Month: January 2022

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Chen, CH; Chiang, CY; Wu, CW; Wang, CT; Chau, LK in MDPI published article about in [Chen, Chien-Hsing] Natl Pingtung Univ Sci & Technol, Dept Biomechatron Engn, Pingtung 91201, Taiwan; [Chiang, Chang-Yue] Natl Yunlin Univ Sci & Technol, Grad Sch Engn Sci & Technol, Touliu 64002, Yunlin, Taiwan; [Chiang, Chang-Yue; Wu, Chin-Wei] Natl Yunlin Univ Sci & Technol, Bachelor Program Interdisciplinary Studies, Touliu 64002, Yunlin, Taiwan; [Wang, Chien-Tsung] Natl Yunlin Univ Sci & Technol, Dept Chem & Mat Engn, Touliu 64002, Yunlin, Taiwan; [Chau, Lai-Kwan] Natl Chung Cheng Univ, Dept Chem & Biochem, Chiayi 62102, Taiwan; [Chau, Lai-Kwan] Natl Chung Cheng Univ, Ctr Nano Biodetect, Chiayi 62102, Taiwan in 2021.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

In this research, a direct, simple and ultrasensitive fiber optic particle plasmon resonance (FOPPR) biosensing platform for immunoglobulin G (IgG) detection was developed using a gold nanoparticle/graphene oxide (AuNP/GO) composite as signal amplification element. To obtain the best analytical performance of the sensor, experimental parameters including the surface concentration of GO on the AuNPs, formation time of the GO, the concentration of the anti-IgG and incubation time of anti-IgG were optimized. The calibration plots displayed a good linear relationship between the sensor response (Delta I/I-0) and the logarithm of the analyte concentrations over a linear range from 1.0 x 10(-10) to 1.0 x 10(-6) g/mL of IgG under the optimum conditions. A limit of detection (LOD) of 0.038 ng/mL for IgG was calculated from the standard calibration curve. The plot has a linear relationship (correlation coefficient, R = 0.9990). The analytical performance of present work’s biosensor was better than that of our previously reported mixed self-assembled monolayer of 11-mercaptoundecanoic acid/6-mercapto-1-hexanol (MUA/MCH = 1:4) method by about three orders of magnitude. The achieved good sensitivity may be attributed to the synergistic effect between GO and AuNPs in this study. In addition, GO could immobilize more antibodies due to the abundant carboxylic groups on its surface. Furthermore, we also demonstrated that the results from this sensor have good reproducibility, with coefficients of variation (CVs) < 8% for IgG. Therefore, the present strategy provides a novel and convenient method for chemical and biochemical quantification and determination. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Chen, CH; Chiang, CY; Wu, CW; Wang, CT; Chau, LK or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Synthesis and characterization of a new MeCAT reagent containing a photocleavable linker for labeling of proteins and peptides in mass spectrometric analyses WOS:000449443900027 published article about QUANTITATIVE-PROTEOMICS; RELATIVE QUANTIFICATION; SULFENIC ACID; DERIVATIVES; RELEASE in [Benda, David; Beck, Sebastian; Linscheid, Michael W.] Humboldt Univ, Dept Chem, Brook Taylor Str 2, D-12489 Berlin, Germany in 2019.0, Cited 28.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The quantification of proteins and peptides becomes more important besides mere identification in modern life sciences. Therefore, we have developed a new reagent that adds to the known metall-coded affinity tagging strategy employed in molecular and elemental mass spectrometry containing a photocleavable linker. A synthesis route was developed that provides the new reagent in good yields. The stability of the synthesized reagents was assessed under different temperature and illumination conditions. Labeling reactions were carried out at peptide and protein level, while also the fragmentation behavior of labeled peptides was assessed. In additional experiments, the photocleavability of the new reagent was examined. Upon irradiation with ultraviolet light, the photoproducts were liberated and could be used for quantification of labeled peptides.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Benda, D; Beck, S; Linscheid, MW or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Computed Properties of C4H14Cl2N2S2. In 2020.0 CARBOHYD POLYM published article about FOREIGN-BODY RESPONSE; GLYCOL) HYDROGELS; MICHAEL ADDITION; CROSS-LINKING; STEM-CELLS; RESISTANCE; COATINGS; RELEASE; CULTURE in [Zhang, Yabin; Liu, Shuyan; Li, Tianyu; Zhang, Luqing; Azhar, Umair; Ma, Jiachen; Zhai, Congcong; Zong, Chuanyong; Zhang, Shuxiang] Univ Jinan, Sch Chem & Chem Engn, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China in 2020.0, Cited 49.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

In this work, a facile click reaction strategy is employed to form hydrogels in situ with cytocompatibility, biodegradability, self-healing property and resistance to protein. The thiol-functionalized zwitterionic carboxybetaine methacrylate copolymer, which take part as a cross-linker in the thiol-ene click reaction with the methacrylated hyaluronic acid. The hydrogels are obtained under the physiological condition without the presence of any copper catalyst and UV light. The hydrogel consisting of zwitterionic component shows an obvious reduction in protein adsorption and cell adhesion and avoid non-targeted factor interference in the biological experiments. The hydrogels also demonstrate adjustable degradation behavior. Human mesenchymal stem cells (hMSCs) are easily encapsulated into the hydrogels and remains metabolically active, indicating the excellent biocompatibility of the hydrogels. Additionally, the result of the cytokine secretion assays (IL-6 and TNF-alpha) has shown that this clickable hydrogel can serve to suppress inflammatory reactions and is beneficial for in vivo applications. Based on the above results, this clickable hydrogel with excellent performance can be an amenable platform for 3D cell encapsulation.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, YB; Liu, SY; Li, TY; Zhang, LQ; Azhar, U; Ma, JC; Zhai, CC; Zong, CY; Zhang, SX or send Email.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy WOS:000657027700001 published article about DRUG-DELIVERY; DOXORUBICIN; MICELLES; BEHAVIOR; CELL in [Curcio, Manuela; Paoli, Alessandro; Cirillo, Giuseppe; Forestiero, Martina; Giordano, Francesca; Mauro, Loredana; Amantea, Diana; Nicoletta, Fiore Pasquale; Iemma, Francesca] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy; [Di Pietro, Sebastiano; Di Bussolo, Valeria] Univ Pisa, Dept Pharm, Via Bonanno Pisano 33, I-56126 Pisa, Italy in 2021.0, Cited 42.0. Recommanded Product: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

Recommanded Product: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Curcio, M; Paoli, A; Cirillo, G; Di Pietro, S; Forestiero, M; Giordano, F; Mauro, L; Amantea, D; Di Bussolo, V; Nicoletta, FP; Iemma, F or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Preparation and characterization of carboxymethyl cellulose containing quaternized chitosan for potential drug carrier WOS:000533508600136 published article about FACILE FABRICATION; HYDROGEL FILMS; DELIVERY; PH; MICELLES; RELEASE in [Wang, Fang; Zhang, Qian; Huang, Kexin; Li, Jiarui; Wang, Kun; Zhang, Kai; Tang, Xinyue] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China; [Wang, Fang] Jiangsu Key Lab Chem & Utilizat Agr & Forest Biom, Nanjing, Jiangsu, Peoples R China in 2020.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. COA of Formula: C4H14Cl2N2S2

The objective of this study was to synthesize and characterize cystamine dihydrochloride (CYS) crosslinked carboxymethyl cellulose/quaternized chitosan (CMC/HACC) composite hydrogel film. Firstly, the glycidyl-based quaternary ammonium chitosan derivative (HACC) was synthesized using nucleophilic substitution reaction. Then HACC was analyzed by FTIR, (HNMR)-H-1 spectra and the composite films at different blending ratio of CMC and HACC were studied by rheology measurement, mechanical and swelling tests. When the composite films were prepared under optimized conditions (CMC: HACC = 7:1), they showed excellent mechanical properties (with improved 93.3% tensile strength and 2.3% elongation at break) and swellability (equilibrium swelling ratio increased 270%) compared to pure CMC film. 5-Fluorouracil (5-FU) was used as drug model which has broad-spectrum anticancer properties. The 5-FU/CMC/HACC composite films showed redox and pH responsive of drug release properties along with well biocompatibility. The in vitro cytotoxicity and cell apoptosis studies showed the drug loaded composite films with obvious toxicity against HepG2 cells especially in the presence of GSH. In addition, CMC/HACC composite films showed good antibacterial against S. aureus and E. coli, while pure CMC film had no antimicrobial activities. It can be concluded that CMC/HACC composite films can be potentially used as targeted drug delivery system. (C) 2019 Elsevier B.V. All rights reserved.

Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, F; Zhang, Q; Huang, KX; Li, JR; Wang, K; Zhang, K; Tang, XY or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about PHOTOLUMINESCENCE SENSING PLATFORM; CYTOCHROME-C; INNER FILTER; ONE-POT; GRAPHENE; HEMOGLOBIN; CYTOTOXICITY; STABILITY; EVOLUTION; MYOGLOBIN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21771003]; Provincial Natural Science Research Program of the Higher Education institutions of Anhui Province [KJ2018A0460]; Anhui Provincial Natural Science FoundationNatural Science Foundation of Anhui Province [1908085ME153]. Published in ELSEVIER in AMSTERDAM ,Authors: Wu, FY; Cheng, YS; Wang, DM; Li, ML; Lu, WS; Xu, XY; Zhou, XH; Wei, XW. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Formula: C4H14Cl2N2S2

Nitrogen-doped MoS2 quantum dots (N-MoS2 QDs) were synthesized via a facile hydrothermal approach, and exhibited high fluorescence quantum yield (QY, 14.9%), excellent photostability, biocompatibility and water solubility. A novel method with good selectivity and sensitivity was established to assay hematin using N-MoS2 QDs as a fluorescent probe based on inner filter effect (IFE). Fluorescent quenching of N-MoS2 QDs has a fine linear dependence with the concentration of hematin in the range of 0.5-15 mu mol/L and a limit of detection of 0.32 mu mol/L (S/N = 3). By the detection method, average concentration of hematin in real health human erythrocytes was measured as 22.5 +/- 3.9 mu mol/L. And, recoveries range varied from 94 to 108% through standard recovery experiment. The N-MoS2 QDs probe shows excellent photostability, low cytotoxicity and anti-interference ability for hematin assay, which may become a promising method for the test of hematin in human blood.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Wu, FY; Cheng, YS; Wang, DM; Li, ML; Lu, WS; Xu, XY; Zhou, XH; Wei, XW or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 J MATER SCI published article about SIDE-CHAIN LENGTH; APPENDED NAPHTHALIMIDE; BLUE PHOTOLUMINESCENCE; HIGHLY FLUORESCENT; POLYMER; DYES; EMISSION; CHEMOSENSORS; SENSOR; IONS in [Shah, Tanveer-Ul-Hassan; Tahir, Mudassir Hussain; Liu, Hewen] Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China in 2019.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Tedious polymeric modifications, laborious syntheses, low water solubility, high cytotoxicity and low quantum yields are still the major concerns related to fluorescent materials used for biosensing applications. Here we report one-pot facile synthesis of polyethylene glycol (PEG)-modified cystamine-based multifunctional fluorescent dyes named as CPEG-168, CPEG-1000 and CPEG-2000, which can be used for biosensing and detection of both cations and anions in pure aqueous medium. Rapid response toward thiols could be achieved due to the presence of disulfide functionality and reversible redox property between thiol and disulfide. A cyclic structure is formed by (NH-H) intramolecular hydrogen bonding to produce electron dense region for strong fluorescence emission. The presence of -NH group made them sensitive toward Cu2+ ions, while excellent sensitivity toward pH and F- ions was provided by intramolecular hydrogen bonding between -NH groups. The increase in chain length of PEGs enhanced the fluorescence emission intensities due to the formation of more rigid structure, and hence, the desired quantum yields can be tuned by changing the chain length of PEG. The aforementioned properties along with high brightness in aqueous solution, at biological pH and temperature range, make these fluorescent dyes potential candidates for biosensing applications and detection of cations and anions.

Welcome to talk about 56-17-7, If you have any questions, you can contact Shah, TUH; Tahir, MH; Liu, HW or send Email.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX in ROYAL SOC CHEMISTRY published article about CD8 T-CELLS; REGULATORY T; MECHANISMS; ANTI-CTLA-4; INHIBITION; EXPRESSION; RESPONSES in [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Peking Union Med Coll, Tianjin Key Lab Biomat, Inst Biomed Engn, Tianjin 300192, Peoples R China; [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Chinese Acad Med Sci, Tianjin 300192, Peoples R China; [Han, Yanfeng] Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia; [Xu, Haiyan] Chinese Acad Med Sci, Inst Bas Sci, Sch Basic Med, Peking Union Med Coll, Beijing 100005, Peoples R China; [Kong, Deling] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China in 2020.0, Cited 25.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Combined blockades of CTLA-4 and PD-1 can yield better overall complementary clinical outcomes than individual blockades, but the response rates are still relatively low. To investigate the anti-tumor effects of various combined strategies, we designed various spherical nucleotide nanoparticles (SNPs) loaded with CTLA-4 aptamer (cSNPs), PD-1 siRNA (pSNPs) or both (hybrid SNPs, or hSNPs). The results demonstrated that hSNPs could promote significantly stronger anti-tumor immune responses in a nonredundant fashion than the mixture of pSNPs and cSNPs (pSNPs & cSNPs). We reasoned that this is because all individual immune cells could receive both CTLA-4 and PD-1 blockades when they engulfed hSNPs, but it is much less likely that individual immune cells could receive both CTLA-4 and PD-1 blockades as many of them may not take both pSNPs and cSNPS from pSNPs & cSNPs. Further results revealed that the synergistic immune stimulatory effects of CTLA-4 and PD-1 blockades in the form of hSNPs were at least partly through regulating the immune suppressive function of both Tregs and TIM3(+)exhausted-like CD8 T cells and allowing effector T cells to expand. This mechanism is not identical to earlier reported mechanisms of CTLA-4 and PD-1 blockades.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Quantifying Strain via Buckling Instabilities in Surface-Modified Polymer Brushes WOS:000541512200040 published article about ELASTIC-MODULI; THIN; FILMS; METROLOGY; WRINKLES; STRESS; CAST in [Thompson, Brittany J.; Logan, Phillip K.; Stafford, Christopher M.] NIST, Mat Sci & Engn Div, Gaithersburg, MD 20899 USA; [Reese, Cassandra M.; Guo, Wei; Thompson, Brittany J.; Logan, Phillip K.; Patton, Derek L.] Univ Southern Mississippi, Sch Polymer Sci & Engn, Hattiesburg, MS 39406 USA in 2020.0, Cited 41.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

A compressive strain applied to bilayer films (e.g., a thin film adhered to a thick substrate) can lead to buckled or wrinkled morphologies, which has many important applications in stretchable electronics, anticounterfeit technology, and high-precision micrometrology and nano-metrology. A number of buckling-based metrology methods have been developed to quantify the residual stress and viscoelastic properties of polymer thin films. However, in some systems (e.g., solvent-induced swelling or thermal strain), the compressive strain is unknown or difficult to measure. We present a quantitative method of measuring the compressive strain of wrinkled polymer films and coatings with knowledge of the skin thickness, wrinkle wavelength, and wrinkle amplitude. The derived analytical expression is validated with a well-studied model system, e.g., a stiff, thin film bonded to a thick, compliant substrate. After validation, we use our expression to quantify the applied swelling strain of previously reported wrinkled poly(styrene-alt-maleic anhydride) brush surfaces. Finally, the applied strain is used to rationalize the observed persistence length of aligned wrinkles created during atomic force microscopy lithography and subsequent solvent exposure.

Welcome to talk about 56-17-7, If you have any questions, you can contact Reese, CM; Guo, W; Thompson, BJ; Logan, PK; Stafford, CM; Patton, DL or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about FILLER-ELASTOMER INTERACTIONS; EPOXIDIZED NATURAL-RUBBER; COUPLING AGENTS; SURFACE MODIFICATION; NANOCOMPOSITES; NANOPARTICLES; PARTICLES; TIME, Saw an article supported by the . Published in ELSEVIER SCI LTD in OXFORD ,Authors: Wang, XF; Wu, LL; Yu, HW; Xiao, TL; Li, HM; Yang, J. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Modified silica-based isoprene rubber (IR) composite has been designed and prepared by using a multi-functional silane, 2-aminoethyl 2-(3-triethoxysilylpropyl)aminoethyl disulfide (ATD), as coupling agent. Such modification significantly improved the dispersity of silica in the corresponding composites, as verified by SEM observation. And the hardness, tensile strength, stress at definite elongation, tear strength and temperature rise as well as the value of dynamic loss coefficient ranging from 0 degrees C to 80 degrees C of silica/IR vulcanized composites, are significantly improved, especially with low ATD dosage (2-4 phr). This modification of silica-based IR composite by employing ATD as coupling agent provides a facile and effective method to prepare silica-based rubber composites with improved mechanical properties and low hysteresis.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, XF; Wu, LL; Yu, HW; Xiao, TL; Li, HM; Yang, J or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem