In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 272437-84-0,3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid, as follows.272437-84-0
The acid (a) in tetrahydrofuran (50 ml) and triethylamine (4.7 ml) was cooled to [0C] and [ISOBUTYLCHLOROFORMATE] (4.02 ml) was added dropwise and the solution was stirred at [0C] for 2 hours, when it was filtered into a stirred solution of sodium borohydride (3.14 g) in ice/water (50 ml). The mixture was stirred at [0C] for 1 hour and allowed to warm to room temperature. It was acidified with 2M hydrochloric acid, evaporated to half volume, and the resulting product was collected, washed with water and dried in vacuo, to give a white solid (4.5 g). MS (-ve ion electrospray) [M/Z] 194 (M-H)-
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. 272437-84-0, We look forward to the emergence of more reaction modes in the future.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/2992; (2004); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem