Category: 38642-74-9

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 38642-74-9, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 38642-74-9, Name is 2-Cyano-phenothiazine, molecular formula is C13H8N2S

Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? – A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection

Purpose: Only a fraction of the currently established low-molecular weight antioxidants exhibit cytoprotective activity in living cells, which is considered a prerequisite for their potential clinical usefulness in Parkinson?s disease or stroke. Post hoc structure-activity relationship analyses have predicted that increased lipophilicity and enhanced radical stabilization could contribute to such cytoprotective activity. Methods: We have synthesized a series of novel phenothiazine-type antioxidants exhibiting systematic variation in their lipophilicity and radical stabilization. Phenothiazine was chosen as lead structure for its superior activity at baseline. The novel compounds were evaluated for their neuroprotective potency in cell culture, and for their primary molecular targets. Results: Lipophilicity was associated with enhanced cytoprotective activity, but only to a certain threshold (logP ? 7). Benzannulation likewise produced improved cytoprotectants that exhibited very low EC50 values of ~8?nM in cultivated neuronal cells. Inhibition of global protein oxidation was the best molecular predictor of cytoprotective activity, followed by the inhibition of membrane protein autolysis. In contrast, the inhibition of lipid peroxidation in isolated brain lipids and the suppression of intracellular oxidant accumulation were poor predictors of cytoprotective activity, primarily as they misjudged the cellular advantage of high lipophilicity. Conclusions: Lipophilicity, radical stabilization and molecular weight appear to form an uneasy triangle, in which a slightly faulty selection may readily abolish neuroprotective activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 38642-74-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 38642-74-9, in my other articles.

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Application of 38642-74-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, Application of 38642-74-9, molcular formula is C13H8N2S, introducing its new discovery.

Method for synthesizing N – aryl phenothiazine compounds (by machine translation)

The invention discloses a method for synthesizing N – aryl phenothiazine compounds, which belongs to the technical field of organic chemistry. In order to indole compounds 1 and phenothiazine 2 as reaction raw material, cuprous bromide as a catalyst, in a polar aprotic solvent, under the air atmosphere of the reaction, the obtained N – aryl substituted phenothiazine compounds 3. The invention using air as the oxidizing agent, with green, economic, and environmental protection, the use of the indole and phenothiazine between dehydrogenation C (sp2 ) – H/N – H cross-coupling, constructing the model C – N key, widens the N – aryl phenothiazine compound synthesis method. (by machine translation)

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Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.category: thiazines, Name is 2-Cyano-phenothiazine, molecular formula is C13H8N2S, category: thiazines. In a Article, authors is Tang, Shan£¬once mentioned of category: thiazines

Electrochemical Oxidative C?H Amination of Phenols: Access to Triarylamine Derivatives

Dehydrogenative C?H/N?H cross-coupling serves as one of the most straightforward and atom-economical approaches for C?N bond formation. In this work, an electrochemical reaction protocol has been developed for the oxidative C?H amination of unprotected phenols under undivided electrolytic conditions. Neither metal catalysts nor chemical oxidants are needed to facilitate the dehydrogenation process. A series of triarylamine derivatives could be obtained with good functional-group tolerance. The electrolysis is scalable and can be performed at ambient conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: thiazines. In my other articles, you can also check out more blogs about category: thiazines

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Electric Literature of 38642-74-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.Electric Literature of 38642-74-9, Name is 2-Cyano-phenothiazine, molecular formula is C13H8N2S. In a Article, authors is Sasano, Yusuke£¬once mentioned of Electric Literature of 38642-74-9

2-Azaadamantane N-oxyl (AZADO)/Cu Catalysis Enables Chemoselective Aerobic Oxidation of Alcohols Containing Electron-Rich Divalent Sulfur Functionalities

The chemoselective oxidation of alcohols containing electron-rich sulfur functionalities (e.g., 1,3-dithianes and sulfides) into their corresponding carbonyl compounds with the sulfur groups can sometimes be a demanding task in modern organic chemistry. A reliable method for this transformation, which features azaadamantane-type nitroxyl radical/copper catalysis using ambient air as the terminal oxidant is reported. The superiority of the developed method was demonstrated by comparing it with various conventional alcohol oxidation methods.

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Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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Efficient and regioselective synthesis of phenothiazine via ferric citrate catalyzed C-S/C-N cross-coupling

Efficient C-S and C-N cross-coupling reactions have been developed for regioselective, scalable and environmentally benign synthesis of substituted phenothiazine derivatives. Cross-coupling reactions were demonstrated on various challenging substrates using non-toxic, highly economical, readily available ferric citrate as a catalyst to get desired product with high regioselectivity. Atom economy is the added advantage of this protocol since additional N-protection step before coupling and eventual deprotection of the same to obtain the desired product arenot required. To the best of our knowledge, this is the first report on the use of inexpensive ferric citrate as a catalyst without involving any ligand for the synthesis of regioselectively substituted phenothiazine.

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Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

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Identification of a non peptidic RANTES antagonist

A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50 = 3 muM) was found to inhibit specific binding of 125I-RANTES, but not 125I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Application of 38642-74-9, One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Marivingt-Mounir, Cecile, mentioned the application of Application of 38642-74-9, Name is 2-Cyano-phenothiazine, molecular formula is C13H8N2S

A Facile Synthesis of Cyanophenothiazines

A one-pot synthesis of 1, 3 and 4-cyanophenothiazines and a two-step approach to 2-cyanoisomer have been developed. The condensation of 2-aminobenzenethiol and 2,3 or 3,4-dihalogenobenzonitriles followed by Smiles rearrangement or by intramolecular aromatic substitution gave the desired ring systmes.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Electric Literature of 38642-74-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 38642-74-9, molcular formula is C13H8N2S, introducing its new discovery.

PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS

The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 2-Cyano-phenothiazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 38642-74-9, Name is 2-Cyano-phenothiazine, molecular formula is C13H8N2S

Synthesis of deuterium-labeled cyamemazine and monodesmethyl cyamemazine

A novel approach is presented for the synthesis of cyamemazine maleate and N-desmethyl cyamemazine maleate using a 10-(amino-2-methylpropyl)phenothiazine derivative. This method was successfully applied to the synthesis of [ 2H6]cyamemazine maleate and N-desmethyl-[ 2H3]cyamemazine maleate.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of 2-Cyano-phenothiazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 38642-74-9, in my other articles.

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem

 

Related Products of 38642-74-9, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. Related Products of 38642-74-9, name is 2-Cyano-phenothiazine. In an article£¬Which mentioned a new discovery about Related Products of 38642-74-9

A metal- and oxidizing-reagent-free anodic para-selective amination of anilines with phenothiazines

A highly para-selective amination of anilines with phenothiazines for producing various functionalized 10-aryl-10H-phenothiazines is reported. The oxidative amination reaction proceeds electrochemically at room temperature, thereby avoiding the use of metals and oxidizing reagents with excellent functional group tolerance and broad substrate scope.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about Related Products of 38642-74-9 is helpful to your research. Related Products of 38642-74-9

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem