Authors Andrgie, AT; Birhan, YS; Mekonnen, TW; Hanurry, EY; Darge, HF; Lee, RH; Chou, HY; Tsai, HC in MDPI published article about DRUG-DELIVERY; NANOPARTICLES; COMBINATION; MICELLES; CELLS in [Andrgie, Abegaz Tizazu; Birhan, Yihenew Simegniew; Mekonnen, Tefera Worku; Hanurry, Endiries Yibru; Darge, Haile Fentahun; Chou, Hsiao-Ying; Tsai, Hsieh-Chih] Natl Taiwan Univ Sci & Technol, Grad Inst Appl Sci & Technol, Taipei 106, Taiwan; [Lee, Rong-Ho] Natl Chung Hsing Univ, Dept Chem Engn, Taichung 402, Taiwan; [Tsai, Hsieh-Chih] Natl Taiwan Univ Sci & Technol, Adv Membrane Mat Ctr, Taipei 106, Taiwan in 2020.0, Cited 47.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7
Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient therapy. In this study, redox-responsive disulfide bond-containing amphiphilic heparin-chlorambucil conjugated polymeric prodrugs were designed and synthesized to enhance anti-tumor activities of chlorambucil. The conjugated prodrug could be self-assembled to form spherical vesicles with 61.33% chlorambucil grafting efficiency. The cell viability test results showed that the prodrug was biocompatible with normal cells (HaCaT) and that it selectively killed tumor cells (HeLa cells). The uptake of prodrugs by HeLa cells increased with time. Therefore, the designed prodrugs can be a better alternative as delivery vehicles for the chlorambucil controlled release in cancer cells.
Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Andrgie, AT; Birhan, YS; Mekonnen, TW; Hanurry, EY; Darge, HF; Lee, RH; Chou, HY; Tsai, HC or send Email.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem