Day: November 9, 2021

I found the field of Polymer Science very interesting. Saw the article Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin published in 2019.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Li, JB (corresponding author), Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, 263 Kaiyuan Rd, Luoyang 471023, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-epsilon-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to delivery doxorubicin (DOX) into tumor cells. PCBMA-SS-PCL-SS-PCBMA was obtained by following steps: i) introducing disulfide bonds through end-group modification of PCL diol with cystamine dihydrochloride; ii) preparing PCL-RAFT macromolecular chain transfer agent by EDC/NHS chemistry; iii) RAFT polymerization of zwitterionic monomer. Self-assembling from PCBMA-SS-PCL-SS-PCBMA, polymeric micelles had many advantages, such as ultra-low protein absorption in serum and obvious reduction-responsiveness in the presence of DTT. Furthermore, DOX-loaded micelles exhibited high stability upon centrifugation and lyophilization, a fast intracellular drug release and enhanced drug efficacy due to GSH-triggered PCBMA shell shedding and micellar reassembling. Thus, the polymeric micelles integrated several functions and properties could be prospectively utilized as valuable nanocarriers in cancer chemotherapeutics.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Li, SZ; Pei, MJ; Wan, TT; Yang, HJ; Gu, SJ; Tao, YZ; Liu, X; Zhou, YS; Xu, WL; Xiao, P in [Li, Shangzhi; Pei, Minjie; Wan, Tingting; Yang, Hongjun; Gu, Shaojin; Tao, Yongzhen; Liu, Xin; Zhou, Yingshan] Wuhan Text Univ, Coll Mat Sci & Engn, Wuhan 430073, Peoples R China; [Zhou, Yingshan; Xu, Weilin] Wuhan Text Univ, Key Lab Green Proc & Funct Text New Text Mat, Minist Educ, Wuhan 430073, Peoples R China; [Xiao, Pu] Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia published Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials in 2020.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Natural hydrogels are widely investigated for biomedical applications because of their structures similar to extracellular matrix of native tissues, possessing excellent biocompatibility and biodegradability. However, they are often susceptible to mechanical disruption. In this study, self-healing hyaluronic acid (HA) hydrogels are fabricated through a facile dynamic covalent Schiff base reaction. Dialdehyde-modified HA (AHA) precursor was synthesized, and then the AHA/cystamine dihydrochloride (AHA/Cys) hydrogels were formed by blending AHA and Cys at acidic pH levels. By varying Cys to AHA ratio, the hydrogel morphology, swelling and kinetics of gelation could be controlled. Gelation occurred fast, which was predominantly attributed to Schiff base reaction between the dialdehyde groups on AHA and amimo groups on Cys. The hydrogel exhibited improved mechanical properties with increase in Cys content. Furthermore, due to dynamic imine bonds, this hydrogel demonstrated excellent self-healing ability based on the stress after mechanical disruption. Also, it was found to be pH-responsive and injectable. Taken together, this kind of hyaluronic acid hydrogel can provide promising future for various biomedical applications in drug delivery, bioprinting, smart robots and tissue regeneration.

