With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. , Electric Literature of 147118-35-2, 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, molecular formula is C31H39O4PSi, belongs to thiazines compound. In a document, author is Le, Tam Minh, introduce the new discover.
Synthesis and Transformation of (-)-Isopulegol-Based Chiral -Aminolactones and -Aminoamides
A library of isopulegol-based -amino acid derivatives has been developed from commercially-available (-)-isopulegol. Michael addition of primary and secondary amines towards ,-unsaturated -lactones was accomplished resulting in -aminolactones in highly-stereoselective reactions. Ring-opening of -aminolactones with different amines furnished excellent yields of -aminoamides. Moreover, the applicability of aminolactones in peptide synthesis was examined by opening the lactone ring with – and -aminoesters, providing dipeptides as promising chiral substrates for the synthesis of foldamers. The antiproliferative activities of -aminolactones and -aminoamides were explored, and the structure-activity relationships were studied from the aspects of the stereochemistry of the monoterpene ring and the substituent effects on the -aminoamide ring system. The N-unsubstituted (-)-isopulegol-based -aminoamides exhibited considerable antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF7 and MDA-MB-231).
Electric Literature of 147118-35-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 147118-35-2 is helpful to your research.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem