Month: October 2021

Category: thiazines. Li, Y; Zhou, LH; Zhu, BD; Xiang, JJ; Du, J; He, MW; Fan, XX; Zhang, PF; Zeng, RS; Gong, P in [Li, Ying; Zeng, Ruosheng] Guilin Univ Elect Technol, Sch Mat Sci & Engn, Sch Life & Environm Sci, Guilin 541004, Peoples R China; [Li, Ying; Zhou, Lihua; Xiang, Jingjing; Zhang, Pengfei; Gong, Ping] Chinese Acad Sci, Guangdong Key Lab Nanomed,Shenzhen Inst Adv Techn, Shenzhen Engn Lab Nanomed & Nanoformulat,Inst Bio, CAS Key Lab Hlth Informat,CAS HK Joint Lab Biomat, Shenzhen 518055, Peoples R China; [Zhou, Lihua; He, Manwen] Shenzhen Inst Technol, Sch Appl Biol, 1 Jiangjunmao, Shenzhen 518116, Peoples R China; [Zhu, Baode] Xiangnan Univ, Coll Chem Biol & Environm Engn, Chenzhou 423043, Peoples R China; [Du, Jian] Shandong First Med Univ, Dept Urol, Affiliated Hosp 1, 16766 Jingshi Rd, Jinan 250000, Peoples R China; [Fan, Xingxing] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau, Peoples R China; [Zeng, Ruosheng] Guangxi Univ, Sch Phys Sci & Technol, Nanning 530004, Peoples R China published A glutathione-activated carrier-free nanodrug of triptolide as a trackable drug delivery system for monitoring and improving tumor therapy in 2021.0, Cited 50.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Triptolide (TP) is one of the most common systemic treatments for inflammatory and immune diseases in China for centuries. However, TP exhibits some disadvantages, such as poor solubility in water, poor bioavailability, liver toxicity, renal toxicity, and other side effects. In order to reduce the adverse effects of TP, researchers have developed numerous strategies to address the adverse properties of triptolide. Nano-carrier-based triptolide delivery systems represent an emerging technology and are one of the strategies of nanomedicine that combines diagnostic and therapeutic applications in a single agent. In this approach, we developed a glutathione-activated carrier-free nanodrug of triptolide (CyssTPN) as a trackable drug delivery system. In this system, CyssTP self-assemble to form a carrier-free nanodrug, which possesses a monodisperse spherical morphology with hydrodynamic average sizes of about 50 nm. In addition, CyssTPN had good stability under different physiological conditions (pH, high salt, etc.). Apart from cellular imaging and cell uptake, CyssTPN can be tracked by the activation of TP ability in real-time and applied for cancer cell treatment efficiently. The result showed that CyssTPN could improve solubility, reduce the side effects, and increase the bioavailability of triptolide. It could also track triptolide activation timely and tumor therapy successfully.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Li, Y; Zhou, LH; Zhu, BD; Xiang, JJ; Du, J; He, MW; Fan, XX; Zhang, PF; Zeng, RS; Gong, P or concate me.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. In 2019.0 CHEM COMMUN published article about BONDS; FILMS in [Lee, Jong Pil; Hwang, Hyemin; Chae, Songa; Kim, Jong-Man] Hanyang Univ, Dept Chem Engn, Seoul 04763, South Korea; [Kim, Jong-Man] Hanyang Univ, Inst Nano Sci & Technol, Seoul 04763, South Korea in 2019.0, Cited 35.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A reversibly mechanochromic conjugated polymer has been developed. The polymer, polydiacetylene (PDA), obtained by thermal polymerization of a diphenyldisulfide-containing bisdiacetylene undergoes a blue-to-green color change upon grinding. The original blue color of the PDA is regenerated via a metastable red-color state by utilizing a thermochromic (heating-cooling) process.

SDS of cas: 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Lee, JP; Hwang, H; Chae, S; Kim, JM or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Computed Properties of C4H14Cl2N2S2. In 2019.0 COMPOS PART A-APPL S published article about CROSS-LINKING; INTERFACE; VULCANIZATION; NANOCOMPOSITES; REINFORCEMENT; FABRICATION; NANOSHEETS; HYBRIDS; ROBUST; MODEL in [Wang, Jian; Fei, Guoxia; Pan, Yunqi; Zhang, Kaiye; Hao, Shuai; Zheng, Zhuo; Xia, Hesheng] Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China in 2019.0, Cited 59.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The simultaneous reduction and functionalization of graphene oxide (GO) was achieved through a chemical grafting reaction with cystamine dihydrochloride (CDHC), a novel functional agent with dynamic disulfide bond. CDHC-reduced GO (CGO) can be uniformly and stably dispersed in the aqueous phase. Furthermore, CGO reinforced styrene-butadiene rubber (SBR) composites with highly filled silica content were prepared by a latex mixing and coagulation process. TEM confirmed both CGO and silica can be uniformly dispersed in the rubber matrix. The dynamic disulfide bonds of the grafted CDHC in the CGO can participate in the subsequent vulcanization of SBR rubber through disulfide exchange reactions, thereby forming a tight interaction between GO and rubber. Compared with normally reduced GO system, the mechanical and thermal properties of CGOcontaining rubber nanocomposites were significantly improved. The results show that CGO is effective to reinforce rubber composites, which has the potential to be used for tire rubber materials.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, J; Fei, GX; Pan, YQ; Zhang, KY; Hao, S; Zheng, Z; Xia, HS or concate me.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Oxygenated theranostic nanoplatforms with intracellular agglomeration behavior for improving the treatment efficacy of hypoxic tumors WOS:000459363800012 published article about ALBUMIN-MNO2 NANOPARTICLES; FE3O4 NANOPARTICLES; HIGHLY EFFICIENT; IN-SITU; DELIVERY; CELL; THERAPY; RESISTANCE; ENHANCE; MICROENVIRONMENT in [Zhou, Jun; Xue, Chencheng; Li, Menghuan; Luo, Zhong] Chongqing Univ, Sch Life Sci, Chongqing 400044, Peoples R China; [Hu, Yan; Chen, Qiufang; Li, Yanan; Li, Ke; Song, Guanbin; Cai, Kaiyong] Chongqing Univ, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China; [Hou, Yanhua] Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Chongqing 401331, Peoples R China in 2019.0, Cited 62.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Hypoxia plays vital roles in the development of tumor resistance against typical anticancer therapies and local reoxygenation has proved effective to overcome the hypoxia-induced chemoresistance. Perfluorocarbon (PFC) is an FDA approved oxygen carrier and currently vigorously investigated for oxygen delivery to tumors. This study reports a perfluorocarbon and etoposide (EP) loaded porous hollow Fe3O4-based theranostic nanoplatform capable of delivering oxygen to solid tumors to enhance their susceptibility against EP. Results show that oxygen could be released at a moderate rate from the porous hollow magnetic Fe3O4 nanoparticles (PHMNPs) over an extended period of time, therefore effectively reducing the hypoxia-induced EP resistance of tumor cells. Moreover, the surface of PHMNPs was modified with lactobionic acid (LA)-containing amphiphilic polymers via hydrophobic interaction, which could provide targeting effect against certain types of tumors. The hydrophilic moiety would be subsequently shed by the intratumoral GSH after cellular internalization and result in the agglomeration of nanocarriers inside tumor cells, consequently impeding the nanoparticle exocytosis to enhance their intracellular retention. The enhanced retention could elevate the intracellular EP level and effectively boost the tumor cell killing effect. In addition to the therapeutic benefits, the Fe3O4 nanocage could also be used for the magnetic resonance imaging of the tumor area. The assorted benefits of the composite nanosystem are anticipated to be advantageous for the treatment of drug-resistant hypoxic tumors.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Zhou, J; Xue, CC; Hou, YH; Li, MH; Hu, Y; Chen, QF; Li, YA; Li, K; Song, GB; Cai, KY; Luo, Z or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Formula: C4H14Cl2N2S2. Recently I am researching about ELECTRON-TRANSFER; BISIMIDE DYES; FLUORESCENCE; ASSEMBLIES; DESIGN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21561162004, N_CityU113/15]; Hong Kong Research Grants CouncilHong Kong Research Grants Council [CityU 11300017, CityU 11300318, CityU T42-103/16-N]; City University of Hong KongCity University of Hong Kong; Hong Kong Research Grants CouncilHong Kong Research Grants Council. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

This communication reports novel luminescent rhenium(I)-polypyridine complexes appended with a perylene diimide (PDI) or benzoperylene monoimide (BPMI) moiety through a non-conjugated linker. The photophysical and photochemical properties originating from the interactions of the metal polypyridine and perylene units were exploited to afford new cellular reagents with thiol-sensing capability and excellent photocytotoxic activity.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Yip, AMH; Shum, J; Liu, HW; Zhou, HP; Jia, MQ; Niu, N; Li, YX; Yu, C; Lo, KKW or concate me.. Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Polythiolactone-Decorated Silica Particles: A Versatile Approach for Surface Functionalization, Catalysis and Encapsulation WOS:000645991700001 published article about POLYMERIC MULTILAYER CAPSULES; MESOPOROUS SILICA; THIOLACTONE CHEMISTRY; GOLD NANOPARTICLES; COLLOIDAL SILICA; DRUG CARRIER; ONE-POT; LIGHT; NANOSTRUCTURES; THERAPY in [Kurka, Dustin Werner; Niehues, Maximilian; Ravoo, Bart Jan] Westfalische Wilhelms Univ Munster, Inst Organ Chem, Ctr Soft Nanosci, Corrensstr 36, D-48149 Munster, Germany; [Kurka, Dustin Werner; Niehues, Maximilian; Ravoo, Bart Jan] Busso Peus Str 10, D-48149 Munster, Germany; [Kudruk, Sergej; Gerke, Volker] Westfalische Wilhelms Univ Munster, Inst Med Biochem, Ctr Mol Biol Inflammat, Von Esmarch Str 56, D-48149 Munster, Germany in 2021.0, Cited 98.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The surface chemistry of colloidal silica has tremendous effects on its properties and applications. Commonly the design of silica particles is based on their de novo synthesis followed by surface functionalization leading to tailormade properties for a specific purpose. Here, the design of robust precursor polymer-decorated silica nano- and microparticles is demonstrated, which allows for easy post-modification by polymer embedded thiolactone chemistry. To obtain this organic-inorganic hybrid material, silica particles (SiO2P) were functionalized via surface-initiated atom transfer radical polymerization (SI-ATRP) with poly(2-hydroxyethyl acrylate) (PHEA)-poly(thiolactone acrylamide (PThlAm) co-polymer brushes. Exploiting the versatility of thiolactone post-modification, a system was developed that could be used in three exemplary applications: 1) the straightforward molecular post-functionalization to tune the surface polarity, and therefore the dispersibility in various solvents; 2) the immobilization of metal nanoparticles into the polymer brushes via the in situ formation of free thiols that preserved catalytic activity in a model reaction; 3) the formation of redox-responsive, permeable polymer capsules by crosslinking the thiolactone moieties with cystamine dihydrochloride (CDH) followed by dissolution of the silica core.

SDS of cas: 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Kurka, DW; Niehues, M; Kudruk, S; Gerke, V; Ravoo, BJ or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about TUMOR MICROENVIRONMENT; FLUORESCENT-PROBE; NANOPARTICLES; ACTIVATION; SOFT, Saw an article supported by the National Funds for Distinguished Young Scientists [51725202]; Key Project of Shanghai Science and Technology CommissionScience & Technology Commission of Shanghai Municipality (STCSM) [19JC1412000]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51872094, 81974274]; National Science Foundation for the Young Scientists of China [51702211, 21805090]; National Key R&D Program of China [2018YFA0107900]; Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong. SDS of cas: 56-17-7. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Glutathione (GSH) plays a vital role in maintaining biological redox homeostasis. Accordingly, accurate imaging of glutathione in vivo is of great significance. Herein, we propose a magnetic resonance energy transfer (MRET) strategy based on a distance-dependent magnetic exchange coupling effect (MECE), which can realize GSH detection within tumors in vivo by susceptibility weighted imaging (SWI). Fe3O4 nanoparticles (NPs) and CoFe2O4 NPs linked with cystamine (Fe3O4-S-S-CoFe2O4) have been successfully designed as SWI nanoprobes. After the disulfide bonds are broken by excess GSH in the tumor, the increase in the distance between Fe3O4 NPs and CoFe2O4 NPs will induce a decrease of MECE and magnetic susceptibility. As a result, the changes in the SWI signals are used for tumor GSH detection in vivo. Experimental results in vitro and in vivo demonstrate that the Fe3O4-S-S-CoFe2O4 SWI nanoprobe can sensitively detect concentrations of GSH in tumors. Hence, this strategy not only improves the sensitivity of the GSH response in SWI but also provides a powerful basis for the design of other responsive functional MRI nanoprobes.

SDS of cas: 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, K; Zhang, HL; Shen, AJ; Zhao, PR; Meng, XF; Chen, XY; Liu, Y; Liu, YY; Gong, T; Wu, WL; Fang, XM; Wang, PJ; Bu, WB or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. In 2020.0 NANO LETT published article about ULTRASENSITIVE DETECTION; TUMOR MICROENVIRONMENT; PROTEIN-DETECTION; RATIONAL DESIGN; NANOPARTICLES; NANOMATERIALS; CELLS; STRATEGY; SIGNALS; PROBES in [Tang, Xiaoxue; Gong, Xuanqing; Li, Ao; Lin, Hongyu; Gao, Jinhao] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, MOE Lab Spectrochem Anal & Instrumentat, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China; [Tang, Xiaoxue; Gong, Xuanqing; Li, Ao; Lin, Hongyu; Gao, Jinhao] Xiamen Univ, Dept Biol Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China; [Peng, Chenyu; Zhang, Xianzhong] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Peoples R China; [Chen, Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA in 2020.0, Cited 54.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Molecular probes featuring promising capabilities including specific targeting, high signal-to-noise ratio, and in situ visualization of deep tissues are in great demand for tumor diagnosis and therapy. F-19 magnetic resonance imaging (MRI) techniques incorporating stimuli-responsive probes are anticipated to be highly beneficial for specific detection and imaging of tumors because of negligible background and deep tissue penetration. Herein, we report a cascaded multi-responsive self-assembled nanoprobe, which enables sequential redox-triggered and near-infrared (NIR) irradiation-induced F-19 MR signal activation/amplification for sensing and imaging. Specifically, we designed and synthesized a cascaded multiresponsive F-19-bearing nanoprobe based on the self-assembly of amphiphilic redox-responsive F-19-containing polymers and NIR-absorbing indocyanine green (ICG) molecules. It could realize the activation of F-19 signals in the reducing tumor microenvironment and subsequent signal amplification via the photothermal process. This stepwise two-stage activation/amplification of F-19 signals was validated by F-19 NMR and MRI both in vitro and in vivo. The multiresponsive F-19 nanoprobes capable of cascaded F-19 signal activation/amplification and photothermal effect exertion can provide accurate sensing and imaging of tumors.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Tang, XX; Gong, XQ; Li, A; Lin, HY; Peng, CY; Zhang, XZ; Chen, XY; Gao, JH or concate me.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Zhou, J; Wu, RN; Chen, YR; Tan, YB in ELSEVIER published article about in [Zhou, Jing; Wu, Ruonan; Chen, Yanru; Tan, Yebang] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China; [Tan, Yebang] Shandong Univ, Key Lab Special Funct Aggregated Mat, Minist Educ, Jinan 250100, Peoples R China in 2021.0, Cited 42.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

A triply responsive amphiphilic polymer containing poly (ethylene glycol) (PEG) and pyrene linked by a disulfide bond (PEO-SS-PY) was synthesized. Benefiting from its amphiphilicity, PEO-SS-PY could self-assemble into 126 nm micelles in water. PEO-SS-PY with CB[7] forms a 1:1 pseudorotaxane polymer (PEO-SS-Py@CB[7]) in aqueous solution. After the formation of host-guest complex, the micelles size increased to 136 nm and the fluorescence emission intensity increased. Glutathione would break the disulfide bond, leading to the dissociation of the micelles. Spermine and adamantanamine hydrochloride would dissociate the host-guest complex, leading to change of micelle size and decrease of fluorescence intensity. More interestingly, this self-assembly micelle displayed highly sensitive response to Fe3+. Because the effective absorption of Fe3+ hindered the absorption of PEO-SS-Py@CB[7] at the excitation wavelength of 405 nm, Fe3+ distinctly quenched the fluorescence emission of PEO-SS-Py@CB[7], whereas, a very low changes of intensity was observed for other metal ions. Results of this paper provide a new idea for the combination of metal ion detection and controlled release.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Zhou, J; Wu, RN; Chen, YR; Tan, YB or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ in AMER CHEMICAL SOC published article about in [Zheng, Meng; Yang, Zhipeng; Wu, Haigang; Liu, Yang; Xia, Xue; Ruan, Weimin] Henan Univ, Henan & Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng 475004, Henan, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Zhang, Jinchao] Hebei Univ, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag, Coll Chem & Environm Sci,Minist Educ, Baoding 071002, Hebei, Peoples R China; [Chen, Shizhu; Yin, Huijun] Natl Inst Pharmaceut R&D Co Ltd, China Resources Pharmaceut Grp Ltd, Beijing 102206, Peoples R China; [Wright, Amanda; Lee, Albert] Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW 2109, Australia; [Lu, Jeng-Wei] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore; [Yin, Huijun] Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China; [Wang, Yingze] Hebei Univ Sci & Technol, Coll Biol Sci & Engn, Shijiazhuang 050018, Hebei, Peoples R China in 2019.0, Cited 38.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering RNA (siRNA) delivery system limits its clinical application. Here, we report a bioreducible and less-cationic siRNA delivery carrier by conjugating Zn(II)-dipicolylamine complexes (Zn-DPA) onto hyaluronic acid (HA) via a redox-sensitive disulfide (-SS-) linker. Such polymer conjugates can formulate stable siRNA nanomedicines via coordination between zinc ions of DPA and the anionic phosphate of siRNA. After the conjugates are taken up by cells, intracellular reduction stimulus subsequently triggers the release of siRNAs and elucidates the desired RNAi effect. Our studies showed the formulated siRNA nanomedicines can be efficiently delivered into tumor cells/tissues and mediates less cytotoxicities both in vitro and in vivo. More importantly, when applied in a xenograft glioblastoma tumor model, this siRNA nanomedicine demonstrated significantly enhanced antitumor ability comparing to naked siRNA. This work demonstrates that such bioreducible Zn-DPA-functionalized HA conjugates without using cationic material as a siRNA carrier represents a promising direction for RNAi-based cancer therapy.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ or concate me.. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem