Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner.7689-03-4, Name is Campathecin, SMILES is [C@@]5(C2=C(C(N1CC4=C(C1=C2)N=C3C=CC=CC3=C4)=O)COC5=O)(CC)O, belongs to thiazines compound. However, they have proven to be challenging because of the mutual inactivation of both catalysts. In a document, author is Haggam, Reda A., introduce the new discover, Quality Control of Campathecin.
An Efficient Route for Synthesis of a New Class of Quinazolines: Synthesis of Thiazino-, Thiadiazolo-, and Thiazolo- Quinazoline Derivatives
The addition of amino group of anthranilic acid to isothiocyanate 2 provided cinnamoyl thiourea derivative 3. The compound 3 underwent different types of cyclization depending on conditions. The quinazolinthione of type 5 was obtained by treatment with Na2CO3. Quinazolinthione 5 underwent a series of transformation and oxidation reactions to form a new class of quinazoline and thiazoloquinazoline derivatives. All the compounds were tested against antimicrobial and antitumor activity.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem