Computed Properties of C4H14Cl2N2S2. I found the field of Chemistry; Science & Technology – Other Topics; Materials Science; Physics very interesting. Saw the article Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer published in 2019.0, Reprint Addresses Xu, PS (corresponding author), Univ South Carolina, Dept Discovery & Biomed Sci, Coll Pharm, 715 Sumter, Columbia, SC 29208 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.
Clinical application of drug cocktails for cancer therapy is limited by their severe systemic toxicity. To solve a catch-22 dilemma between safety and efficacy for drug cocktails, a heterotargeted nanococktail (PPPDMA) with traceless linkers is developed. In the PPPDMA nanogel, a heterotargeting strategy is employed to improve its tumor selective targeting efficacy by overcoming the cancer cell monoligand density limitation. Benefitting from its glutathione and reactive oxygen species responsiveness, the loaded paclitaxel and doxorubicin can be quickly and tracelessly released into the cytoplasm in their original form, which bestows upon PPPDMA nanogels the capability to overwhelm the processing capacity of the cancer cell’s P-glycoprotein efflux pump, and ultimately kill them without inducing side effects. The PPPDMA treatment reduced its tumor burden over 99% (in tumor weight) and 96% (in tumor number). Most importantly, no detectable tumor in more than half of the PPPDMA treated mice was observed. It is concluded that traceless linker and heterotargeted nanococktail strategy can be a safe and effective approach for cancer treatment.
Welcome to talk about 56-17-7, If you have any questions, you can contact Sui, BL; Cheng, C; Wang, MM; Hopkins, E; Xu, PS or send Email.. Computed Properties of C4H14Cl2N2S2
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem