The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. , Quality Control of 2-Methyl-4,6-bis((octylthio)methyl)phenol, 110553-27-0, Name is 2-Methyl-4,6-bis((octylthio)methyl)phenol, molecular formula is C25H44OS2, belongs to thiazines compound. In a document, author is Chiari, John B., introduce the new discover.
Sex-Specific Differences of Steroid Receptors Following Exposure to Environmentally Relevant Concentrations of Phenothiazine in Fundulus heteroclitus
Phenothiazine (PTZ) is a heterocyclic thiazine compound used for industrial and medical purposes. Through environmental surveillance studies, PTZ was found being discharged into a local river in Connecticut. Phenothiazine has been shown to act similarly to endocrine disrupting chemicals. This study sought to identify sex specific hormone receptor changes inFundulus heteroclitusin response to PTZ exposure.Fundulus heteroclitus,also known as mummichog, are small fish native to the Atlantic coast of the United States and Canada. They reside in brackish waters and can survive harsh toxic environments. This model organism is native to the polluted waters found in Connecticut. In this study, fish were exposed to PTZ concentrations of 0.5 ppm, 1.0 ppm, and 2.0 ppm for 1 week. Following exposure, brain, liver, and gonad tissues were harvested; cDNA was synthesized; and mRNA expression was assessed for 6 different hormone receptors. Compared with vehicle control (ethanol) differences in mRNA expression, levels of hormone receptors were observed in various tissues from male and female fish. Many of the tissues assessed showed changes in expression level, while only female liver and testis showed no change. These results implicate PTZ as a potential endocrine disrupting compound to mummichog at environmentally relevant concentrations.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 110553-27-0, in my other articles. Quality Control of 2-Methyl-4,6-bis((octylthio)methyl)phenol.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem