Day: January 20, 2022

An article Thermo- and redox-responsive dumbbell-shaped copolymers: from structure design to the LCST-UCST transition WOS:000509934700006 published article about TRANSFER RADICAL POLYMERIZATION; SELF-ASSEMBLY BEHAVIOR; BLOCK-COPOLYMERS; STAR POLYMERS; THERMORESPONSIVE POLYMERS; UNIMOLECULAR MICELLES; GENE DELIVERY; DRUG; TEMPERATURE; PDMAEMA in [Zou, Hui; Wu, Qiliang; Li, Qianwei; Zhou, Li; Hou, Xiao-Hua] Hefei Univ Technol, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Hefei 230009, Anhui, Peoples R China; [Zou, Hui; Wu, Qiliang; Li, Qianwei; Zhou, Li; Hou, Xiao-Hua] Hefei Univ Technol, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China; [Wang, Chunyao; Yuan, Weizhong] Tongji Univ, Sch Mat Sci & Engn, Shanghai 201804, Peoples R China in 2020.0, Cited 64.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

A dumbbell-shaped copolymer (PDMAEMA)(4)-PCL-SS-PCL-(PDMAEMA)(4) with a lower critical solution temperature (LCST) and redox responses was first synthesized by the combination of ring opening polymerization (ROP), click chemistry and atom transfer radical polymerization (ATRP). Then a dumbbell-shaped copolymer (PDMAPS)(4)-PCL-SS-PCL-(PDMAPS)(4) with an upper critical solution temperature (UCST) and redox responses was obtained through the quaternization reaction between DMAEMA and excess 1,3-propane sultone. Both (PDMAEMA)(4)-PCL-SS-PCL-(PDMAEMA)(4) and (PDMAPS)(4)-PCL-SS-PCL-(PDMAPS)(4) were amphiphilic, and they could self-assemble into spherical micelles under certain conditions. Benefitting from the LCST-type thermoresponse of PDMAEMA and UCST-type thermoresponse of PDMAPS, both dumbbell-shaped copolymers (PDMAEMA)(4)-PCL-SS-PCL-(PDMAEMA)(4) and (PDMAPS)(4)-PCL-SS-PCL-(PDMAPS)(4) presented temperature-responsive properties. The morphology and size of their assemblies would be changed when the temperature is altered. Meanwhile, due to the redox-response of disulfide bonds, both (PDMAEMA)(4)-PCL-SS-PCL-(PDMAEMA)(4) and (PDMAPS)(4)-PCL-SS-PCL-(PDMAPS)(4) showed redox-responsive properties. When dl-dithiothreitol (DTT) was added into the systems, disulfide bonds were broken, causing the change of (PDMAEMA)(4)-PCL-SS-PCL-(PDMAEMA)(4) to PCL-(PDMAEMA)(4), while (PDMAPS)(4)-PCL-SS-PCL-(PDMAPS)(4) changed into PCL-(PDMAPS)(4). The distributions of R-h for both (PDMAEMA)(4)-PCL-SS-PCL-(PDMAEMA)(4) and (PDMAPS)(4)-PCL-SS-PCL-(PDMAPS)(4) assemblies broadened with asymmetric peaks, giving rise to curves with double peaks. After 24 h, DLS curves became symmetric with a single peak, and the R-h was about half that of the original assemblies. In the meantime, dispersed spherical micelles could be observed by TEM.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zou, H; Wu, QL; Li, QW; Wang, CY; Zhou, L; Hou, XH; Yuan, WZ or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Outcomes of Chronic Turf Toe Repair in Non-athlete Population: A Retrospective Study WOS:000522460400007 published article about STRESS-FRACTURES; INJURIES in [Pinter, Zachariah W.; Farnell, Chason G.; Huntley, Samuel; Patel, Harshadkumar A.; Peng, Jianguang; McMurtrie, James; Ray, Jessyca L.; Naranje, Sameer; Shah, Ashish B.] Univ Alabama Birmingham, Dept Orthopaed Surg, 1313 13th St South, Birmingham, AL 35205 USA in 2020.0, Cited 20.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Background Turf toe injuries, though most common in athletes, can also occur in non-athletes. No study exists in the current literature investigating operative outcomes in non-athlete patients with chronic turf toe injury. In this study, we present our outcomes on operatively treated turf toe injuries in non-athletes in the only cohort yet studied. Methods Using ICD-10 codes, we assembled a cohort of 12 patients who underwent operative repair of chronic turf toe injury from January 2012 through January 2018 at the investigating institution. These 12 patients were evaluated to determine demographic information, method of injury, length of time from injury to surgery, clinical and radiologic characteristics of the injury, and operative outcomes including mean preoperative and postoperative VAS (Visual Analog Scale) scores, preoperative and postoperative FFI (Foot Function Index) scores, and postoperative complications. Results On initial clinical presentation, all 12 patients had local tenderness with associated painful range of motion. Four patients had restricted range of motion, all patients had a positive Lachman test, two had local edema, and eight had hallux valgus deformity. Mean VAS improved from 4.6 (range 2-9) to 1 (range 0-4). Mean FFI improved from 102.5 (range 56-177) to 61.75 (range 23-144). All patients had a negative Lachman test at final follow-up. No patients developed major complications or required revision surgery. Conclusions Our study is the first to investigate operative outcomes following chronic turf toe injury in non-athlete patients. Based on our study, surgeons and patients can expect significant improvement in overall pain and function following surgery.

Welcome to talk about 56-17-7, If you have any questions, you can contact Pinter, ZW; Farnell, CG; Huntley, S; Patel, HA; Peng, JG; McMurtrie, J; Ray, JL; Naranje, S; Shah, AB or send Email.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of Biochemistry & Molecular Biology; Chemistry; Polymer Science very interesting. Saw the article Biodegradable reduction-responsive polymeric micelles for enhanced delivery of melphalan to retinoblastoma cells published in 2019.0, Reprint Addresses Li, J (corresponding author), Jiangnan Univ, Dept Ophthalmol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Melphalan (MEL) is an effective chemotherapeutic agent for treatment of retinoblastoma (Rb) which is the most common childhood malignancy. However, the inherent cardiopulmonary toxicity and hazardous integration limit its therapeutic effect on RB. N-Acetylheparosan (AH), a natural heparin-like polysaccharide in mammals with long circulation effect and good biocompatibility, was linked by d-alpha-tocopherol acid succinate (VES) via and cystamine (CYS) to synthesize reduction-responsive N-acetylheparosan-CYS-Vitamin E succinate (AHV) copolymers. In addition, CYS was replaced by adipic acid dihydrazide (ADH) to obtain a control of non-reduction-responsive polymers N-acetylheparosan-ADH-Vitamin E succinate (ADV). MEL-loaded AHV micelles (MEL/AHV) as well as ADV micelles (MEL/ADV) were prepared with small particle size and high drug loading content. In vitro drug release showed that MEL/AHV micelles presented obvious reduction-triggered release behavior compared with MEL/ADV. In vitro antitumor effects were investigated using WERI-Rb-1 retinoblastoma cells. Cytotoxicity experiments showed that the IC50 of MEL/AHV was significantly lower than that of free MEL and MEL/ADV, suggesting that MEL/AHV enhanced the cytotoxicity against retinoblastoma cells. Furthermore, MEL/AHV micelles were more easily uptaken by multiple pathways compared with MEL/ADV and free MEL. Therefore, MEL/AHV might be a potential delivery system for enhanced delivery of melphalan to Rb cells. (C) 2019 Elsevier B.V. All rights reserved.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Li, J; Wang, JH; Zhang, XT; Xia, X; Zhang, CC or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Synthesis of polyorganophosphazenes and preparation of their polymersomes for reductive/acidic dual-responsive anticancer drugs release WOS:000523092100004 published article about AMPHIPHILIC GRAFT POLYPHOSPHAZENES; IN-VIVO DELIVERY; CO-DELIVERY; ETHYL 4-AMINOBENZOATE; RESISTANCE REVERSAL; NANOCARRIERS; MICELLES; DOXORUBICIN; VESICLES; NANOPARTICLES in [Khan, Rizwan Ullah; Yu, Haojie; Wang, Li; Zain-ul-Abdin; Nazir, Ahsan; Fahad, Shah; Chen, Xiang; Elsharaarani, Tarig] Zhejiang Univ, Coll Chem & Biol Engn, State Key Lab Chem Engn, Hangzhou 310027, Peoples R China; [Zhang, Qian; Xiong, Wei] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310003, Peoples R China in 2020.0, Cited 79.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Computed Properties of C4H14Cl2N2S2

Cancer cells have reductive and acidic environments as compared to the normal body cells. Development of reductive/acidic responsive polymersomes will play a major role in cancer therapy to trigger the release of the loaded drug. In our work, we synthesized three different reductive/acidic dual-responsive polymers, poly[(mPEG-SS-amino) (N,N-diisopropylethylenediamino)phosphazenes] (PPDPs) in different mole ratios of side groups. These PPDPs were characterized by H-1 NMR, P-31 NMR, FT-IR and GPC. After that, the PPDPs were allowed to self-assemble into drug-loaded polymersomes with high loading content and encapsulation efficiency of hydrophilic/hydrophobic anticancer drugs. The hydrophilic anticancer drug doxorubicin hydrochloride (DOX center dot HCl) and hydrophobic drug doxorubicin were used. These PPDPs-based polymersomes showed reductive/acidic stimuli-responsive release of anticancer drugs. Moreover, these polymersomes also exhibited suitable hydrodynamic diameters, which will facilitate the longtime circulation in bloodstream due to avoiding renal clearance and close contact to the tumor cells in vascular sections due to enhanced permeability and retention effect. Collectively, these developed polymersomes may provide an effective platform for anticancer drugs delivery.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Controlled Synthesis of Shell Cross-Linked Helical Poly(phenylborate isocyanide) Nanoparticles with H2O2/Redox Dual Responsiveness and Their Application in Antitumor Drug Delivery WOS:000604600600010 published article about MESOPOROUS SILICA NANOPARTICLES; SENSITIVE VESICLES; RELEASE; OXIDATION; HYPOXIA; PATCHES in [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Hefei 230009, Anhui, Peoples R China; [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China in 2020.0, Cited 36.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

To mimic the helical structure and function of biopolymers, shell cross-linked nanoparticle (P4) composed of left-handed helical poly(phenylborate isocyanide) in core and hydrophilic polyisocyanide in shell was prepared. The phenylborate in the core and the disulfide bonds in the cross-linkage render the nanoparticle with excellent dual stimuli-responsiveness to glutathione (GSH) and H2O2. Nevertheless, it has good stability in normal physiological conditions. Because of the helicity and borate pendants of the core, such nanoparticle has high capacity for anticancer drug loading, for example, the loading capacity of doxorubicin (DOX) was up to 68%. Moreover, the DOX-loaded DOX@P4 showed excellent tumor cell penetration potency and fast drug release. More than 78% of murine breast cancer cell (4T1) can be killed within 48 h, supporting this material with great potential in antitumor drug nanocarriers.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem