As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, molecular formula is C31H39O4PSi. In an article, author is Sirakanyan, Samvel N.,once mentioned of 147118-35-2, Category: thiazines.
On the reactivity of pyrido[3 ‘,2 ‘:4,5]furo(thieno)[3,2-d]pyrimidin-7(8)-ones with some alkyl mono- and di-halides: synthesis of new heterocyclic systems containing thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b]thiazine moiety
Ethyl 1-aminofuro(thieno)[2,3-b]pyridine-2-carboxylates 1 reacted with benzoyl isothiocyanate and gave the relevant thioureido derivatives 2, whose intramolecular cyclization under the action of potassium hydroxide furnished the relevant 9(10)-thioxopyrido[3′,2′:4,5]furo(thieno)[3,2-d]pyrimidin-7(8)-ones 3. Compounds 3 with methyl iodide could give the S-methyl 4 and S,N-dimethyl 5 derivatives. Interestingly 3 by alkylation with alkyl dichlorides (bifunctional reagents) the cyclization to a thiazoline or to a thiazine ring on the [a] side of the pyrimidine ring occurs, with formation of the new pentacyclic systems: furo(thieno)[3,2-d][1,3]thiazolo[3,2-a]pyrimidin-7(8)-ones 6 and furo(thieno)[3′,2’:4,5]pyrimido[2,1-b] [1,3]thiazin-7(8)-ones 7. Moreover compounds 3 by alkylation with p-chlorophenacyl bromide (again a bifunctional reagent) led to the formation of the corresponding S-alkylated compounds 9, whose cyclization furnished structural analogues of compounds 6: p-chlorophenyl-substituted thiazolo[3,2-a] pyrimidin-7(8)-ones 10. The structure of the obtained compounds has been unambiguously confirmed by using a wide spectrum of physico-chemical methods and, in the instance of compounds 6 and 7, also by an alternative synthesis via a double-annelation reaction using a BMMA reagent. Biological tests have shown promising antimicrobial activity against Staphylococcus aureus for some of the synthesized compounds. (C) 2015 Elsevier Ltd. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 147118-35-2, you can contact me at any time and look forward to more communication. Category: thiazines.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem