Day: November 26, 2021

Authors Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ in AMER CHEMICAL SOC published article about in [Zheng, Meng; Yang, Zhipeng; Wu, Haigang; Liu, Yang; Xia, Xue; Ruan, Weimin] Henan Univ, Henan & Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng 475004, Henan, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Zhang, Jinchao] Hebei Univ, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag, Coll Chem & Environm Sci,Minist Educ, Baoding 071002, Hebei, Peoples R China; [Chen, Shizhu; Yin, Huijun] Natl Inst Pharmaceut R&D Co Ltd, China Resources Pharmaceut Grp Ltd, Beijing 102206, Peoples R China; [Wright, Amanda; Lee, Albert] Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW 2109, Australia; [Lu, Jeng-Wei] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore; [Yin, Huijun] Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China; [Wang, Yingze] Hebei Univ Sci & Technol, Coll Biol Sci & Engn, Shijiazhuang 050018, Hebei, Peoples R China in 2019.0, Cited 38.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering RNA (siRNA) delivery system limits its clinical application. Here, we report a bioreducible and less-cationic siRNA delivery carrier by conjugating Zn(II)-dipicolylamine complexes (Zn-DPA) onto hyaluronic acid (HA) via a redox-sensitive disulfide (-SS-) linker. Such polymer conjugates can formulate stable siRNA nanomedicines via coordination between zinc ions of DPA and the anionic phosphate of siRNA. After the conjugates are taken up by cells, intracellular reduction stimulus subsequently triggers the release of siRNAs and elucidates the desired RNAi effect. Our studies showed the formulated siRNA nanomedicines can be efficiently delivered into tumor cells/tissues and mediates less cytotoxicities both in vitro and in vivo. More importantly, when applied in a xenograft glioblastoma tumor model, this siRNA nanomedicine demonstrated significantly enhanced antitumor ability comparing to naked siRNA. This work demonstrates that such bioreducible Zn-DPA-functionalized HA conjugates without using cationic material as a siRNA carrier represents a promising direction for RNAi-based cancer therapy.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 J MOL STRUCT published article about 1 M HCL; CORROSION INHIBITION PERFORMANCE; ECO-FRIENDLY INHIBITOR; X70 STEEL; DERIVATIVES; EXTRACT; MEDIA; EFFICIENCY; COMPOUND in [Sigircik, Gokmen] Cukurova Univ, Fac Sci & Letters, Dept Chem, TR-01330 Adana, Turkey in 2020.0, Cited 43.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. SDS of cas: 56-17-7

Inhibition performance of 2,2′-diaminodiethyl disulfide (DA) was studied against mild steel (MS) corrosion in 0.5 M HCl. Electrochemical impedance spectroscopy (EIS), potentiodynamic (PD) polarization measurements were utilized to investigate the influence of inhibitor concentration and temperature on efficiency, as well as explanation of inhibition mechanism. Scanning electron microscopy (SEM) analysis was utilized to investigate the surface damages due to corrosion, in the absence and presence of inhibitor molecules. PD data revealed that the studied molecule exhibits mixed type inhibitor behavior on steel surface. Moreover, the calculated free adsorption energy (Delta G(ads)(o)) value is 38.45 kJ mol(-1), which indicates to strong adsorptive interaction by both physical and chemical means. UV-Visible study results supported the idea that there is strong interaction between the surface with the molecule, via its -S and -N atoms. As a consequence, 91.7% inhibition efficiency was determined in presence of 1.0 mM DA. (C) 2020 Elsevier B.V. All rights reserved.

Welcome to talk about 56-17-7, If you have any questions, you can contact Sigircik, G or send Email.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Chemistry; Materials Science very interesting. Saw the article A glutathione-activated carrier-free nanodrug of triptolide as a trackable drug delivery system for monitoring and improving tumor therapy published in 2021.0. Computed Properties of C4H14Cl2N2S2, Reprint Addresses Zeng, RS (corresponding author), Guilin Univ Elect Technol, Sch Mat Sci & Engn, Sch Life & Environm Sci, Guilin 541004, Peoples R China.; Zhang, PF; Gong, P (corresponding author), Chinese Acad Sci, Guangdong Key Lab Nanomed,Shenzhen Inst Adv Techn, Shenzhen Engn Lab Nanomed & Nanoformulat,Inst Bio, CAS Key Lab Hlth Informat,CAS HK Joint Lab Biomat, Shenzhen 518055, Peoples R China.; Zeng, RS (corresponding author), Guangxi Univ, Sch Phys Sci & Technol, Nanning 530004, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Triptolide (TP) is one of the most common systemic treatments for inflammatory and immune diseases in China for centuries. However, TP exhibits some disadvantages, such as poor solubility in water, poor bioavailability, liver toxicity, renal toxicity, and other side effects. In order to reduce the adverse effects of TP, researchers have developed numerous strategies to address the adverse properties of triptolide. Nano-carrier-based triptolide delivery systems represent an emerging technology and are one of the strategies of nanomedicine that combines diagnostic and therapeutic applications in a single agent. In this approach, we developed a glutathione-activated carrier-free nanodrug of triptolide (CyssTPN) as a trackable drug delivery system. In this system, CyssTP self-assemble to form a carrier-free nanodrug, which possesses a monodisperse spherical morphology with hydrodynamic average sizes of about 50 nm. In addition, CyssTPN had good stability under different physiological conditions (pH, high salt, etc.). Apart from cellular imaging and cell uptake, CyssTPN can be tracked by the activation of TP ability in real-time and applied for cancer cell treatment efficiently. The result showed that CyssTPN could improve solubility, reduce the side effects, and increase the bioavailability of triptolide. It could also track triptolide activation timely and tumor therapy successfully.

Computed Properties of C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. Recently I am researching about SELF-HEALING ABILITY; SOYBEAN-OIL; CYCLIC CARBONATES; FREE ROUTES; ELASTOMERS; CHEMISTRY; POLYMERS; RECOVERY; DELIVERY; DIAMINES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51873055, 51373046]; Natural Science Foundation of Hebei ProvinceNatural Science Foundation of Hebei Province [B2018202112]; Basic Science Research Program through the National Research Foundation of Korea [2018R1D1A1A09081809]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Dong, JC; Liu, BY; Ding, HN; Shi, JB; Liu, N; Dai, B; Kim, I. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A series of isocyanate-free polyurethanes (NIPUs), showing an intrinsic thermo-healing performance, have been synthesized from sustainable vegetable oil-based cyclic carbonates and bio-based amines. The bio-based contents of the NIPUs are higher than 78%. Their thermo-mechanical and self-healing performances are tailored simply by varying the feed ratios of the amines employed. The biomass linoleic acid dimer-based diamine plays a positive role in maintaining the higher thermal stability and good elasticity of the prepared NIPUs, the cycloaliphatic isophorone diamine contributes to high tensile strength, and cysteine-derived disulfide-containing cystamine (CA) enhances the self-healing efficiency. The combination of intrinsic hydrogen bonds existed in the NIPU matrix with the dynamic exchange reactions of disulfide bonds and the enhanced flexibility of NIPU networks results in 98.1% self-healing efficiency at 25 degrees C. The contributions of disulfide bonds and hydrogen bonds to the healing efficiency were estimated by adjusting the composition of NIPUs, showing that the contribution of disulfide bonds to the healing ability is about 45.3% even at a low amount of CA (6.0 wt%).

Category: thiazines. Welcome to talk about 56-17-7, If you have any questions, you can contact Dong, JC; Liu, BY; Ding, HN; Shi, JB; Liu, N; Dai, B; Kim, I or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Sulfur substitution in a Ni(cyclam) derivative results in lower overpotential for CO2 reduction and enhanced proton reduction WOS:000472449300008 published article about MACROCYCLIC LIGANDS; CARBON-DIOXIDE; COMPLEXES; ELECTROREDUCTION; KINETICS in [Gerschel, P.; Reback, M. L.; Apfel, U-P] Ruhr Univ Bochum, Anorgan Chem 1, Univ Str 150, D-44801 Bochum, Germany; [Warm, K.; Ray, K.] Humboldt Univ, Inst Chem, Brook Taylor Str 2, D-12489 Berlin, Germany; [Farquhar, E. R.] Brookhaven Natl Lab, NSLS 2, CWRU Ctr Synchrotron Biosci, Upton, NY 11973 USA; [Englert, U.] Rhein Westfal TH Aachen, Inst Anorgan Chem, Landoltweg 1, D-52056 Aachen, Germany; [Siegmund, D.; Apfel, U-P] Fraunhofer UMSICHT, Osterfelder Str 3, D-46047 Oberhausen, Germany in 2019.0, Cited 36.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The replacement of the opposing nitrogen atoms in 1,4,8,11-tetraazacyclotetradecane (cyclam) with two sulfur atoms in 1,8-dithia-4,11-diazacyclotetradecane (dithiacyclam) enables the electrochemical reduction of protons and CO(2)via the corresponding nickel(ii) complex at more positive potentials. In addition, a 10-fold enhancement in the proton reduction rate of [Ni(dithiacyclam)](2+) relative to [Ni(cylcam)](2+) was observed. The study provides vital insight into Nature’s choice of employing predominantly sulfur based ligand platforms in achieving biological proton and CO2 reductions.

SDS of cas: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Gerschel, P; Warm, K; Farquhar, ER; Englert, U; Reback, ML; Siegmund, D; Ray, K; Apfel, UP or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about POLYMERS; COVALENT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21434004, 21704056, 91527000]. COA of Formula: C4H14Cl2N2S2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhang, S; Qin, B; Huang, ZH; Xu, JF; Zhang, X. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A new method of supramolecular emulsion interfacial polymerization is developed, which can be used to fabricate supramolecular polymeric nanospheres. We designed a water-soluble monomer containing two maleimide end groups, acting as both building block and surfactant, and an oil-soluble supramonomer bearing two thiol groups connected by quadruple hydrogen bonds. With the assist of ultrasonication, hollow nanospheres can be controllably prepared by thiol-maleimide reaction of two monomers at the emulsion interface, which exhibit good stability and dynamic property. In addition, the encapsulated guest molecules could be controllably released from the supramolecular polymeric nanospheres, owing to their stimuli-responsiveness. It is anticipated that this approach will enrich the methodology of supramolecular polymerization and can be applied to constructing supramolecular materials with controllable structures and functions.

Welcome to talk about 56-17-7, If you have any questions, you can contact Zhang, S; Qin, B; Huang, ZH; Xu, JF; Zhang, X or send Email.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Cascaded Multiresponsive Self-Assembled F-19 MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification WOS:000507151600047 published article about ULTRASENSITIVE DETECTION; TUMOR MICROENVIRONMENT; PROTEIN-DETECTION; RATIONAL DESIGN; NANOPARTICLES; NANOMATERIALS; CELLS; STRATEGY; SIGNALS; PROBES in [Tang, Xiaoxue; Gong, Xuanqing; Li, Ao; Lin, Hongyu; Gao, Jinhao] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, MOE Lab Spectrochem Anal & Instrumentat, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China; [Tang, Xiaoxue; Gong, Xuanqing; Li, Ao; Lin, Hongyu; Gao, Jinhao] Xiamen Univ, Dept Biol Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China; [Peng, Chenyu; Zhang, Xianzhong] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Peoples R China; [Chen, Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA in 2020.0, Cited 54.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Product Details of 56-17-7

Molecular probes featuring promising capabilities including specific targeting, high signal-to-noise ratio, and in situ visualization of deep tissues are in great demand for tumor diagnosis and therapy. F-19 magnetic resonance imaging (MRI) techniques incorporating stimuli-responsive probes are anticipated to be highly beneficial for specific detection and imaging of tumors because of negligible background and deep tissue penetration. Herein, we report a cascaded multi-responsive self-assembled nanoprobe, which enables sequential redox-triggered and near-infrared (NIR) irradiation-induced F-19 MR signal activation/amplification for sensing and imaging. Specifically, we designed and synthesized a cascaded multiresponsive F-19-bearing nanoprobe based on the self-assembly of amphiphilic redox-responsive F-19-containing polymers and NIR-absorbing indocyanine green (ICG) molecules. It could realize the activation of F-19 signals in the reducing tumor microenvironment and subsequent signal amplification via the photothermal process. This stepwise two-stage activation/amplification of F-19 signals was validated by F-19 NMR and MRI both in vitro and in vivo. The multiresponsive F-19 nanoprobes capable of cascaded F-19 signal activation/amplification and photothermal effect exertion can provide accurate sensing and imaging of tumors.

Welcome to talk about 56-17-7, If you have any questions, you can contact Tang, XX; Gong, XQ; Li, A; Lin, HY; Peng, CY; Zhang, XZ; Chen, XY; Gao, JH or send Email.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Metal-Free Room-Temperature Phosphorescent Systems for Pure White-Light Emission and Latent Fingerprint Visualization WOS:000468368100010 published article about ORGANIC MATERIALS; EMITTING-DIODES; DUAL-EMISSION; EFFICIENT; POLYFLUORENE; COPOLYMERS; GUEST; HOST in [Ma, Xiang] East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai 200237, Peoples R China in 2019.0, Cited 69.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. SDS of cas: 56-17-7

Research on metal-free room-temperature phosphorescent (RTP) materials has been a hot topic and made great advances in recent years. However, developing amorphous metal-free RTP compounds whose RTP emission is insensitive to water and oxygen to expand their applications still remains a challenge. Two novel metal-free RTP compounds were facilely designed and synthesized by modifying ureidopyrinidinone (UPy) units on both ends of the phosphors (BrNpA and BrBA). On the basis of their water/oxygen insensitive phosphorescence at different emission wavelengths, pure white-light (CIE coordinates (0.32, 0.33)) emission was obtained by mixing these two compounds. Moreover, visualization of latent fingerprints employing RTP materials as the first application in forensic science, as well as protected quick response codes, was achieved by theses hydrophobic materials.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 J BIOMED MATER RES B published article about MESENCHYMAL STEM-CELLS; OPTIMIZATION; CULTURE; DIFFERENTIATION; EXPANSION; SYSTEM; GROWTH; HMSCS in [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA; [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] Harvard Med Sch, Brigham & Womens Hosp, Div Engn Med, Dept Med, Boston, MA 02115 USA; [Uth, Nicholas; Levinson, Yonatan; Abraham, Eytan] Res & Technol, Walkersville, MD USA; [Artzi, Natalie] Broad Inst Harvard & MIT, Cambridge, MA USA in 2020.0, Cited 33.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Microcarriers, including crosslinked porous gelatin beads (Cultispher G) are widely used as cell carriers for cell therapy applications. Microcarriers can support a range of adherent cell types in stirred tank bioreactor culture, which is scalable up to several thousands of liters. Cultispher G in particular is advantageous for cell therapy applications because it can be dissolved enzymatically, and thus cells can be harvested without the need to perform a large-scale cell-bead filtration step. This enzymatic dissolution, however, is challenged by the slow degradation of the carriers in the presence of enzymes as new extracellular matrix is being deposited by the proliferating cells. This extended dissolution timelimits the yield of cell recovery while compromising cellular viability. We report herein the development of crosslinked porous gelatin beads that afford rapid, stimuli-triggered dissolution for facile cell removal using human mesenchymal stem cells (hMSC) as a model system. We successfully fabricated redox-sensitive beads (RS beads) and studied their cell growth, dissolution time and cell yield, compared to regular gelatin-based beads (Reg beads). We have shown that RS beads allow for much faster dissolution compared to Reg beads, supporting better hMSC detachment and recovery following 8 days of culture in spinner flasks, or in 3L bioreactors. These newly synthesized RS beads show promise as cellular microcarriers and can be used for scale-up manufacturing of different cell types while providing on-demand degradation for facile cell retrieval.

Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Dai, YX; Yue, N; Liu, CX; Cai, XG; Su, X; Bi, XZ; Li, QF; Li, CY; Huang, WL; Qian, H in [Dai, Yuxuan; Yue, Na; Liu, Chunxia; Cai, Xingguang; Su, Xin; Bi, Xinzhou; Li, Qifei; Li, Chengye; Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China published Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates in 2019.0, Cited 36.0. Product Details of 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Lytic peptides have been demonstrated to exhibit obvious advantages in cancer therapy with binding ability toward tumor cells via electrostatic attractions, which are lack of active targeting and aggregation to tumor tissue. In the present study, five conjugated lytic peptides were redesigned and constructed to target gonadotropin releasing hormone receptors (GnRHr), meanwhile, the disulfide bridge was introduced to achieve redox sensitive delivery based on the experience from the preliminary work of lytic peptides P3 and P7. YX-1, was considered to be the most promising for in-depth study. YX-1 possessed high potency (IC50 = 3.16 +/- 0.3 mu M), low hemolytic effect, and cell membrane permeability in human A2780 ovarian cancer cells. Moreover, YX-1 had prominent pro-apoptotic activity by activating the mitochondria-cytochrome c-caspase apoptotic pathway. The study yielded the conjugate YX-1 with superior properties for antineoplastic activity, which makes it a promising potential candidate for targeting cancer therapy.

Welcome to talk about 56-17-7, If you have any questions, you can contact Dai, YX; Yue, N; Liu, CX; Cai, XG; Su, X; Bi, XZ; Li, QF; Li, CY; Huang, WL; Qian, H or send Email.. Product Details of 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem