Authors Xie, YL; Wang, YF; He, ZY; Yang, W; Fu, BS; Zou, GR; Zhang, X; Huang, JG; Zhou, X in AMER CHEMICAL SOC published article about BISULFITE-FREE; TET PROTEINS; 5-FORMYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE; 5-METHYLCYTOSINE; DMTMM; THYMINE; AMINES in [Xie, Yalun; Wang, Yafen; He, Zhiyong; Yang, Wei; Fu, Boshi; Zou, Guangrong; Zhang, Xiong; Huang, Jinguo; Zhou, Xiang] Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Key Lab Biomed Polymers,Minist Educ,Hubei Prov Ke, Wuhan 430072, Hubei, Peoples R China in 2020.0, Cited 34.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7
5-Carboxylcytosine (5caC) plays a vital role in the dynamics of DNA demethylation, and sequencing of its sites will help us dig out more biological functions of 5caC. Herein, we present a novel chemical method to efficiently label 5caC distinguished from other bases in DNA. Combined with bisulfite sequencing, 5caC sites can be located at single-base resolution, and the efficiency of 5caC labeling is 92% based on the Sanger sequencing data. Furthermore, dot blot assays have confirmed that 5caC-containing DNA isolated from HeLa cells was successfully labeled using our method. We expect that our strategy can be further applied to selectively tagging other carboxyl-modified bases and mapping their sites in RNA.
COA of Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem