Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Dual activatable self-assembled nanotheranostics for bioimaging and photodynamic therapy published in 2020.0, Reprint Addresses Yang, HY (corresponding author), Jilin Inst Chem Technol, Coll Mat Sci & Engn, Jilin 132022, Jilin, Peoples R China.; Lee, DS (corresponding author), Sungkyunkwan Univ, Theranost Macromol Res Ctr, Suwon 16419, Gyeonggi Do, South Korea.; Lee, DS (corresponding author), Sungkyunkwan Univ, Sch Chem Engn, Suwon 16419, Gyeonggi Do, South Korea.; Lee, JH (corresponding author), Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiol, Seoul 06351, South Korea.; Lee, JH (corresponding author), Samsung Biomed Res Inst, Ctr Mol & Cellular Imaging, Seoul 06351, South Korea.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.
Multifunctional nanosystems that can transport therapeutic and diagnostic agents into tumor sites and activate their respective functions via tumor-microenvironment recognition are highly desirable for clinical applications. We fabricated pH and redox dual-activatable self-assembled nanotheranostics (named as DA-SNs) via coordination-driven self-assembly of chlorin e6 (Ce6) disulfide-linked pH sensitive polymer ligand, poly (isobutylene-alt-maleic anhydride-graft-methoxy-poly (ethyleneglycol)-graft-imidazole-graft-Cystamine-Ce6) [PIMA-mPEG-API-SS-Ce6], and gadolinium ions (Gd3+). DA-SNs exhibited uniform particle size of similar to 48 nm, excellent stability, and inherent biosafety. Negatively charged DA-SNs could prolong blood circulation time (t(1/2) = 2.91 h) and improve tumor accumulation. Moreover, DA-SNs could undergo surface charge switch from negative charge to positive one in a slightly acidic tumor extracellular environment (pH 6.8), thus enhancing cellular uptake. After entering tumor cells, fluorescence, photodynamic therapeutic activity, and T1MR contrast from DA-SNs could be activated within this intracellular environment with lowered pH and high level of GSH. Importantly, human tumors implanted in mice could be successfully visualized via distinct pH and redox dual-sensitive T1MR contrast and fluorescence imaging, indicating that DA-SNs could serve as a dual-modal MR/fluorescence imaging probe for tumor-targeting diagnosis. In addition, DA-SNs exhibited superior photodynamic therapeutic efficiency with negligible side effects. Therefore, this DA-SN shows great promise for synergistic photodynamic therapy and diagnostic imaging.
About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Fu, Y; Jang, MS; Wang, NN; Li, Y; Wu, T; Lee, JH; Lee, DS; Yang, HY or concate me.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride
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Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem