Month: February 2022

Product Details of 56-17-7. Authors Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ in AMER CHEMICAL SOC published article about in [Zheng, Meng; Yang, Zhipeng; Wu, Haigang; Liu, Yang; Xia, Xue; Ruan, Weimin] Henan Univ, Henan & Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng 475004, Henan, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Zhang, Jinchao] Hebei Univ, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag, Coll Chem & Environm Sci,Minist Educ, Baoding 071002, Hebei, Peoples R China; [Chen, Shizhu; Yin, Huijun] Natl Inst Pharmaceut R&D Co Ltd, China Resources Pharmaceut Grp Ltd, Beijing 102206, Peoples R China; [Wright, Amanda; Lee, Albert] Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW 2109, Australia; [Lu, Jeng-Wei] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore; [Yin, Huijun] Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China; [Wang, Yingze] Hebei Univ Sci & Technol, Coll Biol Sci & Engn, Shijiazhuang 050018, Hebei, Peoples R China in 2019.0, Cited 38.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering RNA (siRNA) delivery system limits its clinical application. Here, we report a bioreducible and less-cationic siRNA delivery carrier by conjugating Zn(II)-dipicolylamine complexes (Zn-DPA) onto hyaluronic acid (HA) via a redox-sensitive disulfide (-SS-) linker. Such polymer conjugates can formulate stable siRNA nanomedicines via coordination between zinc ions of DPA and the anionic phosphate of siRNA. After the conjugates are taken up by cells, intracellular reduction stimulus subsequently triggers the release of siRNAs and elucidates the desired RNAi effect. Our studies showed the formulated siRNA nanomedicines can be efficiently delivered into tumor cells/tissues and mediates less cytotoxicities both in vitro and in vivo. More importantly, when applied in a xenograft glioblastoma tumor model, this siRNA nanomedicine demonstrated significantly enhanced antitumor ability comparing to naked siRNA. This work demonstrates that such bioreducible Zn-DPA-functionalized HA conjugates without using cationic material as a siRNA carrier represents a promising direction for RNAi-based cancer therapy.

Product Details of 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 PHARM DEV TECHNOL published article about POLYMERIC MICELLES; INTRACELLULAR DELIVERY; MULTIDRUG-RESISTANCE; BLOCK-COPOLYMERS; BREAST-CANCER; DRUG; CORE; PLGA; RELEASE; NANOCARRIERS in [Wang, Xu-Feng; Ren, Jin; He, Hai-Qing; Li, Zi-Xin; Zhao, Jian-Guo; Yu, Jing-Mou] Jiujiang Univ, Sch Pharm & Life Sci, 320 Xunyang East Rd, Jiujiang 332000, Peoples R China; [Liang, Liang] Jiujiang Univ, Analyt & Testing Ctr, Jiujiang, Peoples R China; [Xie, Xin] Jiujiang Univ, Coll Basic Med Sci, Jiujiang, Peoples R China in 2019.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

In this study, reduction-sensitive self-assembled polymer nanoparticles based on poly (lactic-co-glycolic acid) (PLGA) and chondroitin sulfate A (CSA) were developed and characterized. PLGA was conjugated with CSA via a disulfide linkage (PLGA-ss-CSA). The critical micelle concentration (CMC) of PLGA-ss-CSA conjugate is 3.5 mu g/mL. The anticancer drug doxorubicin (DOX) was chosen as a model drug, and was effectively encapsulated into the nanoparticles (PLGA-ss-CSA/DOX) with high loading efficiency of 15.1%. The cumulative release of DOX from reduction-sensitive nanoparticles was only 34.8% over 96h in phosphate buffered saline (PBS, pH 7.4). However, in the presence of 20mM glutathione-containing PBS environment, DOX release was notably accelerated and almost complete from the reduction-sensitive nanoparticles up to 96h. Moreover, efficient intracellular DOX release of PLGA-ss-CSA/DOX nanoparticles was confirmed by CLSM assay in A549 cells. In vitro cytotoxicity study showed that the half inhibitory concentrations of PLGA-ss-CSA/DOX nanoparticles and free DOX against A549 cells were 1.141 and 1.825 mu g/mL, respectively. Therefore, PLGA-ss-CSA/DOX nanoparticles enhanced the cytotoxicity of DOX in vitro. These results suggested that PLGA-ss-CSA nanoparticles could be a promising carrier for drug delivery.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, XF; Ren, J; He, HQ; Liang, L; Xie, X; Li, ZX; Zhao, JG; Yu, JM or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Choi, J; Kim, SY in [Choi, Jongseon; Kim, So Yeon] Chungnam Natl Univ, Grad Sch Energy Sci & Technol, Daejeon 34134, South Korea; [Kim, So Yeon] Chungnam Natl Univ, Coll Educ, Dept Chem Engn Educ, Daejeon 34134, South Korea published Photothermally enhanced photodynamic therapy based on glutathione-responsive pheophorbide a-conjugated gold nanorod formulations for cancer theranostic applications in 2020.0, Cited 66.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Nanocarriers have provided a new platform for the selective delivery of therapeutic agents into targeted cells and tissues using safe, efficient, and tractable routes. In particular, the integration of multiple therapeutic/diagnostic modalities into a single system has the great potential of enhancing theranostic efficiency against serious diseases with reduced side effects. In this study, a new light-triggered theranostic system using photosensitizer-conjugated gold nanorods (AuNR) with glutathione (GSH)-sensitive linkages was developed for cancer imaging and combinational phototherapy of photodynamic therapy (PDT) and photothermal therapy (PTT) to achieve a synergistic cancer treatment. AuNRs with various aspect ratios were prepared as photothermal agents, and then a folic acid (FA)-PEG block copolymer (FAP) and pheophorbide a (Pheo) were chemically conjugated to the surface of AuNRs for active tumor targeting and PDT, respectively. The configuration of Pheo-conjugated AuNR nanocarriers has been precisely controlled through adjusting the feed composition ratio and the relationship between aspect ratio and absorption band of AuNRs. In particular, an AuNR with an aspect ratio of 3.84 and longitudinal plasmon resonance at 873 nm (Pheo-conjugated AuNR100) exhibited superior performance in singlet oxygen generation, photothermal conversion effect, and GSH-mediated selective release of Pheo. Moreover, it also showed tumor targeting activity and a PDT-PTT synergistic effect. These results indicate that this multifunctional AuNR system with tumor targeting ability and GSH-sensitive linkages would be highly efficient for noninvasive cancer treatment by integrating cancer imaging diagnostics and synergistic therapy. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Choi, J; Kim, SY or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Cascaded Multiresponsive Self-Assembled F-19 MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification WOS:000507151600047 published article about ULTRASENSITIVE DETECTION; TUMOR MICROENVIRONMENT; PROTEIN-DETECTION; RATIONAL DESIGN; NANOPARTICLES; NANOMATERIALS; CELLS; STRATEGY; SIGNALS; PROBES in [Tang, Xiaoxue; Gong, Xuanqing; Li, Ao; Lin, Hongyu; Gao, Jinhao] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, MOE Lab Spectrochem Anal & Instrumentat, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China; [Tang, Xiaoxue; Gong, Xuanqing; Li, Ao; Lin, Hongyu; Gao, Jinhao] Xiamen Univ, Dept Biol Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China; [Peng, Chenyu; Zhang, Xianzhong] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Peoples R China; [Chen, Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA in 2020.0, Cited 54.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Product Details of 56-17-7

Molecular probes featuring promising capabilities including specific targeting, high signal-to-noise ratio, and in situ visualization of deep tissues are in great demand for tumor diagnosis and therapy. F-19 magnetic resonance imaging (MRI) techniques incorporating stimuli-responsive probes are anticipated to be highly beneficial for specific detection and imaging of tumors because of negligible background and deep tissue penetration. Herein, we report a cascaded multi-responsive self-assembled nanoprobe, which enables sequential redox-triggered and near-infrared (NIR) irradiation-induced F-19 MR signal activation/amplification for sensing and imaging. Specifically, we designed and synthesized a cascaded multiresponsive F-19-bearing nanoprobe based on the self-assembly of amphiphilic redox-responsive F-19-containing polymers and NIR-absorbing indocyanine green (ICG) molecules. It could realize the activation of F-19 signals in the reducing tumor microenvironment and subsequent signal amplification via the photothermal process. This stepwise two-stage activation/amplification of F-19 signals was validated by F-19 NMR and MRI both in vitro and in vivo. The multiresponsive F-19 nanoprobes capable of cascaded F-19 signal activation/amplification and photothermal effect exertion can provide accurate sensing and imaging of tumors.

Product Details of 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Tang, XX; Gong, XQ; Li, A; Lin, HY; Peng, CY; Zhang, XZ; Chen, XY; Gao, JH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Nitrogen-doped MoS2 quantum dots: Facile synthesis and application for the assay of hematin in human blood WOS:000532843000037 published article about PHOTOLUMINESCENCE SENSING PLATFORM; CYTOCHROME-C; INNER FILTER; ONE-POT; GRAPHENE; HEMOGLOBIN; CYTOTOXICITY; STABILITY; EVOLUTION; MYOGLOBIN in [Wu, Feng-Yi; Wei, Xian-Wen] Anhui Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Mol Solids, Anhui Lab Mol Based Mat,Minist Educ,Anhui Key Lab, Wuhu 241000, Peoples R China; [Wu, Feng-Yi; Wang, Dong-Mei; Li, Ming-Ling; Lu, Wen-Sheng; Xu, Xiao-Yong] Chaohu Univ, Sch Chem & Mat Engn, Inst Novel Funct Mat, Hefei 238000, Peoples R China; [Cheng, Yuan-Sheng] Anhui Univ Technol, Sch Chem & Chem Engn, Inst Mat Sci & Engn, Anhui Prov Key Lab Coal Clean Convers & High Valu, Maanshan 243002, Peoples R China; [Zhou, Xiu-Hong] Anhui Agr Univ, Biotechnol Ctr, Hefei 230036, Peoples R China in 2020.0, Cited 51.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Nitrogen-doped MoS2 quantum dots (N-MoS2 QDs) were synthesized via a facile hydrothermal approach, and exhibited high fluorescence quantum yield (QY, 14.9%), excellent photostability, biocompatibility and water solubility. A novel method with good selectivity and sensitivity was established to assay hematin using N-MoS2 QDs as a fluorescent probe based on inner filter effect (IFE). Fluorescent quenching of N-MoS2 QDs has a fine linear dependence with the concentration of hematin in the range of 0.5-15 mu mol/L and a limit of detection of 0.32 mu mol/L (S/N = 3). By the detection method, average concentration of hematin in real health human erythrocytes was measured as 22.5 +/- 3.9 mu mol/L. And, recoveries range varied from 94 to 108% through standard recovery experiment. The N-MoS2 QDs probe shows excellent photostability, low cytotoxicity and anti-interference ability for hematin assay, which may become a promising method for the test of hematin in human blood.

Welcome to talk about 56-17-7, If you have any questions, you can contact Wu, FY; Cheng, YS; Wang, DM; Li, ML; Lu, WS; Xu, XY; Zhou, XH; Wei, XW or send Email.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about CARBON-DIOXIDE; ELECTROCATALYTIC REDUCTION; NICKEL(II) COMPLEXES; CRYSTAL-STRUCTURE; CONVERSION; CATALYST; ELECTROREDUCTION; SELECTIVITY; NI(CYCLAM); BEARING, Saw an article supported by the Fonds of the Chemical Industry (Liebig Grant); Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [AP242/2-1, AP242/5-1]; DFG (Cluster of Excellence Unifying Concepts in Catalysis)German Research Foundation (DFG) [ECX 314-2]; DFG (Heisenberg-Program)German Research Foundation (DFG); Fraunhofer Internal Programs [Attract 097-602175]; Fonds of the Chemical Industry (Kekule fellowship). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gerschel, P; Battistella, B; Siegmund, D; Ray, K; Apfel, UP. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Among the numerous homogeneous electrochemical CO2 reduction catalysts, [Ni(cyclam)](2+) is known as one of the most potent catalysts. Likewise, [Ni(isocyclam)](2+) was reported to enable electrochemical CO2 conversion but has received significantly less attention. However, for both catalysts, a purposeful substitution of a single nitrogen donor group by chalcogen atoms was never reported. In this work, we report a series of isocyclam-based Ni complexes with {ON3}, {SN3}, {SeN3}, and {N-4} moieties and investigated the influence of nitrogen/chalcogen substitution on electrochemical CO2 reduction. While [Ni(isocyclam)](2+) showed the highest selectivity toward CO2 reduction within this series with a Faradaic efficiency of 86% for the generation of CO at an overpotential of -1.20 V and acts as a homogeneous catalyst, the O- and S-containing Ni complexes revealed comparable catalytic activities at ca. 0.3 V milder overpotential but tend to form deposits on the electrode, acting as precursors for a heterogeneous catalysis. Moreover, the heterogeneous species generated from the O- and S-containing complexes enable a catalytic hydride transfer to acetonitrile, resulting in the generation of acetaldehyde. The incorporation of selenium, however, resulted in loss of CO2 reduction activity, mainly leading to hydrogen generation that is also catalyzed by a heterogeneous electrodeposit.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Gerschel, P; Battistella, B; Siegmund, D; Ray, K; Apfel, UP or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin WOS:000473819100091 published article about BLOCK-COPOLYMERS; GRAFT COPOLYMER; NANOPARTICLES; NANOCARRIERS; DELIVERY; THERAPY; PROGRESS; DESIGN in [Jiang, Junting; Li, Junbo; Zhou, Biyu; Niu, Chaohuang; Wang, Wendi; Liang, Ju] Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, 263 Kaiyuan Rd, Luoyang 471023, Peoples R China; [Wu, Wenlan] Henan Univ Sci & Technol, Sch Med, 263 Kaiyuan Rd, Luoyang 471023, Peoples R China in 2019.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-epsilon-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to delivery doxorubicin (DOX) into tumor cells. PCBMA-SS-PCL-SS-PCBMA was obtained by following steps: i) introducing disulfide bonds through end-group modification of PCL diol with cystamine dihydrochloride; ii) preparing PCL-RAFT macromolecular chain transfer agent by EDC/NHS chemistry; iii) RAFT polymerization of zwitterionic monomer. Self-assembling from PCBMA-SS-PCL-SS-PCBMA, polymeric micelles had many advantages, such as ultra-low protein absorption in serum and obvious reduction-responsiveness in the presence of DTT. Furthermore, DOX-loaded micelles exhibited high stability upon centrifugation and lyophilization, a fast intracellular drug release and enhanced drug efficacy due to GSH-triggered PCBMA shell shedding and micellar reassembling. Thus, the polymeric micelles integrated several functions and properties could be prospectively utilized as valuable nanocarriers in cancer chemotherapeutics.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Development of improved dual-diazonium reagents for faster crosslinking of tobacco mosaic virus to form hydrogels WOS:000487104200019 published article about PLANT VIRAL NANOPARTICLES; SUPRAMOLECULAR HYDROGELS; NANOCOMPOSITE HYDROGELS; SURFACE MODIFICATION; SHAPE-MEMORY; CONSTRUCTION; COVALENT; DELIVERY; NANOMATERIALS; PROTEINS in [Chen, Zhuoyue; Yi, Long] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China; [Ma, Dejun; Xi, Zhen] Nankai Univ, Natl Pesticide Engn Res Ctr Tianjin, Dept Chem Biol, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China; [Xi, Zhen] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China in 2019.0, Cited 65.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

New bench-stable reagents with two diazonium sites were designed and synthesized for protein crosslinking. Because of the faster diazonium-tyrosine coupling reaction, hydrogels from the crosslinking of tobacco mosaic virus and the reagent DDA-3 could be prepared within 1 min at room temperature. Furthermore, hydrogels with the introduction of disulfide bonds viaDDA-4 could be chemically degraded by dithiothreitol. Our results provided a facile approach for the direct construction of virus-based hydrogels.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Chemistry very interesting. Saw the article Preparation of functionalized star polymer nanoparticles by RAFT polymerization and their application in positionally assembled enzymes for cascade reactions published in 2019.0. SDS of cas: 56-17-7, Reprint Addresses Cao, H; Tan, TW (corresponding author), Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A well-defined functional star polymer nanoparticle was prepared using an “ arm first” approach via RAFT polymerization. In this work, N-adamantylacrylamide and N-succinimidyl acrylate were copolymerized with N-isopropylacrylamide sucessfully. The obtained diblock copolymer regarded as an “ arm” endowed the star polymer with multiple conjugate functions. By adjusting the amount of crosslinking agent, the size and polydispersity of the star polymer were controlled. With the star polymer as the scaffold, a sequential multi-enzyme system was constructed, where HRP was placed in the inner layer through covalent conjugation, and b-cyclodextrin-modified GOx was assembled in the outer layer through hostguest recognition. More interestingly, the activity of the enzyme modified by b-cyclodextrin was improved. In addition to the enhanced thermal stability, this multienzyme system also exhibited a reduced Km value (from 2.18 mM to 0.39 mM) and an excellent substrate affinity. The specificity constant (Kcat/Km) for GOx in the star polymer@ HRP@ GOx system was 1.7-fold higher than that of the free HRP with free GOx system. This strategy will promote the development of biocatalysis reactions and biosensors as a promising method.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

HPLC of Formula: C4H14Cl2N2S2. Jha, MK; Grannemann, BD; Trombello, JM; Clark, EW; Eidelman, SL; Lawson, T; Greer, TL; Rush, AJ; Trivedi, MH in [Jha, Manish K.; Grannemann, Bruce D.; Trombello, Joseph M.; Clark, E. Will; Eidelman, Sara Levinson; Greer, Tracy L.; Trivedi, Madhukar H.] Univ Texas Southwestern Med Ctr Dallas, Ctr Depress Res & Clin Care, 5323 Harry Hines Blvd, Dallas, TX 75390 USA; [Jha, Manish K.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA; [Jha, Manish K.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA; [Rush, A. John] Duke Natl Univ Singapore, Singapore, Singapore; [Rush, A. John] Duke Med Sch, Dept Psychiat, Durham, NC USA; [Rush, A. John] Texas Tech Univ, Hlth Sci Ctr, Permian Basin, TX USA published A Structured Approach to Detecting and Treating Depression in Primary Care: VitalSign6 Project in 2019.0, Cited 43.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

PURPOSE This report describes outcomes of an ongoing quality-improvement project (VitalSign6) in a large US metropolitan area to improve recognition, treatment, and outcomes of depressed patients in 16 primary care clinics (6 charity clinics, 6 federally qualified health care centers, 2 private clinics serving low-income populations, and 2 private clinics serving patients with either Medicare or private insurance). METHODS Inclusion in this retrospective analysis was restricted to the first 25,000 patients (aged >= 12 years) screened with the 2-item Patient Health Questionnaire (PHQ-2) in the aforementioned quality-improvement project. Further evaluations with self-reports and clinician assessments were recorded for those with positive screen (PHQ-2 >2). Data collected from August 2014 though November 2016 were available at 3 levels: (1) initial PHQ-2 (n = 25,000), (2) positive screen (n = 4,325), and (3) clinician-diagnosed depressive disorder with 18 or more weeks of enrollment (n = 2,160). RESULTS Overall, 17.3% (4,325/25,000) of patients screened positive for depression. Of positive screens, 56.1% (2,426/4,325) had clinician-diagnosed depressive disorder. Of those enrolled for 18 or more weeks, 64.8% were started on measurement-based pharmacotherapy and 8.9% referred externally. Of the 1,400 patients started on pharmacotherapy, 45.5%, 30.2%, 12.6%, and 11.6% had 0, 1, 2, and 3 or more follow-up visits, respectively. Remission rates were 20.3% (86/423), 31.6% (56/177), and 41.7% (68/163) for those with 1, 2, and 3 or more follow-up visits, respectively. Baseline characteristics associated with higher attrition were: non-white, positive drug-abuse screen, lower depression/anxiety symptom severity, and younger age. CONCLUSION Although remission rates are high in those with 3 or more followup visits after routine screening and treatment of depression, attrition from care is a significant issue adversely affecting outcomes.

HPLC of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Jha, MK; Grannemann, BD; Trombello, JM; Clark, EW; Eidelman, SL; Lawson, T; Greer, TL; Rush, AJ; Trivedi, MH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem