Day: November 24, 2021

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2020.0 CHEM COMMUN published article about POLYMERIC MICELLES; EFFICIENCY; SYSTEMS in [Zhu, Chun-Nan] South Cent Univ Nationalities, Coll Biomed Engn, Hubei Key Lab Med Informat Anal & Tumor Diag & Tr, Wuhan 430074, Peoples R China; South Cent Univ Nationalities, Key Lab Cognit Sci, State Ethn Affairs Commiss, Wuhan 430074, Peoples R China in 2020.0, Cited 26.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Poor solid-tumor penetration of nanocarriers limits the drug efficacy. Herein, small-sized copolymeric nanoparticles are prepared for delivering the chemotherapeutic drug DOX into solid tumors deeply and releasing the drug effectively. These small-sized copolymeric nanoparticles represent substantial potential for clinical translation.

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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2019.0 IND ENG CHEM RES published article about ORGANIC MATERIALS; EMITTING-DIODES; DUAL-EMISSION; EFFICIENT; POLYFLUORENE; COPOLYMERS; GUEST; HOST in [Ma, Xiang] East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai 200237, Peoples R China in 2019.0, Cited 69.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Research on metal-free room-temperature phosphorescent (RTP) materials has been a hot topic and made great advances in recent years. However, developing amorphous metal-free RTP compounds whose RTP emission is insensitive to water and oxygen to expand their applications still remains a challenge. Two novel metal-free RTP compounds were facilely designed and synthesized by modifying ureidopyrinidinone (UPy) units on both ends of the phosphors (BrNpA and BrBA). On the basis of their water/oxygen insensitive phosphorescence at different emission wavelengths, pure white-light (CIE coordinates (0.32, 0.33)) emission was obtained by mixing these two compounds. Moreover, visualization of latent fingerprints employing RTP materials as the first application in forensic science, as well as protected quick response codes, was achieved by theses hydrophobic materials.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Modular Assembly of Multimodal Imaging Agents through an Inverse Electron Demand Diels-Alder Reaction WOS:000462260300044 published article about PROSTATE-CANCER; IN-VITRO; CYCLOADDITIONS; FLUORESCENT; TETRAZINES; ANTIBODIES; CHELATORS in [Canovas, Coline; Moreau, Mathieu; Collin, Bertrand; Denat, Franck; Goncalves, Victor] Univ Bourgogne Franche Comte, Univ Bourgogne, CNRS, Inst Chim Mol,UMR6302, 9 Ave Alain Savary, F-21000 Dijon, France; [Vrigneaud, Jean-Marc; Bellaye, Pierre-Simon; Collin, Bertrand] Georges Francois LECLERC Canc Ctr, UNICANCER, 1 Rue Pr Marion, F-21079 Dijon, France in 2019.0, Cited 39.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The combination of two imaging probes on the same biomolecule gives access to targeted bimodal imaging agents that can provide more accurate diagnosis, complementary information, or that may be used in different applications, such as nuclear imaging and fluorescence guided surgery. In this study, we demonstrate that dichlorotetrazine, a small, commercially available compound, can be used as a modular platform to easily assemble various imaging probes. Doubly labeled tetrazines can then be conjugated to a protein through a biorthogonal IEDDA reaction. A series of difunctionalized tetrazine compounds containing various chelating agents and fluorescent dyes was synthesized. As a proof of concept, one of these bimodal probes was conjugated to trastuzumab, previously modified with a constrained alkyne group, and the resulting dual-labeled antibody was evaluated in a mouse model, bearing a HER2-positive tumor. A significant uptake into tumor tissues was observed in vivo, by both SPECT-CT and fluorescence imaging, and confirmed ex vivo in biodistribution studies.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Biswas, G; Jena, BC; Sahoo, S; Samanta, P; Mandal, M; Dhara, D in [Biswas, Gargi; Sahoo, Satyagopal; Samanta, Pousati; Dhara, Dibakar] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India; [Jena, Bikash Chandra; Mandal, Mahitosh] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India published A copper-free click reaction for the synthesis of redox-responsive water-soluble core cross-linked nanoparticles for drug delivery in cancer therapy in 2019.0, Cited 51.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Polymer based core cross-linked nanoparticles (CCNPs) have generated a lot of interest as potential stimuli-responsive drug delivery systems. In the present work, we have synthesized smart redox-responsive water soluble polymeric CCNPs by cross-linking water-soluble PEG based copolymers with bis(acryloyl)cystamine via isoxazoline bond formation through a 1,3-dipolar cycloaddition reaction (click reaction) without using a copper catalyst, in a water-THF mixed solvent. The successful synthesis of CCNPs was confirmed by NMR, GPC and FT-IR measurements. Size distribution of the precursor copolymers and the CCNPs was determined by DLS measurement. AFM and FESEM images have confirmed globular morphology of these CCNPs. Their high stability in a physiological environment makes them effective as potent drug carriers with high loading capacity. MTT assays confirmed the biocompatibility of the synthesized CCNPs. Favourable cellular internalization of these DOX loaded CCNPs into cancer cells and redox-responsive release of DOX therefrom make these CCNP potentially smart vehicles to deliver anticancer drugs into cancer cells.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Biswas, G; Jena, BC; Sahoo, S; Samanta, P; Mandal, M; Dhara, D or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Wang, ZY; Ren, CH; Shang, YN; Yang, CH; Guo, QX; Chu, LP; Liu, JF in FRONTIERS MEDIA SA published article about PEPTIDE; NANOPARTICLES; HYDROGELS; PROTEINS; MATTER in [Wang, Zhongyan; Ren, Chunhua; Yang, Cuihong; Guo, Qingxiang; Chu, Liping; Liu, Jianfeng] Chinese Acad Med Sci & Peking Union Med Coll, Tianjin Key Lab Radiat Med & Mol Nucl Med, Inst Radiat Med, Tianjin, Peoples R China; [Shang, Yuna] Nankai Univ, Coll Life Sci, Tianjin, Peoples R China in 2020.0, Cited 37.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The utilization of nanotechnology to deliver vaccines and modulate immunity has shown great potential in cancer therapy. Peptide-based supramolecular hydrogels as novel vaccine adjuvants have been found to effectively improve the immune response and tumor curative effect. In this study, we designed a set of reduction-responsive self-assembled peptide precursors (Fbp-G(D)F(D)F(D)Y(D)(E, S, or K)-ss-ERGD), which can be reduced by glutathione (GSH) into Fbp-G(D)F(D)F(D)Y(D)(E, S or K)-SH for forming of hydrogel with different surface properties (E-gel, S-gel, and K-gel, respectively). Using the same method, co-assembled hydrogel vaccines (E-vac, S-vac, and K-vac, respectively) can also be prepared by mixing different precursors with antigens before GSH reduction. Through TEM observation of the nanostructure, we found that all the co-assembled hydrogels, especially K-vac, possessed much denser and more unified nanofiber networks as compared with antigen-free hydrogels, which were very suitable for antigen storage and vaccine delivery. Although the three peptides adopted similar beta-sheet secondary structures, the mechanical properties of their resulted co-assembled hydrogel vaccines were obviously different. Compared to E-vac, S-vac had a much weaker mechanical property, while K-vac had a much higher.In vivoexperiments, co-assembled hydrogel vaccines, especially K-vac, also promoted antibody production and anti-tumor immune responses more significantly than the other two vaccines. Our results demonstrated that co-assembled hydrogels formed by peptides and antigens co-assembly could act as effective vaccine delivery systems for boosting antibody production, and different immune effects can be acquired by tuning the surface properties of the involved self-assembling peptides.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2019.0 ACS APPL MATER INTER published article about CYTOPLASMIC DRUG-DELIVERY; HYALURONIC-ACID; IRGD; GLUTATHIONE; POLYMER; THERAPEUTICS; DOXORUBICIN; CELL; NANOCARRIERS; PENETRATION in [Feng, Shuaishuai; Zhao, Ziyan; Liu, Jinhu; Sun, Kaoxiang; Wang, Hongbo; Wu, Zimei] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China; [Wu, Zi-Xin; Guo, Chuanyou] Qingdao Municipal Hosp, Qingdao 266071, Shandong, Peoples R China; [Wu, Zimei] Univ Auckland, Sch Pharm, Auckland 1142, New Zealand in 2019.0, Cited 60.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

This study aimed to develop an efficient step-by-step osteosarcoma (OS)-targeting liposome system functionalized with a redox-cleavable, bone- and cluster of differentiation 44 (CD44)-dual-targeting polymer. Furthermore, the effect of coadministration of a tumor-penetrating peptide, internalizing RGD (iRGD), was investigated. First, a bone-targeting moiety, alendronate (ALN), was conjugated with hyaluronic acid (HA), a ligand for CD44. This ALN-HA conjugate was coupled with DSPE PEG(2000)-COOH through a bioreducible disulfide linker (-SS-) to obtain a functionalized lipid, ALN-HA-SS-L, to be postinserted into preformed liposomes loaded with doxorubicin (DOX). The roles of ALN, HA, and the redox sensitivity of the ALN-HA-SS-L liposomes (ALN-HA-SS-L-L) in the anti-OS effect were critically evaluated against various reference liposomal formulations (with only ALN, HA, or redox sensitivity). ALN-HA-SS-L-L displayed a zeta potential of -26.07 +/- 0.32 mV and selectively disassembled in the presence of a reducing agent, 10 mM glutathione, which can be found in cancer cells. cells. Compared to various reference liposomes, ALN-HA-SS-L-L/DOX had significantly higher cytotoxicity to human OS MG-63 cells alongside high and rapid cellular uptake. In the orthotopic OS nude mouse models, ALN-HA-SS-L-L/DOX showed remarkable tumor growth suppression and prolonged survival time. This result was further improved by the coadministration of iRGD. The antitumor effects of various liposomes were ranked in the same order as the degree of tumor biodistribution shown by in vivo/ex vivo imaging: ALN-HA-SS-L-L coadministered with iRGD > ALN-HA-SS-L-L > HA-SS-L-L > HA-L-L > PEG-L> free drug. ALN-HA-SS-L-L/DOX also reduced the cardiotoxicity of DOX and lung metastases. Overall, this study demonstrated that ALN-HA-SS-L-L/DOX, equipped with bone- and CD44-dual-targeting abilities and redox sensitivity, could be a promising OS-targeted therapy. The efficacy could also be augmented by coadministration of iRGD.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Feng, SS; Wu, ZX; Zhao, ZY; Liu, JH; Sun, KX; Guo, CY; Wang, HB; Wu, ZM or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Yeh, CM; Lin, CH; Han, TY; Xiao, YT; Chen, YA; Chou, HH in ROYAL SOC CHEMISTRY published article about in [Yeh, Chun-Ming; Lin, Chun-Hsiu; Han, Tzung-You; Xiao, Yu-Ting; Chen, Yi-An; Chou, Ho-Hsiu] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan in 2021.0, Cited 62.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

For next-generation electronics, it is crucial to be able to accurately mimic the nature of human skin and develop skin-inspired materials and devices for electronic skin (e-skin) applications. However, it is a great challenge to design such a materials because they require the complex integration of stretchability, skin adhesiveness, transparency, healability, and tactile sensing. Herein, we present the first dual covalently reversible dynamic bond-based polymer that can be integrated with various functional materials and used as a skin-like sensor. A series of polymers was designed using polypropylene glycol (PPG)-based polyurethane (PU) as the polymer backbone, and these polymers could integrate two types of covalent reversible dynamic bonds, Diels-Alder and disulfide bonds, in one polymer for the first time. Based on our design, a polymer was created with the advantages of high stretchability, fast healing abilities (60 degrees C, 5 min), skin adhesion, recyclability, high transparency, and tactile sensing abilities. We provide an alternative strategy for the construction of skin-inspired multifunctional materials for e-skin applications.

Welcome to talk about 56-17-7, If you have any questions, you can contact Yeh, CM; Lin, CH; Han, TY; Xiao, YT; Chen, YA; Chou, HH or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of Polymer Science very interesting. Saw the article One step synthesis of monodisperse thiol-ene clickable polymer microspheres and application on biological functionalization published in 2019.0, Reprint Addresses Zeng, ZH (corresponding author), Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Introducing clickable groups onto polymer microspheres allows the microspheres to be facilely functionalized via a click reaction. In this report, we have synthesized monodisperse PMMA microspheres with clickable double bonds on the surface by one-step RAFT-assisted dispersion photopolymerization using a cyclohexyl-containing macro-RAFT agent as a stabilizer. This macro-RAFT agent, named P(THPAA-b-AA)-TTC, was synthesized by RAFT-mediated block copolymerization of a cyclohexyl-containing monomer (THPAA, obtained by esterification of cis-1,2,3,6-tetrahydrophthalic with 2-hydroxyethyl acrylate) and acrylic acid. The obtained microspheres were analyzed by H-1 NMR and Iodometric method, indicating that the content of carbon double bonds on the microspheres increased with increasing the amount of P(THPAA-b-AA)-TTC in the polymerization feed. We then used a thiolated biotin to perform the photo-click reaction with the cyclohexene double bond on the micro spheres, thereby attaching the biotin unit onto the microspheres. The biotinylated PMMA microspheres were found to be able to effectively immobilize fluorescein isothiocyanate streptavidin (FITC-SAv) via the specific adsorption of biotin to streptavidin, and thus exhibited clear fluorescence under confocal microscope. This study provides a convenient and feasible way to prepare surface-functionalized microspheres, which has great potential in biological applications as well as other fields.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2020.0 CIRC-HEART FAIL published article about CLINICAL CHARACTERISTICS; SODIUM; STRATEGIES; OUTCOMES; BLACKS; THIRST; SYSTEM; WHITES; TRIAL in [Morris, Alanna A.; Nayak, Aditi; D’Souza, Melroy] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA; [Ko, Yi-An] Emory Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA USA; [Felker, G. Michael] Duke Univ, Div Cardiol, Durham, NC USA; [Redfield, Margaret M.] Mayo Clin, Div Cardiol, Rochester, MN USA; [Tang, W. H. Wilson] Cleveland Clin, Div Cardiol, Cleveland, OH 44106 USA; [Testani, Jeffrey M.] Yale Univ, Sch Med, Div Cardiol, New Haven, CT USA; [Butler, Javed] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA in 2020.0, Cited 39.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Background: Black patients have higher rates of hospitalization for acute heart failure than other race/ethnic groups. We sought to determine whether diuretic efficiency is associated with racial differences in risk for rehospitalization after acute heart failure. Methods: A post hoc analysis was performed on 721 subjects (age, 68 +/- 13 years; 22% black) enrolled in 3 acute heart failure clinical trials: ROSE-AHF (Renal Optimization Strategies Evaluation in Acute Heart Failure), DOSE-AHF (Diuretic Optimization Strategy Evaluation in Acute Decompensated Heart Failure), and CARRESS-HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failure). Repeated-measures ANOVA was used to test for a racextime effect on measures of decongestion. Diuretic efficiency was calculated as net fluid balance per total furosemide equivalents. In a subset of subjects, Cox regression was used to examine the association between race and rehospitalization according to plasma renin activity (PRA). Results: Compared with nonblack patients, black patients were younger and more likely to have nonischemic heart failure. During the first 72 to 96 hours, there was greater fluid loss (P=0.001), decrease in NT-proBNP (N-terminal pro-B-type natriuretic peptide;P=0.002), and lower levels of PRA (P<0.0001) in black patients. Diuretic efficiency was higher in black than in nonblack patients (403 [interquartile range, 221-795] versus 325 [interquartile range, 154-698];P=0.014). However, adjustment for baseline PRA attenuated the association between black race and diuretic efficiency. Over a median follow-up of 68 (interquartile range, 56-177) days, there was an increased risk of all-cause and heart failure-specific rehospitalization in nonblack patients with increasing levels of PRA, while the risk of rehospitalization was relatively constant across levels of PRA in black patients. Conclusions: Higher diuretic efficiency in black patients with acute heart failure may be related to racial differences in activity of the renin-angiotensin-aldosterone system. Welcome to talk about 56-17-7, If you have any questions, you can contact Morris, AA; Nayak, A; Ko, YA; D'Souza, M; Felker, GM; Redfield, MM; Tang, WHW; Testani, JM; Butler, J or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Chemistry; Engineering very interesting. Saw the article Photothermally enhanced photodynamic therapy based on glutathione-responsive pheophorbide a-conjugated gold nanorod formulations for cancer theranostic applications published in 2020.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Kim, SY (corresponding author), Chungnam Natl Univ, Coll Educ, Dept Chem Engn Educ, Daejeon 34134, South Korea.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Nanocarriers have provided a new platform for the selective delivery of therapeutic agents into targeted cells and tissues using safe, efficient, and tractable routes. In particular, the integration of multiple therapeutic/diagnostic modalities into a single system has the great potential of enhancing theranostic efficiency against serious diseases with reduced side effects. In this study, a new light-triggered theranostic system using photosensitizer-conjugated gold nanorods (AuNR) with glutathione (GSH)-sensitive linkages was developed for cancer imaging and combinational phototherapy of photodynamic therapy (PDT) and photothermal therapy (PTT) to achieve a synergistic cancer treatment. AuNRs with various aspect ratios were prepared as photothermal agents, and then a folic acid (FA)-PEG block copolymer (FAP) and pheophorbide a (Pheo) were chemically conjugated to the surface of AuNRs for active tumor targeting and PDT, respectively. The configuration of Pheo-conjugated AuNR nanocarriers has been precisely controlled through adjusting the feed composition ratio and the relationship between aspect ratio and absorption band of AuNRs. In particular, an AuNR with an aspect ratio of 3.84 and longitudinal plasmon resonance at 873 nm (Pheo-conjugated AuNR100) exhibited superior performance in singlet oxygen generation, photothermal conversion effect, and GSH-mediated selective release of Pheo. Moreover, it also showed tumor targeting activity and a PDT-PTT synergistic effect. These results indicate that this multifunctional AuNR system with tumor targeting ability and GSH-sensitive linkages would be highly efficient for noninvasive cancer treatment by integrating cancer imaging diagnostics and synergistic therapy. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem