Jiang, JW; Zhong, XM; Zhang, HY; Wang, CL in [Jiang, Jianwei; Zhong, Xiaoming] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China; [Jiang, Jianwei; Zhang, Hongyan; Wang, Chunlei] Zhejiang Canc Hosp, Dept Pharm, 38 Guangji Rd, Hangzhou 310022, Zhejiang, Peoples R China published A novel corona core-shell nanoparticle for enhanced intracellular drug delivery in 2020.0, Cited 26.0. HPLC of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.
Drugs, including small molecule anticancer drugs, have to be delivered and released into the cytoplasm or nucleus in order to elicit a therapeutic effect. In the present study, a novel corona core-shell nanoparticle was proposed for enhanced cellular uptake and light-responsive intracellular release. Light-responsive core-shell nanoparticles, i.e., gold nanoparticles-coated liposomes (CS), were prepared and further modified with hyaluronic acid (HA) (CCS). HA modification enhances the endocytosis of the nanoparticles by HA receptor-expressing cells, while the plasmonic properties of gold nanoparticles enable their light-triggered drug release. The results demonstrated that the uptake of CCS in HA receptor-expressing MDA-MB-231R cells was significantly enhanced compared with unmodified CS. Nanosecond pulsed laser irradiation (700 nm; 100 mJ/cm(2); 5 pulses) rapidly triggered the intracellular release of a fluorescent dye, 6-carboxyfluorescein (6-CF), from CCS and CS trapped in endolysosomes. The released 6-CF was evenly distributed throughout the entire cytosol and nucleus. Finally, the cytotoxicity of doxorubicin towards MDA-MB-231 cells was significantly increased by CCS delivery upon pulsed laser irradiation. In conclusion, with enhanced cellular uptake and light-triggered intracellular release, CCS significantly enhanced the therapeutic effects of doxorubicin, and may serve as a promising avenue for intracellular drug delivery.
About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Jiang, JW; Zhong, XM; Zhang, HY; Wang, CL or concate me.. HPLC of Formula: C4H14Cl2N2S2
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem