A new application about 92-30-8

Interested yet? Read on for other articles about 92-30-8, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/92-30-8.html.

Research speed reading in 2021. While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. , HPLC of Formula: https://www.ambeed.com/products/92-30-8.html, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Thompson, Andrew M., introduce the new discover.

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3] thiazine 8-oxides

A 900 compound nitroimidazole-based library derived from our pretomanid backup program with TB Alliance was screened for utility against human African trypanosomiasis (HAT) by the Drugs for Neglected Diseases initiative. Potent hits included 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3] thiazine 8-oxides, which surprisingly displayed good metabolic stability and excellent cell permeability. Following comprehensive mouse pharmacokinetic assessments on four hits and determination of the most active chiral form, a thiazine oxide counterpart of pretomanid (24) was identified as the best lead. With once daily oral dosing, this compound delivered complete cures in an acute infection mouse model of HAT and increased survival times in a stage 2 model, implying the need for more prolonged CNS exposure. In preliminary SAR findings, antitrypanosomal activity was reduced by removal of the benzylic methylene but enhanced through a phenylpyridine-based side chain, providing important direction for future studies (C) 2017 Elsevier Ltd. All rights reserved.

Interested yet? Read on for other articles about 92-30-8, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/92-30-8.html.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem