Recently I am researching about HEPTAMETHINE CYANINES; TARGETED DELIVERY; IN-VITRO; CANCER; NANOPARTICLES; CHEMOTHERAPY; PRODRUG, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671758, 32000982]; Guangdong Natural Science Fund [2019A1515110222, 2020B1111540001]; Shenzhen Science and Technology Program [JCYJ20200109114616534]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M660219]; Chinese Academy of SciencesChinese Academy of Sciences [Y959101001]; UNSW-CAS Collaborative Research Seed Fund Program [172644KYSB20190059]; SIAT Innovation Program for Excellent Young Researchers [201920]; Guangxi Natural Science FoundationNational Natural Science Foundation of Guangxi Province [2017GXNSFGA198005]; Research Program of Shenzhen Institute of Technology [2111015]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Li, Y; Zhou, LH; Zhu, BD; Xiang, JJ; Du, J; He, MW; Fan, XX; Zhang, PF; Zeng, RS; Gong, P. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Computed Properties of C4H14Cl2N2S2
Triptolide (TP) is one of the most common systemic treatments for inflammatory and immune diseases in China for centuries. However, TP exhibits some disadvantages, such as poor solubility in water, poor bioavailability, liver toxicity, renal toxicity, and other side effects. In order to reduce the adverse effects of TP, researchers have developed numerous strategies to address the adverse properties of triptolide. Nano-carrier-based triptolide delivery systems represent an emerging technology and are one of the strategies of nanomedicine that combines diagnostic and therapeutic applications in a single agent. In this approach, we developed a glutathione-activated carrier-free nanodrug of triptolide (CyssTPN) as a trackable drug delivery system. In this system, CyssTP self-assemble to form a carrier-free nanodrug, which possesses a monodisperse spherical morphology with hydrodynamic average sizes of about 50 nm. In addition, CyssTPN had good stability under different physiological conditions (pH, high salt, etc.). Apart from cellular imaging and cell uptake, CyssTPN can be tracked by the activation of TP ability in real-time and applied for cancer cell treatment efficiently. The result showed that CyssTPN could improve solubility, reduce the side effects, and increase the bioavailability of triptolide. It could also track triptolide activation timely and tumor therapy successfully.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem