Recommanded Product: 56-17-7. In 2020.0 ACS APPL MATER INTER published article about ASSEMBLED NANOPARTICLES; INTRACELLULAR DELIVERY; DRUG-RELEASE; MICELLES; MICROENVIRONMENT; COMBINATION; DOXORUBICIN; NANOSYSTEM; CONJUGATE; LIPOSOMES in [Yin, Shaoping; Gao, Yi; Zhang, Yu; Xu, Jianan; Zhu, Jianping; Li, Juan] China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Peoples R China; [Zhou, Fang; Wang, Guangji] China Pharmaceut Univ, Ctr New Drug Safety Evaluat & Res, Nanjing 210009, Peoples R China; [Gu, Xiaochen] Univ Manitoba, Fac Pharm, Winnipeg, MB R3E 0T5, Canada in 2020.0, Cited 53.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.
Deep tumor penetration, long blood circulation, rapid drug release, and sufficient stability are the most concerning dilemmas of nano-drug-delivery systems for efficient chemotherapy. Herein, we develop reduction/oxidation-responsive hierarchical nanoparticles co-encapsulating paclitaxel (PTX) and pH-stimulated hyaluronidase (pSH) to surmount the sequential biological barriers for precise cancer therapy. Poly(ethylene glycol) diamine (PEG-dia) is applied to collaboratively cross-link the shell of nanoparticles self-assembled by a hyaluronic acid-stearic acid conjugate linked via a disulfide bond (HA-SS-SA, HSS) to fabricate the hierarchical nanoparticles (PHSS). The PTX and pSH coloaded hierarchical nanoparticles (PTX/pSH-PHSS) enhance the stability in normal physiological conditions and accelerate drug release at tumorous pH, and highly reductive or oxidative environments. Functionalized with PEG and HA, the hierarchical nanoparticles preferentially prolong the circulation time, accumulate at the tumor site, and enter MDA-MB-231 cells via CD44-mediated endocytosis. Within the acidic tumor micro-environment, pSH would be partially reactivated to decompose the dense tumor extracellular matrix for deep tumor penetration. Interestingly, PTX/pSH-PHSS could be degraded apace by the completely activated pSH within endo/lysosomes and the intracellular redox micro-environment to facilitate drug release to produce the highest tumor inhibition (93.71%) in breast cancer models.
Recommanded Product: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Yin, SP; Gao, Y; Zhang, Y; Xu, JN; Zhu, JP; Zhou, F; Gu, XC; Wang, GJ; Li, J or send Email.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem