Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2021.0 BIOACT MATER published article about TISSUE; CELL; CLUSTERS; SULFATE; FIBERS; LEADS in [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47906 USA; [Narayanan, Naagarajan; Kuang, Liangju; Lengemann, Paul; Deng, Meng] Purdue Univ, Bindley Biosci Ctr, W Lafayette, IN 47906 USA; [Jia, Zhihao; Kim, Kun Ho; Kuang, Shihuan] Purdue Univ, Dept Anim Sci, W Lafayette, IN 47906 USA; [Shafer, Gabrielle; Bernal-Crespo, Victor] Purdue Univ, Ctr Comparat Translat Res, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47906 USA; [Deng, Meng] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47906 USA in 2021.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.
Volumetric muscle loss (VML) injuries characterized by critical loss of skeletal muscle tissues result in severe functional impairment. Current treatments involving use of muscle grafts are limited by tissue availability and donor site morbidity. In this study, we designed and synthesized an implantable glycosaminoglycan-based hydrogel system consisting of thiolated hyaluronic acid (HA) and thiolated chondroitin sulfate (CS) crosslinked with poly(ethylene glycol) diacrylate to promote skeletal muscle regeneration of VML injuries in mice. The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8. Furthermore, in vivo studies using a murine quadriceps VML model demonstrated that the HA-CS hydrogels supported integration of implants with the surrounding host tissue and facilitated migration of Pax7(+) satellite cells, de novo myofiber formation, angiogenesis, and innervation with minimized scar tissue formation during 4-week implantation. The hydrogel-treated and autograft-treated mice showed similar functional improvements in treadmill performance as early as 1-week post-implantation compared to the untreated groups. Taken together, our results demonstrate the promise of HA-CS hydrogels as regenerative engineering matrices to accelerate healing of skeletal muscle injuries.
Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Narayanan, N; Jia, ZH; Kim, KH; Kuang, LJ; Lengemann, P; Shafer, G; Bernal-Crespo, V; Kuang, SH; Deng, M or send Email.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem