Day: October 25, 2021

HPLC of Formula: C4H14Cl2N2S2. I found the field of Engineering; Materials Science very interesting. Saw the article Simultaneous reduction and surface functionalization of graphene oxide by cystamine dihydrochloride for rubber composites published in 2019.0, Reprint Addresses Xia, HS (corresponding author), Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

The simultaneous reduction and functionalization of graphene oxide (GO) was achieved through a chemical grafting reaction with cystamine dihydrochloride (CDHC), a novel functional agent with dynamic disulfide bond. CDHC-reduced GO (CGO) can be uniformly and stably dispersed in the aqueous phase. Furthermore, CGO reinforced styrene-butadiene rubber (SBR) composites with highly filled silica content were prepared by a latex mixing and coagulation process. TEM confirmed both CGO and silica can be uniformly dispersed in the rubber matrix. The dynamic disulfide bonds of the grafted CDHC in the CGO can participate in the subsequent vulcanization of SBR rubber through disulfide exchange reactions, thereby forming a tight interaction between GO and rubber. Compared with normally reduced GO system, the mechanical and thermal properties of CGOcontaining rubber nanocomposites were significantly improved. The results show that CGO is effective to reinforce rubber composites, which has the potential to be used for tire rubber materials.

HPLC of Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, J; Fei, GX; Pan, YQ; Zhang, KY; Hao, S; Zheng, Z; Xia, HS or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2019.0 ANN FAM MED published article about STAR-ASTERISK-D; MENTAL-HEALTH; LARGE-SCALE; DISORDER; EPIDEMIOLOGY; CLINICIAN; QUESTIONNAIRE; VALIDATION; INSTRUMENT; CITALOPRAM in [Jha, Manish K.; Grannemann, Bruce D.; Trombello, Joseph M.; Clark, E. Will; Eidelman, Sara Levinson; Greer, Tracy L.; Trivedi, Madhukar H.] Univ Texas Southwestern Med Ctr Dallas, Ctr Depress Res & Clin Care, 5323 Harry Hines Blvd, Dallas, TX 75390 USA; [Jha, Manish K.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA; [Jha, Manish K.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA; [Rush, A. John] Duke Natl Univ Singapore, Singapore, Singapore; [Rush, A. John] Duke Med Sch, Dept Psychiat, Durham, NC USA; [Rush, A. John] Texas Tech Univ, Hlth Sci Ctr, Permian Basin, TX USA in 2019.0, Cited 43.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Formula: C4H14Cl2N2S2

PURPOSE This report describes outcomes of an ongoing quality-improvement project (VitalSign6) in a large US metropolitan area to improve recognition, treatment, and outcomes of depressed patients in 16 primary care clinics (6 charity clinics, 6 federally qualified health care centers, 2 private clinics serving low-income populations, and 2 private clinics serving patients with either Medicare or private insurance). METHODS Inclusion in this retrospective analysis was restricted to the first 25,000 patients (aged >= 12 years) screened with the 2-item Patient Health Questionnaire (PHQ-2) in the aforementioned quality-improvement project. Further evaluations with self-reports and clinician assessments were recorded for those with positive screen (PHQ-2 >2). Data collected from August 2014 though November 2016 were available at 3 levels: (1) initial PHQ-2 (n = 25,000), (2) positive screen (n = 4,325), and (3) clinician-diagnosed depressive disorder with 18 or more weeks of enrollment (n = 2,160). RESULTS Overall, 17.3% (4,325/25,000) of patients screened positive for depression. Of positive screens, 56.1% (2,426/4,325) had clinician-diagnosed depressive disorder. Of those enrolled for 18 or more weeks, 64.8% were started on measurement-based pharmacotherapy and 8.9% referred externally. Of the 1,400 patients started on pharmacotherapy, 45.5%, 30.2%, 12.6%, and 11.6% had 0, 1, 2, and 3 or more follow-up visits, respectively. Remission rates were 20.3% (86/423), 31.6% (56/177), and 41.7% (68/163) for those with 1, 2, and 3 or more follow-up visits, respectively. Baseline characteristics associated with higher attrition were: non-white, positive drug-abuse screen, lower depression/anxiety symptom severity, and younger age. CONCLUSION Although remission rates are high in those with 3 or more followup visits after routine screening and treatment of depression, attrition from care is a significant issue adversely affecting outcomes.

Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Jha, MK; Grannemann, BD; Trombello, JM; Clark, EW; Eidelman, SL; Lawson, T; Greer, TL; Rush, AJ; Trivedi, MH or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Computed Properties of C4H14Cl2N2S2. Authors Gote, V; Sharma, AD; Pal, D in MDPI published article about in [Gote, Vrinda; Sharma, Amar Deep; Pal, Dhananjay] Univ Missouri, Sch Pharm, Div Pharmacol & Pharmaceut Sci, 2464 Charlotte St, Kansas City, MO 64108 USA in 2021.0, Cited 50.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Active targeting and overcoming multi-drug resistance (MDR) can be some of the important attributes of targeted therapy for metastatic breast cancer (MBC) and triple-negative breast cancer (TNBC) treatment. In this study, we constructed a hyaluronic acid (HA)-decorated mixed nanomicelles-encapsulating chemotherapeutic agent paclitaxel (PTX) and P-glycoprotein inhibitor ritonavir (RTV). HA was conjugated to poly (lactide) co-(glycolide) (PLGA) polymer by disulfide bonds (HA-ss-PLGA). HA is a natural ligand for CD44 receptors overexpressed in breast cancer cells. Disulfide bonds undergo rapid reduction in the presence of glutathione, present in breast cancer cells. The addition of RTV can inhibit the P-gp and CYP3A4-mediated metabolism of PTX, thus aiding in reversing MDR and sensitizing the cells toward PTX. An in vitro uptake and cytotoxicity study in MBC MCF-7 and TNBC MDA-MB-231 cell lines demonstrated the effective uptake of the nanomicelles and drug PTX compared to non-neoplastic breast epithelium MCF-12A cells. Interestingly, in vitro potency determination showed a reduction in mitochondrial membrane potential and reactive oxygen species in breast cancer cell lines, indicating effective apoptosis of cancer cells. Thus, stimuli-sensitive nanomicelles along with HA targeting and RTV addition can effectively serve as a chemotherapeutic drug delivery agent for MBC and TNBC.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Gote, V; Sharma, AD; Pal, D or concate me.. Computed Properties of C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recommanded Product: 56-17-7. Dong, JC; Liu, BY; Ding, HN; Shi, JB; Liu, N; Dai, B; Kim, I in [Dong, Jincheng; Liu, Binyuan; Ding, Huining] Hebei Univ Technol, Sch Chem Engn & Technol, Hebei Key Lab Funct Polymer, Tianjin 300130, Peoples R China; [Liu, Binyuan; Shi, Junbin; Liu, Ning; Dai, Bin] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China; [Kim, Il] Pusan Natl Univ, Dept Polymer Sci & Engn, Busandaehag Ro 63-2, Busan 46241, South Korea published Bio-based healable non-isocyanate polyurethanes driven by the cooperation of disulfide and hydrogen bonds in 2020.0, Cited 57.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

A series of isocyanate-free polyurethanes (NIPUs), showing an intrinsic thermo-healing performance, have been synthesized from sustainable vegetable oil-based cyclic carbonates and bio-based amines. The bio-based contents of the NIPUs are higher than 78%. Their thermo-mechanical and self-healing performances are tailored simply by varying the feed ratios of the amines employed. The biomass linoleic acid dimer-based diamine plays a positive role in maintaining the higher thermal stability and good elasticity of the prepared NIPUs, the cycloaliphatic isophorone diamine contributes to high tensile strength, and cysteine-derived disulfide-containing cystamine (CA) enhances the self-healing efficiency. The combination of intrinsic hydrogen bonds existed in the NIPU matrix with the dynamic exchange reactions of disulfide bonds and the enhanced flexibility of NIPU networks results in 98.1% self-healing efficiency at 25 degrees C. The contributions of disulfide bonds and hydrogen bonds to the healing efficiency were estimated by adjusting the composition of NIPUs, showing that the contribution of disulfide bonds to the healing ability is about 45.3% even at a low amount of CA (6.0 wt%).

Recommanded Product: 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Dong, JC; Liu, BY; Ding, HN; Shi, JB; Liu, N; Dai, B; Kim, I or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Dosta, P; Ferber, S; Zhang, Y; Wang, K; Ros, A; Uth, N; Levinson, Y; Abraham, E; Artzi, N in WILEY published article about MESENCHYMAL STEM-CELLS; OPTIMIZATION; CULTURE; DIFFERENTIATION; EXPANSION; SYSTEM; GROWTH; HMSCS in [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA; [Dosta, Pere; Ferber, Shiran; Zhang, Yi; Wang, Kui; Ros, Albert; Artzi, Natalie] Harvard Med Sch, Brigham & Womens Hosp, Div Engn Med, Dept Med, Boston, MA 02115 USA; [Uth, Nicholas; Levinson, Yonatan; Abraham, Eytan] Res & Technol, Walkersville, MD USA; [Artzi, Natalie] Broad Inst Harvard & MIT, Cambridge, MA USA in 2020.0, Cited 33.0. Formula: C4H14Cl2N2S2. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Microcarriers, including crosslinked porous gelatin beads (Cultispher G) are widely used as cell carriers for cell therapy applications. Microcarriers can support a range of adherent cell types in stirred tank bioreactor culture, which is scalable up to several thousands of liters. Cultispher G in particular is advantageous for cell therapy applications because it can be dissolved enzymatically, and thus cells can be harvested without the need to perform a large-scale cell-bead filtration step. This enzymatic dissolution, however, is challenged by the slow degradation of the carriers in the presence of enzymes as new extracellular matrix is being deposited by the proliferating cells. This extended dissolution timelimits the yield of cell recovery while compromising cellular viability. We report herein the development of crosslinked porous gelatin beads that afford rapid, stimuli-triggered dissolution for facile cell removal using human mesenchymal stem cells (hMSC) as a model system. We successfully fabricated redox-sensitive beads (RS beads) and studied their cell growth, dissolution time and cell yield, compared to regular gelatin-based beads (Reg beads). We have shown that RS beads allow for much faster dissolution compared to Reg beads, supporting better hMSC detachment and recovery following 8 days of culture in spinner flasks, or in 3L bioreactors. These newly synthesized RS beads show promise as cellular microcarriers and can be used for scale-up manufacturing of different cell types while providing on-demand degradation for facile cell retrieval.

Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Dosta, P; Ferber, S; Zhang, Y; Wang, K; Ros, A; Uth, N; Levinson, Y; Abraham, E; Artzi, N or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. Authors Moon, JD; Sujanani, R; Geng, ZS; Freeman, BD; Segalman, RA; Hawker, CJ in AMER CHEMICAL SOC published article about in [Moon, Joshua D.; Geng, Zhishuai; Segalman, Rachel A.; Hawker, Craig J.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA; [Sujanani, Rahul; Freeman, Benny D.] Univ Texas Austin, John J McKetta Jr Dept Chem Engn, Austin, TX 78712 USA; [Segalman, Rachel A.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA; [Hawker, Craig J.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA in 2021.0, Cited 52.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

Poly(ethylene glycol) (PEG) diacrylate copolymer networks containing pentafluorophenyl active esters can be quantitatively substituted with a wide variety of primary amines, enabling the development of a versatile synthetic platform for the preparation of polymer hydrogel and membrane libraries. By tuning the starting network, a high degree of control over cross-linking density, water uptake, and functional group incorporation can be reproducibly achieved, which is vital for elucidating structure-property relationships in ion transporting membranes. From the same cross-linked scaffold, a diversity of basic, acidic, and solute-chelating moieties were obtained through functionalization, which allows for tailored uptake of basic and acidic organic dyes and metal chloride salts. Ion permeation and sorption measurements for a series of polymer networks with controlled cross-linking density and varied imidazole grafting densities illustrate the ability of this platform to isolate the effect of chemical functionality on ion transport from the effects of cross-linking density and water content.

SDS of cas: 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Moon, JD; Sujanani, R; Geng, ZS; Freeman, BD; Segalman, RA; Hawker, CJ or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. Recently I am researching about TARGETED DELIVERY; COMBINATION THERAPY; DRUG CONJUGATE; CO-DELIVERY; LIGAND; DOXORUBICIN; PACLITAXEL; TUMOR; APOPTOSIS; EFFICACY, Saw an article supported by the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [1R15CA188847-01A1, 1R01AG054839-01A1, 5P20GM109091]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Sui, BL; Cheng, C; Wang, MM; Hopkins, E; Xu, PS. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Clinical application of drug cocktails for cancer therapy is limited by their severe systemic toxicity. To solve a catch-22 dilemma between safety and efficacy for drug cocktails, a heterotargeted nanococktail (PPPDMA) with traceless linkers is developed. In the PPPDMA nanogel, a heterotargeting strategy is employed to improve its tumor selective targeting efficacy by overcoming the cancer cell monoligand density limitation. Benefitting from its glutathione and reactive oxygen species responsiveness, the loaded paclitaxel and doxorubicin can be quickly and tracelessly released into the cytoplasm in their original form, which bestows upon PPPDMA nanogels the capability to overwhelm the processing capacity of the cancer cell’s P-glycoprotein efflux pump, and ultimately kill them without inducing side effects. The PPPDMA treatment reduced its tumor burden over 99% (in tumor weight) and 96% (in tumor number). Most importantly, no detectable tumor in more than half of the PPPDMA treated mice was observed. It is concluded that traceless linker and heterotargeted nanococktail strategy can be a safe and effective approach for cancer treatment.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Sui, BL; Cheng, C; Wang, MM; Hopkins, E; Xu, PS or concate me.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Wang, F; Zhang, Q; Huang, KX; Li, JR; Wang, K; Zhang, K; Tang, XY in ELSEVIER published article about FACILE FABRICATION; HYDROGEL FILMS; DELIVERY; PH; MICELLES; RELEASE in [Wang, Fang; Zhang, Qian; Huang, Kexin; Li, Jiarui; Wang, Kun; Zhang, Kai; Tang, Xinyue] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China; [Wang, Fang] Jiangsu Key Lab Chem & Utilizat Agr & Forest Biom, Nanjing, Jiangsu, Peoples R China in 2020.0, Cited 51.0. Recommanded Product: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

The objective of this study was to synthesize and characterize cystamine dihydrochloride (CYS) crosslinked carboxymethyl cellulose/quaternized chitosan (CMC/HACC) composite hydrogel film. Firstly, the glycidyl-based quaternary ammonium chitosan derivative (HACC) was synthesized using nucleophilic substitution reaction. Then HACC was analyzed by FTIR, (HNMR)-H-1 spectra and the composite films at different blending ratio of CMC and HACC were studied by rheology measurement, mechanical and swelling tests. When the composite films were prepared under optimized conditions (CMC: HACC = 7:1), they showed excellent mechanical properties (with improved 93.3% tensile strength and 2.3% elongation at break) and swellability (equilibrium swelling ratio increased 270%) compared to pure CMC film. 5-Fluorouracil (5-FU) was used as drug model which has broad-spectrum anticancer properties. The 5-FU/CMC/HACC composite films showed redox and pH responsive of drug release properties along with well biocompatibility. The in vitro cytotoxicity and cell apoptosis studies showed the drug loaded composite films with obvious toxicity against HepG2 cells especially in the presence of GSH. In addition, CMC/HACC composite films showed good antibacterial against S. aureus and E. coli, while pure CMC film had no antimicrobial activities. It can be concluded that CMC/HACC composite films can be potentially used as targeted drug delivery system. (C) 2019 Elsevier B.V. All rights reserved.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, F; Zhang, Q; Huang, KX; Li, JR; Wang, K; Zhang, K; Tang, XY or concate me.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry; Polymer Science very interesting. Saw the article Redox-responsive blend hydrogel films based on carboxymethyl cellulose/chitosan microspheres as dual delivery carrier published in 2019.0. COA of Formula: C4H14Cl2N2S2, Reprint Addresses Wang, F (corresponding author), Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A simple method to fabricate redox-responsive composite hydrogel films via incorporating chitosan (CS) micro spheres into carboxymethyl cellulose (CMC) hydrogel using a di-sulphide cross-linker cystamine dihydrochloride (CYS) have done in this paper. Dual drugs, an anticancer, 5-Fluorouracil (5-FU) and an antibiotic, Tetracycline Hydrochloride (TH) were used as model drugs. The prepared composite hydrogel films were characterized using FTIR, SEM, rheology measurement, mechanical and swelling tests. Our results showed that the well dispersed spherical CS microspheres endowed hydrogel film increased mechanical properties and swellability. In vitro drug release displayed an accelerated release under weak acidic or reducing media. The in vitro cytotoxicity and cell apoptosis studies showed the drug-loaded composite film caused enhanced inhibition to HepG2 cells in presence of glutathione (GSH). Moreover, the film has exhibited excellent antimicrobial efficacy against E.coli and Staphylococcus aureus. Therefore, our simple and effective dual drug-loaded system has the potential to be used for cancer therapy in the future. (C) 2019 Elsevier B.V. All rights reserved.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, F; Zhang, Q; Li, XX; Huang, KX; Shao, W; Yao, DW; Huang, CB or concate me.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

SDS of cas: 56-17-7. Recently I am researching about NANOPARTICLES; MICELLE; RELEASE, Saw an article supported by the National Research Foundation of KoreaNational Research Foundation of Korea [NRF-2019R1A4A1024116, NRF-2019R1A2C2085962, NRF-2018M3A9E2024583]; Korea Research Institute of Bioscience & Biotechnology (KRIBB). Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Jeong, C; Kim, J; Kim, YC. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

A multifunctional drug delivery system (MDDS) based on near-infrared (NIR) imaging was developed in various conformations for the accurate diagnosis and therapy of cancer. However, it remains challenging to develop an ideal structure for an MDDS with both exact and variable functionality. Herein, we report a fluorescence color-changeable branched-form heptamethine cyanine dye (PEG-4-CyP) that has both a simple structure and various functionality. The PEG-4-CyP was not only able to construct the nanoparticle (NP) structure by encapsulating DOX (PEG-4-CyP/DOX), but also showed change in the NIR fluorescence color by reacting with glutathione (GSH). The PEG-4-CyP/DOX was broken down in the redox microenvironment inside cancers because of the reduction reaction of PEG-4-CyP to GSH. As a result, the NP disruption, DOX release, and reactivity of PEG-4-CyP to GSH were visualized by NIR fluorescence color-change. Moreover, PEG-4-CyP/DOX showed an excellent chemophototherapeutic effect in cancer cells. This NIR fluorescence color-change strategy demonstrates the applicability of PEG-4-CyP as a novel MDDS able to provide a variety of information with a simple NP structure. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Jeong, C; Kim, J; Kim, YC or concate me.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem