Month: February 2022

An article A novel corona core-shell nanoparticle for enhanced intracellular drug delivery WOS:000523751200029 published article about HYALURONIC-ACID; RELEASE; PERMEABILITY; LIPOSOMES in [Jiang, Jianwei; Zhong, Xiaoming] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China; [Jiang, Jianwei; Zhang, Hongyan; Wang, Chunlei] Zhejiang Canc Hosp, Dept Pharm, 38 Guangji Rd, Hangzhou 310022, Zhejiang, Peoples R China in 2020.0, Cited 26.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Drugs, including small molecule anticancer drugs, have to be delivered and released into the cytoplasm or nucleus in order to elicit a therapeutic effect. In the present study, a novel corona core-shell nanoparticle was proposed for enhanced cellular uptake and light-responsive intracellular release. Light-responsive core-shell nanoparticles, i.e., gold nanoparticles-coated liposomes (CS), were prepared and further modified with hyaluronic acid (HA) (CCS). HA modification enhances the endocytosis of the nanoparticles by HA receptor-expressing cells, while the plasmonic properties of gold nanoparticles enable their light-triggered drug release. The results demonstrated that the uptake of CCS in HA receptor-expressing MDA-MB-231R cells was significantly enhanced compared with unmodified CS. Nanosecond pulsed laser irradiation (700 nm; 100 mJ/cm(2); 5 pulses) rapidly triggered the intracellular release of a fluorescent dye, 6-carboxyfluorescein (6-CF), from CCS and CS trapped in endolysosomes. The released 6-CF was evenly distributed throughout the entire cytosol and nucleus. Finally, the cytotoxicity of doxorubicin towards MDA-MB-231 cells was significantly increased by CCS delivery upon pulsed laser irradiation. In conclusion, with enhanced cellular uptake and light-triggered intracellular release, CCS significantly enhanced the therapeutic effects of doxorubicin, and may serve as a promising avenue for intracellular drug delivery.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Jiang, JW; Zhong, XM; Zhang, HY; Wang, CL or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Narayanan, N; Jia, ZH; Kim, KH; Kuang, LJ; Lengemann, P; Shafer, G; Bernal-Crespo, V; Kuang, SH; Deng, M in KEAI PUBLISHING LTD published article about TISSUE; CELL; CLUSTERS; SULFATE; FIBERS; LEADS in [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47906 USA; [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47906 USA; [Jia, Zhihao; Kim, Kun Ho; Kuang, Shihuan] Purdue Univ, Dept Anim Sci, W Lafayette, IN 47906 USA; [Shafer, Gabrielle; Bernal-Crespo, Victor] Purdue Univ, Ctr Comparat Translat Res, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47906 USA in 2021.0, Cited 47.0. Category: thiazines. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Volumetric muscle loss (VML) injuries characterized by critical loss of skeletal muscle tissues result in severe functional impairment. Current treatments involving use of muscle grafts are limited by tissue availability and donor site morbidity. In this study, we designed and synthesized an implantable glycosaminoglycan-based hydrogel system consisting of thiolated hyaluronic acid (HA) and thiolated chondroitin sulfate (CS) crosslinked with poly(ethylene glycol) diacrylate to promote skeletal muscle regeneration of VML injuries in mice. The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8. Furthermore, in vivo studies using a murine quadriceps VML model demonstrated that the HA-CS hydrogels supported integration of implants with the surrounding host tissue and facilitated migration of Pax7(+) satellite cells, de novo myofiber formation, angiogenesis, and innervation with minimized scar tissue formation during 4-week implantation. The hydrogel-treated and autograft-treated mice showed similar functional improvements in treadmill performance as early as 1-week post-implantation compared to the untreated groups. Taken together, our results demonstrate the promise of HA-CS hydrogels as regenerative engineering matrices to accelerate healing of skeletal muscle injuries.

Welcome to talk about 56-17-7, If you have any questions, you can contact Narayanan, N; Jia, ZH; Kim, KH; Kuang, LJ; Lengemann, P; Shafer, G; Bernal-Crespo, V; Kuang, SH; Deng, M or send Email.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Engineering; Materials Science very interesting. Saw the article Pre-blocked molecular shuttle as an in-situ real-time theranostics published in 2019.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Jiang, C (corresponding author), Fudan Univ, Sch Pharm, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ,State Key, 826 Zhangheng Rd, Shanghai 201203, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where a default supramolecular-dye couple was pre-blocked. The rational design, synthesis, characterization and proof-of-concept of this strategy were described in detail. The drug-release upon reducing environment can be translated into near-infrared (NIR) fluorescence signal (OFF-to-ON), allowing to track the drug-release procedure by multi-modal images including IVIS, FLECT and photoacoustic imaging. The versatile nanotheranostics system can target to triple negative breast tumor via conjugated F3 peptide, and show an improved anti-tumor efficacy with much lower side effect. The intelligent nanotheranostics system based on molecular shuttle provides new reference for precision medicine in preclinical trial and postclinical evaluation.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Sun, T; Zhang, GP; Wang, QB; Guo, ZY; Chen, QJ; Chen, XL; Lu, YF; Zhang, Y; Zhang, YJ; Guo, Q; Gao, X; Cheng, YZ; Jiang, C or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. Zhang, S; Qin, B; Huang, ZH; Xu, JF; Zhang, X in [Zhang, Shuai; Qin, Bo; Huang, Zehuan; Xu, Jiang-Fei; Zhang, Xi] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China published Supramolecular Emulsion Interfacial Polymerization in 2019.0, Cited 52.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A new method of supramolecular emulsion interfacial polymerization is developed, which can be used to fabricate supramolecular polymeric nanospheres. We designed a water-soluble monomer containing two maleimide end groups, acting as both building block and surfactant, and an oil-soluble supramonomer bearing two thiol groups connected by quadruple hydrogen bonds. With the assist of ultrasonication, hollow nanospheres can be controllably prepared by thiol-maleimide reaction of two monomers at the emulsion interface, which exhibit good stability and dynamic property. In addition, the encapsulated guest molecules could be controllably released from the supramolecular polymeric nanospheres, owing to their stimuli-responsiveness. It is anticipated that this approach will enrich the methodology of supramolecular polymerization and can be applied to constructing supramolecular materials with controllable structures and functions.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Interaction of Pt(II) and Au(III) with organic disulfides in hydrochloric aqueous solution WOS:000491830100001 published article about 3,3′-DITHIODIPROPIONIC ACID; DL-HOMOCYSTINE; L-CYSTINE; OXIDATION; PLATINUM(II); KINETICS; REDUCTION; COMPLEXES; GOLD(III); PD(II) in [Petrov, Alexander, I] Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Fed Res Ctr, Krasnoyarsk, Russia; [Novikova, Galina, V; Demina, Anastasia, V; Ivanenko, Timur Y.; Goleva, Elizaveta S.] Siberian Fed Univ, Inst Nonferrous Met & Mat Sci, Krasnoyarsk, Russia in 2019.0, Cited 31.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. SDS of cas: 56-17-7

The interaction of Pt(II) and Au(III) with disulfides (l-cystine, cystamine, dl-homocystine and 3,3?-dithiodipropionic acid) in hydrochloric acid aqueous solutions was studied. In the case of Pt(II), the oxidative addition reaction leads to formation of the Pt(IV) thiol complex. In the case of Au(III) disulfide, binding causes a reduction to Au(0) and oxidation of the disulfide to sulfonic acid. Cyclic voltammetry and different spectroscopic methods were used to study the process. The pattern of influence of the metallic properties for d(8) ions in the direction of the reaction was found.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Pinter, ZW; Farnell, CG; Huntley, S; Patel, HA; Peng, JG; McMurtrie, J; Ray, JL; Naranje, S; Shah, AB in [Pinter, Zachariah W.; Farnell, Chason G.; Huntley, Samuel; Patel, Harshadkumar A.; Peng, Jianguang; McMurtrie, James; Ray, Jessyca L.; Naranje, Sameer; Shah, Ashish B.] Univ Alabama Birmingham, Dept Orthopaed Surg, 1313 13th St South, Birmingham, AL 35205 USA published Outcomes of Chronic Turf Toe Repair in Non-athlete Population: A Retrospective Study in 2020.0, Cited 20.0. Category: thiazines. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Background Turf toe injuries, though most common in athletes, can also occur in non-athletes. No study exists in the current literature investigating operative outcomes in non-athlete patients with chronic turf toe injury. In this study, we present our outcomes on operatively treated turf toe injuries in non-athletes in the only cohort yet studied. Methods Using ICD-10 codes, we assembled a cohort of 12 patients who underwent operative repair of chronic turf toe injury from January 2012 through January 2018 at the investigating institution. These 12 patients were evaluated to determine demographic information, method of injury, length of time from injury to surgery, clinical and radiologic characteristics of the injury, and operative outcomes including mean preoperative and postoperative VAS (Visual Analog Scale) scores, preoperative and postoperative FFI (Foot Function Index) scores, and postoperative complications. Results On initial clinical presentation, all 12 patients had local tenderness with associated painful range of motion. Four patients had restricted range of motion, all patients had a positive Lachman test, two had local edema, and eight had hallux valgus deformity. Mean VAS improved from 4.6 (range 2-9) to 1 (range 0-4). Mean FFI improved from 102.5 (range 56-177) to 61.75 (range 23-144). All patients had a negative Lachman test at final follow-up. No patients developed major complications or required revision surgery. Conclusions Our study is the first to investigate operative outcomes following chronic turf toe injury in non-athlete patients. Based on our study, surgeons and patients can expect significant improvement in overall pain and function following surgery.

Category: thiazines. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about SELF-ASSEMBLED MONOLAYERS; PHOTOCATALYTIC DEGRADATION; COFE2O4 NANOPARTICLES; AL-FE; FERRITE; OXIDE; TIO2; NANOCOMPOSITES; OXIDATION; REDUCTION, Saw an article supported by the Ministry of TextilesMinistry of Textiles, Government of India [6134]; Ministry ofHuman Resource Development, Government of IndiaMinistry of Human Resource Development (MHRD), Government of India [6134]; GGS Indraprastha University Delhi; IIT Kanpur. Published in WILEY in HOBOKEN ,Authors: Tanwar, R; Kumari, R; Mandal, UK; Kar, KK. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

BACKGROUND Decontamination of water by means of photocatalysis is seen as a sustainable solution. However, catalysts with low recovery from liquid suspension remain the main predicament that obstructs their industrial applications. To overcome this shortcoming, a methodology is reported here for the functionalization of nanospinel nickel zinc ferrite by cystamine ligand to develop Ni0.5Zn0.5Fe2O4@cystamine magnetic recyclable catalyst for water decontamination applications. RESULTS The diffraction patterns of bare and functionalized nanoferrites indicated that the cubic inverse spinel structure of the particles was not changed after cystamine functionalization. X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy analyses confirmed the chemical bonding between cystamine and spinel ferrites. The spherical morphology and elemental composition were studied through high-resolution transmission electron spectroscopy (HRTEM) images and energy-dispersive X-ray (EDX) analysis respectively. Deeper understanding of the catalyst’s optical behavior and calculation of the energy band gap were achieved by means of photoluminescence spectroscopy. Magnetic saturation values were calculated from vibrating sample magnetometer (VSM) analysis, and almost negligible change was found. A possible photocatalytic mechanism for the removal of organic dye is proposed. CONCLUSION The present findings imply that the presence of amine groups on the catalyst surface, good dispersibility stability and outstanding catalytic activity make functionalized nanoferrite a suitable candidate for industrial wastewater treatment. Easy synthesis, easy work-up and short reaction times are some of the advantages of the methodology. (c) 2019 Society of Chemical Industry

Welcome to talk about 56-17-7, If you have any questions, you can contact Tanwar, R; Kumari, R; Mandal, UK; Kar, KK or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 INT J BIOL MACROMOL published article about DRUG-RELEASE; SENSITIVE MICELLES; REDOX; NANOPARTICLES; DOXORUBICIN in [Li, Jia; Wang, Jihong; Zhang, Xuetong; Xia, Xin; Zhang, Chenchen] Jiangnan Univ, Dept Ophthalmol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China in 2019.0, Cited 32.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. COA of Formula: C4H14Cl2N2S2

Melphalan (MEL) is an effective chemotherapeutic agent for treatment of retinoblastoma (Rb) which is the most common childhood malignancy. However, the inherent cardiopulmonary toxicity and hazardous integration limit its therapeutic effect on RB. N-Acetylheparosan (AH), a natural heparin-like polysaccharide in mammals with long circulation effect and good biocompatibility, was linked by d-alpha-tocopherol acid succinate (VES) via and cystamine (CYS) to synthesize reduction-responsive N-acetylheparosan-CYS-Vitamin E succinate (AHV) copolymers. In addition, CYS was replaced by adipic acid dihydrazide (ADH) to obtain a control of non-reduction-responsive polymers N-acetylheparosan-ADH-Vitamin E succinate (ADV). MEL-loaded AHV micelles (MEL/AHV) as well as ADV micelles (MEL/ADV) were prepared with small particle size and high drug loading content. In vitro drug release showed that MEL/AHV micelles presented obvious reduction-triggered release behavior compared with MEL/ADV. In vitro antitumor effects were investigated using WERI-Rb-1 retinoblastoma cells. Cytotoxicity experiments showed that the IC50 of MEL/AHV was significantly lower than that of free MEL and MEL/ADV, suggesting that MEL/AHV enhanced the cytotoxicity against retinoblastoma cells. Furthermore, MEL/AHV micelles were more easily uptaken by multiple pathways compared with MEL/ADV and free MEL. Therefore, MEL/AHV might be a potential delivery system for enhanced delivery of melphalan to Rb cells. (C) 2019 Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Synthesis and Guest-Binding Properties of pH/Reduction Dual-Responsive Cyclophane Dimer WOS:000660395900001 published article about MOLECULAR RECOGNITION; DISULFIDE BONDS; CHEMISTRY; MACROCYCLES; COMPLEXES; BREAKING in [Hayashida, Osamu; Tanaka, Yudai; Miyazaki, Takaaki] Fukuoka Univ, Dept Chem, Fac Sci, Nanakuma 8-19-1, Fukuoka 8140180, Japan in 2021.0, Cited 43.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Formula: C4H14Cl2N2S2

A water-soluble cyclophane dimer having two disulfide groups as a reduction-responsive cleavable bond as well as several acidic and basic functional groups as a pH-responsive ionizable group 1 was successfully synthesized. It was found that 1 showed pH-dependent guest-binding behavior. That is, 1 strongly bound an anionic guest, 6-p-toluidinonaphthalene-2-sulfonate (TNS) with binding constant (K/M-1) for 1:1 host-guest complexes of 9.6 x 10(4) M-1 at pH 3.8, which was larger than those at pH 7.4 and 10.7 (6.0 x 10(4) and 2.4 x 10(4) M-1, respectively), indicating a favorable electrostatic interaction between anionic guest and net cationic 1. What is more, release of the entrapped guest molecules by 1 was easily controlled by pH stimulus. Large favorable enthalpies (Delta H) for formation of host-guest complexes were obtained under the pH conditions employed, suggesting that electrostatic interaction between anionic TNS and 1 was the most important driving force for host-guest complexation. Such contributions of Delta H for formation of host-guest complexes decreased along with increased pH values from acidic to basic solutions. Upon addition of dithiothreitol (DTT) as a reducing reagent to an aqueous PBS buffer (pH 7.4) containing 1 and TNS, the fluorescence intensity originating from the bound guest molecules decreased gradually. A treatment of 1 with DTT gave 2, having less guest-binding affinity by the cleavage of disulfide bonds of 1. Consequently, almost all entrapped guest molecules by 1 were released from the host. Moreover, such reduction-responsive cleavage of 1 and release of bound guest molecules was performed more rapidly in aqueous buffer at pH 10.7.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Ang, JJ; Chia, DKA; Chan, DKH in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Ang, Jia Jun; Chia, Daryl Kai Ann; Chan, Dedrick Kok Hong] Natl Univ Hlth Syst, Univ Surg Cluster, Div Colorectal Surg, 1E Kent Ridge Rd, Singapore 119228, Singapore; [Chan, Dedrick Kok Hong] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore in 2021.0, Cited 35.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Background: A preoperative marker for morbidity in patients with colorectal cancer would help to risk stratify patients and allow for timely intervention to avert poor outcomes. We conducted this study to evaluate preoperative lymphocyte-white blood cell ratio (LWR) as a marker of postoperative morbidity. Methods: A prospective cohort of patients who underwent elective surgery for colorectal cancer was reviewed. Three morbidity-related outcomes were described-overall morbidity, multiple morbidities, and severe morbidity, defined as Clavien-Dindo Class >= 3. Univariable and multivariable analyses of presurgical predictors of these three outcomes were performed. Preoperative variables included hemoglobin levels, neoadjuvant therapy, albumin levels, white blood cell count, lymphocyte count, LWR, neutrophil-lymphocyte ratio, and prognostic nutritional index. Results: Of 177 patients, 31.6% (56/177) suffered at least one morbidity, 15.3% (27/177) had multiple morbidities, 7.9% (14/177) suffered severe morbidity. On multivariate analysis, only LWR <0.180 (odds ratio [OR] 2.53, 95% confidence interval [CI] 1.15-5.55) and neoadjuvant therapy (OR 2.49, 95% CI 1.16-5.24) were associated with overall morbidity. For multiple morbidities and severe morbidity, only LWR <0.180 was significantly associated on multivariate analysis with an OR of 2.92 (95% CI 1.19-7.13) and 4.62 (95% CI 1.45-14.73), respectively. Conclusions: LWR is a preoperative marker which can be conveniently applied using standard preoperative blood tests. LWR is an independent risk factor for overall morbidity, multiple morbidities, as well as severe morbidity when used with a cut-off of LWR<1.80. (C) 2020 Elsevier Inc. All rights reserved. SDS of cas: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Ang, JJ; Chia, DKA; Chan, DKH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem