Chemistry is a science major with cience and engineering. , Category: thiazines, The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.Introducing a new discovery about 196597-78-1, Name is 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one, molecular formula is C11H10O2, belongs to thiazines compound. In a document, author is Gomha, Sobhi M..
Synthesis, Characterization, and Molecular Docking of Novel bis-thiazolyl Thienothiophene Derivatives as Promising Cytotoxic Antitumor Drug
A novel, facile reaction for the synthesis of series of bis-thiazole derivatives has been developed from the reaction of the appropriate thiosemicarbazone derivatives and bis-2-bromoacetylthieno[2,3-b]thiophene derivatives in ethanol under reflux. The structures of the newly synthesized products were established on the basis of spectral data (mass, IR, and H-1 and C-13 NMR) and elemental analyses. Fifteen compounds of the synthesized compounds were evaluated for their anticancer activity against human liver hepatocellular carcinoma cell line (HepG2). All compounds showed anticancer activity but differs in potency comparable with the reference drug Cisplatin. Moreover, molecular docking study using MOE software predicted the best binding mode between the most active compound 5o into the active site of human heat-shock protein 90. The computational studies are confirming the results in biological activity.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem