Category: 147118-35-2

As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, molecular formula is C31H39O4PSi. In an article, author is Zieba, Andrzej,once mentioned of 147118-35-2, Formula: C31H39O4PSi.

Application of Thin-Layer Chromatography to the Lipophilicity Analysis of Selected Anticancer Quinobenzothiazine Derivatives

The aim of this work was the application of thin-layer chromatography to the lipophilicity analysis of selected quinobenzothiazine derivatives. These are newly synthesized compounds, which were previously analyzed taking into consideration biological activity and their antiproliferative activity. Experimental lipophilicity parameters (R-M0 and log P-TLC) were determined by use of thin-layer chromatography, and also some theoretical values of lipophilicity were calculated by use of computer programs. The correlation between the experimental and the theoretical values of lipophilicity was found. Also, cluster analysis was performed for the data obtained. Phenothiazine derivatives were modified mainly by introduction of substituents into the nitrogen atom of the thiazine ring. The computer programs applied based on different theoretical approaches gave different values of lipophilicity parameters depending on the kind of substituent in the quinobenzothiazine system. None of the computer programs took into consideration the influence of substituents in a structure of the tested compounds, and in this case, the calculated lipophilicity parameter had the same value for all isomers with the same substituent. Also, none of the computer programs gave values of lipophilicity parameters close to these obtained by experimental method. The results of log P-calc for the compounds 1-13 were quite different according to the computer program used (log P-calc = 1.69-5.98). No computer programs gave values of log P-calc close to values of log P-TLC obtained experimentally. The reason can be the specific special structure of the tested phenothiazine derivatives consisting of tetracyclic system with additional nitrogen atom. It shows that calculation methods can be useless for the preliminary lipophilicity determination of such a kind of compounds.

Interested yet? Keep reading other articles of 147118-35-2, you can contact me at any time and look forward to more communication. Formula: C31H39O4PSi.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Application of 147118-35-2, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate.147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, SMILES is O=C(OC)C[C@H](O[Si](C)(C(C)(C)C)C)CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to thiazines compound. In a article, author is Rode, Navnath D., introduce new discover of the category.

First regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles

The regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles is described for the first time. The iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles using molecular iodine afforded diiodo-compound which on Cul-catalyzed intramolecular C-N coupling reaction gave six-membered 2-aryl-51141,2,4]triazolo[5,1-b][1,3]thiazines, whereas, the five membered 3-aryl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazoles were obtained exclusively when the iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles was carried out using NIS. (C) 2015 Elsevier Ltd. All rights reserved.

Application of 147118-35-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 147118-35-2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Application of 147118-35-2, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate.147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, SMILES is O=C(OC)C[C@H](O[Si](C)(C(C)(C)C)C)CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to thiazines compound. In a article, author is Rode, Navnath D., introduce new discover of the category.

First regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles

The regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles is described for the first time. The iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles using molecular iodine afforded diiodo-compound which on Cul-catalyzed intramolecular C-N coupling reaction gave six-membered 2-aryl-51141,2,4]triazolo[5,1-b][1,3]thiazines, whereas, the five membered 3-aryl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazoles were obtained exclusively when the iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles was carried out using NIS. (C) 2015 Elsevier Ltd. All rights reserved.

Application of 147118-35-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 147118-35-2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Reference of 147118-35-2, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate.147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, SMILES is O=C(OC)C[C@H](O[Si](C)(C(C)(C)C)C)CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to thiazines compound. In a article, author is Le, Tam Minh, introduce new discover of the category.

Synthesis and Transformation of (-)-Isopulegol-Based Chiral -Aminolactones and -Aminoamides

A library of isopulegol-based -amino acid derivatives has been developed from commercially-available (-)-isopulegol. Michael addition of primary and secondary amines towards ,-unsaturated -lactones was accomplished resulting in -aminolactones in highly-stereoselective reactions. Ring-opening of -aminolactones with different amines furnished excellent yields of -aminoamides. Moreover, the applicability of aminolactones in peptide synthesis was examined by opening the lactone ring with – and -aminoesters, providing dipeptides as promising chiral substrates for the synthesis of foldamers. The antiproliferative activities of -aminolactones and -aminoamides were explored, and the structure-activity relationships were studied from the aspects of the stereochemistry of the monoterpene ring and the substituent effects on the -aminoamide ring system. The N-unsubstituted (-)-isopulegol-based -aminoamides exhibited considerable antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF7 and MDA-MB-231).

Reference of 147118-35-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 147118-35-2 is helpful to your research.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, SMILES is O=C(OC)C[C@H](O[Si](C)(C(C)(C)C)C)CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to thiazines compound. In a document, author is Mills, A., introduce the new discover, Recommanded Product: (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate.

Novel temperature-activated humidity-sensitive optical sensor

A novel, colorimetric, temperature-activated humidity indicator is presented, with a colour change based on the semi-reversible aggregation of thiazine dyes (esp. methylene blue, MB) encapsulated within the polymer, hydroxypropyl cellulose (HPC). The initially purple MB/HPC film is activated by heat treatment at 370 degrees C for 4 s, at which point the film (with a colour associated with that of a highly aggregated form of MB; lambda(max) = 530 nm) becomes blue (indicating the presence of monomeric and dimeric MB; i.e. with lambda(max) = 665; 605 nm respectively). The blue, heat-treated MB/HPC films respond to an ambient environment with a relative humidity (RH) exceeding 70% at 21 degrees C within seconds, returning to their initial purple colour. This colour change is irreversible until the film is heat-treated once more. When exposed to a lower RH of up to ca. 47%, the film is stable in its blue form. In contrast, a MB/HPC film treated only at 220 degrees C for 15 s also turns a blue colour and responds in the same way to a RH value of ca. 70%, but it is unstable at moderate RH 37-50% values, so that it gradually returns to its purple form over a period of approximately 6 h. The possible use of the high heat-treated MB/HPC humidity indicator in the packaging of goods that cannot tolerate high RH, such as dry foods and electronics, is discussed. (C) 2016 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 147118-35-2 is helpful to your research. Recommanded Product: (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Related Products of 147118-35-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, SMILES is O=C(OC)C[C@H](O[Si](C)(C(C)(C)C)C)CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to thiazines compound. In a article, author is Mir, Shafia, introduce new discover of the category.

Synthetic Strategies of Benzothiazines: A Mini Review

Benzothiazine is a heterocyclic compound consisting of a benzene ring attached to the 6-membered thiazine ring. The benzothiazines constitute the group of heterocyclic compounds as they have found a variety of industrial uses and show promise as herbicides. Besides this, benzothiazines play an important role in the field of drug discovery as they have the potential to act as drug candidates for the treatment of a large number of diseases including, cancer, vasorelaxant, diabetic, hypertension, mycotic infection and microbial infection. The presence of nitrogen-sulphur axis and similarity in the structure with phenothiazine drugs help the benzothiazines to act as drugs for the treatment of a number of diseases. Herein, we represent different synthetic strategies for the simple and multi-component synthesis of benzothiazine heterocyclic derivatives. The strategies mostly involve the use of 2-aminothiophenol, 1, 3-dicarbonyl compounds or alpha-haloketones. In almost all the strategies, the potential yields have been obtained.

Related Products of 147118-35-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 147118-35-2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, SMILES is O=C(OC)C[C@H](O[Si](C)(C(C)(C)C)C)CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, in an article , author is Sirakanyan, Samvel N., once mentioned of 147118-35-2.

On the reactivity of pyrido[3 ‘,2 ‘:4,5]furo(thieno)[3,2-d]pyrimidin-7(8)-ones with some alkyl mono- and di-halides: synthesis of new heterocyclic systems containing thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b]thiazine moiety

Ethyl 1-aminofuro(thieno)[2,3-b]pyridine-2-carboxylates 1 reacted with benzoyl isothiocyanate and gave the relevant thioureido derivatives 2, whose intramolecular cyclization under the action of potassium hydroxide furnished the relevant 9(10)-thioxopyrido[3′,2′:4,5]furo(thieno)[3,2-d]pyrimidin-7(8)-ones 3. Compounds 3 with methyl iodide could give the S-methyl 4 and S,N-dimethyl 5 derivatives. Interestingly 3 by alkylation with alkyl dichlorides (bifunctional reagents) the cyclization to a thiazoline or to a thiazine ring on the [a] side of the pyrimidine ring occurs, with formation of the new pentacyclic systems: furo(thieno)[3,2-d][1,3]thiazolo[3,2-a]pyrimidin-7(8)-ones 6 and furo(thieno)[3′,2’:4,5]pyrimido[2,1-b] [1,3]thiazin-7(8)-ones 7. Moreover compounds 3 by alkylation with p-chlorophenacyl bromide (again a bifunctional reagent) led to the formation of the corresponding S-alkylated compounds 9, whose cyclization furnished structural analogues of compounds 6: p-chlorophenyl-substituted thiazolo[3,2-a] pyrimidin-7(8)-ones 10. The structure of the obtained compounds has been unambiguously confirmed by using a wide spectrum of physico-chemical methods and, in the instance of compounds 6 and 7, also by an alternative synthesis via a double-annelation reaction using a BMMA reagent. Biological tests have shown promising antimicrobial activity against Staphylococcus aureus for some of the synthesized compounds. (C) 2015 Elsevier Ltd. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 147118-35-2, you can contact me at any time and look forward to more communication. Recommanded Product: (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Reference of 147118-35-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, SMILES is O=C(OC)C[C@H](O[Si](C)(C(C)(C)C)C)CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to thiazines compound. In a article, author is Rode, Navnath D., introduce new discover of the category.

First regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles

The regioselective iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles is described for the first time. The iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles using molecular iodine afforded diiodo-compound which on Cul-catalyzed intramolecular C-N coupling reaction gave six-membered 2-aryl-51141,2,4]triazolo[5,1-b][1,3]thiazines, whereas, the five membered 3-aryl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazoles were obtained exclusively when the iodocyclization reaction of 3-aryl-5-(prop-2-ynylthio)-1H-1,2,4-triazoles was carried out using NIS. (C) 2015 Elsevier Ltd. All rights reserved.

Reference of 147118-35-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 147118-35-2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, molecular formula is C31H39O4PSi. In an article, author is Zieba, Andrzej,once mentioned of 147118-35-2, Category: thiazines.

Application of Thin-Layer Chromatography to the Lipophilicity Analysis of Selected Anticancer Quinobenzothiazine Derivatives

The aim of this work was the application of thin-layer chromatography to the lipophilicity analysis of selected quinobenzothiazine derivatives. These are newly synthesized compounds, which were previously analyzed taking into consideration biological activity and their antiproliferative activity. Experimental lipophilicity parameters (R-M0 and log P-TLC) were determined by use of thin-layer chromatography, and also some theoretical values of lipophilicity were calculated by use of computer programs. The correlation between the experimental and the theoretical values of lipophilicity was found. Also, cluster analysis was performed for the data obtained. Phenothiazine derivatives were modified mainly by introduction of substituents into the nitrogen atom of the thiazine ring. The computer programs applied based on different theoretical approaches gave different values of lipophilicity parameters depending on the kind of substituent in the quinobenzothiazine system. None of the computer programs took into consideration the influence of substituents in a structure of the tested compounds, and in this case, the calculated lipophilicity parameter had the same value for all isomers with the same substituent. Also, none of the computer programs gave values of lipophilicity parameters close to these obtained by experimental method. The results of log P-calc for the compounds 1-13 were quite different according to the computer program used (log P-calc = 1.69-5.98). No computer programs gave values of log P-calc close to values of log P-TLC obtained experimentally. The reason can be the specific special structure of the tested phenothiazine derivatives consisting of tetracyclic system with additional nitrogen atom. It shows that calculation methods can be useless for the preliminary lipophilicity determination of such a kind of compounds.

Interested yet? Keep reading other articles of 147118-35-2, you can contact me at any time and look forward to more communication. Category: thiazines.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

In an article, author is Morak-Mlodawska, Beata, once mentioned the application of 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, molecular formula is C31H39O4PSi, molecular weight is 534.7, MDL number is MFCD09753068, category is thiazines. Now introduce a scientific discovery about this category, Name: (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate.

The double Smiles rearrangement in neutral conditions leading to one of 10-(nitropyridinyl)dipyridothiazine isomers

Phenothiazines are reported to exhibit very promising anticancer, antibacterial, antifungal, anti-inflammatory activities, reversal of multidrug resistance and many other actions. Synthesis of phenotiazines is mostly carried cyclization of o-aminodiphenyl sulfides proceeded through the Smiles rearrangement. The modifications of the phenothiazine structure via the substitution of the benzene ring with the pyridine ring gave various pyridobenzothiazines and dipyridothiazines. The reaction of 3-amino-3′-nitro-2,2′-dipyridinyl sulfide with 4-chloro-3-nitropyridine in sole DMF led to one of four possible isomeric nitropyridinyldipyridothiazines. Two-dimensional H-1 and C-13 NMR experiments (COSY, ROESY, HSQC and HMBC) were used to reveal the right product structure as 10-(3′-nitro-4′-pyridinyl) dipyrido[2,3-b; 2′,3′-e] [1,4]thiazine (10-(3′-nitro-4′-pyridinyl)-1,6-diazaphenothiazine). The final structure confirmation came from a single crystal X-ray analysis. This structure is the result of very rare reaction mechanism involving the double Smiles rearrangement of the S-N type. The tricyclic dipyridothiazine system is unexpectedly almost planar, with the butterfly angle of 176.39(4) between two pyridine rings and 174.17(6)degrees between the halves of the thiazine ring (the NCCS) planes. The pyridinyl substituent is rotated about N10-C11 bond and oriented almost perpendicularly to the tricyclic ring system with the dihedral angle between the two planar systems of 94.93(3)degrees. The nitropyridinyl substituent is located quasi-equatorially with the S center dot center dot center dot N10-C11 angle of 176.92(8)degrees. The nitro group is tilted from the pyridine ring by 128.44(8)degrees. (C) 2016 Elsevier B.V. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 147118-35-2, Name: (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem