Month: December 2021

An article Polymer-Upconverting Nanoparticle Hybrid Micelles for Enhanced Synergistic Chemo-Photodynamic Therapy: Effects of Emission- Absorption Spectral Match WOS:000490658900042 published article about UP-CONVERSION NANOPARTICLES; DRUG-RELEASE; COMBINATION; PLATFORM; POLYPRODRUG; DOXORUBICIN; NANOPROBES in [Chen, Yu; Ren, Jingli; Tian, Di; Li, Yuce; Jiang, Hao; Zhu, Jintao] HUST, Sch Chem & Chem Engn, Minist Educ, Key Lab Mat Chem Energy Convers & Storage, Wuhan 430074, Hubei, Peoples R China in 2019.0, Cited 41.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Chemo-photodynamic combined therapy is promising in cancer treatment, although low tissue penetration of visible light for activating photosensitizers (e.g., chlorin e6, Ce6) limited its broad applications. Combination of upcoverting nanoparticles (UCNPs) with the photosensitizers endows us with the possibility to utilize highly tissue penetrable near-infrared light; nevertheless, the mismatch between absorption of common photosensitizers (lambda(abs), mainly red) and emission of UCNPs (lambda(em), mainly green) resulted in low energy utilization and unsatisfied therapeutic efficacy in the current UCNP-PDT (photodymanic therapy) platforms. To resolve this problem, herein, we construct polymer-UCNP hybrid micelles (PUHMs) for codelivery of doxorubicin (DOX) and Ce6, and systemically studied the effects of spectral match between lambda(em) of UCNPs and lambda(abs) of Ce6 on efficiency of synergistic chemo-photodynamic therapy. Compared with spectrally mismatched PUHMs, the spectrally matched PUHMs can significantly enhance the utilization efficiency of upconverted emission energy to activate the photosensitizers and generate more reactive oxygen species (ROS) for enhanced photodynamic therapy. Meanwhile, as the assembled structure of PUHMs can be destroyed by the oxidation of ROS upon 980 nm laser irradiation because of the hydrophobic-hydrophilic transformation of poly(propylene sulfide) (PPS) segment, the spectrally matched PUHMs triggered faster release of DOX, thus resulting in more effective chemotherapy. As a result, the spectrally matched PUHMs induced more prominent cytotoxicity and superior synergistic therapeutic effect for cancer cells in vitro. Our results demonstrated that such spectrally matched PUHMs provide us with an effective strategy for photodynamic-chemo synergistic therapy.

Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Combined pH-responsive chemotherapy and glutathione-triggered photosensitization to overcome drug-resistant hepatocellular carcinoma – a SPP/JPP Young Investigator Award paper WOS:000582305700009 published article about MESOPOROUS SILICA NANOPARTICLES; MULTIDRUG-RESISTANCE; PHOTODYNAMIC THERAPY; COMBINATION THERAPY; CANCER-THERAPY; DELIVERY; NANOMEDICINE; STRATEGIES in [Lo, Pui-Chi] City Univ Hong Kong, Dept Biomed Sci, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China; City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China in 2020.0, Cited 31.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Doxorubicin (DOX) resistance, which results in a reduced accumulation of DOX in the nucleus and hence decreased DNA damage, is a major challenge for chemotherapy against hepatocellular carcinoma. In this paper, we combined chemotherapy with photodynamic therapy (PDT) to combat DOX-resistant human hepatocellular carcinoma cells. We have prepared the polymeric micelles conjugating with DOX and zinc(II) phthalocyanine (ZnPc) through a pH-responsive hydrazone linker and a glutathione (GSH)-responsive disulfide linker, respectively. The polymeric micelles (DOX-ZnPc-micelles) exhibited a spherical shape with a size of about 98 mn diameter and showed excellent stability in aqueous solution. Due to the self-quenching of the ZnPc inside the micelles, DOX-ZnPc-micelles did not emit fluorescence upon red light irradiation. Drug release experiments verified that DOX and ZnPc could be released under acidic conditions and reducing environments, respectively. A higher concentration of DOX was internalized into DOX-resistant R-HepG2 cells through the delivery of polymeric micelles when compared with the free DOX, hence DOX-ZnPc-micelles exhibited a significant enhancement in anticancer activity. The IC50 value of DOX against R-HepG2 cells was found to be 21 mu M when combined with PDT and it was 5-fold less than that of a single treatment of DOX (102 mu M). The DOX-ZnPc-micelles could induce cell apoptosis and necrosis on R-HepG2 cells by combined therapeutic modalities, while these micelles induced only apoptosis on IiepG2 cells. We have demonstrated that utilization of polymeric micelles can significantly enhance the cellular uptake and cytotoxicity of DOX against R-HepG2 cells when compared with free DOX. Moreover, PDT can act as an adjuvant therapeutic modality and combine with chemotherapy to further improve therapeutic efficacy. Overall speaking, DOX-ZnPc-micelles can overcome DOX resistance and induce a synergistic therapeutic effect against DOX-resistant R-HepG2 cells, hence improving the therapeutic efficacy when compared with monotherapy.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Redox-Sensitive Clustered Ultrasmall Iron Oxide Nanoparticles for Switchable T-2/T-1-Weighted Magnetic Resonance Imaging Applications WOS:000515196200018 published article about ALGINATE NANOGELS; DRUG-DELIVERY; TUMOR; SIZE; GLUTATHIONE; T-1; ACCUMULATION; PENETRATION; ASSEMBLIES; MICELLES in [Ma, Dan; Zhang, Jiulong; Peng, Chen; Shi, Xiangyang] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Canc Ctr, Shanghai 200072, Peoples R China; [Ma, Dan; Shi, Menghan; Li, Xin; Fan, Yu; Jiang, Tingting; Shi, Xiangyang] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China; [Sun, Kai] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA; [Peng, Chen] Ninghai First Hosp, Ningbo 315600, Peoples R China in 2020.0, Cited 44.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Development of novel activable dual-mode T-1/T-2-weighted magnetic resonance (MR) contrast agents with the same composition for dynamic precision imaging of tumors has been a challenging task. Here, we demonstrated a strategy to prepare clustered Fe3O4 nanoparticles (NPs) with redox-responsiveness to tumor microenvironment to achieve switchable T-2/T-1-weighted dual-mode MR imaging applications. In this study, we first synthesized ultrasmall Fe3O4 NPs with an average size of 3.3 nm and an r, relaxivity of 4.3 mM(-1) s(-1), and then cross-linked the single Fe3O4 NPs using cystamine dihydrochloride (Cys) to form clustered Fe3O4/Cys NPs. The Fe3O4 nanoclusters (NCs) possess desirable colloidal stability, cytocompatibility, high r(2) relaxivity (26.4 mM(-1) s(-1)), and improved cellular uptake efficiency. Importantly, with the redox-responsiveness of the disulfide bond of Cys, the Fe3O4 NCs can be dissociated to form single particles under a reducing condition, hence displaying a switchable T-2/T-1-weighted MR imaging property that can be utilized for dynamic precision imaging of cancer cells in vitro and a subcutaneous tumor model in vivo due to the reductive intracellular environment of cancer cells and the tumor microenvironment. With the tumor reductive microenvironment-mediated switching of T-2 to T-1 MR effect and the ultrasmall size of the single particles that can pass through the kidney filter, the developed Fe3O4 NCs may be used as a promising switchable T-2/T-1 dual-mode MR contrast agent for precision imaging of different biosystems.

Welcome to talk about 56-17-7, If you have any questions, you can contact Ma, D; Shi, MH; Li, X; Zhang, JL; Fan, Y; Sun, K; Jiang, TT; Peng, C; Shi, XY or send Email.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2020.0 BIOMACROMOLECULES published article about PERIODATE-OXIDATION; SERUM GALECTIN-3; CANCER; PECTIN; EXPRESSION; METASTASIS; INHIBITION; THERAPY; TUMORS; CELLS in [Subramanian, Suresh; Mallia, Madhava B.; Dash, Ashutosh] BARC, Radiopharmaceut Div, Mumbai 400085, Maharashtra, India; [Subramanian, Suresh; Mallia, Madhava B.; Dash, Ashutosh] Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, India; [Repaka, Krishnamohan] Board Radiat & Isotope Technol, Navi Mumbai 400703, India; [Balakrishnan, Biji; Kaur, Shahdeep; Chandan, Rajeet; Bhardwaj, Prateek; Banerjee, Rinti] Indian Inst Technol, Nanomed Lab, Dept Biosci & Bioengn, Mumbai 400076, Maharashtra, India in 2020.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Galectin-3 (gal-3) plays a crucial role in various cellular events associated to tumor metastasis and progression. In this direction, gal-3 binding core-shell glyconanoparticles based on citrus pectin (CP) have been designed for targeted, trigger-responsive combination drug delivery. Depolymerization via periodate oxidation in heterogeneous medium yielded low-molecular weight dialdehyde oligomers (CPDA) of CP with a gal-3 binding property (K-d = 160.90 mu M). CPDA-based core-shell nanoparticles prepared to enhance the gal-3 binding specificity via a multivalent ligand presentation have shown to reduce homotypic cellular aggregation, tumor cell binding with endothelial cells, and endothelial tube formation, the major steps involved in the progression of cancer. Immune-fluorescence and flow cytometric analysis confirmed significant reduction in gal-3 expression on MDA-MB 231 cancer cells upon incubation with nanoparticles. An on-demand tumor microenvironment-responsive release of drugs at low pH and high concentrations of glucose and glutathione prevailing in tumor milieu was achieved by introducing a cleavable Schiff’s base, a boronate ester, and disulfide linkages within the shell of the nanoparticles. Nanoparticles with encapsulated sulindac in the core and doxorubicin (DOX) in the shell demonstrated target specificity and enhanced internalization with synergistic cytotoxic effects with a 30-fold reduction in IC50 in DOX-resistant, triple-negative MDA-MB 231 breast cancer cells. Nanoparticles were radiolabeled with 131I radioisotopes with >= 80% efficiency while retaining its gal-3 binding property. Biodistribution studies of radiolabeled placebo nanoparticles and drug-loaded CPDA nanoparticles demonstrated proof of concept of gal-3 targeting seen as preferential accumulation in the gal-3-expressing tissues of the gastric tract. The CPDA core-shell nanoparticles are thus promising platforms for gal-3 targeting and inhibition of gal-3-mediated processes involved in cancer progression with a potential of radiolabeling for in vivo monitoring or delivering therapeutic doses of radiation and on-demand triggered, target-specific drug release.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Product Details of 56-17-7. Recently I am researching about CHEMISTRY; DESIGN; GELS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51973073, 51622303, 51703080]; Natural Science Foundation of Hubei Scientific Committee [2018CFA059]; Applied and Fundamental Frontier Program of Wuhan [2019010701011409]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Jo, YH; Li, SQ; Zuo, C; Zhang, Y; Gan, HH; Li, SB; Yu, LP; He, D; Xie, XL; Xue, ZG. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Compared with liquid electrolytes, the solid polymer electrolyte (SPE), which possesses improved thermal and mechanical stability, is believed the broadest potential application for satisfying the safety needs of advanced electro-chemical devices. However, some breakable SPEs could lead to catastrophic failure of batteries that triggered by a short circuit. In the present contribution, a new class of SPE containing disulfide bonds and urea groups is reported. The hydrogen bonding between the urea groups and disulfide metathesis reaction endows the SPE with a high level of self-healing without external stimuli at room temperature as well as ultrafast self-healing at elevated temperatures. The completely healed SPE with extreme damage shows a high self-healing efficiency and no changes in the ionic conductivity and cycling performance of the solid-state lithium-metal/LiFePO4 cell compared to the pristine one.

Welcome to talk about 56-17-7, If you have any questions, you can contact Jo, YH; Li, SQ; Zuo, C; Zhang, Y; Gan, HH; Li, SB; Yu, LP; He, D; Xie, XL; Xue, ZG or send Email.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

HPLC of Formula: C4H14Cl2N2S2. I found the field of Chemistry very interesting. Saw the article Combined pH-responsive chemotherapy and glutathione-triggered photosensitization to overcome drug-resistant hepatocellular carcinoma – a SPP/JPP Young Investigator Award paper published in 2020.0, Reprint Addresses Lo, PC (corresponding author), City Univ Hong Kong, Dept Biomed Sci, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Doxorubicin (DOX) resistance, which results in a reduced accumulation of DOX in the nucleus and hence decreased DNA damage, is a major challenge for chemotherapy against hepatocellular carcinoma. In this paper, we combined chemotherapy with photodynamic therapy (PDT) to combat DOX-resistant human hepatocellular carcinoma cells. We have prepared the polymeric micelles conjugating with DOX and zinc(II) phthalocyanine (ZnPc) through a pH-responsive hydrazone linker and a glutathione (GSH)-responsive disulfide linker, respectively. The polymeric micelles (DOX-ZnPc-micelles) exhibited a spherical shape with a size of about 98 mn diameter and showed excellent stability in aqueous solution. Due to the self-quenching of the ZnPc inside the micelles, DOX-ZnPc-micelles did not emit fluorescence upon red light irradiation. Drug release experiments verified that DOX and ZnPc could be released under acidic conditions and reducing environments, respectively. A higher concentration of DOX was internalized into DOX-resistant R-HepG2 cells through the delivery of polymeric micelles when compared with the free DOX, hence DOX-ZnPc-micelles exhibited a significant enhancement in anticancer activity. The IC50 value of DOX against R-HepG2 cells was found to be 21 mu M when combined with PDT and it was 5-fold less than that of a single treatment of DOX (102 mu M). The DOX-ZnPc-micelles could induce cell apoptosis and necrosis on R-HepG2 cells by combined therapeutic modalities, while these micelles induced only apoptosis on IiepG2 cells. We have demonstrated that utilization of polymeric micelles can significantly enhance the cellular uptake and cytotoxicity of DOX against R-HepG2 cells when compared with free DOX. Moreover, PDT can act as an adjuvant therapeutic modality and combine with chemotherapy to further improve therapeutic efficacy. Overall speaking, DOX-ZnPc-micelles can overcome DOX resistance and induce a synergistic therapeutic effect against DOX-resistant R-HepG2 cells, hence improving the therapeutic efficacy when compared with monotherapy.

HPLC of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Gao, D; Lo, PC or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. In 2020.0 J BIOMED MATER RES B published article about MESENCHYMAL STEM-CELLS; OPTIMIZATION; CULTURE; DIFFERENTIATION; EXPANSION; SYSTEM; GROWTH; HMSCS in [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA; [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] Harvard Med Sch, Brigham & Womens Hosp, Div Engn Med, Dept Med, Boston, MA 02115 USA; [Uth, Nicholas; Levinson, Yonatan; Abraham, Eytan] Res & Technol, Walkersville, MD USA; [Artzi, Natalie] Broad Inst Harvard & MIT, Cambridge, MA USA in 2020.0, Cited 33.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Microcarriers, including crosslinked porous gelatin beads (Cultispher G) are widely used as cell carriers for cell therapy applications. Microcarriers can support a range of adherent cell types in stirred tank bioreactor culture, which is scalable up to several thousands of liters. Cultispher G in particular is advantageous for cell therapy applications because it can be dissolved enzymatically, and thus cells can be harvested without the need to perform a large-scale cell-bead filtration step. This enzymatic dissolution, however, is challenged by the slow degradation of the carriers in the presence of enzymes as new extracellular matrix is being deposited by the proliferating cells. This extended dissolution timelimits the yield of cell recovery while compromising cellular viability. We report herein the development of crosslinked porous gelatin beads that afford rapid, stimuli-triggered dissolution for facile cell removal using human mesenchymal stem cells (hMSC) as a model system. We successfully fabricated redox-sensitive beads (RS beads) and studied their cell growth, dissolution time and cell yield, compared to regular gelatin-based beads (Reg beads). We have shown that RS beads allow for much faster dissolution compared to Reg beads, supporting better hMSC detachment and recovery following 8 days of culture in spinner flasks, or in 3L bioreactors. These newly synthesized RS beads show promise as cellular microcarriers and can be used for scale-up manufacturing of different cell types while providing on-demand degradation for facile cell retrieval.

Welcome to talk about 56-17-7, If you have any questions, you can contact Dosta, P; Ferber, S; Zhang, Y; Wang, K; Ros, A; Uth, N; Levinson, Y; Abraham, E; Artzi, N or send Email.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Polythiolactone-Decorated Silica Particles: A Versatile Approach for Surface Functionalization, Catalysis and Encapsulation WOS:000645991700001 published article about POLYMERIC MULTILAYER CAPSULES; MESOPOROUS SILICA; THIOLACTONE CHEMISTRY; GOLD NANOPARTICLES; COLLOIDAL SILICA; DRUG CARRIER; ONE-POT; LIGHT; NANOSTRUCTURES; THERAPY in [Kurka, Dustin Werner; Niehues, Maximilian; Ravoo, Bart Jan] Westfalische Wilhelms Univ Munster, Inst Organ Chem, Ctr Soft Nanosci, Corrensstr 36, D-48149 Munster, Germany; [Kurka, Dustin Werner; Niehues, Maximilian; Ravoo, Bart Jan] Busso Peus Str 10, D-48149 Munster, Germany; [Kudruk, Sergej; Gerke, Volker] Westfalische Wilhelms Univ Munster, Inst Med Biochem, Ctr Mol Biol Inflammat, Von Esmarch Str 56, D-48149 Munster, Germany in 2021.0, Cited 98.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. COA of Formula: C4H14Cl2N2S2

The surface chemistry of colloidal silica has tremendous effects on its properties and applications. Commonly the design of silica particles is based on their de novo synthesis followed by surface functionalization leading to tailormade properties for a specific purpose. Here, the design of robust precursor polymer-decorated silica nano- and microparticles is demonstrated, which allows for easy post-modification by polymer embedded thiolactone chemistry. To obtain this organic-inorganic hybrid material, silica particles (SiO2P) were functionalized via surface-initiated atom transfer radical polymerization (SI-ATRP) with poly(2-hydroxyethyl acrylate) (PHEA)-poly(thiolactone acrylamide (PThlAm) co-polymer brushes. Exploiting the versatility of thiolactone post-modification, a system was developed that could be used in three exemplary applications: 1) the straightforward molecular post-functionalization to tune the surface polarity, and therefore the dispersibility in various solvents; 2) the immobilization of metal nanoparticles into the polymer brushes via the in situ formation of free thiols that preserved catalytic activity in a model reaction; 3) the formation of redox-responsive, permeable polymer capsules by crosslinking the thiolactone moieties with cystamine dihydrochloride (CDH) followed by dissolution of the silica core.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about FACILE FABRICATION; HYDROGEL FILMS; DELIVERY; PH; MICELLES; RELEASE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31200451]. Published in ELSEVIER in AMSTERDAM ,Authors: Wang, F; Zhang, Q; Huang, KX; Li, JR; Wang, K; Zhang, K; Tang, XY. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

The objective of this study was to synthesize and characterize cystamine dihydrochloride (CYS) crosslinked carboxymethyl cellulose/quaternized chitosan (CMC/HACC) composite hydrogel film. Firstly, the glycidyl-based quaternary ammonium chitosan derivative (HACC) was synthesized using nucleophilic substitution reaction. Then HACC was analyzed by FTIR, (HNMR)-H-1 spectra and the composite films at different blending ratio of CMC and HACC were studied by rheology measurement, mechanical and swelling tests. When the composite films were prepared under optimized conditions (CMC: HACC = 7:1), they showed excellent mechanical properties (with improved 93.3% tensile strength and 2.3% elongation at break) and swellability (equilibrium swelling ratio increased 270%) compared to pure CMC film. 5-Fluorouracil (5-FU) was used as drug model which has broad-spectrum anticancer properties. The 5-FU/CMC/HACC composite films showed redox and pH responsive of drug release properties along with well biocompatibility. The in vitro cytotoxicity and cell apoptosis studies showed the drug loaded composite films with obvious toxicity against HepG2 cells especially in the presence of GSH. In addition, CMC/HACC composite films showed good antibacterial against S. aureus and E. coli, while pure CMC film had no antimicrobial activities. It can be concluded that CMC/HACC composite films can be potentially used as targeted drug delivery system. (C) 2019 Elsevier B.V. All rights reserved.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Zhang, YB; Liu, SY; Li, TY; Zhang, LQ; Azhar, U; Ma, JC; Zhai, CC; Zong, CY; Zhang, SX in [Zhang, Yabin; Liu, Shuyan; Li, Tianyu; Zhang, Luqing; Azhar, Umair; Ma, Jiachen; Zhai, Congcong; Zong, Chuanyong; Zhang, Shuxiang] Univ Jinan, Sch Chem & Chem Engn, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China published Cytocompatible and non-fouling zwitterionic hyaluronic acid-based hydrogels using thiol-ene click chemistry for cell encapsulation in 2020.0, Cited 49.0. Recommanded Product: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

In this work, a facile click reaction strategy is employed to form hydrogels in situ with cytocompatibility, biodegradability, self-healing property and resistance to protein. The thiol-functionalized zwitterionic carboxybetaine methacrylate copolymer, which take part as a cross-linker in the thiol-ene click reaction with the methacrylated hyaluronic acid. The hydrogels are obtained under the physiological condition without the presence of any copper catalyst and UV light. The hydrogel consisting of zwitterionic component shows an obvious reduction in protein adsorption and cell adhesion and avoid non-targeted factor interference in the biological experiments. The hydrogels also demonstrate adjustable degradation behavior. Human mesenchymal stem cells (hMSCs) are easily encapsulated into the hydrogels and remains metabolically active, indicating the excellent biocompatibility of the hydrogels. Additionally, the result of the cytokine secretion assays (IL-6 and TNF-alpha) has shown that this clickable hydrogel can serve to suppress inflammatory reactions and is beneficial for in vivo applications. Based on the above results, this clickable hydrogel with excellent performance can be an amenable platform for 3D cell encapsulation.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, YB; Liu, SY; Li, TY; Zhang, LQ; Azhar, U; Ma, JC; Zhai, CC; Zong, CY; Zhang, SX or send Email.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem