Day: October 20, 2021

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Yeh, CM; Lin, CH; Han, TY; Xiao, YT; Chen, YA; Chou, HH in ROYAL SOC CHEMISTRY published article about in [Yeh, Chun-Ming; Lin, Chun-Hsiu; Han, Tzung-You; Xiao, Yu-Ting; Chen, Yi-An; Chou, Ho-Hsiu] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan in 2021.0, Cited 62.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

For next-generation electronics, it is crucial to be able to accurately mimic the nature of human skin and develop skin-inspired materials and devices for electronic skin (e-skin) applications. However, it is a great challenge to design such a materials because they require the complex integration of stretchability, skin adhesiveness, transparency, healability, and tactile sensing. Herein, we present the first dual covalently reversible dynamic bond-based polymer that can be integrated with various functional materials and used as a skin-like sensor. A series of polymers was designed using polypropylene glycol (PPG)-based polyurethane (PU) as the polymer backbone, and these polymers could integrate two types of covalent reversible dynamic bonds, Diels-Alder and disulfide bonds, in one polymer for the first time. Based on our design, a polymer was created with the advantages of high stretchability, fast healing abilities (60 degrees C, 5 min), skin adhesion, recyclability, high transparency, and tactile sensing abilities. We provide an alternative strategy for the construction of skin-inspired multifunctional materials for e-skin applications.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Yeh, CM; Lin, CH; Han, TY; Xiao, YT; Chen, YA; Chou, HH or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. Authors Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ in AMER CHEMICAL SOC published article about in [Zheng, Meng; Yang, Zhipeng; Wu, Haigang; Liu, Yang; Xia, Xue; Ruan, Weimin] Henan Univ, Henan & Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng 475004, Henan, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Liang, Xing-Jie] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China; [Chen, Shizhu; Zhang, Jinchao] Hebei Univ, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag, Coll Chem & Environm Sci,Minist Educ, Baoding 071002, Hebei, Peoples R China; [Chen, Shizhu; Yin, Huijun] Natl Inst Pharmaceut R&D Co Ltd, China Resources Pharmaceut Grp Ltd, Beijing 102206, Peoples R China; [Wright, Amanda; Lee, Albert] Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW 2109, Australia; [Lu, Jeng-Wei] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore; [Yin, Huijun] Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China; [Wang, Yingze] Hebei Univ Sci & Technol, Coll Biol Sci & Engn, Shijiazhuang 050018, Hebei, Peoples R China in 2019.0, Cited 38.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering RNA (siRNA) delivery system limits its clinical application. Here, we report a bioreducible and less-cationic siRNA delivery carrier by conjugating Zn(II)-dipicolylamine complexes (Zn-DPA) onto hyaluronic acid (HA) via a redox-sensitive disulfide (-SS-) linker. Such polymer conjugates can formulate stable siRNA nanomedicines via coordination between zinc ions of DPA and the anionic phosphate of siRNA. After the conjugates are taken up by cells, intracellular reduction stimulus subsequently triggers the release of siRNAs and elucidates the desired RNAi effect. Our studies showed the formulated siRNA nanomedicines can be efficiently delivered into tumor cells/tissues and mediates less cytotoxicities both in vitro and in vivo. More importantly, when applied in a xenograft glioblastoma tumor model, this siRNA nanomedicine demonstrated significantly enhanced antitumor ability comparing to naked siRNA. This work demonstrates that such bioreducible Zn-DPA-functionalized HA conjugates without using cationic material as a siRNA carrier represents a promising direction for RNAi-based cancer therapy.

Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Zheng, M; Yang, ZP; Chen, SZ; Wu, HG; Liu, Y; Wright, A; Lu, JW; Xia, X; Lee, A; Zhang, JC; Yin, HJ; Wang, YZ; Ruan, WM; Liang, XJ or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Huang, YW; Li, YZ; Tang, ZL; Su, QP; Liao, TT; Gu, YX; Lin, XF; Zu, XH; Lin, WJ; Yi, GB in [Huang, Yunwei; Li, Yanzhe; Tang, Zilun; Su, Qiuping; Liao, Tingting; Lin, Xiaofeng; Zu, Xihong; Lin, Wenjing; Yi, Guobin] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China; [Gu, Yuxin] Guangzhou Kinte Ind Co Ltd, Guangdong Prov Key Lab Adv Coatings Res & Dev, Guangzhou 510300, Peoples R China published Dual-Responsive Cross-Linked Micelles from Amphiphilic Four-Arm Star Copolymers with Different Block Ratios for Triggering DOX Release in 2020.0, Cited 33.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

The four-arm star copolymers poly(methacrylic acid)-poly(2-hydroxyethyl methacrylate-disulfide similar to)-poly(poly(ethylene glycol) methyl ether methacrylate) (4AS-PMAA(x)-(PHEMA-SS similar to)(y)-PPEGMA(z)) with four different block ratios were synthesized and could self-assembled into cross-linked polymer micelles for the exploration of the structure-property relationship. The cross-linked polymer micelles in aqueous solution had low critical micelle concentration (CMC) values (1.9-4.6 mg/L), which exhibited better stability than non-cross-linked micelles. The CMC value decreased with the increase of the length of inner PMAA core and hydrophobic PHEMA cross-linked middle layer. The blank and doxorubicin (DOX)-loaded micelles with different block ratios were prepared by dialysis with the particle sizes of 120-240 nm. The longer inner PMAA core and cross-linked middle layer enhanced the drug loading content (DLC) results and led to relatively bigger particle sizes of polymer micelles. The in vitro DOX release data revealed that DOX-loaded micelles had low DOX cumulative release percentages of 18-37% after 110 h at pH 7.4, but up to 83-90% when introducing reductant GSH at pH 5.0. The 4AS-PMAA(21.2)-(PHEMASS approximate to)(13.1)-PPEGMA(5.1) micelles with the longest PMAA core had the largest cumulative release of 90.1%. The DOX release process and mechanism of the micelles at different conditions fitted well with the semi-empirical equation. Overall, the results demonstrated that the block ratios and pH/redox-responsiveness of these four-arm star copolymers could be well-controlled and their self-assembled cross-linked micelles as anticancer drug carrier system could be improved by optimizing the different ratios.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Huang, YW; Li, YZ; Tang, ZL; Su, QP; Liao, TT; Gu, YX; Lin, XF; Zu, XH; Lin, WJ; Yi, GB or concate me.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Authors Lee, JP; Hwang, H; Chae, S; Kim, JM in ROYAL SOC CHEMISTRY published article about BONDS; FILMS in [Lee, Jong Pil; Hwang, Hyemin; Chae, Songa; Kim, Jong-Man] Hanyang Univ, Dept Chem Engn, Seoul 04763, South Korea; [Kim, Jong-Man] Hanyang Univ, Inst Nano Sci & Technol, Seoul 04763, South Korea in 2019.0, Cited 35.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

A reversibly mechanochromic conjugated polymer has been developed. The polymer, polydiacetylene (PDA), obtained by thermal polymerization of a diphenyldisulfide-containing bisdiacetylene undergoes a blue-to-green color change upon grinding. The original blue color of the PDA is regenerated via a metastable red-color state by utilizing a thermochromic (heating-cooling) process.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Lee, JP; Hwang, H; Chae, S; Kim, JM or concate me.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Modular core-shell polymeric nanoparticles mimicking viral structures for vaccination published in 2019.0. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Hennink, WE (corresponding author), Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CG Utrecht, Netherlands.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Recent advances in the development of protein-based vaccines have expanded the opportunities for preventing and treating both infectious diseases as well as cancer. However, the development of readily and efficient antigen delivery systems capable of stimulating strong cytotoxic T-lymphocyte (CTL) responses remains a challenge. With the attempt to closely mimic the properties of viruses in terms of their size and molecular organization, we constructed RNA (which is a ligand for Toll-like receptor 7 (TLR7) and TLR8) and antigen-loaded nanoparticles resembling the structural organization of viruses. Cationic polymers containing either azide or bicyclo[6.1.0]nonyne (BCN) groups were synthesized as electrostatic glue that binds negatively charged single stranded RNA (PolyU) to form a self-crosslinked polyplex core. An azide-modified model antigen (ovalbumin, OVA) and a BCN-modified mannosylated or galactosylated polymer were sequentially conjugated to the RNA core via disulfide bonds using copper free click chemistry to form the shell of the polyplexes. The generated reducible virus mimicking particles (VMPs) with a diameter of 200 nm and negatively surface charge (-14 mV) were colloidally stable in physiological conditions. The immunogenicity of these VMP vaccines was evaluated both in vitro and in vivo. The surface mannosylated VMPs (VMP-Man) showed 5 times higher cellular uptake by bone marrow derived DCs (BMDCs) compared to galactosylated VMP (VMP-Gal) counterpart. Moreover, VMP-Man efficiently activated DCs and greatly facilitated MHC I Ag presentation in vitro. Vaccination of mice with VMP-Man elicited strong OVA-specific CTL responses as well as humoral immune responses. These results demonstrate that the modular core-shell polymeric nanoparticles described in this paper are superior in inducing strong and durable immune responses compared to adjuvanted protein subunit vaccines and offer therefore a flexible platform for personalized vaccines.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Lou, B; De Beuckelaer, A; Boonstra, E; Li, DD; De Geest, BG; De Koker, S; Mastrobattista, E; Hennink, WE or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

An article Experimental and Theoretical Studies on a Simple S-S-Bridged Dimeric Schiff Base: Selective Chromo-Fluorogenic Chemosensor for Nanomolar Detection of Fe2+ & Al3+ Ions and Its Varied Applications WOS:000514827200057 published article about FLUORESCENCE TURN-ON; MOLECULAR-STRUCTURE; LIVING CELLS; COLORIMETRIC SENSOR; ALZHEIMERS-DISEASE; REVERSIBLE SENSOR; IRON-METABOLISM; AQUEOUS-MEDIA; ALUMINUM IONS; LUMO ANALYSIS in [Devi, Duraisamy Parimala; Abiram, Angamuthu] Karunya Inst Technol & Sci Deemed Be Univ, Dept Phys, Coimbatore 641114, Tamil Nadu, India; [David, Charles Immanuel; Bhuvanesh, Nanjan; Jayaraj, Haritha; Prabhu, Jeyaraj; Nandhakumar, Raju] Karunya Inst Technol & Sci Deemed Be Univ, Dept Chem, Coimbatore 641114, Tamil Nadu, India; [Thamilselvan, Annadurai] CSIR, Electro Organ Div, Cent Electrochem Res Inst, CECRI, Karaikkudi 630003, Tamil Nadu, India in 2020.0, Cited 105.0. SDS of cas: 56-17-7. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7

A simple S-S (disulfide)-bridged dimeric Schiff base probe, L, has been designed, synthesized, and successfully characterized for the specific recognition of Al3+ and Fe2+ ions as fluorometric and colorimetric turn-on responses in a dimethylformamide (DMF)-H2O solvent mixture, respectively. The probe L and each metal ion bind through a 1:1 complex stoichiometry, and the plausible sensing mechanism is proposed based on the inhibition of the photoinduced electron transfer process (PET). The reversible chemosensor L showed high sensitivity toward Al3+ and Fe2+ ions, which was analyzed by fluorescence and UV-vis spectroscopy techniques up to nanomolar detection limits, 38.26 X 10(-9) and 17.54 x 10(-9) M, respectively. These experimental details were advocated by density functional theory (DFT) calculations. The practical utility of the chemosensor L was further demonstrated in electrochemical sensing, in vitro antimicrobial activity, molecular logic gate function, and quantification of the trace amount of Al3+ and Fe2+ ions in real water samples.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact David, CI; Bhuvanesh, N; Jayaraj, H; Thamilselvan, A; Devi, DP; Abiram, A; Prabhu, J; Nandhakumar, R or concate me.. SDS of cas: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Biswas, G; Jena, BC; Sahoo, S; Samanta, P; Mandal, M; Dhara, D in [Biswas, Gargi; Sahoo, Satyagopal; Samanta, Pousati; Dhara, Dibakar] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India; [Jena, Bikash Chandra; Mandal, Mahitosh] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India published A copper-free click reaction for the synthesis of redox-responsive water-soluble core cross-linked nanoparticles for drug delivery in cancer therapy in 2019.0, Cited 51.0. Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Polymer based core cross-linked nanoparticles (CCNPs) have generated a lot of interest as potential stimuli-responsive drug delivery systems. In the present work, we have synthesized smart redox-responsive water soluble polymeric CCNPs by cross-linking water-soluble PEG based copolymers with bis(acryloyl)cystamine via isoxazoline bond formation through a 1,3-dipolar cycloaddition reaction (click reaction) without using a copper catalyst, in a water-THF mixed solvent. The successful synthesis of CCNPs was confirmed by NMR, GPC and FT-IR measurements. Size distribution of the precursor copolymers and the CCNPs was determined by DLS measurement. AFM and FESEM images have confirmed globular morphology of these CCNPs. Their high stability in a physiological environment makes them effective as potent drug carriers with high loading capacity. MTT assays confirmed the biocompatibility of the synthesized CCNPs. Favourable cellular internalization of these DOX loaded CCNPs into cancer cells and redox-responsive release of DOX therefrom make these CCNP potentially smart vehicles to deliver anticancer drugs into cancer cells.

Recommanded Product: 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Biswas, G; Jena, BC; Sahoo, S; Samanta, P; Mandal, M; Dhara, D or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Xu, JW; Ma, SJ; Li, Y; Li, XW; Ou, JJ; Ye, ML in [Xu, Junwen; Ma, Shujuan; Li, Ya; Li, Xiaowei; Ou, Junjie; Ye, Mingliang] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China; [Xu, Junwen; Li, Xiaowei; Ou, Junjie; Ye, Mingliang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China published Thiol-functionalized PIM-1 for removal and sensing for mercury (II) in 2020.0, Cited 58.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Polymers of intrinsic microporosity (PIMs) are a class of microporous polymers with rigid and contorted molecular structures. The special structures lead to incomplete space occupation, and the pores of PIMs originate from the formed void. In this work, we made attempts to expand the applications of PIMs to the aspect of heavy metal removal. First, PIM-1 was synthesized using tetrafluoroterephthalonitrile (TFTPN) and 5,5′,6,6′-tetrahydroxy-3,3,3′,3′-tetramethyl-1,1′-spirobisindane (TTSBI) as precursors. The primary PIM-1 was quite hydrophobic, and thus could not be evenly dispersed in water, resulting in low adsorption capacity for mercury ions (Hg2+). A conversion of nitrile group in PIM-1 to thiol group was then carried out by two steps, namely carboxylation and introduction of thiol groups. The carboxylation made the polymers more active, and the final thiol-functionalization provided the polymers with hydrophilicity and affinity for Hg2+. The thiolethyl modified PIM-1 (assigned as PIM-G) and thiophenyl modified (assigned as PIM-B) possessed maximum Hg2+ adsorption capacity of 136 mg g(-1) and 127 mg g(-1) at pH 5, respectively. Besides, the thiol-functionalized PIMs had fluorescence property and showed potential in sensing for Hg2+.

Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Xu, JW; Ma, SJ; Li, Y; Li, XW; Ou, JJ; Ye, ML or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about GROWTH-FACTOR DELIVERY; OSTEOGENIC DIFFERENTIATION; TISSUE; SCAFFOLDS; BONE; CELL; CHITOSAN; FAK/MAPK; COMPOSITES; MORPHOLOGY, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31771040, 51621002]. Category: thiazines. Published in MDPI in BASEL ,Authors: Wang, LX; Dong, SY; Liu, YT; Ma, YF; Zhang, JJ; Yang, ZG; Jiang, W; Yuan, Y. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Injectable hydrogels have been widely applied in the field of regenerative medicine. However, current techniques for injectable hydrogels are facing a challenge when trying to generate a biomimetic, porous architecture that is well-acknowledged to facilitate cell behaviors. In this study, an injectable, interconnected, porous hyaluronic acid (HA) hydrogel based on an in-situ bubble self-generation and entrapment process was developed. Through an amide reaction between HA and cystamine dihydrochloride activated by EDC/NHS, CO2 bubbles were generated and were subsequently entrapped inside the substrate due to a rapid gelation-induced retention effect. HA hydrogels with different molecular weights and concentrations were prepared and the effects of the hydrogel precursor solution’s concentration and viscosity on the properties of hydrogels were investigated. The results showed that HA10-10 (10 wt.%, MW 100,000 Da) and HA20-2.5 (2.5 wt.%, MW 200,000 Da) exhibited desirable gelation and obvious porous structure. Moreover, HA10-10 represented a high elastic modulus (32 kPa). According to the further in vitro and in vivo studies, all the hydrogels prepared in this study show favorable biocompatibility for desirable cell behaviors and mild host response. Overall, such an in-situ hydrogel with a self-forming bubble and entrapment strategy is believed to provide a robust and versatile platform to engineer injectable hydrogels for a variety of applications in tissue engineering, regenerative medicine, and personalized therapeutics.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, LX; Dong, SY; Liu, YT; Ma, YF; Zhang, JJ; Yang, ZG; Jiang, W; Yuan, Y or concate me.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. In 2019.0 POLYM CHEM-UK published article about SIRNA DELIVERY; TEMPERATURE; MICELLES; TARGET; NANOPARTICLE; CD44 in [Chen, Jiaojiao; Wu, Ming; Veroniaina, Hanitrarimalala; Mukhopadhyay, Subhankar; Li, Juequan; Wu, Zhenghong; Qi, Xiaole] China Pharmaceut Univ, Key Lab Modern Chinese Med, Nanjing 21000, Jiangsu, Peoples R China; [Chen, Jiaojiao] Yantai Yuhuangding Hosp, Yantai 264000, Peoples R China; [Wu, Ziheng] Monash Univ, Parkville Campus, Parkville, Vic 3052, Australia in 2019.0, Cited 31.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Recently, interest in stimuli-responsive core-shell nanogels as drug delivery systems for tumor therapy has increased. Here, a temperature-activated drug locking and glutathione-triggered drug unlocking nanogel is designed, which is composed of hyaluronic acid (HA) conjugated with poly(N-isopropylacrylamide) (PNIPAAm) using a disulfide bond as the linker (HA-SS-PNIPAAm, H-SS-P). After injection into the systemic circulation, these synthetic copolymers endure temperature-motivated lock behaviors to form nanogels due to the thermosensitive lipophilic transformation of PNIPAAm, accompanied by doxorubicin (DOX) locking into the cavities of the nanogels. When they reach tumor cells, these nanogels exhibit glutathione (GSH)-triggered opening behavior to unlock the drugs for tumor therapy. The transmission electron microscopy (TEM) results demonstrate that the H-SS-P copolymer solutions are irregular at room temperature, while spherical structures (similar to 30 nm) can be observed below 37 degrees C, but dissociate in the presence of 40 mM GSH. Based on flow cytometry and fluorescence microscopy analyses, observations reveal that H-SS-P@DOX nanogels are intracellularly taken up into human lung cancer cells (A549) via HA-receptor mediated endocytosis. More importantly, these nanogels possess much higher tumor targeting capacity than free DOX and efficiently enhance the antitumor effect with reduced systemic toxicity in 4T1 tumor-bearing mice.

Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Chen, JJ; Wu, M; Veroniaina, H; Mukhopadhyay, S; Li, JQ; Wu, ZH; Wu, ZH; Qi, XL or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem