Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Recently I am researching about TUMOR MICROENVIRONMENT; FLUORESCENT-PROBE; NANOPARTICLES; ACTIVATION; SOFT, Saw an article supported by the National Funds for Distinguished Young Scientists [51725202]; Key Project of Shanghai Science and Technology CommissionScience & Technology Commission of Shanghai Municipality (STCSM) [19JC1412000]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51872094, 81974274]; National Science Foundation for the Young Scientists of China [51702211, 21805090]; National Key R&D Program of China [2018YFA0107900]; Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride
Glutathione (GSH) plays a vital role in maintaining biological redox homeostasis. Accordingly, accurate imaging of glutathione in vivo is of great significance. Herein, we propose a magnetic resonance energy transfer (MRET) strategy based on a distance-dependent magnetic exchange coupling effect (MECE), which can realize GSH detection within tumors in vivo by susceptibility weighted imaging (SWI). Fe3O4 nanoparticles (NPs) and CoFe2O4 NPs linked with cystamine (Fe3O4-S-S-CoFe2O4) have been successfully designed as SWI nanoprobes. After the disulfide bonds are broken by excess GSH in the tumor, the increase in the distance between Fe3O4 NPs and CoFe2O4 NPs will induce a decrease of MECE and magnetic susceptibility. As a result, the changes in the SWI signals are used for tumor GSH detection in vivo. Experimental results in vitro and in vivo demonstrate that the Fe3O4-S-S-CoFe2O4 SWI nanoprobe can sensitively detect concentrations of GSH in tumors. Hence, this strategy not only improves the sensitivity of the GSH response in SWI but also provides a powerful basis for the design of other responsive functional MRI nanoprobes.
About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB or concate me.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem