Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials.26978-64-3, Name is 4-Hydroxybutane-1-sulfonic acid, belongs to thiazines compound, is a common compound. In a pantent, author is Yuan, Chen, once mentioned the new application about 26978-64-3, Formula: https://www.ambeed.com/products/26978-64-3.html.
Discovery of [1,2,4]Triazole Derivatives as New Metallo-beta-Lactamase Inhibitors
The emergence and spread of metallo-beta-lactamase (MBL)-mediated resistance to beta-lactam antibacterials has already threatened the global public health. A clinically useful MBL inhibitor that can reverse beta-lactam resistance has not been established yet. We here report a series of [1,2,4]triazole derivatives and analogs, which displayed inhibition to the clinically relevant subclass B1 (Verona integron-encoded MBL-2) VIM-2. 3-(4-Bromophenyl)-6,7-dihydro-5H-[1,2,4]triazolo [3,4-b][1,3]thiazine (5l) manifested the most potent inhibition with an IC50 (half-maximal inhibitory concentration) value of 38.36 mu M. Investigations of 5l against other B1 MBLs and the serine beta-lactamases (SBLs) revealed the selectivity to VIM-2. Molecular docking analyses suggested that 5l bound to the VIM-2 active site via the triazole involving zinc coordination and made hydrophobic interactions with the residues Phe61 and Tyr67 on the flexible L1 loop. This work provided new triazole-based MBL inhibitors and may aid efforts to develop new types of inhibitors combating MBL-mediated resistance.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 26978-64-3 is helpful to your research. Formula: https://www.ambeed.com/products/26978-64-3.html.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem