Extended knowledge of C4H14Cl2N2S2

Category: thiazines. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX or concate me.

An article Hybrid spherical nucleotide nanoparticles can enhance the synergistic anti-tumor effect of CTLA-4 and PD-1 blockades WOS:000562594200007 published article about CD8 T-CELLS; REGULATORY T; MECHANISMS; ANTI-CTLA-4; INHIBITION; EXPRESSION; RESPONSES in [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Peking Union Med Coll, Tianjin Key Lab Biomat, Inst Biomed Engn, Tianjin 300192, Peoples R China; [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Chinese Acad Med Sci, Tianjin 300192, Peoples R China; [Han, Yanfeng] Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia; [Xu, Haiyan] Chinese Acad Med Sci, Inst Bas Sci, Sch Basic Med, Peking Union Med Coll, Beijing 100005, Peoples R China; [Kong, Deling] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China in 2020.0, Cited 25.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Category: thiazines

Combined blockades of CTLA-4 and PD-1 can yield better overall complementary clinical outcomes than individual blockades, but the response rates are still relatively low. To investigate the anti-tumor effects of various combined strategies, we designed various spherical nucleotide nanoparticles (SNPs) loaded with CTLA-4 aptamer (cSNPs), PD-1 siRNA (pSNPs) or both (hybrid SNPs, or hSNPs). The results demonstrated that hSNPs could promote significantly stronger anti-tumor immune responses in a nonredundant fashion than the mixture of pSNPs and cSNPs (pSNPs & cSNPs). We reasoned that this is because all individual immune cells could receive both CTLA-4 and PD-1 blockades when they engulfed hSNPs, but it is much less likely that individual immune cells could receive both CTLA-4 and PD-1 blockades as many of them may not take both pSNPs and cSNPS from pSNPs & cSNPs. Further results revealed that the synergistic immune stimulatory effects of CTLA-4 and PD-1 blockades in the form of hSNPs were at least partly through regulating the immune suppressive function of both Tregs and TIM3(+)exhausted-like CD8 T cells and allowing effector T cells to expand. This mechanism is not identical to earlier reported mechanisms of CTLA-4 and PD-1 blockades.

Category: thiazines. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem