Day: December 24, 2021

Authors Yeh, CM; Lin, CH; Han, TY; Xiao, YT; Chen, YA; Chou, HH in ROYAL SOC CHEMISTRY published article about in [Yeh, Chun-Ming; Lin, Chun-Hsiu; Han, Tzung-You; Xiao, Yu-Ting; Chen, Yi-An; Chou, Ho-Hsiu] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan in 2021.0, Cited 62.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

For next-generation electronics, it is crucial to be able to accurately mimic the nature of human skin and develop skin-inspired materials and devices for electronic skin (e-skin) applications. However, it is a great challenge to design such a materials because they require the complex integration of stretchability, skin adhesiveness, transparency, healability, and tactile sensing. Herein, we present the first dual covalently reversible dynamic bond-based polymer that can be integrated with various functional materials and used as a skin-like sensor. A series of polymers was designed using polypropylene glycol (PPG)-based polyurethane (PU) as the polymer backbone, and these polymers could integrate two types of covalent reversible dynamic bonds, Diels-Alder and disulfide bonds, in one polymer for the first time. Based on our design, a polymer was created with the advantages of high stretchability, fast healing abilities (60 degrees C, 5 min), skin adhesion, recyclability, high transparency, and tactile sensing abilities. We provide an alternative strategy for the construction of skin-inspired multifunctional materials for e-skin applications.

Welcome to talk about 56-17-7, If you have any questions, you can contact Yeh, CM; Lin, CH; Han, TY; Xiao, YT; Chen, YA; Chou, HH or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A in [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Dept Polymer Engn, POB 51335-1996, Tabriz, Iran; [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Inst Polymer Mat, POB 51335-1996, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Sahand Univ Technol, Dept Chem Engn, POB 51335-1996, Tabriz, Iran published Effect of grafting ratio of poly(propylene imine) dendrimer onto gold nanoparticles on the properties of colloidal hybrids, their DOX loading and release behavior and cytotoxicity in 2019.0, Cited 60.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A facile method via grafting to approach was used to synthesize hybrid gold-dendrimer nanoparticles. To this end, gold nanoparticles (GNPs) were synthesized via Turkevich method and 5th-generation cystamine-cored poly (propylene imine) (PPI) dendrimer was synthesized by iterative Michael addition and hydrogenation reactions. To prepare hybrid nanoparticles, aqueous solution of dendrimer was poured into colloidal solution of GNPs to form gold-S interactions which resulted in hybrid gold-dendrimer nanoparticles. UV-VIS-NIR and Raman spectroscopies, dynamic light scattering (DLS), thermogravimetric analysis (TGA) and field-emission scanning electron microscopy (FE-SEM) were utilized to confirm the surface modification of GNPs by PPI dendrimer. Cytotoxicity study through MIT assay against human fibroblast (FBS) cells showed appropriate proliferation of cells in presence of hybrid nanoparticles whereas higher grafting ratio of dendrimers induced more toxicity due to existence of peripheral amine groups. Also, hybrid gold-dendrimer nanoparticles were used as DOX nano-carriers. Results showed that carriers did not release the drug at pH = 7.4 significantly while up to 92.8% of drug release was measured at pH = 5.3. Also, higher grafting ratio limited the drug release due to shielding effect of grafted dendrimers.

Welcome to talk about 56-17-7, If you have any questions, you can contact Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H; Kahaie-Khosrowshahi, A or send Email.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

COA of Formula: C4H14Cl2N2S2. In 2019.0 CHEM COMMUN published article about BONDS; FILMS in [Lee, Jong Pil; Hwang, Hyemin; Chae, Songa; Kim, Jong-Man] Hanyang Univ, Dept Chem Engn, Seoul 04763, South Korea; [Kim, Jong-Man] Hanyang Univ, Inst Nano Sci & Technol, Seoul 04763, South Korea in 2019.0, Cited 35.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A reversibly mechanochromic conjugated polymer has been developed. The polymer, polydiacetylene (PDA), obtained by thermal polymerization of a diphenyldisulfide-containing bisdiacetylene undergoes a blue-to-green color change upon grinding. The original blue color of the PDA is regenerated via a metastable red-color state by utilizing a thermochromic (heating-cooling) process.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Fang, Y; Zhou, J; Ding, X; Ling, GH; Yu, SS in [Fang, Yu; Yu, Shanshan] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Emergency, Wuhan 430030, Hubei, Peoples R China; [Zhou, Jun; Ding, Xun; Ling, Gonghao] Wuhan Univ, Zhongnan Hosp, Dept Radiol, Wuhan 430071, Hubei, Peoples R China published Pulmonary fibrosis in critical ill patients recovered from COVID-19 pneumonia: Preliminary experience in 2020.0, Cited 18.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Objective: To investigate chest computed tomography (CT) findings associated with severe COVID-19 pneumonia in the early recovery period. Methods: We retrospectively analyzed the cases of patients diagnosed with severe COVID-19 pneumonia at a single center between January 12, 2020, and March 16, 2020. The twelve ICU patients studied had been diagnosed SARS-CoV-2 (COVID-19) nucleic acid positive. Patient clinical symptoms were relieved or disappeared, and basic clinical information and laboratory test results were collected. The study focused on the most recent CT imaging characteristics. Results: The average age of the 12 patients was 58.8 +/- 16.2 years. The most prevalent symptoms were fever (100%), dyspnea (100%), and cough (83.3%). All patients experienced acute respiratory distress syndrome (ARDS), of which 9 were moderate to severe. Six patients used noninvasive ventilators, and 4 patients used mechanical ventilation. One patient was treated with extracorporeal membrane oxygenation (ECMO). The lymphocyte count decreased to 0.67 +/- 0.3 (x 10 /L). The average day from illness onset to the last follow-up CT was 56.1 +/- 7.7 d. The CT results showed a decrease in ground glass opacities (GGO), whereas fibrosis gradually increased. The common CT features included GGO (10/12, 83.3%), subpleural line (10/12, 83.3%), fibrous stripes (12/12, 100%), and traction bronchiectasis (10/12, 83.3%). Eight patients (66.7%) showed predominant reticulation and interlobular thickening. Four patients (33.3%) showed predominant GGO. Lung segments involved were 174/216 (80.6%). Conclusions: Fibrous stripes and GGO are common CT signs in critically ill patients with COVID-19 pneumonia in the early recovery period. Signs of pulmonary fibrosis in survivors should be carefully monitored. (C) 2020 Elsevier Inc. All rights reserved.

COA of Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about POLYMERIC MICELLES; CANCER THERAPEUTICS; ANTITUMOR-ACTIVITY; NANOCARRIERS; RELEASE; NANOTECHNOLOGY; NANOMEDICINE; CHALLENGES; TRANSPORT; CRLX101, Saw an article supported by the Novartis, Cambridge, MA. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Metcalf, CA; Svenson, S; Hwang, J; Tripathi, S; Gangal, G; Kabir, S; Lazarus, D; Cole, R; Sweryda-Krawiec, B; Shum, P; Brown, D; Case, RI; van der Poll, D; Rohde, E; Harlfinger, S; Teng, CH; Eliasof, S. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Product Details of 56-17-7

Novel nanoparticle drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally varied linkers that attached the drug payloads to a beta-cyclodextrin-PEG copolymer to form self-assembled nanoparticles. In vitro release studies revealed a diversity of release rates driven by linker structure activity relationships (SARs). Improved in vivo pharmacokinetics (PK) for the cabazitaxel (CBTX) NDCs with glycinate-containing (1c) and hexanoate-containing linkers (2c) were demonstrated, along with high and sustained tumor levels (>168 h of released drug in tumor tissues). This led to potent efficacy and survival in both taxane- and docetaxel-resistant in vivo anticancer mouse efficacy models. Overall, the CBTX-hexanoate NDC 2c (CRLX522), demonstrated optimal and improved in vivo PK (plasma and tumor) and efficacy profile versus those of the parent drug, and the results support the potential therapeutic use of CRLX522 as a new anticancer agent.

Welcome to talk about 56-17-7, If you have any questions, you can contact Metcalf, CA; Svenson, S; Hwang, J; Tripathi, S; Gangal, G; Kabir, S; Lazarus, D; Cole, R; Sweryda-Krawiec, B; Shum, P; Brown, D; Case, RI; van der Poll, D; Rohde, E; Harlfinger, S; Teng, CH; Eliasof, S or send Email.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2020.0 J BIOMED MATER RES A published article about POLY(AMIDOAMINE)-FUNCTIONALIZED GRAPHENE OXIDE; PAMAM DENDRIMERS; DRUG CARRIERS; GENE DELIVERY; IN-VITRO; NANOPARTICLES; NANOCARRIERS; REDUCTION; BIOAVAILABILITY; ENCAPSULATION in [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Fac Polymer Engn, POB 51335-1996, Tabriz, Iran; [Najafi, Faezeh; Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Inst Polymer Mat, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Sahand Univ Technol, Fac Chem Engn, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Sahand Univ Technol, Tissue Engn & Stem Cells Res Ctr, Tabriz, Iran; [Kahaie-Khosrowshahi, Amir] Azarbaijan Shahid Madani Univ, Fac Engn, Tissue Engn & Stem Cells Res Ctr, Tabriz, Iran in 2020.0, Cited 74.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Many of new chemical discovered in pharmaceutical industry are hydrophobic compounds. Various techniques have been used to overcome solubility problems of hydrophobic drugs in aqueous media. In the meantime, dendrimers have been considered for sustainability, nanoscale size, high carry capacity, tunable terminal functional groups in terms of drug delivery and solubility. In this work, we have synthesized poly(propylene imine) (PPI) dendrimer up to fifth generation using reduction of nitrile groups after Michael addition and also, polyamidoamine (PAMAM) dendrimer up to fourth generation using Michael addition and amidation reactions. fourth and fifth generations of PPI dendrimer and fourth and third generations of PAMAM dendrimer in different concentrations were used to evaluate the solubility of two hydrophobic drugs (tetracycline and dexamethasone). Furthermore, cytotoxicity of dendrimers and dendrimers/drugs hybrids was studied. The results showed that with increasing concentrations and also the generation of dendrimers, the solubility of these two hydrophobic drugs was increased. Cytotoxicity study through MTT assay against Osteoblast-like cell line (MG-63 cells) showed that dendrimers were relatively cytotoxic where adding dexamethasone caused higher cytotoxicity. However, tetracycline showed no significant effect on cytotoxicity whereas prevented cell proliferation.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. Narayanan, N; Jia, ZH; Kim, KH; Kuang, LJ; Lengemann, P; Shafer, G; Bernal-Crespo, V; Kuang, SH; Deng, M in [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47906 USA; [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47906 USA; [Jia, Zhihao; Kim, Kun Ho; Kuang, Shihuan] Purdue Univ, Dept Anim Sci, W Lafayette, IN 47906 USA; [Shafer, Gabrielle; Bernal-Crespo, Victor] Purdue Univ, Ctr Comparat Translat Res, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47906 USA published Biomimetic glycosaminoglycan-based scaffolds improve skeletal muscle regeneration in a Murine volumetric muscle loss model in 2021.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Volumetric muscle loss (VML) injuries characterized by critical loss of skeletal muscle tissues result in severe functional impairment. Current treatments involving use of muscle grafts are limited by tissue availability and donor site morbidity. In this study, we designed and synthesized an implantable glycosaminoglycan-based hydrogel system consisting of thiolated hyaluronic acid (HA) and thiolated chondroitin sulfate (CS) crosslinked with poly(ethylene glycol) diacrylate to promote skeletal muscle regeneration of VML injuries in mice. The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8. Furthermore, in vivo studies using a murine quadriceps VML model demonstrated that the HA-CS hydrogels supported integration of implants with the surrounding host tissue and facilitated migration of Pax7(+) satellite cells, de novo myofiber formation, angiogenesis, and innervation with minimized scar tissue formation during 4-week implantation. The hydrogel-treated and autograft-treated mice showed similar functional improvements in treadmill performance as early as 1-week post-implantation compared to the untreated groups. Taken together, our results demonstrate the promise of HA-CS hydrogels as regenerative engineering matrices to accelerate healing of skeletal muscle injuries.

Welcome to talk about 56-17-7, If you have any questions, you can contact Narayanan, N; Jia, ZH; Kim, KH; Kuang, LJ; Lengemann, P; Shafer, G; Bernal-Crespo, V; Kuang, SH; Deng, M or send Email.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Modular Assembly of Multimodal Imaging Agents through an Inverse Electron Demand Diels-Alder Reaction WOS:000462260300044 published article about PROSTATE-CANCER; IN-VITRO; CYCLOADDITIONS; FLUORESCENT; TETRAZINES; ANTIBODIES; CHELATORS in [Canovas, Coline; Moreau, Mathieu; Collin, Bertrand; Denat, Franck; Goncalves, Victor] Univ Bourgogne Franche Comte, Univ Bourgogne, CNRS, Inst Chim Mol,UMR6302, 9 Ave Alain Savary, F-21000 Dijon, France; [Vrigneaud, Jean-Marc; Bellaye, Pierre-Simon; Collin, Bertrand] Georges Francois LECLERC Canc Ctr, UNICANCER, 1 Rue Pr Marion, F-21079 Dijon, France in 2019.0, Cited 39.0. Computed Properties of C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The combination of two imaging probes on the same biomolecule gives access to targeted bimodal imaging agents that can provide more accurate diagnosis, complementary information, or that may be used in different applications, such as nuclear imaging and fluorescence guided surgery. In this study, we demonstrate that dichlorotetrazine, a small, commercially available compound, can be used as a modular platform to easily assemble various imaging probes. Doubly labeled tetrazines can then be conjugated to a protein through a biorthogonal IEDDA reaction. A series of difunctionalized tetrazine compounds containing various chelating agents and fluorescent dyes was synthesized. As a proof of concept, one of these bimodal probes was conjugated to trastuzumab, previously modified with a constrained alkyne group, and the resulting dual-labeled antibody was evaluated in a mouse model, bearing a HER2-positive tumor. A significant uptake into tumor tissues was observed in vivo, by both SPECT-CT and fluorescence imaging, and confirmed ex vivo in biodistribution studies.

Computed Properties of C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Khan, RU; Yu, HJ; Wang, L; Zhang, Q; Xiong, W; Zain-ul-Abdin; Nazir, A; Fahad, S; Chen, X; Elsharaarani, T in SPRINGER published article about AMPHIPHILIC GRAFT POLYPHOSPHAZENES; IN-VIVO DELIVERY; CO-DELIVERY; ETHYL 4-AMINOBENZOATE; RESISTANCE REVERSAL; NANOCARRIERS; MICELLES; DOXORUBICIN; VESICLES; NANOPARTICLES in [Khan, Rizwan Ullah; Yu, Haojie; Wang, Li; Zain-ul-Abdin; Nazir, Ahsan; Fahad, Shah; Chen, Xiang; Elsharaarani, Tarig] Zhejiang Univ, Coll Chem & Biol Engn, State Key Lab Chem Engn, Hangzhou 310027, Peoples R China; [Zhang, Qian; Xiong, Wei] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310003, Peoples R China in 2020.0, Cited 79.0. Category: thiazines. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Cancer cells have reductive and acidic environments as compared to the normal body cells. Development of reductive/acidic responsive polymersomes will play a major role in cancer therapy to trigger the release of the loaded drug. In our work, we synthesized three different reductive/acidic dual-responsive polymers, poly[(mPEG-SS-amino) (N,N-diisopropylethylenediamino)phosphazenes] (PPDPs) in different mole ratios of side groups. These PPDPs were characterized by H-1 NMR, P-31 NMR, FT-IR and GPC. After that, the PPDPs were allowed to self-assemble into drug-loaded polymersomes with high loading content and encapsulation efficiency of hydrophilic/hydrophobic anticancer drugs. The hydrophilic anticancer drug doxorubicin hydrochloride (DOX center dot HCl) and hydrophobic drug doxorubicin were used. These PPDPs-based polymersomes showed reductive/acidic stimuli-responsive release of anticancer drugs. Moreover, these polymersomes also exhibited suitable hydrodynamic diameters, which will facilitate the longtime circulation in bloodstream due to avoiding renal clearance and close contact to the tumor cells in vascular sections due to enhanced permeability and retention effect. Collectively, these developed polymersomes may provide an effective platform for anticancer drugs delivery.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. In 2020.0 BIOMATER SCI-UK published article about CD8 T-CELLS; REGULATORY T; MECHANISMS; ANTI-CTLA-4; INHIBITION; EXPRESSION; RESPONSES in [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Peking Union Med Coll, Tianjin Key Lab Biomat, Inst Biomed Engn, Tianjin 300192, Peoples R China; [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Chinese Acad Med Sci, Tianjin 300192, Peoples R China; [Han, Yanfeng] Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia; [Xu, Haiyan] Chinese Acad Med Sci, Inst Bas Sci, Sch Basic Med, Peking Union Med Coll, Beijing 100005, Peoples R China; [Kong, Deling] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China in 2020.0, Cited 25.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Combined blockades of CTLA-4 and PD-1 can yield better overall complementary clinical outcomes than individual blockades, but the response rates are still relatively low. To investigate the anti-tumor effects of various combined strategies, we designed various spherical nucleotide nanoparticles (SNPs) loaded with CTLA-4 aptamer (cSNPs), PD-1 siRNA (pSNPs) or both (hybrid SNPs, or hSNPs). The results demonstrated that hSNPs could promote significantly stronger anti-tumor immune responses in a nonredundant fashion than the mixture of pSNPs and cSNPs (pSNPs & cSNPs). We reasoned that this is because all individual immune cells could receive both CTLA-4 and PD-1 blockades when they engulfed hSNPs, but it is much less likely that individual immune cells could receive both CTLA-4 and PD-1 blockades as many of them may not take both pSNPs and cSNPS from pSNPs & cSNPs. Further results revealed that the synergistic immune stimulatory effects of CTLA-4 and PD-1 blockades in the form of hSNPs were at least partly through regulating the immune suppressive function of both Tregs and TIM3(+)exhausted-like CD8 T cells and allowing effector T cells to expand. This mechanism is not identical to earlier reported mechanisms of CTLA-4 and PD-1 blockades.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem