Category: 3080-99-7

As a common heterocyclic compound, it belong thiazines compound,3,4-Dihydro-2H-benzo[b][1,4]thiazine,3080-99-7,Molecular formula: C8H9NS,mainly used in chemical industry, its synthesis route is as follows.,3080-99-7

To a round bottom flask charged with compound 16-1 (151 mg, 1.0 mmol) and methyl 4-(bromomethyl)benzoate (228 mg, 1.0 mmol) in DMF (5 mL) was added K2CO3 (276 mg, 2.0 mmol). The resulting mixture was allowed to stir for 2 h at 80 C. The mixture was cooled to room temperature and after addition of water (15 mL) extracted with EtOAc (3 x 15 mL). The combined organic extracts were washed with brine (20 mL), dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by flash chromatography (0 – 50% EtOAc/hexanes) to afford as colorless oil (110 mg, 37%).1H NMR (CDCI3) delta 8.00, 7.33 (AlphaAlpha’ChiChi’ multiplet, AX + J AX = 8.4 Hz, 4H), 7.08 (dd, / = 7.7 Hz, 1.5 Hz, 1H), 6.90 (incompletely resolved ddd approaching dt, average of two larger / = 7.8 Hz, additional / = 1.1 Hz, 1H), 6.63 (incompletely resolved ddd approaching dt, average of two larger / = 7.5 Hz, additional / = 0.8 Hz, 1H), 6.54 (dd, 7 = 8.3 Hz, 0.7 Hz, 1H), 4.57 (s, 2H), 3.90 (s, 3H), 3.69, 3.08 (AlphaAlpha’ChiChi’ multiplet, AX + J AX = 10.4 Hz, 4H). 13C NMR (CDCI3) delta 166.9, 143.8, 143.4, 130.1 (2C), 129.1, 128.0, 126.6 (2C), 126.1, 118.0, 117.8, 113.2, 56.3, 52.1, 50.6, 25.9. ESI LRMS: [M+H]+, mlz 300.2.

With the synthetic route has been constantly updated, we look forward to future research findings about 3,4-Dihydro-2H-benzo[b][1,4]thiazine,belong thiazines compound

Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; KOZIKOWSKI, Alan; SHEN, Sida; BERGMAN, Joel; (100 pag.)WO2017/142883; (2017); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

A common heterocyclic compound, the thiazines compound, name is 3,4-Dihydro-2H-benzo[b][1,4]thiazine,cas is 3080-99-7, mainly used in chemical industry, its synthesis route is as follows.

In a manner similar to the method described in Example 1-1, using 3,4-dihydro-2H-benzo[1,4]thiazine in place of 1,2,3,4-tetrahydroquinoline, 239 mg (yield: 63%) of the captioned compound was obtained.1H-NMR (ppm) (300 MHz, CDCl3) 6.98 (1H, dd, J = 1.8, 7.9 Hz), 6.86 (1H, ddd, J = 1.8, 7.3, 8.5 Hz), 6.78 (1H, d, J = 8.2 Hz), 6.69-6.65 (2H, m), 6.61-6.5 (1H, ddd, J = 1.2, 7.6, 8.5 Hz), 4.61 (1H, d, J = 8.2 Hz), 3.85 (3H, s), 3.60-3.51 (3H, m), 3.14-2.96 (4H, m), 2.55-2.50 (1H, m), 2.41 (3H, s), 2.38-2.32 (1H, m), 2.23-2.12 (2H, m), 1.91-1.47 (5H, m), 1.12-1.00 (1H, m) IR (cm-1) (KBr) 2924, 1735, 1606, 1584, 1483, 1438, 1373, 1338, 1275, 1257, 1176, 1148, 1112, 1079, 1047, 1006, 937, 907, 891, 854, 793, 744

As the rapid development of chemical substances, we look forward to future research findings about 3080-99-7

Reference£º
Patent; TORAY INDUSTRIES, INC.; EP1555266; (2005); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3080-99-7,3,4-Dihydro-2H-benzo[b][1,4]thiazine,as a common compound, the synthetic route is as follows.

Example 9: Synthesis of 2- (2, 3-DIHYDROBENZOLL, 4] thiazin-4-ylmethyl)-1, 1, 1-TRIFLUORO-4- (5- fluoro-2-methoxyphenyl)-4-methylpentan-2-ol A solution of 2- [2- (5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane (118 mg) and 3, 4-dihydro-2H-1, 4-benzothiazine (H. I. EL-SUBBAGH et AL., Arch. Pharm. Med. Chem., 1999, 332, pp. 19-24) (122 mg) in dimethylformamide (1 mL) was heated at 140C for 73 hours. The resulting mixture was diluted with diethyl ether, washed with saturated aqueous sodium bicarbonate, water and brine, dried over magnesium sulfate, filtered, and concentrated in vacuo. The residue was purified by radial chromatography with a chromatotron (eluted with 0% to 1% ethyl acetate-hexanes) to give the title compound as a white solid (53.5 mg), m. p. 103C-104C.

3080-99-7 3,4-Dihydro-2H-benzo[b][1,4]thiazine 151064, athiazines compound, is more and more widely used in various.

Reference£º
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2004/63163; (2004); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

3080-99-7, 3,4-Dihydro-2H-benzo[b][1,4]thiazine is a thiazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(3d) Potassium carbonate (5.2 g, 37.7 mmol) and methyl 4-(bromomethyl)benzoate (2.8 g, 12.6 mmol) were added to a solution of (3c) (1.9 g, 12.6 mmol) in 20 mL of anhydrous DMF. The reaction mixture was heated to 80 C. overnight. After cooling to rt, the solid was filtered off and rinsed with DMF. The filtrate was concentrated in vacuo and the residue was purified on silica gel column to provide methyl 4-(2,3-dihydro-4H-1,4-benzothiazin-4-ylmethyl)benzoate (3.02 g, 80%).

As the paragraph descriping shows that 3080-99-7 is playing an increasingly important role.

Reference£º
Patent; Duan, Jingwu; Jiang, Bin; Chen, Lihua; Lu, Zhonghui; Barbosa, Joseph; Pitts, William J.; US2003/229084; (2003); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

3080-99-7, 3,4-Dihydro-2H-benzo[b][1,4]thiazine is a thiazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a manner similar to the method described in Example 1-1, using 3,4-dihydro-2H-benzo[1,4]thiazine in place of 1,2,3,4-tetrahydroquinoline, 239 mg (yield: 63%) of the captioned compound was obtained.1H-NMR (ppm) (300 MHz, CDCl3) 6.98 (1H, dd, J = 1.8, 7.9 Hz), 6.86 (1H, ddd, J = 1.8, 7.3, 8.5 Hz), 6.78 (1H, d, J = 8.2 Hz), 6.69-6.65 (2H, m), 6.61-6.5 (1H, ddd, J = 1.2, 7.6, 8.5 Hz), 4.61 (1H, d, J = 8.2 Hz), 3.85 (3H, s), 3.60-3.51 (3H, m), 3.14-2.96 (4H, m), 2.55-2.50 (1H, m), 2.41 (3H, s), 2.38-2.32 (1H, m), 2.23-2.12 (2H, m), 1.91-1.47 (5H, m), 1.12-1.00 (1H, m) IR (cm-1) (KBr) 2924, 1735, 1606, 1584, 1483, 1438, 1373, 1338, 1275, 1257, 1176, 1148, 1112, 1079, 1047, 1006, 937, 907, 891, 854, 793, 744

3080-99-7 3,4-Dihydro-2H-benzo[b][1,4]thiazine 151064, athiazines compound, is more and more widely used in various.

Reference£º
Patent; TORAY INDUSTRIES, INC.; EP1555266; (2005); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3080-99-7,3,4-Dihydro-2H-benzo[b][1,4]thiazine,as a common compound, the synthetic route is as follows.

To a round bottom flask charged with compound 16-1 (151 mg, 1.0 mmol) and methyl 4-(bromomethyl)benzoate (228 mg, 1.0 mmol) in DMF (5 mL) was added K2CO3 (276 mg, 2.0 mmol). The resulting mixture was allowed to stir for 2 h at 80 C. The mixture was cooled to room temperature and after addition of water (15 mL) extracted with EtOAc (3 x 15 mL). The combined organic extracts were washed with brine (20 mL), dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by flash chromatography (0 – 50% EtOAc/hexanes) to afford as colorless oil (110 mg, 37%).1H NMR (CDCI3) delta 8.00, 7.33 (AlphaAlpha’ChiChi’ multiplet, AX + J AX = 8.4 Hz, 4H), 7.08 (dd, / = 7.7 Hz, 1.5 Hz, 1H), 6.90 (incompletely resolved ddd approaching dt, average of two larger / = 7.8 Hz, additional / = 1.1 Hz, 1H), 6.63 (incompletely resolved ddd approaching dt, average of two larger / = 7.5 Hz, additional / = 0.8 Hz, 1H), 6.54 (dd, 7 = 8.3 Hz, 0.7 Hz, 1H), 4.57 (s, 2H), 3.90 (s, 3H), 3.69, 3.08 (AlphaAlpha’ChiChi’ multiplet, AX + J AX = 10.4 Hz, 4H). 13C NMR (CDCI3) delta 166.9, 143.8, 143.4, 130.1 (2C), 129.1, 128.0, 126.6 (2C), 126.1, 118.0, 117.8, 113.2, 56.3, 52.1, 50.6, 25.9. ESI LRMS: [M+H]+, mlz 300.2.

The synthetic route of 3080-99-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; KOZIKOWSKI, Alan; SHEN, Sida; BERGMAN, Joel; (100 pag.)WO2017/142883; (2017); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem