A common heterocyclic compound, 92-30-8,2-(Trifluoromethyl)-10H-phenothiazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 92-30-8
92-30-8, General procedure: To a stirred solution of phenothiazine or 2-(trifluoromethyl)-10H-phenothiazine (3 mmol) in dichloromethane (20 mL), K2CO3 (5 mmol) and propargyl bromide (5 mmol) were added carefully and the reaction mixture was refluxed for 7 h. After the reaction, the system was concentrated under vacuum, the residue was dissolved in EtOAc (40 mL) and washed by pure water and brine, and dried over anhydrous Na2SO4 and concentrated under vacuum to afford crude products 8a-8b, which were used in the next reaction without further purification.
This compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92-30-8,2-(Trifluoromethyl)-10H-phenothiazine,its application will become more common.
Reference£º
Article; Zhang, Jun-Xia; Guo, Jiao-Mei; Zhang, Ting-Ting; Lin, Hong-Jun; Qi, Nai-Song; Li, Zhen-Guo; Zhou, Ji-Chun; Zhang, Zhen-Zhong; Molecules; vol. 23; 6; (2018);,
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