Welcome to talk about 56-17-7, If you have any questions, you can contact Li, SZ; Pei, MJ; Wan, TT; Yang, HJ; Gu, SJ; Tao, YZ; Liu, X; Zhou, YS; Xu, WL; Xiao, P or send Email.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 CARBOHYD POLYM published article about POTENTIAL APPLICATION; ACYLHYDRAZONE; PROPERTY; ADHESIVE in [Li, Shangzhi; Pei, Minjie; Wan, Tingting; Yang, Hongjun; Gu, Shaojin; Tao, Yongzhen; Liu, Xin; Zhou, Yingshan] Wuhan Text Univ, Coll Mat Sci & Engn, Wuhan 430073, Peoples R China; [Zhou, Yingshan; Xu, Weilin] Wuhan Text Univ, Key Lab Green Proc & Funct Text New Text Mat, Minist Educ, Wuhan 430073, Peoples R China; [Xiao, Pu] Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia in 2020.0, Cited 47.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Natural hydrogels are widely investigated for biomedical applications because of their structures similar to extracellular matrix of native tissues, possessing excellent biocompatibility and biodegradability. However, they are often susceptible to mechanical disruption. In this study, self-healing hyaluronic acid (HA) hydrogels are fabricated through a facile dynamic covalent Schiff base reaction. Dialdehyde-modified HA (AHA) precursor was synthesized, and then the AHA/cystamine dihydrochloride (AHA/Cys) hydrogels were formed by blending AHA and Cys at acidic pH levels. By varying Cys to AHA ratio, the hydrogel morphology, swelling and kinetics of gelation could be controlled. Gelation occurred fast, which was predominantly attributed to Schiff base reaction between the dialdehyde groups on AHA and amimo groups on Cys. The hydrogel exhibited improved mechanical properties with increase in Cys content. Furthermore, due to dynamic imine bonds, this hydrogel demonstrated excellent self-healing ability based on the stress after mechanical disruption. Also, it was found to be pH-responsive and injectable. Taken together, this kind of hyaluronic acid hydrogel can provide promising future for various biomedical applications in drug delivery, bioprinting, smart robots and tissue regeneration.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article One step synthesis of monodisperse thiol-ene clickable polymer microspheres and application on biological functionalization WOS:000456751000004 published article about BLOCK-COPOLYMER NANOASSEMBLIES; RAFT DISPERSION POLYMERIZATION; NANOPARTICLES; MORPHOLOGY; PROTEINS; DELIVERY; UNIFORM; STYRENE; ACID; DRUG in [Huang, Yongping; Yuan, Jiayu; Tang, Jianhua; Yang, Jianwen; Zeng, Zhaohua] Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China; [Yang, Jianwen; Zeng, Zhaohua] Sun Yat Sen Univ, Minist Educ, Key Lab Polymer Composite & Funct Mat, Guangzhou 510275, Guangdong, Peoples R China in 2019.0, Cited 53.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Introducing clickable groups onto polymer microspheres allows the microspheres to be facilely functionalized via a click reaction. In this report, we have synthesized monodisperse PMMA microspheres with clickable double bonds on the surface by one-step RAFT-assisted dispersion photopolymerization using a cyclohexyl-containing macro-RAFT agent as a stabilizer. This macro-RAFT agent, named P(THPAA-b-AA)-TTC, was synthesized by RAFT-mediated block copolymerization of a cyclohexyl-containing monomer (THPAA, obtained by esterification of cis-1,2,3,6-tetrahydrophthalic with 2-hydroxyethyl acrylate) and acrylic acid. The obtained microspheres were analyzed by H-1 NMR and Iodometric method, indicating that the content of carbon double bonds on the microspheres increased with increasing the amount of P(THPAA-b-AA)-TTC in the polymerization feed. We then used a thiolated biotin to perform the photo-click reaction with the cyclohexene double bond on the micro spheres, thereby attaching the biotin unit onto the microspheres. The biotinylated PMMA microspheres were found to be able to effectively immobilize fluorescein isothiocyanate streptavidin (FITC-SAv) via the specific adsorption of biotin to streptavidin, and thus exhibited clear fluorescence under confocal microscope. This study provides a convenient and feasible way to prepare surface-functionalized microspheres, which has great potential in biological applications as well as other fields.

Welcome to talk about 56-17-7, If you have any questions, you can contact Huang, YP; Yuan, JY; Tang, JH; Yang, JW; Zeng, ZH or send Email.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. In 2021.0 CHEM ENG J published article about PI INTERACTIONS; FLOW-CONTROL; TRANSPORT; MEMBRANES; HYDROGELS; DRIVEN; FIELD in [Li, Yicheng; Du, Mengqi; Yang, Li; Bao, Yunjia; Xu, Yewei; Chang, Guanjun] Southwest Univ Sci & Technol, State Key Lab Environm Friendly Energy Mat, Mianyang 621010, Sichuan, Peoples R China; [Li, Yicheng; Du, Mengqi; Yang, Li; Bao, Yunjia; Xu, Yewei; Chang, Guanjun] Southwest Univ Sci & Technol, Sch Mat Sci & Engn, Mianyang 621010, Sichuan, Peoples R China; [Li, Yicheng; Yin, Qiang] China Acad Engn Phys, Res Ctr Laser Fus, Mianyang 621900, Sichuan, Peoples R China; [Yang, Li; Chang, Guanjun] Univ Penn, Dept Chem & Biomol Engn, Philadelphia, PA 19104 USA; [Lan, Yang] UCL, Dept Chem Engn, Torrington Pl, London WC1E 7JE, England in 2021.0, Cited 55.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Biomimetic actuators have seemingly infinite potential for use in previously unexplored areas. However, large stresses and a rapid water response are difficult to realize in soft actuators, owing to which their practical applicability is currently limited. In this paper, a new method for designing and fabricating humidity-responsive sturdy hard actuator. By combining a rigid matrix and hydrophilic water domains consisting of dynamic interlocking cation-? blocks, high-performance polymer actuator was synthesized that swell rapidly in response to a water gradient in their environment, resulting in unprecedentedly large stresses. More critically, the strong interlocking cation-? blocks reform and the intermolecular distance is reduced when the water is removed, allowing the deformed actuator to revert its original shape. The proposed design principle can potentially be extended to produce different types of sturdy actuators with rapid water responsiveness.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Category: thiazines. Authors Yang, X; Cheng, Q; Monnier, V; Charles, L; Karoui, H; Ouari, O; Gigmes, D; Wang, RB; Kermagoret, A; Bardelang, D in WILEY-V C H VERLAG GMBH published article about in [Yang, Xue; Charles, Laurence; Karoui, Hakim; Ouari, Olivier; Gigmes, Didier; Kermagoret, Anthony; Bardelang, David] Aix Marseille Univ, CNRS, ICR, Marseille, France; [Cheng, Qian; Wang, Ruibing] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macau, Peoples R China; [Monnier, Valerie] Aix Marseille Univ, CNRS, Cent Marseille, FSCM,Spectropole, Marseille, France in 2021.0, Cited 87.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Molecular machines are ubiquitous in nature and function away from equilibrium by consuming fuels to produce appropriate work. Chemists have recently excelled at mimicking the fantastic job performed by natural molecular machines with synthetic systems soluble in organic solvents. In efforts toward analogous systems working in water, we show that guest molecules can be exchanged in the synthetic macrocycle cucurbit[7]uril by involving kinetic traps, and in such a way as modulating energy wells and kinetic barriers using pH, light, and redox stimuli. Ditolyl-viologen can also be exchanged using the best kinetic trap and interfaced with alginate, thus affording pH-responsive blue, fluorescent hydrogels. With tunable rate and binding constants toward relevant guests, cucurbiturils may become excellent ring molecules for the construction of advanced molecular machines working in water.

Category: thiazines. Welcome to talk about 56-17-7, If you have any questions, you can contact Yang, X; Cheng, Q; Monnier, V; Charles, L; Karoui, H; Ouari, O; Gigmes, D; Wang, RB; Kermagoret, A; Bardelang, D or send Email.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about POLYMERIC MICELLES; INTRACELLULAR DELIVERY; MULTIDRUG-RESISTANCE; BLOCK-COPOLYMERS; BREAST-CANCER; DRUG; CORE; PLGA; RELEASE; NANOCARRIERS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81860631]; Scientific Research Fund of Jiangxi Provincial Health Commission [20195633, 20195632]; Innovative Scientific Research Foundation of Jiujiang University [2013KJ13]. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Wang, XF; Ren, J; He, HQ; Liang, L; Xie, X; Li, ZX; Zhao, JG; Yu, JM. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. HPLC of Formula: C4H14Cl2N2S2

In this study, reduction-sensitive self-assembled polymer nanoparticles based on poly (lactic-co-glycolic acid) (PLGA) and chondroitin sulfate A (CSA) were developed and characterized. PLGA was conjugated with CSA via a disulfide linkage (PLGA-ss-CSA). The critical micelle concentration (CMC) of PLGA-ss-CSA conjugate is 3.5 mu g/mL. The anticancer drug doxorubicin (DOX) was chosen as a model drug, and was effectively encapsulated into the nanoparticles (PLGA-ss-CSA/DOX) with high loading efficiency of 15.1%. The cumulative release of DOX from reduction-sensitive nanoparticles was only 34.8% over 96h in phosphate buffered saline (PBS, pH 7.4). However, in the presence of 20mM glutathione-containing PBS environment, DOX release was notably accelerated and almost complete from the reduction-sensitive nanoparticles up to 96h. Moreover, efficient intracellular DOX release of PLGA-ss-CSA/DOX nanoparticles was confirmed by CLSM assay in A549 cells. In vitro cytotoxicity study showed that the half inhibitory concentrations of PLGA-ss-CSA/DOX nanoparticles and free DOX against A549 cells were 1.141 and 1.825 mu g/mL, respectively. Therefore, PLGA-ss-CSA/DOX nanoparticles enhanced the cytotoxicity of DOX in vitro. These results suggested that PLGA-ss-CSA nanoparticles could be a promising carrier for drug delivery.

HPLC of Formula: C4H14Cl2N2S2. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about END GROUP REMOVAL; DENDRITIC CELLS; DELIVERY-SYSTEMS; OVALBUMIN; NANOGELS; ANTIGENS; SIZE; PH; IMMUNOGENICITY; IMMUNOTHERAPY, Saw an article supported by the China Scholarship Council (CSC)China Scholarship Council. Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Lou, B; De Beuckelaer, A; Boonstra, E; Li, DD; De Geest, BG; De Koker, S; Mastrobattista, E; Hennink, WE. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Category: thiazines

Recent advances in the development of protein-based vaccines have expanded the opportunities for preventing and treating both infectious diseases as well as cancer. However, the development of readily and efficient antigen delivery systems capable of stimulating strong cytotoxic T-lymphocyte (CTL) responses remains a challenge. With the attempt to closely mimic the properties of viruses in terms of their size and molecular organization, we constructed RNA (which is a ligand for Toll-like receptor 7 (TLR7) and TLR8) and antigen-loaded nanoparticles resembling the structural organization of viruses. Cationic polymers containing either azide or bicyclo[6.1.0]nonyne (BCN) groups were synthesized as electrostatic glue that binds negatively charged single stranded RNA (PolyU) to form a self-crosslinked polyplex core. An azide-modified model antigen (ovalbumin, OVA) and a BCN-modified mannosylated or galactosylated polymer were sequentially conjugated to the RNA core via disulfide bonds using copper free click chemistry to form the shell of the polyplexes. The generated reducible virus mimicking particles (VMPs) with a diameter of 200 nm and negatively surface charge (-14 mV) were colloidally stable in physiological conditions. The immunogenicity of these VMP vaccines was evaluated both in vitro and in vivo. The surface mannosylated VMPs (VMP-Man) showed 5 times higher cellular uptake by bone marrow derived DCs (BMDCs) compared to galactosylated VMP (VMP-Gal) counterpart. Moreover, VMP-Man efficiently activated DCs and greatly facilitated MHC I Ag presentation in vitro. Vaccination of mice with VMP-Man elicited strong OVA-specific CTL responses as well as humoral immune responses. These results demonstrate that the modular core-shell polymeric nanoparticles described in this paper are superior in inducing strong and durable immune responses compared to adjuvanted protein subunit vaccines and offer therefore a flexible platform for personalized vaccines.

Welcome to talk about 56-17-7, If you have any questions, you can contact Lou, B; De Beuckelaer, A; Boonstra, E; Li, DD; De Geest, BG; De Koker, S; Mastrobattista, E; Hennink, WE or send Email.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Product Details of 56-17-7. Dai, YX; Yue, N; Liu, CX; Cai, XG; Su, X; Bi, XZ; Li, QF; Li, CY; Huang, WL; Qian, H in [Dai, Yuxuan; Yue, Na; Liu, Chunxia; Cai, Xingguang; Su, Xin; Bi, Xinzhou; Li, Qifei; Li, Chengye; Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Huang, Wenlong; Qian, Hai] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China published Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates in 2019.0, Cited 36.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Lytic peptides have been demonstrated to exhibit obvious advantages in cancer therapy with binding ability toward tumor cells via electrostatic attractions, which are lack of active targeting and aggregation to tumor tissue. In the present study, five conjugated lytic peptides were redesigned and constructed to target gonadotropin releasing hormone receptors (GnRHr), meanwhile, the disulfide bridge was introduced to achieve redox sensitive delivery based on the experience from the preliminary work of lytic peptides P3 and P7. YX-1, was considered to be the most promising for in-depth study. YX-1 possessed high potency (IC50 = 3.16 +/- 0.3 mu M), low hemolytic effect, and cell membrane permeability in human A2780 ovarian cancer cells. Moreover, YX-1 had prominent pro-apoptotic activity by activating the mitochondria-cytochrome c-caspase apoptotic pathway. The study yielded the conjugate YX-1 with superior properties for antineoplastic activity, which makes it a promising potential candidate for targeting cancer therapy.

Product Details of 56-17-7. Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Zhang, XQ; Ren, XM; Tang, JY; Wang, JT; Zhang, X; He, P; Yao, C; Bian, WH; Sun, LZ in TAYLOR & FRANCIS LTD published article about LOADING CAPACITY; DRUG; DOXORUBICIN; APATINIB; NANOMEDICINE; THERAPEUTICS; CONJUGATE in [Zhang, Xiaoqing; Ren, Xiaomei; Tang, Jiayin; Wang, Jiangtao; He, Peng; Yao, Chang; Bian, Weihe] Nanjing Univ Chinese Med, Jiangsu Prov Hosp TCM, Dept Mastopathy, Affiliated Hosp, Nanjing, Peoples R China; [Zhang, Xiang; Sun, Lizhu] Xuzhou Med Univ, Affiliated Shuyang Hosp, Dept Oncol, Suqian, Peoples R China in 2020.0, Cited 42.0. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid-g-cystamine dihydrochloride-poly-epsilon-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 receptors, leading to selective accumulation at the tumor site and uptake by MCF-7/ADR cells. Under high concentrations of cellular glutathione (GSH), the nanocarrier was degraded rapidly with complete release of its encapsulated drugs. Released APA effectively inhibited the function of the P-glycoprotein (P-gp) drug pump and improved the sensitivity of MDR cells to chemotherapeutic agents, leading to the recovery of PTX chemosensitivity in MDR cells. As expected, this newly developed intelligent drug delivery system could effectively control MDR, both in vitro and in vivo.

Bye, fridends, I hope you can learn more about C4H14Cl2N2S2, If you have any questions, you can browse other blog as well. See you lster.. Name: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem