Authors Li, XF; Zhang, W; Lin, J; Wu, H; Yao, YC; Zhang, JY; Yang, CR in ROYAL SOC CHEMISTRY published article about in [Li, Xiaofang; Zhang, Wen; Lin, Jing; Wu, Hao; Yao, Yucen; Zhang, Jiayi; Yang, Chunrong] Jiamusi Univ, Coll Pharm, 258 Xuefu St, Jiamusi 154007, Heilongjiang, Peoples R China in 2021.0, Cited 42.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7
The application of combination immune-chemotherapy makes up for the limitation of monotherapy and achieves superior antitumor activity against cancer. However, combinational therapy is always restricted by poor tumor targeted drug delivery efficacy. Herein, novel T cell membrane cloaking tumor microenvi-ronment-responsive nanoparticles (PBA modified T cell membrane cloaking hyaluronic acid (HA)-disulfide bond-vitamin E succinate/curcumin, shortened as RCM@T) were developed. T cell membrane cloaking not only serves as a protection shell for sufficient drug delivery but also acts as a programmed cell death-1(PD-1) antibody to selectively bind the PD-Li of tumor cells. When RCM@T is intravenously administrated into the blood stream, it accumulates at tumor sites and responds to an acidic pH to achieve a ‘membrane escape effect and expose the HA residues of RCM for tumor targeted drug delivery. RCM accumulates in the cytoplasm via CD44 receptor mediated endocytosis and intracellularly releases antitumor drug in the intracellular redox microenvironment for tumor chemotherapy. T cell membrane debris targets the PD-Llof tumor cells for tumor immunotherapy, which not only directly kills tumor cells, but also improves the CD8(+) T cell level and facilitates effector cytokine release. Taken together, the as-constructed RCM@T creates a new way for the rational design of a drug delivery system via the combination of stimuli-responsive drug release, chemotherapeutical agent delivery and cell membrane based immune checkpoint blockade immunotherapy.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem