Research speed reading in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.. , COA of Formula: https://www.ambeed.com/products/7143-01-3.html, 7143-01-3, Name is Methanesulfonic anhydride, molecular formula is C2H6O5S2, belongs to thiazines compound. In a document, author is Salem, Marwa S., introduce the new discover.
Design, Synthesis and Antiproliferative Activity of Novel Heterocycles from 6-Iodo-2-phenyl-4H-benzo[d][1,3]thiazine-4-thione
The present work is dedicated to utilize the reactivity of 6-iodo-2-phenyl-4H-benzo[d][1,3]thiazine-4-thione to motivate new different heterocyclic systems namely, quinazoline-4(3H)-thione,benzimidazol-2(3H)-one, pyrazole and thiadiazole derivatives which have been structurally characterized with spectroscopic data such as IR, (HNMR)-H-1 and mass spectra. The synthesized compounds were evaluated for the anticancer activity against HePG-2 and MCF-7 cell lines. 1-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-(6-iodo-2-phenyl-4-thioxoquinazolin-3(4H)-yl)ethanone and ethyl 3-(2-(2-(6-iodo-2-phenyl-4-thioxoquinazolin-3(4H)-yl)acetyl)hydrazono)butanoate showed the highest cytotoxic activities against the two cell lines comparable to that of the reference compound doxorubicin. Most of the synthesized compounds also exhibited good cytotoxic activity.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem