New Advances in Chemical Research, May 2021.Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, nano-ceramics, preparation and modification of special coatings. 196597-78-1, Name is 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one, belongs to thiazines compound, is a common compound. In a pantent, author is Gomha, Sobhi M., once mentioned the new application about 196597-78-1, COA of Formula: https://www.ambeed.com/products/196597-78-1.html.
Synthesis, Characterization, and Molecular Docking of Novel bis-thiazolyl Thienothiophene Derivatives as Promising Cytotoxic Antitumor Drug
A novel, facile reaction for the synthesis of series of bis-thiazole derivatives has been developed from the reaction of the appropriate thiosemicarbazone derivatives and bis-2-bromoacetylthieno[2,3-b]thiophene derivatives in ethanol under reflux. The structures of the newly synthesized products were established on the basis of spectral data (mass, IR, and H-1 and C-13 NMR) and elemental analyses. Fifteen compounds of the synthesized compounds were evaluated for their anticancer activity against human liver hepatocellular carcinoma cell line (HepG2). All compounds showed anticancer activity but differs in potency comparable with the reference drug Cisplatin. Moreover, molecular docking study using MOE software predicted the best binding mode between the most active compound 5o into the active site of human heat-shock protein 90. The computational studies are confirming the results in biological activity.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem