Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Category: thiazines, 82911-69-1, Name is N-(9-Fluorenylmethoxycarbonyloxy)succinimide, molecular formula is C19H15NO5, belongs to thiazines compound. In a document, author is Badrey, Mohamed G., introduce the new discover.
An Approach to Polysubstituted Triazipines, Thiadiazoles and Thiazoles Based on Benzopyran Moiety Through The Utility of Versatile Hydrazonoyl Halides as In Vitro Monoamine Oxidase Inhibitors
The chromene compound 1 is used as a key intermediate for synthesis of new heterocyclic compounds, and it reacted with hydrazonoyl chlorides in presence of TEA to give the amidrazone derivatives 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, which were cyclized to the corresponding triazepines 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h on boiling with sodium ethoxide. Conversion of compound 1 to the methylthiocarbamate derivative 6 was performed through its reaction with carbon disulfide and KOH followed by treatment with methyl iodide. Compound 6 reacted with hydrazonoyl chlorides in presence of TEA to give thiadiazoles 8a, 8b, 8c, 8d, 8e, 8f, 8g. In addition, chromene 1 combined with aminodithiocarbamic acid in DMF under reflux to furnish the thiosemicarbazide derivative 9, which in turn interacted with several hydrazonoyl chlorides to give the thiazole derivatives 11a, 11b, 11c, 11d, 11e. The structures of the prepared compounds were confirmed from their spectroscopic data and elemental analysis. The synthesized compounds were tested against both monoamine oxidase (MAO)-A and MAO-B and corrected to analyses showed good inhibitory activities especially against MAO-A.
I am very proud of our efforts over the past few months and hope to 82911-69-1 help many people in the next few years. Category: thiazines.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem