Day: November 25, 2021

An article Bioorthogonal click chemistries enable simultaneous spatial patterning of multiple proteins to probe synergistic protein effects on fibroblast function WOS:000555693800041 published article about INTERSTITIAL CELL PHENOTYPE; GROWTH-FACTORS; HYDROGELS; FIBROSIS; CALCIFICATION; ELASTICITY; ACTIVATION; CULTURE; SYSTEMS in [Ma, Hao; Caldwell, Alexander S.; Azagarsamy, Malar A.; Rodriguez, Andrea Gonzalez; Anseth, Kristi S.] Univ Colorado Boulder, Dept Chem & Biol Engn, Boulder, CO 80303 USA; [Ma, Hao; Caldwell, Alexander S.; Azagarsamy, Malar A.; Rodriguez, Andrea Gonzalez; Anseth, Kristi S.] Univ Colorado Boulder, BioFrontiers Inst, Boulder, CO 80303 USA in 2020.0, Cited 40.0. Recommanded Product: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Three biorthogonal click reactions, a photoinitiated thiol-yne reaction, an azide-alkyne cycloaddition, and a methyltetrazine-transcyclooctene Diels Alder, were used to independently control the presentation of several bioactive proteins to valvular interstitial cells (VICs) in hydrogel scaffolds. Tethered fibroblast growth factor (FGF-2) was found to suppress myofibroblast activation (from 48 +/- 7% to 17 +/- 6%) and promote proliferation (from 10 +/- 2% to 54 +/- 3%) at a concentration of 10 ng/mL. In the presence of the pro-fibrotic cytokine transforming growth factor-beta (TGF-beta 1), FGF-2 could protect the VIC fibroblast phenotype, even at much higher concentrations of TGF-beta 1 than that of FGF-2. With respect to the fibrocalcific VIC phenotype, TGF-beta 1 and bone-morphogenic protein-2 (BMP-2) were found to synergistically promote calcific nodule formation (a five-fold increase in nodules compared to TGF-beta 1 or BMP-2 alone). Exploiting the orthogonal click reactions, FGF-2, TGF-beta 1 and BMP-2 combinations were patterned into distinct regions on a hydrogel to control VIC activation and nodule formation. Cellular crosstalk between separate regions of the same scaffold was affected by the size of each region as well as the interfacial area between different regions. Collectively, these results demonstrate the versatility and robustness of a photoinitiated thiol-yne reaction to template pendant functionalities that allow for the bioconjugation of multiple proteins. This approach maintains protein bioactivity, providing an in vitro platform capable of achieving a better understanding of the complex mechanisms involved in tissue fibrosis.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2019.0 J APPL POLYM SCI published article about FOCAL ADHESION KINASE; HYALURONIC-ACID; MECHANICAL-PROPERTIES; MATRIX; PHOSPHORYLATION; DIFFERENTIATION; CARTILAGE; KINETICS in [Kuang, Liangju; Damayanti, Nur P.; Jiang, Chunhui; Fei, Xing; Liu, Wenjie; Narayanan, Naagarajan; Irudayaraj, Joseph; Campanella, Osvaldo; Deng, Meng] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 USA; [Kuang, Liangju; Damayanti, Nur P.; Jiang, Chunhui; Liu, Wenjie; Narayanan, Naagarajan; Irudayaraj, Joseph; Deng, Meng] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47907 USA; [Deng, Meng] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA; [Deng, Meng] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA in 2019.0, Cited 39.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Cell encapsulation within 3D hydrogels is an attractive approach to develop effective cell-based therapies. However, little is known about how cells respond to the dynamic microenvironment resulting from hydrogel gelation-based cell encapsulation. Here, a tunable biomimetic hydrogel system that possesses alterable gelation kinetics and biologically relevant matrix stiffness is developed to study 3D dynamic cellular responses during encapsulation. Hydrogels are synthesized by crosslinking thiolated hyaluronic acid and thiolated chondroitin sulfate with poly(ethylene glycol) diacrylate under cell-compatible conditions. Hydrogel properties are tailored by altering thiol substitution degrees of glycosaminoglycans or molecular weights of crosslinkers. Encapsulation of human mesenchymal stem cells through hydrogel gelation reveals high cell viability as well as a three-stage gelation-dependent cellular response in real-time focal adhesion kinase (FAK) phosphorylation in live single cells. Furthermore, stiffer hydrogels result in higher equilibrium FAK activity and enhanced actin protrusions. Our results demonstrate the promise of hydrogel-mediated cellular responses during cell encapsulation. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47212.

Welcome to talk about 56-17-7, If you have any questions, you can contact Kuang, LJ; Damayanti, NP; Jiang, CH; Fei, X; Liu, WJ; Narayanan, N; Irudayaraj, J; Campanella, O; Deng, M or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Yu, K; Yang, XY; He, LH; Zheng, R; Min, J; Su, HY; Shan, SY; Jia, QM in [Yu, Kun; He, Lihua; Zheng, Rong; Min, Jie; Su, Hongying; Shan, Shaoyun; Jia, Qingming] Kunming Univ Sci & Technol, Fac Chem Engn, 727 South Jingming Rd, Kunming 650500, Yunnan, Peoples R China; [Yang, Xiyao] Kunming Univ Sci & Technol, Fac Life Sci & Technol, 727 South Jingming Rd, Kunming 650500, Yunnan, Peoples R China published Facile preparation of pH/reduction dual-stimuli responsive dextran nanogel as environment-sensitive carrier of doxorubicin in 2020.0, Cited 39.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Dual and multi-stimuli responsive polymeric nanoparticles that can respond to two or more signals have been demonstrated as prospective drug carriers with enhanced tumor accumulation and on-demand drug release profiles. In this study, dextran-based (Dex-SS) nanogels were developed via a facile method based on the disulfide containing Schiff base formation between polyaldehyde dextran and cystamine in water-in-oil inverse microemulsion. Acidic and reductive (GSH) environment sensitive degradation behaviors of the resulted nanogels were investigated by morphology analysis of the treated nanogels using SEM imaging. Doxorubicin (DOX) was covalently conjugated into the dextran nanogels via Schiff base linkages, and pH/GSH dual sensitive drug release profiles were demonstrated. Effective cell uptake of the DOX-loaded nanogels was finally identified by human cancer cell line of H1299. Take advantage of the acidic and reductive tumor microenvironment, the dual-stimuli responsive Dex-SS nanogels can serve as micmenvironment-sensitive drug delivery systems for tumor therapy.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates WOS:000475378400038 published article about CANCER; PRODRUG; RICH; ACTIVATION; MECHANISMS; RESISTANCE; ARGININE; THERAPY; LYSINE in [Dai, Yuxuan; Yue, Na; Liu, Chunxia; Cai, Xingguang; Su, Xin; Bi, Xinzhou; Li, Qifei; Li, Chengye; Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China in 2019.0, Cited 36.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Product Details of 56-17-7

Lytic peptides have been demonstrated to exhibit obvious advantages in cancer therapy with binding ability toward tumor cells via electrostatic attractions, which are lack of active targeting and aggregation to tumor tissue. In the present study, five conjugated lytic peptides were redesigned and constructed to target gonadotropin releasing hormone receptors (GnRHr), meanwhile, the disulfide bridge was introduced to achieve redox sensitive delivery based on the experience from the preliminary work of lytic peptides P3 and P7. YX-1, was considered to be the most promising for in-depth study. YX-1 possessed high potency (IC50 = 3.16 +/- 0.3 mu M), low hemolytic effect, and cell membrane permeability in human A2780 ovarian cancer cells. Moreover, YX-1 had prominent pro-apoptotic activity by activating the mitochondria-cytochrome c-caspase apoptotic pathway. The study yielded the conjugate YX-1 with superior properties for antineoplastic activity, which makes it a promising potential candidate for targeting cancer therapy.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2019.0 COMPOS PART A-APPL S published article about CROSS-LINKING; INTERFACE; VULCANIZATION; NANOCOMPOSITES; REINFORCEMENT; FABRICATION; NANOSHEETS; HYBRIDS; ROBUST; MODEL in [Wang, Jian; Fei, Guoxia; Pan, Yunqi; Zhang, Kaiye; Hao, Shuai; Zheng, Zhuo; Xia, Hesheng] Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China in 2019.0, Cited 59.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The simultaneous reduction and functionalization of graphene oxide (GO) was achieved through a chemical grafting reaction with cystamine dihydrochloride (CDHC), a novel functional agent with dynamic disulfide bond. CDHC-reduced GO (CGO) can be uniformly and stably dispersed in the aqueous phase. Furthermore, CGO reinforced styrene-butadiene rubber (SBR) composites with highly filled silica content were prepared by a latex mixing and coagulation process. TEM confirmed both CGO and silica can be uniformly dispersed in the rubber matrix. The dynamic disulfide bonds of the grafted CDHC in the CGO can participate in the subsequent vulcanization of SBR rubber through disulfide exchange reactions, thereby forming a tight interaction between GO and rubber. Compared with normally reduced GO system, the mechanical and thermal properties of CGOcontaining rubber nanocomposites were significantly improved. The results show that CGO is effective to reinforce rubber composites, which has the potential to be used for tire rubber materials.

Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, J; Fei, GX; Pan, YQ; Zhang, KY; Hao, S; Zheng, Z; Xia, HS or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2019.0 ACS BIOMATER SCI ENG published article about MESOPOROUS SILICA NANOPARTICLES; UP-CONVERSION NANOPARTICLES; SYNERGISTIC THERAPY; DELIVERY; PLATFORM; CANCER; NANOPLATFORM; SYSTEMS; PH in [Zhou, Shuai; Ding, Chendi; Wang, Yang; Fu, Jiajun] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China; [Jiang, Wei] Nanjing Univ Sci & Technol, Natl Special Superfine Powder Engn Res Ctr, Nanjing 210094, Jiangsu, Peoples R China; [Fu, Jiajun] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 52.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Integrating multimodality bioimaging and multiple stimuli-responsive controlled drug release properties into one single nanosystem for therapeutic application is highly desirable but still remains a challenge. Herein, we coated a hollow mesoporous silica shell on to upconversion nanoparticles (UCNPs) and conjugated pillarene-based supramolecular valves on to surface of UCNPs@hm-SiO2 using amine-coumarin phototriggers to obtain the multifunctional nanoparticles, UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5]. Benefiting from the core shell structured UCNPs, the UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5] can serve as efficient contrast agents for upconversion luminescence and T-1-weighted magnetic resonance imaging in vitro/in vivo. More importantly, depending on exquisitely designed supramolecular valves, UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5] can realize zero-premature release under normal physiological conditions (pH 7.4), which produces minimal damage to normal tissue, whereas this nanosystem can respond to several disease-related signals, including acid (most cancers), alkali (metabolic alkalosis), and Zn2+ (Alzheimer’s disease), along with two external stimuli, including near-infrared (NIR) light and reductive electrical potential, via altering the spatial structure of pseudorotaxanes, disassembling the molecular stalks, or undergoing photochemical reactions, ultimately resulting in opening of the gatekeepers and release of encapsulated drugs. The multifunctional UCNP-based nanoparticles were endowed with such quintuple stimuli-responsive controlled release characteristics. Specifically, in anticancer application, the rational utilization of the two of them, acid and NIR light, could regulate the release amount and rate of DOX from UCNPs@hm-SiO2-Cou-Cys-DOX/WP[S], accelerate the accumulation of DOX in cell nuclei, and thereby promote the cancer cell apoptosis, indicating that the nanomaterials have promising application in cancer treatment. This study provides a novel design strategy for constructing multifunctional UCNP-based nanoparticles with multiple stimuli-responsive drug release features, which have great potential in diagnosis and therapy of relevant diseases as theranostic nanomedicines.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Siirila, J; Karesoja, M; Pulkkinen, P; Malho, JM; Tenhu, H in PERGAMON-ELSEVIER SCIENCE LTD published article about VINYLCAPROLACTAM-BASED MICROGELS; PHASE-TRANSITION BEHAVIOR; GOLD CLUSTER MOLECULES; N-VINYLCAPROLACTAM; 1-ANILINO-8-NAPHTHALENE SULFONATE; NANOPARTICLES; FLUORESCENCE; POLYMERS; RELEASE; DELIVERY in [Siirila, Joonas; Karesoja, Mikko; Pulkkinen, Petri; Tenhu, Heikki] Univ Helsinki, Dept Chem, PB 55, FIN-00014 Helsinki, Finland; [Malho, Jani-Markus] Aalto Univ, Dept Appl Phys, FI-00076 Espoo, Finland in 2019.0, Cited 64.0. HPLC of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Soft poly(N-vinylcaprolactam) (PNVCL) based nanogels were prepared and surface-decorated with gold nanoparticles (AuNPs). The applicability of the hybrid nanogels (PNVCL-AuNPs) as carriers for low molar mass substances was of special interest. AuNPs protected with a mixture of 11-azidoundecanothiol and 11-mercaptoundecanoic acid were bound to propargyl functionalized PNVCL based nanogels. Acidic groups on the surfaces of AuNPs and PNVCL based nanogels stabilize the particle dispersions against precipitation above the phase transition temperature of PNVCL. Both the neat PNVCL nanogels and the PVCL-AuNPs shrink upon heating the dispersions. Even though the AuNPs are mainly located in the soft surface layer of the nanogels, the PNVCL-AuNPs respond to visible light as well as to radio-frequency (RF) irradiation by shrinking due to the AuNPs acting as nanoheaters. Interactions of linear PNVCL, PNVCL nanogels and PNVCL-AuNPs with two fluorescent probes were studied as function of increasing temperature. Once bound to the polymer the fluorescent probe may or may not be released from it, depending on its polarity and water solubility. Presence of AuNPs changed the release behavior of the water soluble charged fluorescent probe from the nanogels.

HPLC of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Siirila, J; Karesoja, M; Pulkkinen, P; Malho, JM; Tenhu, H or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about ELECTRON-TRANSFER; BISIMIDE DYES; FLUORESCENCE; ASSEMBLIES; DESIGN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21561162004, N_CityU113/15]; Hong Kong Research Grants CouncilHong Kong Research Grants Council [CityU 11300017, CityU 11300318, CityU T42-103/16-N]; City University of Hong KongCity University of Hong Kong; Hong Kong Research Grants CouncilHong Kong Research Grants Council. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recommanded Product: 56-17-7

This communication reports novel luminescent rhenium(I)-polypyridine complexes appended with a perylene diimide (PDI) or benzoperylene monoimide (BPMI) moiety through a non-conjugated linker. The photophysical and photochemical properties originating from the interactions of the metal polypyridine and perylene units were exploited to afford new cellular reagents with thiol-sensing capability and excellent photocytotoxic activity.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

HPLC of Formula: C4H14Cl2N2S2. Recently I am researching about ALBUMIN-MNO2 NANOPARTICLES; FE3O4 NANOPARTICLES; HIGHLY EFFICIENT; IN-SITU; DELIVERY; CELL; THERAPY; RESISTANCE; ENHANCE; MICROENVIRONMENT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11832008, 51773023, 51602034, 51603024, 51825302, 21734002]; National Key R&D Program of China [2016YFC1100300, 2017YFB0702603]; Innovation Project on Industrial Generic Key Technologies of Chongqing [cstc2015zdcy-ztzx120003]; Natural Science Foundation of Chongqing Municipal GovernmentNatural Science Foundation of Chongqing [cstc2018jcyjAX0368]; People’s Livelihood Special Innovation Projects of Chongqing CSTC [cstc2017shmsA130071]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2018CDQYSM0036]; Innovation Team in University of Chongqing Municipal Government [CXTDX201601002]; Graduate Research and Innovation Foundation of Chongqing, China [CYB18070]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Zhou, J; Xue, CC; Hou, YH; Li, MH; Hu, Y; Chen, QF; Li, YA; Li, K; Song, GB; Cai, KY; Luo, Z. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Hypoxia plays vital roles in the development of tumor resistance against typical anticancer therapies and local reoxygenation has proved effective to overcome the hypoxia-induced chemoresistance. Perfluorocarbon (PFC) is an FDA approved oxygen carrier and currently vigorously investigated for oxygen delivery to tumors. This study reports a perfluorocarbon and etoposide (EP) loaded porous hollow Fe3O4-based theranostic nanoplatform capable of delivering oxygen to solid tumors to enhance their susceptibility against EP. Results show that oxygen could be released at a moderate rate from the porous hollow magnetic Fe3O4 nanoparticles (PHMNPs) over an extended period of time, therefore effectively reducing the hypoxia-induced EP resistance of tumor cells. Moreover, the surface of PHMNPs was modified with lactobionic acid (LA)-containing amphiphilic polymers via hydrophobic interaction, which could provide targeting effect against certain types of tumors. The hydrophilic moiety would be subsequently shed by the intratumoral GSH after cellular internalization and result in the agglomeration of nanocarriers inside tumor cells, consequently impeding the nanoparticle exocytosis to enhance their intracellular retention. The enhanced retention could elevate the intracellular EP level and effectively boost the tumor cell killing effect. In addition to the therapeutic benefits, the Fe3O4 nanocage could also be used for the magnetic resonance imaging of the tumor area. The assorted benefits of the composite nanosystem are anticipated to be advantageous for the treatment of drug-resistant hypoxic tumors.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Modified silica-based isoprene rubber composite by a multi -functional silane: Preparation and its mechanical and dynamic mechanical properties WOS:000581970300084 published article about FILLER-ELASTOMER INTERACTIONS; EPOXIDIZED NATURAL-RUBBER; COUPLING AGENTS; SURFACE MODIFICATION; NANOCOMPOSITES; NANOPARTICLES; PARTICLES; TIME in [Wang, Xuefei; Li, Huaming; Yang, Jun] Xiangtan Univ, Coll Chem, Xiangtan 411105, Hunan, Peoples R China; [Wang, Xuefei; Wu, Lingling; Yu, Haiwen; Xiao, Tongliang; Yang, Jun] Zhuzhou Times New Mat Technol Co Ltd, Zhuzhou 412007, Hunan, Peoples R China in 2020.0, Cited 42.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Modified silica-based isoprene rubber (IR) composite has been designed and prepared by using a multi-functional silane, 2-aminoethyl 2-(3-triethoxysilylpropyl)aminoethyl disulfide (ATD), as coupling agent. Such modification significantly improved the dispersity of silica in the corresponding composites, as verified by SEM observation. And the hardness, tensile strength, stress at definite elongation, tear strength and temperature rise as well as the value of dynamic loss coefficient ranging from 0 degrees C to 80 degrees C of silica/IR vulcanized composites, are significantly improved, especially with low ATD dosage (2-4 phr). This modification of silica-based IR composite by employing ATD as coupling agent provides a facile and effective method to prepare silica-based rubber composites with improved mechanical properties and low hysteresis.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem