03/9/2021 News Awesome Chemistry Experiments For C12H12N2S

This is the end of this tutorial post, and I hope it has helped your research about 139-65-1. Category: thiazines.

While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 139-65-1, Name is 4,4-Thiodianiline, belongs to thiazines compound, is a common compound. In a pantent, author is Sebbar, N. K., once mentioned the new application about 139-65-1, Category: thiazines.

Crystal structure of 4-benzyl-2H-benzo[b][1,4] thiazin-3(4H)-one

In the title compound, C15H13NOS, the thiazine ring adopts a twisted boat conformation and the dihedral angle between the aromatic rings is 86.54 (4)degrees. In the crystal, molecules are linked by weak C-H center dot center dot center dot O interactions, resulting in chains along [010].

This is the end of this tutorial post, and I hope it has helped your research about 139-65-1. Category: thiazines.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

2 Sep 2021 News The Absolute Best Science Experiment for C12H12N2S

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Synthesis, Cytotoxicity Evaluation, Molecular Docking and Utility of Novel Chalcones as Precursors for Heterocycles Incorporating Pyrazole Moiety

Background: Chalcones, 2-pyrazolines and thiazoles have been reported to possess various pharmacological activities. Objective: Synthesis of new chalcones and utilizing them as a building block for constructing a series of thiazole derivatives and evaluating some of them as anticancer agents. Method: The new compounds were synthesized via stirring at room temperature or thermal heating. Cytotoxic evaluation of the new synthesized compounds was tested using the method of Skehan et al. Moreover, the computational studies were performed using MOE 2014.09 software. Result: A series of new chalcones were prepared by the reaction of ethyl 3-acetyl-1-aryl-5-methyl-1H-pyrazole-4-carboxylate with a number of substituted benzaldehydes. One of these chalcones was used as a building block for constructing a pyrazoline ring via its reaction with thiosemicarbazide. The produced carbothioamide derivative was used for the preparation of two series of thiazole derivatives by its reaction with a number of hydrazonoyl chlorides. Moreover, reaction of 3-acetylpyrazole thiosemicarbazone derivative with a number of N-aryl-2-oxopropane hydrazonoyl chlorides afforded 5-arylazothiazole derivatives. The assigned structures for all the newly synthesized compounds were confirmed on the basis of elemental analyses and spectral data. Some of the newly synthesized chalcones and thiazoles were tested for their cytotoxicity against human colon carcinoma cell line (HCT-116) and the molecular docking was carried out on the most active compound 3f. Conclusion: The results of the anticancer activity revealed that compounds 3f, 3e, 3c and 3b have promising activities compared with the standard drug Doxorubicin. Moreover, the computational studies confirm the results of biological activity. Also, the ADME profile study showed that compound 3f can be considered as a promising drug by conducting good pharmacokinetic and medicinal chemistry tests.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

1 Sep 2021 News Awesome and Easy Science Experiments about C12H12N2S

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Antimicrobial Properties of Substituted Quino [3,2-b]benzo[1,4] thiazines

Our previous studies demonstrated that among phenothiazines several derivatives could be found showing strong antiproliferative actions and the property of inhibiting inducible tumor necrosis factor alpha (TNF alpha) production in human blood cultures. The aim of this investigation was to determine potential antimicrobial actions of forty four new phenothiazine derivatives with the quinobenzothiazine structure. The compounds showed differential antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans depending on the compound structures, concentrations and bacterial strains. More specifically, 6-(1-methyl-2-piperidylethyl) quinobenzothiazine displayed strongest actions against S. aureus and E. coli whereas 6-methanesulfonylaminobutyl-9-methylthioquinobenzothiazine exhibited the most universal antimicrobial properties. The correlation between antimicrobial activity and the chemical structure of quinobenzothiazines was discussed.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

1 Sep 2021 News Our Top Choice Compound: C12H12N2S

Formula: https://www.ambeed.com/products/139-65-1.html, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 139-65-1 is helpful to your research.

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Synthesis of New Azoles and Azolopyrimidines Incorporating Morpholine Moiety as Potent Anti-Tumor Agents

A new series of morpholinyl-chalcones 2a-d was prepared by reaction of 2-oxo-N,4-diarylbut-3-enehydrazonoyl chlorides 1a-d with morpholine. These chalcones were used as a building block for constructing pyrazoles 3a-d and 3,4-dihydropyrimidine-2(1H)-thione 6 via their reaction with phenylhydrazine and thiourea, respectively. Moreover, a new series of azolopyrimidine derivatives 11a,b, 15, 17, 19, and 21 incorporating morpholine moiety were synthesized by reaction of 1-morpholino-4-phenyl 1 (2 phenylhydrazono)but-3-en-2-one (2a) with a number of heterocyclic amines in the presence of a catalytic amount of acetic acid. The assigned structures for all the newly synthesized compounds were confirmed on the basis of elemental analyses and spectral data and the mechanisms of their formation were also discussed. All the synthesized compounds were tested for in vitro activities against two antitumor cell lines, human lung cancer (A-549) and human hepatocellular carcinoma (HepG-2) compared with the employed standard antitumor drug (cisplatin) and the results revealed that compounds 6, 8c and 17 have promising activities compared with cisplatin.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemical Properties and Facts of C12H12N2S

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A new series of thiazolyl pyrazoline derivatives linked to benzo[1,3]dioxole moiety: Synthesis and evaluation of antimicrobial and anti-proliferative activities

2-(5-(Benzo[d][1,3]dioxol-5-yl)-3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-substituted phenyl)thiazole (7) and thiazole derivatives (9) were synthesized via reaction of 4,5-dihydro-1H-pyrazoles (5a,b) with substituted phenacyl bromide and a number of alpha-halo-compounds respectively. Also, (E)-2-(5-(benzo[d][1,3]dioxol-5-yl)-3-(naphthalen-1-yl)-4,5 dihydro-1H-pyrazol-1-yl)-4-methyl-5-(substituted phenyldiazenyl)thiazole (11) were prepared through reactions of carbothioamide (5a,b) with hydrazonoyl halides. In addition, thioamides (5a-b) were used as starting materials for preparation of thiazoles (12a-b) and benzylidene thiazoles (13a-b). Most of synthesized compounds show interesting biological properties as antimicrobial and antiproliferative activities, the results of minimum inhibitory concentration showed that pyrazole derivative 7c (MIC: 0.23 mg/mL) showed better results when compared with 11c and 12a (MIC: 0.1-0.125 mg/mL) as obtained from their MIC values. On the other hand, 2-(5-(benzo[d][1,3]dioxol-5-yl)-3-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-chlorophenyl) thiazole (7c) can be considered as the most promising anti-proliferative agent against HCT-116 cancer cells owing to its notable inhibitory effect on HCT-116 cells with an IC50 value of 6.19 mu M.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Interesting scientific research on 4,4-Thiodianiline

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Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. , Electric Literature of 139-65-1, 139-65-1, Name is 4,4-Thiodianiline, molecular formula is C12H12N2S, belongs to thiazines compound. In a document, author is Pitre, Spencer P., introduce the new discover.

Understanding the Kinetics and Spectroscopy of Photoredox Catalysis and Transition-Metal-Free Alternatives

CONSPECTUS: Over the past decade, the field of photoredox catalysis has gained increasing attention in synthetic organic chemistry because of its wide applicability in sustainable free-radical-mediated processes. Numerous examples have shown that under carefully optimized conditions, efficient and highly selective processes can be developed through excitation of a photosensitizer using inexpensive, readily available light sources. However, despite all of these recent advancements, some generalizations and/or misconceptions have become part of the photoredox culture, and often many of these discoveries lack in-depth investigations into the excited-state kinetics and underlying mechanisms. In this Account, we begin with a tutorial for understanding both the redox properties of excited states and how to measure the kinetics of excited-state processes. We discuss the generalization of direct excitation of closed-shell species to generate more potent reductive or oxidative excited states, using the helium atom as a quantitative example. We also outline how to apply redox potentials to calculate whether the proposed electron transfer events are thermodynamically feasible. In the second half of our tutorial, we discuss how to measure the kinetics of excited-state processes using techniques such as steady-state and time-resolved fluorescence and transient spectroscopy and how to apply the data using Stem-Volmer and kinetic analysis. Then we shift gears to discuss our recent contributions to the field of photoredox catalysis. Our lab focuses on developing transition metal-free alternatives to ruthenium and iridium bipyridyl complexes for these transformations, with the goal of developing systems in which the reaction kinetics is more favorable. We have found that methylene blue, a member of the thiazine dye family, can be employed in photoredox processes such as oxidative hydroxylations of arylboronic acids to phenols. Interestingly, we were able to demonstrate that methylene blue is more efficient for this reaction than Ru(bpy)(3)Cl-2, which upon further examination using transient spectroscopic techniques we were able to relate to the reductive quenching ability of the aliphatic amine. Recently we were also successful in applying methylene blue for radical trifluoromethylation reactions, which is discussed in detail. Finally, we have also demonstrated that common organic electron donors, such as alpha-sexithiophene, can be used in photoredox processes, which we demonstrate using the dehalogenation of vic-dibromides as a model system. This is a particularly interesting system because well-defined, long-lived intermediates allowed us to fully characterize the catalytic cycle. Once again, through an in-depth kinetic analysis we were able to gain valuable insights into our reaction mechanism, which demonstrates how powerful a tool proper kinetic analysis can be in the design and optimization of photoredox processes.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Our Top Choice Compound: 139-65-1

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Synthesis of Antifungal Agents from Xanthene and Thiazine Dyes and Analysis of Their Effects

Indoor fungi growth is an increasing home health problem as our homes are more tightly sealed. One thing that limits durability of the antifungal agents is the scarcity of reactive sites on many surfaces to attach these agents. In order to increase graft yield of photosensitizers to the fabrics, poly(acrylic acid-co-styrene sulfonic acid-co-vinyl benzyl rose bengal or phloxine B) were polymerized and then grafted to electrospun fabrics. In an alternative process, azure A or toluidine blue O were grafted to poly(acrylic acid), which was subsequently grafted to nanofiber-based and microfiber-based fabrics. The fabrics grafted with photosensitizers induced antifungal effects on all seven types of fungi in the order of rose bengal > phloxine B > toluidine blue O > azure A, which follows the quantum yield production of singlet oxygen for these photoactive dyes. Their inhibition rates for inactivating fungal spores decreased in the order of P. cinnamomi, T. viride, A. niger, A. fumigatus, C. globosum, P. funiculosum, and M. grisea, which is associated with lipid composition in membrane and the morphology of fungal spores. The antifungal activity was also correlated with the surface area of fabric types which grafted the photosensitizer covalently on the surface as determined by the bound color strength.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Top Picks: new discover of C12H12N2S

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Comparative transcriptome analysis of Anguilla japonica livers following exposure to methylene blue

The thiazine dye methylene blue is widely used as a disinfectant and antidote in veterinary medicine. Here, we compared transcriptome differences in the liver of Anguilla japonica exposed to methylene blue using Illumina RNA sequencing technology. A total of 75,953,174 and 86,499,866 clean reads with an average length of 126bp from control and treatment groups respectively. A total of 148,238 transcripts were assembled, with 62,152 components were assembled. Overall, 416,991 unigenes were checked against the National Center of Biotechnology Information, Non-redundant, Cluster of Orthologous Groups (COG), and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Of these, 18,541 genes were judged to be differently expressed. The gene ontology (GO) terms molecular function and biological process were the most enriched in protein binding, followed by ATP binding and regulation of transcription, and DNA-dependent. KEGG pathway analysis revealed significant enrichment of N-glycan biosynthesis and the citrate cycle. This study determined that unigenes related to transmembrane transport and drug metabolism in A.japonica were differentially expressed following exposure to methylene blue. These findings can shed insight into the mechanism of methylene blue metabolism in this economically important species.

This is the end of this tutorial post, and I hope it has helped your research about 139-65-1. Application In Synthesis of 4,4-Thiodianiline.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

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Efficient and Easy One-Pot Synthesis of New 3,5-Dioxo-thiazolo[2,3-a] pyrimidine-6-carbonitrile and 4,6-Dioxo-pyrimido[2,1-b][1,3]thiazine-7-carbonitrile Derivatives

An easy, fast, and cheap way for the synthesis of the new 3,5-dioxo-thiazolo[2,3-a] pyrimidine-6-carbonitriles and 4,6-dioxo-pyrimido[2,1-b][1,3]thiazine-7-carbonitriles using epoxides alpha-functionalized.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

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Synthesis and Structural Properties of N-(2-bromo-4-nitmphenyl)-3-methoxy-4-oxo-3,4-dihydro-2H-benzole 1,2] thiazine-3-carboxamide 1,1-dioxide: A Comparative Experimental and Quantum Chemical Study

N-(2-bromo-4-nitrophenyl)-3-methoxy-4-oxo-3,4-dihydro-2H-benzo[e] [1,2] thiazine-3-carboxamide-1,1-dioxide was synthesized in three step process with 86 % overall yield. The final structure of compound was evaluated by using spectroscoanalytical methods (H-1-NMR and FT-IR). Suitable crystals were obtained by slow evaporation method, and the final structure was confirmed unequivocally by performing single crystal X-ray diffraction (XRD) studies. Geometric parameters were calculated at B3LYP/6-3 1G (d, p) method with the help of Gaussian 09 software to validate spectrosopic and single crystal X-ray results. The computed data corroborated nicely with the experimental results (spectroscopic and X-ray). Frontier molecular orbitals (FMOs) and reactivity indices revealed the reactivity of benzothiazine derivative. Molecular electrostatic potential (MEP) was measured to understand the electro or nucleophilic nature of compound. Mulliken and natural population charge analysis (NBO) was carried out to prove inter and intramolecular hydrogen bonding.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem