trifluoromethyl)-10H-phenothiazine, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Choukade, Ritumbhara, introduce the new discover.

Characterization of biogenically synthesized silver nanoparticles for therapeutic applications and enzyme nanocomplex generation

The present study describes green synthesis of silver nanoparticles (AgNPs) and inulin hydrolyzing enzyme nanocomplexes (ENC) usingAzadirachta indica(Ai) andPunica granatum(Pg) leaf extracts. Surface topology and physico-chemical characteristics of AgNPs were studied using surface plasmon resonance (SPR), FTIR, SEM, AFM and EDX analyses. Particle size analysis using dynamic light scattering and AFM studies revealed thatAi-AgNPs (76.4 nm) were spherical in shape having central bigger nano-regime with smaller surroundings whilePg-AgNPs (72.1 nm) and ENCs (Inulinase-Pg-AgNPs similar to 145 nm) were spherical particles having smooth surfaces.Pg-AgNPs exhibited significant photocatalysis of a thiazine dye, methylene blue. BothAi-andPg-AgNPs showed selective antibacterial action by inhibiting pathogenicBacillus cereus, while the probioticLactobacillusstrains remained unaffected.Ai-AgNPs showed potential anti-biofilm effect (30% viability) onB. cereusbiofilms.Pg-AgNPs showed anti-cancer effect against human colon cancer cell lines (Caco-2) resulting in 40% cell death in 48 h. Enzymes (inulinase, L-asparaginase and glucose oxidase) were successfully immobilized onto nanoparticles together with the biogenic synthesis of AgNPs and recyclability of the Inulinase-Pg-AgNPs complex was demonstrated. The study elaborates characteristics of green synthesized nanoparticles and their potential applications as anti-cancer, antibacterial and antioxidant nano drugs that could be used in food and nutraceutical industries. Enzyme immobilization on AgNPs without any toxic cross-linker opens up newer possibilites in enzyme-nanocomplex research.

Quality Control of 2-(Trifluoromethyl)-10H-phenothiazine, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 92-30-8.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. , Quality Control of 2-(Trifluoromethyl)-10H-phenothiazine, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Choukade, Ritumbhara, introduce the new discover.

Characterization of biogenically synthesized silver nanoparticles for therapeutic applications and enzyme nanocomplex generation

The present study describes green synthesis of silver nanoparticles (AgNPs) and inulin hydrolyzing enzyme nanocomplexes (ENC) usingAzadirachta indica(Ai) andPunica granatum(Pg) leaf extracts. Surface topology and physico-chemical characteristics of AgNPs were studied using surface plasmon resonance (SPR), FTIR, SEM, AFM and EDX analyses. Particle size analysis using dynamic light scattering and AFM studies revealed thatAi-AgNPs (76.4 nm) were spherical in shape having central bigger nano-regime with smaller surroundings whilePg-AgNPs (72.1 nm) and ENCs (Inulinase-Pg-AgNPs similar to 145 nm) were spherical particles having smooth surfaces.Pg-AgNPs exhibited significant photocatalysis of a thiazine dye, methylene blue. BothAi-andPg-AgNPs showed selective antibacterial action by inhibiting pathogenicBacillus cereus, while the probioticLactobacillusstrains remained unaffected.Ai-AgNPs showed potential anti-biofilm effect (30% viability) onB. cereusbiofilms.Pg-AgNPs showed anti-cancer effect against human colon cancer cell lines (Caco-2) resulting in 40% cell death in 48 h. Enzymes (inulinase, L-asparaginase and glucose oxidase) were successfully immobilized onto nanoparticles together with the biogenic synthesis of AgNPs and recyclability of the Inulinase-Pg-AgNPs complex was demonstrated. The study elaborates characteristics of green synthesized nanoparticles and their potential applications as anti-cancer, antibacterial and antioxidant nano drugs that could be used in food and nutraceutical industries. Enzyme immobilization on AgNPs without any toxic cross-linker opens up newer possibilites in enzyme-nanocomplex research.

Quality Control of 2-(Trifluoromethyl)-10H-phenothiazine, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 92-30-8.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, belongs to thiazines compound, is a common compound. In a pantent, author is Pluta, Krystian, once mentioned the new application about 92-30-8, Product Details of 92-30-8.

Azaphenothiazines – promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties

For the last two decades, classical phenothiazines have attracted attention of researchers, as the hitherto investigations have revealed many significant biological activities within this class of compounds, other than originally discovered neuroleptic ones. Important, new pharmaceutical results on phenothiazines, as 10-substituted dibenzothiazines, were recently highlighted in several reviews. Azaphenothiazines are structurally modified phenothiazines by substitution of one or both benzene rings in the phenothiazine ring system with the azine rings, such as: pyridine, pyridazine, pyrimidine, pyrazine, 1,2,4-triazine, quinoline, quinoxaline, benzoxazine and benzothiazine. They form over 50 different heterocyclic systems, of tri-, tetra-, penta- and hexacyclic structures, and contain from one to even four azine nitrogen atoms. This review summarizes the methodical knowledge on azaphenothiazines, referring to their nomenclature, synthesis, structure analysis and above all significant varied biological activities, examined in vitro and in vivo. It describes, in addition, current trends in the synthesis of azaphenothiazines. The influence of the azaphenothiazine ring system, the nature of the substituents, predominantly at the thiazine nitrogen atom, as well as at the azine nitrogen atom and carbon atom, on the biological activities, were also discussed. (C) 2017 Elsevier Masson SAS. All rights reserved.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Research speed reading in 2021. While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. , HPLC of Formula: https://www.ambeed.com/products/92-30-8.html, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Thompson, Andrew M., introduce the new discover.

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3] thiazine 8-oxides

A 900 compound nitroimidazole-based library derived from our pretomanid backup program with TB Alliance was screened for utility against human African trypanosomiasis (HAT) by the Drugs for Neglected Diseases initiative. Potent hits included 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3] thiazine 8-oxides, which surprisingly displayed good metabolic stability and excellent cell permeability. Following comprehensive mouse pharmacokinetic assessments on four hits and determination of the most active chiral form, a thiazine oxide counterpart of pretomanid (24) was identified as the best lead. With once daily oral dosing, this compound delivered complete cures in an acute infection mouse model of HAT and increased survival times in a stage 2 model, implying the need for more prolonged CNS exposure. In preliminary SAR findings, antitrypanosomal activity was reduced by removal of the benzylic methylene but enhanced through a phenylpyridine-based side chain, providing important direction for future studies (C) 2017 Elsevier Ltd. All rights reserved.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, belongs to thiazines compound, is a common compound. In a pantent, author is Yusni, Effendi Mohd, once mentioned the new application about 92-30-8, Reference of 92-30-8.

Removal behaviour of a thiazine, an azo and a triarylmethane dyes from polluted kaolinitic soil using electrokinetic remediation technology

In this study, we investigated the potentiality of the electro-kinetic remediation (EKR) technique for the removal of organic dyes polluted soil. Methylene blue (MB), methyl orange (MO), and phenol red (PR) are representing a thiazine, an azo, and a tryarilmethane dye respectively, which was spiked with kaolinite were selected as a model for pollutant dyes tests. An EKR tool (15 cm length) equipped with a DC electric current with the maximum values of 30 V. Graphite electrodes were used for both anode and cathode was set up for two weeks operation. As a result, only 40-55 % of dye was removed from the soil sections by using distilled water. However, by the addition of some electrolytes; the percentage of dyes removed from the soil increased from 73-76 % and 85-89 % for sodium sulphate, and monosodium dihydrogen phosphate, respectively. It resulted that 55-64 % of dyes was removed without controlling the pH. The significant improvement was achieved by controlling the pH of the system. By controlling the pH in the cathode chamber, only 23 % of MB, 25 % of MO, and 18 % of PR dyes remain in the soil sections, respectively. While by controlling the pH in the anode chamber, almost 90 % of tested dyes could be removed from the kaolinite chamber effectively. The movement of a thiazine dye, from the anode to the cathode chamber was controlled by electro-migration and electro-osmosis phenomena. An azo dye transported from the cathode to the anode chamber by a similar process. However, a triarylmethane dye was removed from the soil sections by only electro-osmosis process. For three kinds of tested dyes, it were found that electro-osmotic flow moving from the anode to the cathode directions. The ageing of dye affects the removal percentage of the dye. (C) 2015 Elsevier Ltd. All rights reserved.

Reference of 92-30-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 92-30-8.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem