Day: December 16, 2021

HPLC of Formula: C4H14Cl2N2S2. I found the field of Polymer Science very interesting. Saw the article Efficient preparation of chemically crosslinked recyclable photodeformable azobenzene polymer fibers with high processability and reconstruction ability via a facile post-crosslinking method published in 2020.0, Reprint Addresses Zhang, HQ (corresponding author), Nankai Univ, State Key Lab Med Chem Biol, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Key Lab Funct Polymer Mat,Minist Educ, Tianjin 300071, Peoples R China.; Zhang, HQ (corresponding author), Nankai Univ, Coll Chem, Tianjin 300071, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Chemically crosslinked recyclable photodeformable azobenzene (azo) polymer actuators with good stability (toward organic solvents and higher temperatures) and high processability and reconstruction ability hold great promise in many applications, but their development remains a challenging task. Herein, we report on for the first time a facile and highly efficient post-crosslinking method for addressing this issue. It involves first the synthesis of side-chain polymers bearing N-hydroxysuccinimide (NHS) carboxylate-substituted azo mesogens, fabrication of uniaxially oriented fibers from these azo polymers by the simple melt spinning method, and their subsequent post-crosslinking with cystamine (a diamine containing a disulfide bond) under mild conditions. The resulting chemically crosslinked fibers not only showed rapid and reversible photoinduced bending and unbending at ambient temperature as well as high mechanical strength and good solvent/heating stability, but also could be easily recycled into processable azo polymers in the presence of a reducing agent that can cleave the disulfide bond into thiol groups (i.e., tributylphosphine). In particular, the occurrence of the post-crosslinking reaction only on the thin surface layers of the azo polymer fibers afforded recycled polymers with large amounts of NHS carboxylate-substituted azo mesogens (together with a small amount of oxygen/heating-sensitive thiolsubstituted ones) in the first several (at least 5) recycling processes, thus allowing highly efficient reconstruction of photodeformable fibers with excellent photomobile properties by applying melt spinning and post-cross-linking (by using cystamine) methods. The strategy presented here opens the new possibility to the facile and efficient development of various advanced chemically crosslinked recyclable photodriven actuators.

HPLC of Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Luo, TT; Han, JT; Zhao, F; Pan, XH; Tian, BC; Ding, XJ; Zhang, J in [Luo, Tingting; Han, Jingtian; Zhao, Feng; Pan, Xiaohong; Tian, Baocheng; Ding, Xiujuan; Zhang, Jing] Binzhou Med Univ, Sch Pharm, 346 Guanhai Rd, Yantai 264003, Peoples R China published Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy in 2019.0, Cited 44.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Novel chitosan-cystamine-retinoic acid conjugate (CS-SS-RA) was synthesized and could self-assemble into redox-sensitive micelles in aqueous environment with low critical micelle concentration value. CS-SS-RA micelles were characterized with spherical shape, desirable particle size, negative zeta potential, high paclitaxel (PTX) loading and encapsulation efficiency and redox-sensitivity. Hemolysis and cytotoxicity studies proved the safety of CS-SS-RA micelles for intravenous administration. Cytotoxicity study against HepG2 cells and the growth inhibition study on three-dimensional multicellular tumor spheroids (MCTSs) revealed that PTX-loaded CS-SS-RA micelles exhibited higher antitumor activity than free PTX. The in vitro cellular uptake profiles of FITC-labeled CS-SS-RA micelles evaluated via confocal laser scanning microscopy and flow cytometry indicated that CS-SS-RA micelles could enhance cellular uptake efficiency of PTX, and their internalization by HepG2 cells were mediated by clathrin-mediated endocytosis and macropinocytosis. These results demonstrated that CS-SS-RA micelles could be developed as a promising platform for intracellular delivery of hydrophobic antitumor agents.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer WOS:000486717700001 published article about TARGETED DELIVERY; COMBINATION THERAPY; DRUG CONJUGATE; CO-DELIVERY; LIGAND; DOXORUBICIN; PACLITAXEL; TUMOR; APOPTOSIS; EFFICACY in [Sui, Binglin; Cheng, Chen; Wang, Mingming; Hopkins, Elijah; Xu, Peisheng] Univ South Carolina, Dept Discovery & Biomed Sci, Coll Pharm, 715 Sumter, Columbia, SC 29208 USA in 2019.0, Cited 40.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Clinical application of drug cocktails for cancer therapy is limited by their severe systemic toxicity. To solve a catch-22 dilemma between safety and efficacy for drug cocktails, a heterotargeted nanococktail (PPPDMA) with traceless linkers is developed. In the PPPDMA nanogel, a heterotargeting strategy is employed to improve its tumor selective targeting efficacy by overcoming the cancer cell monoligand density limitation. Benefitting from its glutathione and reactive oxygen species responsiveness, the loaded paclitaxel and doxorubicin can be quickly and tracelessly released into the cytoplasm in their original form, which bestows upon PPPDMA nanogels the capability to overwhelm the processing capacity of the cancer cell’s P-glycoprotein efflux pump, and ultimately kill them without inducing side effects. The PPPDMA treatment reduced its tumor burden over 99% (in tumor weight) and 96% (in tumor number). Most importantly, no detectable tumor in more than half of the PPPDMA treated mice was observed. It is concluded that traceless linker and heterotargeted nanococktail strategy can be a safe and effective approach for cancer treatment.

Welcome to talk about 56-17-7, If you have any questions, you can contact Sui, BL; Cheng, C; Wang, MM; Hopkins, E; Xu, PS or send Email.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Hayashida, O; Tanaka, Y; Miyazaki, T in [Hayashida, Osamu; Tanaka, Yudai; Miyazaki, Takaaki] Fukuoka Univ, Dept Chem, Fac Sci, Nanakuma 8-19-1, Fukuoka 8140180, Japan published Synthesis and Guest-Binding Properties of pH/Reduction Dual-Responsive Cyclophane Dimer in 2021.0, Cited 43.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A water-soluble cyclophane dimer having two disulfide groups as a reduction-responsive cleavable bond as well as several acidic and basic functional groups as a pH-responsive ionizable group 1 was successfully synthesized. It was found that 1 showed pH-dependent guest-binding behavior. That is, 1 strongly bound an anionic guest, 6-p-toluidinonaphthalene-2-sulfonate (TNS) with binding constant (K/M-1) for 1:1 host-guest complexes of 9.6 x 10(4) M-1 at pH 3.8, which was larger than those at pH 7.4 and 10.7 (6.0 x 10(4) and 2.4 x 10(4) M-1, respectively), indicating a favorable electrostatic interaction between anionic guest and net cationic 1. What is more, release of the entrapped guest molecules by 1 was easily controlled by pH stimulus. Large favorable enthalpies (Delta H) for formation of host-guest complexes were obtained under the pH conditions employed, suggesting that electrostatic interaction between anionic TNS and 1 was the most important driving force for host-guest complexation. Such contributions of Delta H for formation of host-guest complexes decreased along with increased pH values from acidic to basic solutions. Upon addition of dithiothreitol (DTT) as a reducing reagent to an aqueous PBS buffer (pH 7.4) containing 1 and TNS, the fluorescence intensity originating from the bound guest molecules decreased gradually. A treatment of 1 with DTT gave 2, having less guest-binding affinity by the cleavage of disulfide bonds of 1. Consequently, almost all entrapped guest molecules by 1 were released from the host. Moreover, such reduction-responsive cleavage of 1 and release of bound guest molecules was performed more rapidly in aqueous buffer at pH 10.7.

Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Glutathione-responsive disassembly of disulfide dicyanine for tumor imaging with reduction in background signal intensity WOS:000508008300009 published article about CYANINE DYES; IN-VIVO; PHOTODYNAMIC THERAPY; CANCER; NANOPARTICLES; RELEASE; NANOMEDICINE; CHEMOTHERAPY; DOXORUBICIN; METASTASES in [Mo, Shanyan; Zhang, Xiaoting; Hameed, Sadaf; Zhou, Yiming; Dai, Zhifei] Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China; [Mo, Shanyan] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China in 2020.0, Cited 58.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Near-infrared (NIR) fluorescence imaging has been proved as an effective modality in identifying the tumor border and distinguishing the tumor cells from healthy tissue during the oncological surgery. Developing NIR fluorescent probes with high tumor to background (T/B) signal is essential for the complete debulking of the tumor, which will prolong the survival rate of tumor patients. However, the nonspecific binding and always-on properties of the conventional fluorescent probes leads to high background signals and poor specificity. Method: To address this problem, glutathione (GSH)-responsive, two disulfide-bonded dicyanine dyes (ss-diCy5 and ss-diNH800CW) were synthesized. As synthesized dyes are quenched under normal physiological conditions, however, once reached to the tumor site, these dyes are capable of emitting strong fluorescence signals primarily because of the cleavage of the disulfide bond in the tumor microenvironment with high GSH concentration. Besides, the GSH-responsive behavior of these dyes was monitored using the UV-vis and fluorescence spectroscopy. The diagnostic accuracy of the aforementioned dyes was also tested both in tumor cells and 4T1-bearing mice. Results: The fluorescence signal intensity of disulfide dicyanine dyes was quenched up to 89% compared to the mono cyanine dyes, thus providing a very low fluorescence background. However, when the disulfide dicyanine dye reaches the tumor site, the dicyanine is cleaved by GSH into two mono-dyes with high fluorescence strength, thus producing strong fluorescent signals upon excitation. The fluorescent signal of the dicyanine was enhanced by up to 27-fold after interacting with the GSH solution. In vivo xenografts tumor studies further revealed that the fluorescence signals of aforementioned dyes can be quickly recovered in the solid tumor. Conclusion: In summary, the disulfide dicyanines dyes can provide a promising platform for specific tumor-activatable fluorescence imaging with improved T/B value.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Product Details of 56-17-7. Authors Chen, CH; Chiang, CY; Wu, CW; Wang, CT; Chau, LK in MDPI published article about in [Chen, Chien-Hsing] Natl Pingtung Univ Sci & Technol, Dept Biomechatron Engn, Pingtung 91201, Taiwan; [Chiang, Chang-Yue] Natl Yunlin Univ Sci & Technol, Grad Sch Engn Sci & Technol, Touliu 64002, Yunlin, Taiwan; [Chiang, Chang-Yue; Wu, Chin-Wei] Natl Yunlin Univ Sci & Technol, Bachelor Program Interdisciplinary Studies, Touliu 64002, Yunlin, Taiwan; [Wang, Chien-Tsung] Natl Yunlin Univ Sci & Technol, Dept Chem & Mat Engn, Touliu 64002, Yunlin, Taiwan; [Chau, Lai-Kwan] Natl Chung Cheng Univ, Dept Chem & Biochem, Chiayi 62102, Taiwan; [Chau, Lai-Kwan] Natl Chung Cheng Univ, Ctr Nano Biodetect, Chiayi 62102, Taiwan in 2021.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

In this research, a direct, simple and ultrasensitive fiber optic particle plasmon resonance (FOPPR) biosensing platform for immunoglobulin G (IgG) detection was developed using a gold nanoparticle/graphene oxide (AuNP/GO) composite as signal amplification element. To obtain the best analytical performance of the sensor, experimental parameters including the surface concentration of GO on the AuNPs, formation time of the GO, the concentration of the anti-IgG and incubation time of anti-IgG were optimized. The calibration plots displayed a good linear relationship between the sensor response (Delta I/I-0) and the logarithm of the analyte concentrations over a linear range from 1.0 x 10(-10) to 1.0 x 10(-6) g/mL of IgG under the optimum conditions. A limit of detection (LOD) of 0.038 ng/mL for IgG was calculated from the standard calibration curve. The plot has a linear relationship (correlation coefficient, R = 0.9990). The analytical performance of present work’s biosensor was better than that of our previously reported mixed self-assembled monolayer of 11-mercaptoundecanoic acid/6-mercapto-1-hexanol (MUA/MCH = 1:4) method by about three orders of magnitude. The achieved good sensitivity may be attributed to the synergistic effect between GO and AuNPs in this study. In addition, GO could immobilize more antibodies due to the abundant carboxylic groups on its surface. Furthermore, we also demonstrated that the results from this sensor have good reproducibility, with coefficients of variation (CVs) < 8% for IgG. Therefore, the present strategy provides a novel and convenient method for chemical and biochemical quantification and determination. Product Details of 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Fluorinated Redox-Responsive Poly(amidoamine) as a Vaccine Delivery System for Antitumor Immunotherapy WOS:000458937900026 published article about ANTIGEN; SIRNA; NANOPARTICLES; LIPOSOMES; NANOGELS; ADJUVANT; IMMUNITY; AMINE)S in [Yuan, Hongyuan; Yang, Yong; Xue, Wei; Liu, Zonghua] Jinan Univ, Key Lab Biomat, Guangdong Higher Educ Inst, Dept Biomed Engn, West Huangpu Rd 601, Guangzhou 510632, Guangdong, Peoples R China in 2019.0, Cited 23.0. COA of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about METAL-ORGANIC FRAMEWORKS; HOST-GUEST INTERACTIONS; RADICAL POLYMERIZATION; HOLLOW NANOFIBERS; CROSS-LINKING; IMMOBILIZATION; COLOCALIZATION; COPOLYMERS; SCAFFOLDS; EFFICIENT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21436002]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Chen, ZW; Cao, H; Tan, TW. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A well-defined functional star polymer nanoparticle was prepared using an “ arm first” approach via RAFT polymerization. In this work, N-adamantylacrylamide and N-succinimidyl acrylate were copolymerized with N-isopropylacrylamide sucessfully. The obtained diblock copolymer regarded as an “ arm” endowed the star polymer with multiple conjugate functions. By adjusting the amount of crosslinking agent, the size and polydispersity of the star polymer were controlled. With the star polymer as the scaffold, a sequential multi-enzyme system was constructed, where HRP was placed in the inner layer through covalent conjugation, and b-cyclodextrin-modified GOx was assembled in the outer layer through hostguest recognition. More interestingly, the activity of the enzyme modified by b-cyclodextrin was improved. In addition to the enhanced thermal stability, this multienzyme system also exhibited a reduced Km value (from 2.18 mM to 0.39 mM) and an excellent substrate affinity. The specificity constant (Kcat/Km) for GOx in the star polymer@ HRP@ GOx system was 1.7-fold higher than that of the free HRP with free GOx system. This strategy will promote the development of biocatalysis reactions and biosensors as a promising method.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 ACS BIOMATER SCI ENG published article about ANTIGEN; SIRNA; NANOPARTICLES; LIPOSOMES; NANOGELS; ADJUVANT; IMMUNITY; AMINE)S in [Yuan, Hongyuan; Yang, Yong; Xue, Wei; Liu, Zonghua] Jinan Univ, Key Lab Biomat, Guangdong Higher Educ Inst, Dept Biomed Engn, West Huangpu Rd 601, Guangzhou 510632, Guangdong, Peoples R China in 2019.0, Cited 23.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 56-17-7

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

Recommanded Product: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Yuan, HY; Yang, Y; Xue, W; Liu, ZH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Li, Y; Zhou, LH; Zhu, BD; Xiang, JJ; Du, J; He, MW; Fan, XX; Zhang, PF; Zeng, RS; Gong, P in ROYAL SOC CHEMISTRY published article about HEPTAMETHINE CYANINES; TARGETED DELIVERY; IN-VITRO; CANCER; NANOPARTICLES; CHEMOTHERAPY; PRODRUG in [Li, Ying; Zeng, Ruosheng] Guilin Univ Elect Technol, Sch Mat Sci & Engn, Sch Life & Environm Sci, Guilin 541004, Peoples R China; [Li, Ying; Zhou, Lihua; Xiang, Jingjing; Zhang, Pengfei; Gong, Ping] Chinese Acad Sci, Guangdong Key Lab Nanomed,Shenzhen Inst Adv Techn, Shenzhen Engn Lab Nanomed & Nanoformulat,Inst Bio, CAS Key Lab Hlth Informat,CAS HK Joint Lab Biomat, Shenzhen 518055, Peoples R China; [Zhou, Lihua; He, Manwen] Shenzhen Inst Technol, Sch Appl Biol, 1 Jiangjunmao, Shenzhen 518116, Peoples R China; [Zhu, Baode] Xiangnan Univ, Coll Chem Biol & Environm Engn, Chenzhou 423043, Peoples R China; [Du, Jian] Shandong First Med Univ, Dept Urol, Affiliated Hosp 1, 16766 Jingshi Rd, Jinan 250000, Peoples R China; [Fan, Xingxing] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau, Peoples R China; [Zeng, Ruosheng] Guangxi Univ, Sch Phys Sci & Technol, Nanning 530004, Peoples R China in 2021.0, Cited 50.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Triptolide (TP) is one of the most common systemic treatments for inflammatory and immune diseases in China for centuries. However, TP exhibits some disadvantages, such as poor solubility in water, poor bioavailability, liver toxicity, renal toxicity, and other side effects. In order to reduce the adverse effects of TP, researchers have developed numerous strategies to address the adverse properties of triptolide. Nano-carrier-based triptolide delivery systems represent an emerging technology and are one of the strategies of nanomedicine that combines diagnostic and therapeutic applications in a single agent. In this approach, we developed a glutathione-activated carrier-free nanodrug of triptolide (CyssTPN) as a trackable drug delivery system. In this system, CyssTP self-assemble to form a carrier-free nanodrug, which possesses a monodisperse spherical morphology with hydrodynamic average sizes of about 50 nm. In addition, CyssTPN had good stability under different physiological conditions (pH, high salt, etc.). Apart from cellular imaging and cell uptake, CyssTPN can be tracked by the activation of TP ability in real-time and applied for cancer cell treatment efficiently. The result showed that CyssTPN could improve solubility, reduce the side effects, and increase the bioavailability of triptolide. It could also track triptolide activation timely and tumor therapy successfully.

Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem