A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6192-52-5, Name is 4-Methylbenzenesulfonic acid hydrate, molecular formula is C7H10O4S. In an article, author is Wang, Hecheng,once mentioned of 6192-52-5, COA of Formula: C7H10O4S.
Mass Spectral Profile for Rapid Differentiating Beta-Lactams from Their Ring-Opened Impurities
High performance liquid chromatography tandem mass spectrometry (HPLC MS) has been widely used for beta-lactam antibiotics determination. However, its application to identify impurities of these frequently used drugs is not sufficient at present. In this job, characteristic profiles of the collision induced dissociation (CID) spectra of both beta-lactams and ring-opened beta-lactams were extracted from the MS data of six beta-lactam antibiotics and their forty-five impurities, and were confirmed by the MS data reported in the literature. These characteristics have been successfully applied to rapid differentiation of beta-lactam and ring-opened beta-lactam impurities in cefixime, cefdinir, and cefaclor. However, these characteristic profiles can only be obtained under low activating voltage. They did not display in the high energy activated CID spectra. Diagnostic fragmentations for determining the localization of double bond and substituents on the thiazine ring and the side chain were also observed. In addition, several characteristic fragmentations are hopeful to be used to differentiate the configurations of C-2 on the thiazine ring of ring-opened impurities, which is generally disadvantageous of mass spectrometry. Taken together, forty-five impurities were identified from the capsules of cefixime, cefdinir, and cefaclor.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem