Day: November 23, 2021

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2021.0 MACROMOLECULES published article about VISIBLE-LIGHT; COMPLEX COACERVATION; RAFT POLYMERIZATION; COPOLYMER VESICLES; NANOPARTICLES; MONOMERS; SEQUENCE; WATER in [Wang, Ye; Li, Chao; Ma, Lei; Wang, Xiyu; Wang, Kai; Lu, Xinhua; Cai, Yuanli] Soochow Univ, Coll Chem Chem Engn & Mat Sci, State Local Joint Engn Lab Novel Funct Polymer Ma, Suzhou 215123, Peoples R China in 2021.0, Cited 54.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Development of spatially restricted liquid-liquid phase separation (LLPS) systems emulating biomolecular condensates is a major challenge in coacervating materials science, due to lack of approaches for spatially restricted coacervation of sequence-defined zwitterionic segments resembling intrinsically disordered proteins. Herein, we present interfacial LLPS-driven polymerization-induced electrostatic self-assembly, namely, interfacial LLPS-PIESA. The asymmetric charge sequence patterning of zwitterionic growing segments is achieved via spontaneous polymerization of ion-pair monomers within a nanopartide core-shell interface. We show that charge sequence can profoundly affect the self-coacervation, leading to droplet dispersions, dense coacervates, and free-standing hydrogels. Moreover, the interfacial LLPS-PIESA shows a programmed hierarchical condensation self-assembly mechanism involving vesicles-to-lamellae transition, interfacial self-coacervation, lamellae-to-sheets transition, layer-by-layer sheet self-assembly, spatially restricted condensation and agglomeration, and redispersing into fibril network condensates under dynamic evolving surface charge regulation. The spatially restricted asymmetric charge sequence patterning, interfacial self-coacervation, and programmed hierarchical condensation self-assembly, all these elements can serve as the primary principles for the asymmetric charge sequence patterning design of hierarchically nanostructured condensates that emulate cellular biomolecular condensates.

Welcome to talk about 56-17-7, If you have any questions, you can contact Wang, Y; Li, C; Ma, L; Wang, XY; Wang, K; Lu, XH; Cai, YL or send Email.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. I found the field of Chemistry; Polymer Science very interesting. Saw the article Redox-responsive nanoparticles based on Chondroitin Sulfate and Docetaxel prodrug for tumor targeted delivery of Docetaxel published in 2021.0, Reprint Addresses Li, LB; Zhai, GX (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Pharmaceut,Minist Educ,Key Lab Chem Biol, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

In this paper, a novel redox-responsive nanoparticles has been designed for targeted delivery of docetaxel (DTX). Chondroitin sulfate (CS) was used to construct the nanoparticles due to the ability of tumor targeting through binding with CD44 receptor that overexpresses on the surfaces of various tumor cells. A redox-responsive small-molecular DTX prodrug was prepared through modifying with cystamine containing disulfide bonds (Cys-DTX). Then the DTX prodrug was grafted to the CS to construct the amphiphilic polymer (CS-ss-DTX). Further, Cys-DTX/CS-ss-DTX nanoparticles were formed by self-assembly of amphiphilic polymer and incorporation of free Cys-DTX prodrug. This category of nanosized DTX delivery system was expected for not only exhibiting high permeability and cytotoxicity of Cys-DTX prodrug, but also targeting transportation of encapsulated redox-responsive Cys-DTX prodrug. According to results of related researches on physicochemical properties and biological evaluation, the novel redox-responsive Cys-DTX/CS-ss-DTX nanoparticles increased amount of DTX released from the nanoparticles in reductive environment, improved permeability in tumor tissues, enhanced cytotoxicity and decreased side effects compared with free DTX. All of these results showed that this kind of Cys-DTX/CS-ss-DTX nanoparticles were worthy of being expectation in tumor chemotherapy in future.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Gerschel, P; Warm, K; Farquhar, ER; Englert, U; Reback, ML; Siegmund, D; Ray, K; Apfel, UP in [Gerschel, P.; Reback, M. L.; Apfel, U-P] Ruhr Univ Bochum, Anorgan Chem 1, Univ Str 150, D-44801 Bochum, Germany; [Warm, K.; Ray, K.] Humboldt Univ, Inst Chem, Brook Taylor Str 2, D-12489 Berlin, Germany; [Farquhar, E. R.] Brookhaven Natl Lab, NSLS 2, CWRU Ctr Synchrotron Biosci, Upton, NY 11973 USA; [Englert, U.] Rhein Westfal TH Aachen, Inst Anorgan Chem, Landoltweg 1, D-52056 Aachen, Germany; [Siegmund, D.; Apfel, U-P] Fraunhofer UMSICHT, Osterfelder Str 3, D-46047 Oberhausen, Germany published Sulfur substitution in a Ni(cyclam) derivative results in lower overpotential for CO2 reduction and enhanced proton reduction in 2019.0, Cited 36.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The replacement of the opposing nitrogen atoms in 1,4,8,11-tetraazacyclotetradecane (cyclam) with two sulfur atoms in 1,8-dithia-4,11-diazacyclotetradecane (dithiacyclam) enables the electrochemical reduction of protons and CO(2)via the corresponding nickel(ii) complex at more positive potentials. In addition, a 10-fold enhancement in the proton reduction rate of [Ni(dithiacyclam)](2+) relative to [Ni(cylcam)](2+) was observed. The study provides vital insight into Nature’s choice of employing predominantly sulfur based ligand platforms in achieving biological proton and CO2 reductions.

Welcome to talk about 56-17-7, If you have any questions, you can contact Gerschel, P; Warm, K; Farquhar, ER; Englert, U; Reback, ML; Siegmund, D; Ray, K; Apfel, UP or send Email.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Synthesis of crosslinkable diblock terpolymers PDPA-b-P(NMS-co-OEG) and preparation of shell-crosslinked pH/redox-dual responsive micelles as smart nanomaterials WOS:000494684600050 published article about BLOCK-COPOLYMER MICELLES; CONTROLLED-RELEASE; POLYMERIC MICELLES; DRUG-DELIVERY; TRIGGERED RELEASE; PH; NANOPARTICLES; CORE; DOXORUBICIN; LOCATION in [Sun, Jingjing; Sheng, Ruilong] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Radiol, Shanghai 200072, Peoples R China; [Sun, Jingjing; Wang, Zhao; Cao, Amin; Sheng, Ruilong] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet & Self Assembly Chem Organ Funct, Lingling Rd 345, Shanghai 200032, Peoples R China; [Wang, Zhao] Jinling Inst Technol, Dept Mat, Nanjing 211169, Jiangsu, Peoples R China; [Sheng, Ruilong] Univ Madeira, CQM Ctr Quim Madeira, Campus Penteada, P-9000390 Funchal, Portugal in 2019.0, Cited 39.0. Computed Properties of C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Crosslinked polymer nanomaterials have attracted great attention due to their stability and highly controllable drug delivery; herein, a series of well-defined amphiphilic PDPA-b-P(NMS-co-OEG) diblock terpolymers (P1-P3) were designed and prepared via RAFT polymerization and were self-assembled into non-cross-linked (NCL) nanomicelles, which were further prepared into shell-cross-linked (SCL) micelles via cystamine-based in situ shell cross-linking. Using P3 as an optimized polymer, SCL-P3 micelles were prepared, which demonstrated remarkable pH/redox-dual responsive behaviour. For drug delivery, camptothecin (CPT)-loaded SCL-P3 micelles were prepared and showed much higher CPT-loading capability than their NCL-P3 counterparts. Notably, the SCL-P3 micelles showed good synergistic pH/redox-dual responsive CPT release properties, making them potential smart nanocarriers for drug delivery.

Computed Properties of C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Sun, JJ; Wang, Z; Cao, A; Sheng, RL or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Sulfur substitution in a Ni(cyclam) derivative results in lower overpotential for CO2 reduction and enhanced proton reduction WOS:000472449300008 published article about MACROCYCLIC LIGANDS; CARBON-DIOXIDE; COMPLEXES; ELECTROREDUCTION; KINETICS in [Gerschel, P.; Reback, M. L.; Apfel, U-P] Ruhr Univ Bochum, Anorgan Chem 1, Univ Str 150, D-44801 Bochum, Germany; [Warm, K.; Ray, K.] Humboldt Univ, Inst Chem, Brook Taylor Str 2, D-12489 Berlin, Germany; [Farquhar, E. R.] Brookhaven Natl Lab, NSLS 2, CWRU Ctr Synchrotron Biosci, Upton, NY 11973 USA; [Englert, U.] Rhein Westfal TH Aachen, Inst Anorgan Chem, Landoltweg 1, D-52056 Aachen, Germany; [Siegmund, D.; Apfel, U-P] Fraunhofer UMSICHT, Osterfelder Str 3, D-46047 Oberhausen, Germany in 2019.0, Cited 36.0. HPLC of Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The replacement of the opposing nitrogen atoms in 1,4,8,11-tetraazacyclotetradecane (cyclam) with two sulfur atoms in 1,8-dithia-4,11-diazacyclotetradecane (dithiacyclam) enables the electrochemical reduction of protons and CO(2)via the corresponding nickel(ii) complex at more positive potentials. In addition, a 10-fold enhancement in the proton reduction rate of [Ni(dithiacyclam)](2+) relative to [Ni(cylcam)](2+) was observed. The study provides vital insight into Nature’s choice of employing predominantly sulfur based ligand platforms in achieving biological proton and CO2 reductions.

Welcome to talk about 56-17-7, If you have any questions, you can contact Gerschel, P; Warm, K; Farquhar, ER; Englert, U; Reback, ML; Siegmund, D; Ray, K; Apfel, UP or send Email.. HPLC of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Engineering; Materials Science very interesting. Saw the article Bioorthogonal click chemistries enable simultaneous spatial patterning of multiple proteins to probe synergistic protein effects on fibroblast function published in 2020.0. SDS of cas: 56-17-7, Reprint Addresses Anseth, KS (corresponding author), Univ Colorado Boulder, Dept Chem & Biol Engn, Boulder, CO 80303 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Three biorthogonal click reactions, a photoinitiated thiol-yne reaction, an azide-alkyne cycloaddition, and a methyltetrazine-transcyclooctene Diels Alder, were used to independently control the presentation of several bioactive proteins to valvular interstitial cells (VICs) in hydrogel scaffolds. Tethered fibroblast growth factor (FGF-2) was found to suppress myofibroblast activation (from 48 +/- 7% to 17 +/- 6%) and promote proliferation (from 10 +/- 2% to 54 +/- 3%) at a concentration of 10 ng/mL. In the presence of the pro-fibrotic cytokine transforming growth factor-beta (TGF-beta 1), FGF-2 could protect the VIC fibroblast phenotype, even at much higher concentrations of TGF-beta 1 than that of FGF-2. With respect to the fibrocalcific VIC phenotype, TGF-beta 1 and bone-morphogenic protein-2 (BMP-2) were found to synergistically promote calcific nodule formation (a five-fold increase in nodules compared to TGF-beta 1 or BMP-2 alone). Exploiting the orthogonal click reactions, FGF-2, TGF-beta 1 and BMP-2 combinations were patterned into distinct regions on a hydrogel to control VIC activation and nodule formation. Cellular crosstalk between separate regions of the same scaffold was affected by the size of each region as well as the interfacial area between different regions. Collectively, these results demonstrate the versatility and robustness of a photoinitiated thiol-yne reaction to template pendant functionalities that allow for the bioconjugation of multiple proteins. This approach maintains protein bioactivity, providing an in vitro platform capable of achieving a better understanding of the complex mechanisms involved in tissue fibrosis.

SDS of cas: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Ma, H; Caldwell, AS; Azagarsamy, MA; Rodriguez, AG; Anseth, KS or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. In 2019.0 INT J BIOL MACROMOL published article about DRUG-RELEASE; SENSITIVE MICELLES; REDOX; NANOPARTICLES; DOXORUBICIN in [Li, Jia; Wang, Jihong; Zhang, Xuetong; Xia, Xin; Zhang, Chenchen] Jiangnan Univ, Dept Ophthalmol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China in 2019.0, Cited 32.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Melphalan (MEL) is an effective chemotherapeutic agent for treatment of retinoblastoma (Rb) which is the most common childhood malignancy. However, the inherent cardiopulmonary toxicity and hazardous integration limit its therapeutic effect on RB. N-Acetylheparosan (AH), a natural heparin-like polysaccharide in mammals with long circulation effect and good biocompatibility, was linked by d-alpha-tocopherol acid succinate (VES) via and cystamine (CYS) to synthesize reduction-responsive N-acetylheparosan-CYS-Vitamin E succinate (AHV) copolymers. In addition, CYS was replaced by adipic acid dihydrazide (ADH) to obtain a control of non-reduction-responsive polymers N-acetylheparosan-ADH-Vitamin E succinate (ADV). MEL-loaded AHV micelles (MEL/AHV) as well as ADV micelles (MEL/ADV) were prepared with small particle size and high drug loading content. In vitro drug release showed that MEL/AHV micelles presented obvious reduction-triggered release behavior compared with MEL/ADV. In vitro antitumor effects were investigated using WERI-Rb-1 retinoblastoma cells. Cytotoxicity experiments showed that the IC50 of MEL/AHV was significantly lower than that of free MEL and MEL/ADV, suggesting that MEL/AHV enhanced the cytotoxicity against retinoblastoma cells. Furthermore, MEL/AHV micelles were more easily uptaken by multiple pathways compared with MEL/ADV and free MEL. Therefore, MEL/AHV might be a potential delivery system for enhanced delivery of melphalan to Rb cells. (C) 2019 Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer WOS:000486717700001 published article about TARGETED DELIVERY; COMBINATION THERAPY; DRUG CONJUGATE; CO-DELIVERY; LIGAND; DOXORUBICIN; PACLITAXEL; TUMOR; APOPTOSIS; EFFICACY in [Sui, Binglin; Cheng, Chen; Wang, Mingming; Hopkins, Elijah; Xu, Peisheng] Univ South Carolina, Dept Discovery & Biomed Sci, Coll Pharm, 715 Sumter, Columbia, SC 29208 USA in 2019.0, Cited 40.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Clinical application of drug cocktails for cancer therapy is limited by their severe systemic toxicity. To solve a catch-22 dilemma between safety and efficacy for drug cocktails, a heterotargeted nanococktail (PPPDMA) with traceless linkers is developed. In the PPPDMA nanogel, a heterotargeting strategy is employed to improve its tumor selective targeting efficacy by overcoming the cancer cell monoligand density limitation. Benefitting from its glutathione and reactive oxygen species responsiveness, the loaded paclitaxel and doxorubicin can be quickly and tracelessly released into the cytoplasm in their original form, which bestows upon PPPDMA nanogels the capability to overwhelm the processing capacity of the cancer cell’s P-glycoprotein efflux pump, and ultimately kill them without inducing side effects. The PPPDMA treatment reduced its tumor burden over 99% (in tumor weight) and 96% (in tumor number). Most importantly, no detectable tumor in more than half of the PPPDMA treated mice was observed. It is concluded that traceless linker and heterotargeted nanococktail strategy can be a safe and effective approach for cancer treatment.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about ELASTIC-MODULI; THIN; FILMS; METROLOGY; WRINKLES; STRESS; CAST, Saw an article supported by the NSF Graduate Research Fellowship ProgramNational Science Foundation (NSF) [DGE-1445151]; NSF NRT program Interface [DGE-1449999]. SDS of cas: 56-17-7. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Reese, CM; Guo, W; Thompson, BJ; Logan, PK; Stafford, CM; Patton, DL. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A compressive strain applied to bilayer films (e.g., a thin film adhered to a thick substrate) can lead to buckled or wrinkled morphologies, which has many important applications in stretchable electronics, anticounterfeit technology, and high-precision micrometrology and nano-metrology. A number of buckling-based metrology methods have been developed to quantify the residual stress and viscoelastic properties of polymer thin films. However, in some systems (e.g., solvent-induced swelling or thermal strain), the compressive strain is unknown or difficult to measure. We present a quantitative method of measuring the compressive strain of wrinkled polymer films and coatings with knowledge of the skin thickness, wrinkle wavelength, and wrinkle amplitude. The derived analytical expression is validated with a well-studied model system, e.g., a stiff, thin film bonded to a thick, compliant substrate. After validation, we use our expression to quantify the applied swelling strain of previously reported wrinkled poly(styrene-alt-maleic anhydride) brush surfaces. Finally, the applied strain is used to rationalize the observed persistence length of aligned wrinkles created during atomic force microscopy lithography and subsequent solvent exposure.

Welcome to talk about 56-17-7, If you have any questions, you can contact Reese, CM; Guo, W; Thompson, BJ; Logan, PK; Stafford, CM; Patton, DL or send Email.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. Recently I am researching about ELECTROCHEMICAL IMMUNOSENSOR; GOLD NANOPARTICLES; CANCER DETECTION; PSA; BIOMARKER; BIOSENSOR; IMMOBILIZATION; NANOMATERIALS; NANOTUBES; MORTALITY, Saw an article supported by the . Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Cevik, E. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

In this study, electrochemical immunosensors were developed for the detection of prostate specific antigen (PSA) using ferrocene (Fc) and polyamidoamine dendrimer (PAMAM) constructs. The biosensor fabrication was designed by modifying the screen-printed gold electrode (Au) with ferrocene cored dendrimers (FcPAMAM) synthesized in three different generations. The self-assembled monolayer principle was followed, to obtain sensitive, selective and disposable electrodes. Therefore, the Au electrodes were modified with cysteamine (Cys) to obtain a functional surface for FcPAMAM dendrimers to bind. Dendrimer generations were attached to this surface using a cross-linker (glutaraldehyde) so that a suitable surface was obtained for binding of biological components. The Monoclonal PSA antibody (anti-PSA) was immobilized on the Au electrode surface which coated with dendrimer, and (Au/Cys/FcPAMAM/anti-PSA) biosensing electrode was obtained. The PSA detection performances of electrochemical impedance spectroscopy (EIS) and Amperometry based immunosensors exhibited very low detection limits; 0.001 ng mL(-1) and 0.1 pg mL(-1), respectively. In addition, EIS and Amperometry based biosensors using Au/Cys/FcPAMAM/anti-PSA sensing electrode were represented excellent linear ranges of 0.01 ng mL(-1) to 100 ng mL(-1) and 0.001 ng mL(-1) to 100 ng mL(-1). In order to determine the applicability recovery and selectivity tests were performed using three different proteins in human serum.

SDS of cas: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Cevik, E or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem