Day: November 12, 2021

In 2019.0 CHEM COMMUN published article about NEUTRAL PH; PROTEINS; TYROSINE; PEPTIDOGLYCAN; HYDRAZONES; STABILITY; LIGATION; REAGENTS; PEPTIDE in [Parmar, Sangeeta; Pawar, Sharad P.; Iyer, Ramkumar; Kalia, Dimpy] IISER Bhopal, Dept Chem, Bhopal Bypass Rd, Bhopal 462066, Madhya Pradesh, India in 2019.0, Cited 51.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

A technically simple approach for rapid, high-yielding and site-selective bioconjugation has been developed for both in vitro and cellular applications. This method involves the generation of maleimido-phosphonium ylides via 4-nitrophenol catalysis under physiological conditions followed by their Wittig reactions with aldehyde-appended biomolecules.

Welcome to talk about 56-17-7, If you have any questions, you can contact Parmar, S; Pawar, SP; Iyer, R; Kalia, D or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about BLOCK-COPOLYMER MICELLES; CONTROLLED-RELEASE; POLYMERIC MICELLES; DRUG-DELIVERY; TRIGGERED RELEASE; PH; NANOPARTICLES; CORE; DOXORUBICIN; LOCATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21002116, 21372251]; ARDITI-Agencia Regional para o Desenvolvimento da Investigacao Tecnologia e Inovacao [M1420-01-0145-FEDER-000005, ARDITI-2017-ISG-003]; FCT-Fundacao para a Ciencia e a Tecnologia (CQM, Portuguese Government funds) [PEst-OE/QUI/UI0674/2019]; project PROEQUI PRAM-Reforco do Investimento em Equipamentos e Infraestruturas Cientificas na RAM [M1420-01-0145-FEDER-000008]; Jinling Institute of Technology [jit-b-201828]. SDS of cas: 56-17-7. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Sun, JJ; Wang, Z; Cao, A; Sheng, RL. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Crosslinked polymer nanomaterials have attracted great attention due to their stability and highly controllable drug delivery; herein, a series of well-defined amphiphilic PDPA-b-P(NMS-co-OEG) diblock terpolymers (P1-P3) were designed and prepared via RAFT polymerization and were self-assembled into non-cross-linked (NCL) nanomicelles, which were further prepared into shell-cross-linked (SCL) micelles via cystamine-based in situ shell cross-linking. Using P3 as an optimized polymer, SCL-P3 micelles were prepared, which demonstrated remarkable pH/redox-dual responsive behaviour. For drug delivery, camptothecin (CPT)-loaded SCL-P3 micelles were prepared and showed much higher CPT-loading capability than their NCL-P3 counterparts. Notably, the SCL-P3 micelles showed good synergistic pH/redox-dual responsive CPT release properties, making them potential smart nanocarriers for drug delivery.

SDS of cas: 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Product Details of 56-17-7. I found the field of Cardiovascular System & Cardiology very interesting. Saw the article Atrial Arrhythmias in Clinically Manifest Cardiac Sarcoidosis: Incidence, Burden, Predictors, and Outcomes published in 2020.0, Reprint Addresses Birnie, D (corresponding author), Univ Ottawa, Heart Inst, Div Cardiol, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Background: Recent data have suggested a substantial incidence of atrial arrhythmias (AAs) in cardiac sarcoidosis (CS). Our study aims were to first assess how often AAs are the presenting feature of previously undiagnosed CS. Second, we used prospective follow-up data from implanted devices to investigate AA incidence, burden, predictors, and response to immunosuppression. Methods and Results: This project is a substudy of the CHASM-CS (Cardiac Sarcoidosis Multicenter Prospective Cohort Study; NCT01477359). Inclusion criteria were presentation with clinically manifest cardiac sarcoidosis, treatment-naive status, and implanted with a device that reported accurate AA burden. Data were collected at each device interrogation visit for all patients and all potential episodes of AA were adjudicated. For each intervisit period, the total AA burden was obtained. A total of 33 patients met the inclusion criteria (aged 56.1 +/- 7.7 years, 45.5% women). Only 1 patient had important AAs as a part of the initial CS presentation. During a median follow-up of 49.1 months, 11 of 33 patients (33.3%) had device-detected AAs, and only 2 (6.1%) had a clinically significant AA burden. Both patients had reduced burden after CS was successfully treated and there was no residual fluorodeoxyglucose uptake on positron emission tomography scan. Conclusions: First, we found that AAs are a rare presenting feature of clinically manifest cardiac sarcoidosis. Second, AAs occurred in a minority of patients at follow-up; the burden was very low in most patients. Only 2 patients had clinically significant AA burden, and both had a reduction after CS was treated. REGISTRATION: URL: https://www.clinicaltrials.gov; unique identifier NCT01477359.

Product Details of 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Weng, W; Wiefels, C; Chakrabarti, S; Nery, PB; Celiker-Guler, E; Healey, JS; Hruczkowski, TW; Quinn, FR; Promislow, S; Medor, MC; Spence, S; Odabashian, R; Alqarawi, W; Juneau, D; de Kemp, R; Leung, E; Beanlands, R; Birnie, D or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Liu, WB; Kang, SM; Xu, XH; Zhou, L; Liu, N; Wu, ZQ in [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Hefei 230009, Anhui, Peoples R China; [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China published Controlled Synthesis of Shell Cross-Linked Helical Poly(phenylborate isocyanide) Nanoparticles with H2O2/Redox Dual Responsiveness and Their Application in Antitumor Drug Delivery in 2020.0, Cited 36.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

To mimic the helical structure and function of biopolymers, shell cross-linked nanoparticle (P4) composed of left-handed helical poly(phenylborate isocyanide) in core and hydrophilic polyisocyanide in shell was prepared. The phenylborate in the core and the disulfide bonds in the cross-linkage render the nanoparticle with excellent dual stimuli-responsiveness to glutathione (GSH) and H2O2. Nevertheless, it has good stability in normal physiological conditions. Because of the helicity and borate pendants of the core, such nanoparticle has high capacity for anticancer drug loading, for example, the loading capacity of doxorubicin (DOX) was up to 68%. Moreover, the DOX-loaded DOX@P4 showed excellent tumor cell penetration potency and fast drug release. More than 78% of murine breast cancer cell (4T1) can be killed within 48 h, supporting this material with great potential in antitumor drug nanocarriers.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Welcome to talk about 56-17-7, If you have any questions, you can contact Liu, WB; Kang, SM; Xu, XH; Zhou, L; Liu, N; Wu, ZQ or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about REDOX-RESPONSIVE MICELLES; MULTIDRUG-RESISTANCE; DELIVERY SYSTEM; CO-DELIVERY; TARGETING DELIVERY; IN-VITRO; PACLITAXEL; NANOPARTICLES; DOCETAXEL, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1704172]; Key Program for Basic Research of Universities in Henan province [19A350231]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M640686]. Category: thiazines. Published in ELSEVIER in AMSTERDAM ,Authors: Hou, L; Tian, CY; Chen, DD; Yuan, YJ; Yan, YS; Huang, QX; Zhang, HJ; Zhang, ZZ. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Multidrug resistance (MDR) is a major reason for anticancer chemotherapy failure, and P-glycoprotein (P-gp) over-expressing on tumor cells is considered as the important target to overcome MDR. Emerging reports have showed that vitamin E (VE) can cause significant reversal of MDR due to inhibition of ATPase activity. Accordingly, we synthesized hyaluronic acid (HA) conjugated vitamin E succinate (VES) polymer, which can self-assemble into micelles and thus achieve high drug (paclitaxel (PTX) used as model drug) encapsulation as well as tumor accumulation owing to the enhanced permeability and retention (EPR) effect and HA active targeting ability. In addition, the linker between HA and VES utilized in this work was disulfide bond with reduction-sensitive property, which would respond to high glutathione (GSH) concentration in tumor cytoplasmic environment and trigger HA-CYS-VES polymer disassociation and drug release. In vitro, PTX loaded HA-CYS-VES demonstrated enhanced cytotoxicity, high apoptosis-inducing activities and reversal effects of PTX on MCF-7/Adr cells, compared to PTX. Also, cellular uptake and intracellular PTX accumulation tests displayed that PTX loaded HA-CYS-VES could more efficiently enter tumor cells and selectively release drug in cytosol so as to facilitate its function on microtubule. More importantly, PTX loaded HA-CYS-VES showed better tumor targeting ability, improved antitumor efficacy and low adverse effects on tumor-bearing mice. In conclusion, PTX loaded HA-CYS-VES exhibited a great potential for reversing MDR in anticancer chemotherapeutics.

Category: thiazines. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. In 2019.0 ANN FAM MED published article about STAR-ASTERISK-D; MENTAL-HEALTH; LARGE-SCALE; DISORDER; EPIDEMIOLOGY; CLINICIAN; QUESTIONNAIRE; VALIDATION; INSTRUMENT; CITALOPRAM in [Jha, Manish K.; Grannemann, Bruce D.; Trombello, Joseph M.; Clark, E. Will; Eidelman, Sara Levinson; Greer, Tracy L.; Trivedi, Madhukar H.] Univ Texas Southwestern Med Ctr Dallas, Ctr Depress Res & Clin Care, 5323 Harry Hines Blvd, Dallas, TX 75390 USA; [Jha, Manish K.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA; [Jha, Manish K.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA; [Rush, A. John] Duke Natl Univ Singapore, Singapore, Singapore; [Rush, A. John] Duke Med Sch, Dept Psychiat, Durham, NC USA; [Rush, A. John] Texas Tech Univ, Hlth Sci Ctr, Permian Basin, TX USA in 2019.0, Cited 43.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

PURPOSE This report describes outcomes of an ongoing quality-improvement project (VitalSign6) in a large US metropolitan area to improve recognition, treatment, and outcomes of depressed patients in 16 primary care clinics (6 charity clinics, 6 federally qualified health care centers, 2 private clinics serving low-income populations, and 2 private clinics serving patients with either Medicare or private insurance). METHODS Inclusion in this retrospective analysis was restricted to the first 25,000 patients (aged >= 12 years) screened with the 2-item Patient Health Questionnaire (PHQ-2) in the aforementioned quality-improvement project. Further evaluations with self-reports and clinician assessments were recorded for those with positive screen (PHQ-2 >2). Data collected from August 2014 though November 2016 were available at 3 levels: (1) initial PHQ-2 (n = 25,000), (2) positive screen (n = 4,325), and (3) clinician-diagnosed depressive disorder with 18 or more weeks of enrollment (n = 2,160). RESULTS Overall, 17.3% (4,325/25,000) of patients screened positive for depression. Of positive screens, 56.1% (2,426/4,325) had clinician-diagnosed depressive disorder. Of those enrolled for 18 or more weeks, 64.8% were started on measurement-based pharmacotherapy and 8.9% referred externally. Of the 1,400 patients started on pharmacotherapy, 45.5%, 30.2%, 12.6%, and 11.6% had 0, 1, 2, and 3 or more follow-up visits, respectively. Remission rates were 20.3% (86/423), 31.6% (56/177), and 41.7% (68/163) for those with 1, 2, and 3 or more follow-up visits, respectively. Baseline characteristics associated with higher attrition were: non-white, positive drug-abuse screen, lower depression/anxiety symptom severity, and younger age. CONCLUSION Although remission rates are high in those with 3 or more followup visits after routine screening and treatment of depression, attrition from care is a significant issue adversely affecting outcomes.

Recommanded Product: 56-17-7. Welcome to talk about 56-17-7, If you have any questions, you can contact Jha, MK; Grannemann, BD; Trombello, JM; Clark, EW; Eidelman, SL; Lawson, T; Greer, TL; Rush, AJ; Trivedi, MH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a beta-Cyclodextrin-PEG Copolymer Based Delivery Platform published in 2019.0. Recommanded Product: 56-17-7, Reprint Addresses Metcalf, CA (corresponding author), Novartis Inst BioMed Res Inc, 181 Massachusetts Ave, Cambridge, MA 02139 USA.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Novel nanoparticle drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drug discovery studies. The NDCs utilized structurally varied linkers that attached the drug payloads to a beta-cyclodextrin-PEG copolymer to form self-assembled nanoparticles. In vitro release studies revealed a diversity of release rates driven by linker structure activity relationships (SARs). Improved in vivo pharmacokinetics (PK) for the cabazitaxel (CBTX) NDCs with glycinate-containing (1c) and hexanoate-containing linkers (2c) were demonstrated, along with high and sustained tumor levels (>168 h of released drug in tumor tissues). This led to potent efficacy and survival in both taxane- and docetaxel-resistant in vivo anticancer mouse efficacy models. Overall, the CBTX-hexanoate NDC 2c (CRLX522), demonstrated optimal and improved in vivo PK (plasma and tumor) and efficacy profile versus those of the parent drug, and the results support the potential therapeutic use of CRLX522 as a new anticancer agent.

Welcome to talk about 56-17-7, If you have any questions, you can contact Metcalf, CA; Svenson, S; Hwang, J; Tripathi, S; Gangal, G; Kabir, S; Lazarus, D; Cole, R; Sweryda-Krawiec, B; Shum, P; Brown, D; Case, RI; van der Poll, D; Rohde, E; Harlfinger, S; Teng, CH; Eliasof, S or send Email.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. I found the field of Chemistry; Polymer Science very interesting. Saw the article Novel dual responsive alginate-based magnetic nanogels for onco-theranostics published in 2019.0, Reprint Addresses Peng, N; Liu, Y (corresponding author), Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Coal Convers & New Carbon Mat Hubei Prov, Wuhan 430081, Hubei, Peoples R China.; Liu, Y (corresponding author), Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

The aim of this work was to obtain a novel onco-theranostic system for early diagnosis and improved chemotherapeutic outcome. Hybrid nanogels with magnetic and dual responsive properties were fabricated by covalently attaching superparamagnetic iron oxide nanoparticles (SPIONs) with a disulfide-modified alginate derivative, while simultaneously encapsulating the anticancer drug doxorubicin. The resulting nanogels exhibited magnetic-targeted characteristics, high drug loading content, co-triggered release behavior, high toxicity to tumor cells, low side effects to normal cells, and magnetic resonance imaging (MRI) functions. These findings proved that the hybrid nanogels have great potential as novel tumor-targeting nano-theranostic agents for simultaneous MRI imaging and efficient anti-tumor treatment.

Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Peng, N; Ding, X; Wang, ZY; Cheng, Y; Gong, ZW; Xu, XJ; Gao, XF; Cai, Q; Huang, SW; Liu, Y or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

COA of Formula: C4H14Cl2N2S2. I found the field of Materials Science very interesting. Saw the article Fluorinated Redox-Responsive Poly(amidoamine) as a Vaccine Delivery System for Antitumor Immunotherapy published in 2019.0, Reprint Addresses Liu, ZH (corresponding author), Jinan Univ, Key Lab Biomat, Guangdong Higher Educ Inst, Dept Biomed Engn, West Huangpu Rd 601, Guangzhou 510632, Guangdong, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

COA of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Yuan, HY; Yang, Y; Xue, W; Liu, ZH or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article NIR-II Dual-Modal Optical Coherence Tomography and Photoacoustic Imaging-Guided Dose-Control Cancer Chemotherapy WOS:000535175700026 published article about DRUG-DELIVERY SYSTEMS; ANTICANCER DRUGS; LIPID NANOCAPSULES; SORAFENIB; CELL; NANOPARTICLES; MICELLES; INHIBITOR; MODELS in [Liu, Yubin; Xu, Mengze; Dai, Yunlu; Zhao, Qi; Zhu, Lipeng; Guan, Xiaowen; Li, Gang; Yuan, Zhen] Univ Macau, Fac Hlth Sci, Canc Ctr, Taipa 999078, Macao, Peoples R China; [Yuan, Zhen] Univ Macau, Ctr Cognit & Brain Sci, Taipa 999078, Macao, Peoples R China; [Liu, Yubin] Fujian Normal Univ, Coll Photon & Elect Engn, Fuzhou 350007, Peoples R China; [Yang, Sihua] South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Peoples R China; [Yang, Sihua] South China Normal Univ, Coll Biophoton, Inst Laser Life Sci, Guangzhou 510631, Peoples R China in 2020.0, Cited 42.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. HPLC of Formula: C4H14Cl2N2S2

In this study, an organic nanodrug delivery platform was constructed as a biocompatible cancer chemotherapeutic system, in which clinically approved sorafenib was loaded in the redox-responsive polymeric micelles, enabling dose-control release of drug to cancer tissues. In addition, visualizing tumor microenvironment changes is also essential for cancer chemotherapy, which can provide a priori and feedback control of drug delivery with reduced side effects. Therefore, second near-infrared window (NIR-II) dual-modal optical coherence tomography (OCT) and photoacoustic imaging were performed for real-time visualization of the tumor microenvironment changes in vivo during chemotherapy. In particular, the tumor angiogenesis, the vascular networks density change, and the quantitative total hemoglobin concentration and oxygen saturation of cancer tissues were carefully characterized for individually optimized cancer chemotherapy. It was discovered that the final tumor growth inhibition by dual-modal imaging-guided dose-control chemotherapy can be up to 94.6% during a 30-day treatment, which is much higher than the efficacy from presently utilized tumor treatment options. Herein, the combination of a redox-responsive theranostic agent and NIR-II dual-modal OCT and photoacoustic imaging paved a novel avenue both for guiding dosage control of antiangiogenic drugs to avoid toxic effects and for monitoring and inspecting tumor microenvironment changes while substantially enhancing tumor penetration and antitumor efficacy.

HPLC of Formula: C4H14Cl2N2S2. Welcome to talk about 56-17-7, If you have any questions, you can contact Liu, YB; Xu, MZ; Dai, YL; Zhao, Q; Zhu, LP; Guan, XW; Li, G; Yang, SH; Yuan, Z or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem